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Yr Athro Robert Jones
Athro ac Ymgynghorydd mewn Oncoleg Feddygol
- JonesRH7@caerdydd.ac.uk
- +44 29208 79035
- Adeilad Syr Martin Evans, Rhodfa'r Amgueddfa, Caerdydd, CF10 3AX
- Sylwebydd y cyfryngau
Trosolwyg
Ar hyn o bryd rwy'n Arweinydd Treialon Canser Cyfnod Cynnar yng Nghymru, Cyfarwyddwr Meddygol Cyswllt RD&I yng Nghanolfan Ganser Felindre, ac rwy'n arweinydd Solid Tumour ar gyfer Canolfan Meddygaeth Canser Arbrofol Caerdydd. Cyrhaeddais Gaerdydd yn 2009, ar ôl ymgymryd â swydd Gwyddonydd Clinigwyr CRUK yn dilyn fy hyfforddiant Oncoleg Meddygol yn y Beatson yn Glasgow.
Sefydlais unig Uned Treialon Cam 1 Canser Cymru ac agorais ei gyntaf erioed mewn Treial Dynol ac arwain recriwtio byd-eang arno. Ar ôl esblygu o fan cychwyn sero mae gennym dîm o tua 20 aelod o staff erbyn hyn. Rwyf wedi bod yn Brif Ymchwilydd ar gyfer tua 40 o Dreialon Cyfnod Cynnar ac rwy'n Brif Ymchwilydd ar ddau dreial Portffolio Cenedlaethol dan Arweiniad Ymchwilydd, FAKTION a FURVA. Adroddwyd FURVA yng nghyfarfod Cymdeithas Oncoleg Feddygol Ewrop (2020) a FAKTION yng Nghymdeithas Oncoleg Glinigol America (Chicago 2019, a 2022). Derbyniodd FAKTION sylw sylweddol yn y cyfryngau ac mae llwyddiant y treial hwn wedi cyfrannu at gymhwysiad llwybr cyflym o inihibitor AKT dosbarth cyntaf i'r FDA. https://www.youtube.com/watch?v=4DkiQaKzAIg&feature=youtu.be
Cyhoeddiad
2024
- Fizazi, K. et al. 2024. Targeted inhibition of CYP11A1 in castration-resistant prostate cancer. NEJM Evidence 3(1) (10.1056/EVIDoa2300171)
2023
- Jones, R. H. et al. 2023. Safety and tolerability of long-term treatment with darolutamide in patients with metastatic castration-resistant prostate cancer. Prostate Cancer and Prostatic Diseases (10.1038/s41391-023-00740-9)
- Macaulay, V. M. et al. 2023. A Phase Ib/II study of IGF-neutralising antibody xentuzumab with enzalutamide in metastatic castration-resistant prostate cancer. British Journal of Cancer 129, pp. 965-973. (10.1038/s41416-023-02380-1)
- Beresford, M. et al. 2023. Fulvestrant plus vandetanib versus placebo for the treatment of patients with metastatic breast cancer resistant to aromatase inhibitor therapy (FURVA): a multicentre, Phase 2, randomised controlled trial. BJC Reports 1(1), article number: 13. (10.1038/s44276-023-00016-8)
- Glaviano, A. et al. 2023. PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer. Molecular Cancer 22, article number: 138. (10.1186/s12943-023-01827-6)
- Arana Echarri, A., Struszczak, L., Beresford, M., Campbell, J. P., Jones, R. H., Thompson, D. and Turner, J. E. 2023. Immune cell status, cardiorespiratory fitness and body composition among breast cancer survivors and healthy women: a cross sectional study. Frontiers in Physiology 14, article number: 1107070. (10.3389/fphys.2023.1107070)
- Kristeleit, R. et al. 2023. A Phase 1/2 trial of SRA737 (a Chk1 inhibitor) administered orally in patients with advanced cancer. British Journal of Cancer (10.1038/s41416-023-02279-x)
- Jones, R. et al. 2023. A Phase I/II trial of Oral SRA737 (a Chk1 Inhibitor) given in combination with low-dose gemcitabine in patients with advanced cancer. Clinical Cancer Research 29(2), pp. 331-340. (10.1158/1078-0432.CCR-22-2074)
2022
- Saad, F. et al. 2022. Patient-reported outcomes with olaparib plus abiraterone versus placebo plus abiraterone for metastatic castration-resistant prostate cancer: a randomised, double-blind, phase 2 trial. The Lancet Oncology 23(10), pp. 1297-1307. (10.1016/S1470-2045(22)00498-3)
- Banerjee, S. et al. 2022. A phase I trial of CT900, a novel α-folate receptor-mediated thymidylate synthase inhibitor, with expansion cohorts in patients with high grade serous ovarian cancer. Clinical Cancer Research 22, article number: 1268. (10.1158/1078-0432.CCR-22-1268)
- Howell, S. J. et al. 2022. Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive, HER2-negative breast cancer (FAKTION): overall survival, updated progression-free survival, and expanded biomarker analysis from a randomised, phase 2 trial. The Lancet Oncology 23(7), pp. 851-864. (10.1016/s1470-2045(22)00284-4)
2021
- Seligmann, J. F. et al. 2021. Inhibition of WEE1 is effective in TP53- and RAS-mutant metastatic colorectal cancer: a randomized trial (FOCUS4-C) comparing adavosertib (AZD1775) with active monitoring. Journal of Clinical Oncology 39(33), pp. 3705-3715. (10.1200/JCO.21.01435)
- Arana Echarri, A. et al. 2021. A phenomic perspective on factors influencing breast cancer treatment: integrating aging and lifestyle in blood and tissue biomarker profiling. Frontiers in Immunology 11, article number: 616188. (10.3389/fimmu.2020.616188)
2020
- Jones, R. H. et al. 2020. Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive breast cancer (FAKTION): a multicentre, randomised, controlled, phase 2 trial. Lancet Oncology 21(3), pp. 345-347. (10.1016/S1470-2045(19)30817-4)
- Hong, D. S. et al. 2020. Tisotumab vedotin in previously treated recurrent or metastatic cervical cancer. Clinical Cancer Research 26(6), pp. 1220-1228. (10.1158/1078-0432.CCR-19-2962)
- Peltola, K. J. et al. 2020. ODM-204, a novel dual Inhibitor of CYP17A1 and androgen receptor: early results from phase I dose escalation in men with castration-resistant prostate cancer. European Urology Focus 6(1), pp. 63-70. (10.1016/j.euf.2018.08.022)
2019
- de Bono, J. S. et al. 2019. Tisotumab vedotin in patients with advanced or metastatic solid tumours (InnovaTV 201): a first-in-human, multicentre, phase 1-2 trial. Lancet Oncology 20(3), pp. 383-393. (10.1016/S1470-2045(18)30859-3)
2018
- Basu, B. et al. 2018. Vistusertib (dual m-TORC1/2 inhibitor) in combination with paclitaxel in patients with high-grade serous ovarian and squamous non-small-cell lung cancer. Annals of Oncology 29(9), pp. 1918-1925. (10.1093/annonc/mdy245)
- Clarke, N. et al. 2018. Olaparib combined with abiraterone in patients with metastatic castration-resistant prostate cancer: a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Oncology 19(7), pp. 975-986. (10.1016/S1470-2045(18)30365-6)
2017
- Garcia Martin, I., Janssen, A., Jones, R., Grimstead, J. W., Penketh, R. J. A., Baird, D. M. and John, R. M. 2017. Telomere length heterogeneity in placenta revealed with high-resolution telomere length analysis. Placenta 59, pp. 61-68. (10.1016/j.placenta.2017.09.007)
- Scurr, M. et al. 2017. Effect of modified vaccinia Ankara–5T4 and low-dose cyclophosphamide on antitumor immunity in metastatic colorectal cancer: A randomized clinical trial. JAMA Oncology 3(10), article number: e172579. (10.1001/jamaoncol.2017.2579)
- Scurr, M. J. et al. 2017. Low-dose cyclophosphamide induces anti-tumor T-cell responses which associate with survival in metastatic colorectal cancer. Clinical Cancer Research, article number: clincanres.0895.2017. (10.1158/1078-0432.CCR-17-0895)
- Scurr, M. et al. 2017. MVA-5T4 immunotherapy and low-dose cyclophosphamide for advanced colorectal cancer (TaCTiCC): An open-label, randomized phase I/II trial.. Journal of Clinical Oncology 35(7), pp. 154-154. (10.1200/JCO.2017.35.7_suppl.154)
2016
- Reza, M. et al. 2016. Bone scan index and progression-free survival data for progressive metastatic castration-resistant prostate cancer patients who received ODM-201 in the ARADES multicentre study. European Urology Focus 2(5), pp. 547-552. (10.1016/j.euf.2016.01.005)
2014
- Fizazi, K. et al. 2014. Activity and safety of ODM-201 in patients with progressive metastatic castration-resistant prostate cancer (ARADES): an open-label phase 1 dose-escalation and randomised phase 2 dose expansion trial. Lancet Oncology 15(9), pp. 975-985. (10.1016/S1470-2045(14)70240-2)
- Greenow, K. R., Clarke, A. R., Williams, G. T. and Jones, R. 2014. Wnt-driven intestinal tumourigenesis is suppressed by Chk1 deficiency but enhanced by conditional haploinsufficiency. Oncogene 33, pp. 4089-4096. (10.1038/onc.2013.371)
2009
- Greenow, K. R., Clarke, A. R. and Jones, R. H. 2009. Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation. Oncogene 28(11), pp. 1443-1453. (10.1038/onc.2008.482)
2006
- Robinson, H. M. R., Jones, R. H., Walker, M., Zachos, G., Brown, R., Cassidy, J. and Gillespie, D. A. F. 2006. Chk1-dependent slowing of S-phase progression protects DT40 B-lymphoma cells against killing by the nucleoside analogue 5-fluorouracil. Oncogene 25(39), pp. 5359-5369. (10.1038/sj.onc.1209532)
2004
- Jones, R. H., Reubi, J., Millan, D. and Vasey, P. 2004. Octreotide: an active agent in epithelial ovarian carcinoma?. The Lancet Oncology 5(4), pp. 251-253. (10.1016/S1470-2045(04)01430-5)
2003
- Jones, R. H. and Vasey, P. A. 2003. Part II: Testicular cancer - management of advanced disease. The Lancet Oncology 4(12), pp. 738-747. (10.1016/S1470-2045(03)01279-8)
- Jones, R. H., Goldstein, D., Kurtovic, J., Keogh, G. and Riordan, S. M. 2003. Compression of liver parenchyma by a malignant hepatic cyst a previously unreported manifestation of metastatic gastric cancer [Letter]. The American Journal of Gastroenterology 98(5), pp. 1211-1213. (10.1016/S0002-9270(03)00170-9)
- Jones, R. H., Ryan, M. and Friedlander, M. 2003. Carboplatin hypersensitivity reactions: re-treatment with cisplatin desensitisation. Gynecologic Oncology 89(1), pp. 112-115. (10.1016/S0090-8258(03)00066-0)
- Jones, R. H. and Vasey, P. A. 2003. New directions in testicular cancer; molecular determinants of oncogenesis and treatment success. European Journal of Cancer 39(2), pp. 147-156. (10.1016/S0959-8049(02)00612-3)
2001
- Twelves, C. and Jones, R. H. 2001. Oral uracil-tegafur: an alternative to intravenous 5-fluorouracil?. Expert Opinion on Pharmacotherapy 2(9), pp. 1495-1505. (10.1517/14656566.2.9.1495)
1990
- Millar, J. B., McGowan, C. H., Lenaers, G., Jones, R. and Russell, P. 1990. p80cdc25 mitotic inducer is the tyrosine phosphatase that activates p34cdc2 kinase in fission yeast. Embo Journal 10(13), pp. 5610-5621.
1989
- Jones, R. and Jones, N. C. 1989. Mammalian cAMP-responsive element can activate transcription in yeast and binds a yeast factor(s) that resembles the mammalian transcription factor ATF. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490 86(7), pp. 2176-2180.
1988
- Jones, R., Moreno, S., Nurse, P. and Jones, N. C. 1988. Expression of the SV40 promoter in fission yeast: identification and characterization of an AP-1-like factor. Cell 53(4), pp. 659-667. (10.1016/0092-8674(88)90581-8)
Articles
- Fizazi, K. et al. 2024. Targeted inhibition of CYP11A1 in castration-resistant prostate cancer. NEJM Evidence 3(1) (10.1056/EVIDoa2300171)
- Jones, R. H. et al. 2023. Safety and tolerability of long-term treatment with darolutamide in patients with metastatic castration-resistant prostate cancer. Prostate Cancer and Prostatic Diseases (10.1038/s41391-023-00740-9)
- Macaulay, V. M. et al. 2023. A Phase Ib/II study of IGF-neutralising antibody xentuzumab with enzalutamide in metastatic castration-resistant prostate cancer. British Journal of Cancer 129, pp. 965-973. (10.1038/s41416-023-02380-1)
- Beresford, M. et al. 2023. Fulvestrant plus vandetanib versus placebo for the treatment of patients with metastatic breast cancer resistant to aromatase inhibitor therapy (FURVA): a multicentre, Phase 2, randomised controlled trial. BJC Reports 1(1), article number: 13. (10.1038/s44276-023-00016-8)
- Glaviano, A. et al. 2023. PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer. Molecular Cancer 22, article number: 138. (10.1186/s12943-023-01827-6)
- Arana Echarri, A., Struszczak, L., Beresford, M., Campbell, J. P., Jones, R. H., Thompson, D. and Turner, J. E. 2023. Immune cell status, cardiorespiratory fitness and body composition among breast cancer survivors and healthy women: a cross sectional study. Frontiers in Physiology 14, article number: 1107070. (10.3389/fphys.2023.1107070)
- Kristeleit, R. et al. 2023. A Phase 1/2 trial of SRA737 (a Chk1 inhibitor) administered orally in patients with advanced cancer. British Journal of Cancer (10.1038/s41416-023-02279-x)
- Jones, R. et al. 2023. A Phase I/II trial of Oral SRA737 (a Chk1 Inhibitor) given in combination with low-dose gemcitabine in patients with advanced cancer. Clinical Cancer Research 29(2), pp. 331-340. (10.1158/1078-0432.CCR-22-2074)
- Saad, F. et al. 2022. Patient-reported outcomes with olaparib plus abiraterone versus placebo plus abiraterone for metastatic castration-resistant prostate cancer: a randomised, double-blind, phase 2 trial. The Lancet Oncology 23(10), pp. 1297-1307. (10.1016/S1470-2045(22)00498-3)
- Banerjee, S. et al. 2022. A phase I trial of CT900, a novel α-folate receptor-mediated thymidylate synthase inhibitor, with expansion cohorts in patients with high grade serous ovarian cancer. Clinical Cancer Research 22, article number: 1268. (10.1158/1078-0432.CCR-22-1268)
- Howell, S. J. et al. 2022. Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive, HER2-negative breast cancer (FAKTION): overall survival, updated progression-free survival, and expanded biomarker analysis from a randomised, phase 2 trial. The Lancet Oncology 23(7), pp. 851-864. (10.1016/s1470-2045(22)00284-4)
- Seligmann, J. F. et al. 2021. Inhibition of WEE1 is effective in TP53- and RAS-mutant metastatic colorectal cancer: a randomized trial (FOCUS4-C) comparing adavosertib (AZD1775) with active monitoring. Journal of Clinical Oncology 39(33), pp. 3705-3715. (10.1200/JCO.21.01435)
- Arana Echarri, A. et al. 2021. A phenomic perspective on factors influencing breast cancer treatment: integrating aging and lifestyle in blood and tissue biomarker profiling. Frontiers in Immunology 11, article number: 616188. (10.3389/fimmu.2020.616188)
- Jones, R. H. et al. 2020. Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive breast cancer (FAKTION): a multicentre, randomised, controlled, phase 2 trial. Lancet Oncology 21(3), pp. 345-347. (10.1016/S1470-2045(19)30817-4)
- Hong, D. S. et al. 2020. Tisotumab vedotin in previously treated recurrent or metastatic cervical cancer. Clinical Cancer Research 26(6), pp. 1220-1228. (10.1158/1078-0432.CCR-19-2962)
- Peltola, K. J. et al. 2020. ODM-204, a novel dual Inhibitor of CYP17A1 and androgen receptor: early results from phase I dose escalation in men with castration-resistant prostate cancer. European Urology Focus 6(1), pp. 63-70. (10.1016/j.euf.2018.08.022)
- de Bono, J. S. et al. 2019. Tisotumab vedotin in patients with advanced or metastatic solid tumours (InnovaTV 201): a first-in-human, multicentre, phase 1-2 trial. Lancet Oncology 20(3), pp. 383-393. (10.1016/S1470-2045(18)30859-3)
- Basu, B. et al. 2018. Vistusertib (dual m-TORC1/2 inhibitor) in combination with paclitaxel in patients with high-grade serous ovarian and squamous non-small-cell lung cancer. Annals of Oncology 29(9), pp. 1918-1925. (10.1093/annonc/mdy245)
- Clarke, N. et al. 2018. Olaparib combined with abiraterone in patients with metastatic castration-resistant prostate cancer: a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Oncology 19(7), pp. 975-986. (10.1016/S1470-2045(18)30365-6)
- Garcia Martin, I., Janssen, A., Jones, R., Grimstead, J. W., Penketh, R. J. A., Baird, D. M. and John, R. M. 2017. Telomere length heterogeneity in placenta revealed with high-resolution telomere length analysis. Placenta 59, pp. 61-68. (10.1016/j.placenta.2017.09.007)
- Scurr, M. et al. 2017. Effect of modified vaccinia Ankara–5T4 and low-dose cyclophosphamide on antitumor immunity in metastatic colorectal cancer: A randomized clinical trial. JAMA Oncology 3(10), article number: e172579. (10.1001/jamaoncol.2017.2579)
- Scurr, M. J. et al. 2017. Low-dose cyclophosphamide induces anti-tumor T-cell responses which associate with survival in metastatic colorectal cancer. Clinical Cancer Research, article number: clincanres.0895.2017. (10.1158/1078-0432.CCR-17-0895)
- Scurr, M. et al. 2017. MVA-5T4 immunotherapy and low-dose cyclophosphamide for advanced colorectal cancer (TaCTiCC): An open-label, randomized phase I/II trial.. Journal of Clinical Oncology 35(7), pp. 154-154. (10.1200/JCO.2017.35.7_suppl.154)
- Reza, M. et al. 2016. Bone scan index and progression-free survival data for progressive metastatic castration-resistant prostate cancer patients who received ODM-201 in the ARADES multicentre study. European Urology Focus 2(5), pp. 547-552. (10.1016/j.euf.2016.01.005)
- Fizazi, K. et al. 2014. Activity and safety of ODM-201 in patients with progressive metastatic castration-resistant prostate cancer (ARADES): an open-label phase 1 dose-escalation and randomised phase 2 dose expansion trial. Lancet Oncology 15(9), pp. 975-985. (10.1016/S1470-2045(14)70240-2)
- Greenow, K. R., Clarke, A. R., Williams, G. T. and Jones, R. 2014. Wnt-driven intestinal tumourigenesis is suppressed by Chk1 deficiency but enhanced by conditional haploinsufficiency. Oncogene 33, pp. 4089-4096. (10.1038/onc.2013.371)
- Greenow, K. R., Clarke, A. R. and Jones, R. H. 2009. Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation. Oncogene 28(11), pp. 1443-1453. (10.1038/onc.2008.482)
- Robinson, H. M. R., Jones, R. H., Walker, M., Zachos, G., Brown, R., Cassidy, J. and Gillespie, D. A. F. 2006. Chk1-dependent slowing of S-phase progression protects DT40 B-lymphoma cells against killing by the nucleoside analogue 5-fluorouracil. Oncogene 25(39), pp. 5359-5369. (10.1038/sj.onc.1209532)
- Jones, R. H., Reubi, J., Millan, D. and Vasey, P. 2004. Octreotide: an active agent in epithelial ovarian carcinoma?. The Lancet Oncology 5(4), pp. 251-253. (10.1016/S1470-2045(04)01430-5)
- Jones, R. H. and Vasey, P. A. 2003. Part II: Testicular cancer - management of advanced disease. The Lancet Oncology 4(12), pp. 738-747. (10.1016/S1470-2045(03)01279-8)
- Jones, R. H., Goldstein, D., Kurtovic, J., Keogh, G. and Riordan, S. M. 2003. Compression of liver parenchyma by a malignant hepatic cyst a previously unreported manifestation of metastatic gastric cancer [Letter]. The American Journal of Gastroenterology 98(5), pp. 1211-1213. (10.1016/S0002-9270(03)00170-9)
- Jones, R. H., Ryan, M. and Friedlander, M. 2003. Carboplatin hypersensitivity reactions: re-treatment with cisplatin desensitisation. Gynecologic Oncology 89(1), pp. 112-115. (10.1016/S0090-8258(03)00066-0)
- Jones, R. H. and Vasey, P. A. 2003. New directions in testicular cancer; molecular determinants of oncogenesis and treatment success. European Journal of Cancer 39(2), pp. 147-156. (10.1016/S0959-8049(02)00612-3)
- Twelves, C. and Jones, R. H. 2001. Oral uracil-tegafur: an alternative to intravenous 5-fluorouracil?. Expert Opinion on Pharmacotherapy 2(9), pp. 1495-1505. (10.1517/14656566.2.9.1495)
- Millar, J. B., McGowan, C. H., Lenaers, G., Jones, R. and Russell, P. 1990. p80cdc25 mitotic inducer is the tyrosine phosphatase that activates p34cdc2 kinase in fission yeast. Embo Journal 10(13), pp. 5610-5621.
- Jones, R. and Jones, N. C. 1989. Mammalian cAMP-responsive element can activate transcription in yeast and binds a yeast factor(s) that resembles the mammalian transcription factor ATF. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490 86(7), pp. 2176-2180.
- Jones, R., Moreno, S., Nurse, P. and Jones, N. C. 1988. Expression of the SV40 promoter in fission yeast: identification and characterization of an AP-1-like factor. Cell 53(4), pp. 659-667. (10.1016/0092-8674(88)90581-8)
Bywgraffiad
Rwyf wedi cael fy hyfforddi mewn meddygaeth a gwyddoniaeth. Cynhaliais fy ngradd feddygol yn Rhydychen ac yna hyfforddais fel Oncolegydd Meddygol yn Glasgow. Cwblheais fy PhD yn labordy Nic Jones yn Llundain, ac rwyf wedi gwneud cyfnodau ymchwil byr gyda Paul Russell a Frank McCormick yng Nghaliffornia. Cefais fy mhenodi'n Uwch Ddarlithydd Ymgynghorol mewn Oncoleg Feddygol ym Mryste yn 2003 a chefais Gymrodoriaeth Gwyddonydd Clinigwyr CRUK yn 2005. Mae'r wobr hon wedi'i chynllunio i hyrwyddo ymchwil wyddonol sy'n berthnasol yn glinigol, a chynhaliais hyn yn labordy Alan Clark yng Nghaerdydd. Wedi hynny deuthum yn swydd Uwch Lecurer yng Nghaerdydd a alluogodd fi i sefydlu unig uned dreialu cam 1 Canser Cymru. Cefais fy ngwneud yn Gadeirydd llawn ym mis Chwefror 2022.
