Yr Athro Eddie Wang

2022

• Morgan, H. J. et al. 2022. CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis. Journal of Clinical Investigation 132(21), article number: e150750. (10.1172/JCI150750)
• Statkute, E., Wang, E. and Stanton, R. 2022. An optimised CRISPR/Cas9 adenovirus vector (AdZ-CRISPR) for high throughput cloning of sgRNA, using enhanced sgRNA and Cas9 variants. Human Gene Therapy 33(17-18), pp. 990-1001. (10.1089/hum.2021.120)
• Crozier, T. W. et al. 2022. Quantitative proteomic analysis of SARS-CoV-2 infection of primary human airway ciliated cells and lung epithelial cells demonstrates the effectiveness of SARS-CoV-2 innate immune evasion. Wellcome Open Research 7, article number: 224. (10.12688/wellcomeopenres.17946.1)
• Fielding, C. A. et al. 2022. SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies. eLife 11 (10.7554/eLife.74489)
• Wang, E. C., Fielding, C. A. and Stanton, R. J. 2022. Concerns over functional experiments, interpretation, and required controls. Journal of Clinical Investigation 132(5), article number: e157369. (10.1172/JCI157369)
• Nightingale, K. et al. 2022. Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex. Proceedings of the National Academy of Sciences 119(6), article number: e2108173119. (10.1073/pnas.2108173119)

2021

• Wickenhagen, A. et al. 2021. A prenylated dsRNA sensor protects against severe COVID-19. Science 374(6567), pp. 535-536. (10.1126/science.abj3624)
• Vlachava, V. et al. 2021. Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus. Journal of Clinical Investigation 131(4), article number: e139296. (10.1172/JCI139296)

2020

• Ahmed, R. et al. 2020. CD57+ Memory T Cells Proliferate In Vivo. Cell Reports 33(11), article number: 108501. (10.1016/j.celrep.2020.108501)
• Lau, B. et al. 2020. Human Cytomegalovirus long non-coding RNA1.2 suppresses extracellular release of the pro-inflammatory Cytokine IL-6 by blocking NF-κB activation. Frontiers in Cellular and Infection Microbiology 10, article number: 361. (10.3389/fcimb.2020.00361)
• Elasifer, H. et al. 2020. Downregulation of HLA-I by the molluscum contagiosum virus mc080 impacts NK-cell recognition and promotes CD8+ T-cell evasion. Journal of General Virology 101, pp. 863-872. (10.1099/jgv.0.001417)

2019

• Collins, F. L., Stone, M. D., Turton, J., McCabe, L. R., Wang, E. C. and Williams, A. S. 2019. Oestrogen-deficiency induces bone loss by modulating CD14+ monocyte and CD4+ T cell DR3 expression and serum TL1A levels. BMC Musculoskeletal Disorders 20(1), article number: 326. (10.1186/s12891-019-2704-z)
• Nobre, L. V. et al. 2019. Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions. eLife 8, article number: e49894. (10.7554/eLife.49894)

2018

• Boelen, L. et al. 2018. Inhibitory killer cell immunoglobulin-like receptors strengthen CD8+ T cell-mediated control of HIV-1, HCV, and HTLV-1. Science Immunology 3(29), article number: eaao2892. (10.1126/sciimmunol.aao2892)
• Patel, M., Vlachava, V., Forbes, S. K., Fielding, C. A., Stanton, R. J. and Wang, E. 2018. HCMV-encoded NK modulators: Lessons from in vitro and in vivo genetic variation. Frontiers in Immunology 9, article number: 2214. (10.3389/fimmu.2018.02214)
• Nightingale, K. et al. 2018. High-definition analysis of host protein stability during human cytomegalovirus infection reveals antiviral factors and viral evasion mechanisms. Cell Host and Microbe 24(3), pp. 447-460.e11. (10.1016/j.chom.2018.07.011)
• Wang, E. C. Y. et al. 2018. Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses. Proceedings of the National Academy of Sciences 115(19), pp. 4998-5003. (10.1073/pnas.1720950115)
• Malhotra, N. et al. 2018. RORα-expressing T regulatory cells restrain allergic skin inflammation. Science Immunology 3(21), article number: eaao6923. (10.1126/sciimmunol.aao6923)

2017

• Singh, R. et al. 2017. Death receptor 3 regulates distinct pathological attributes of acute versus chronic murine allergic lung inflammation. Cellular Immunology 320, pp. 62-70. (10.1016/j.cellimm.2017.09.005)
• Collins, F. L. et al. 2017. CCL3 and MMP-9 are induced by TL1A during death receptor 3 (TNFRSF25)-dependent osteoclast function and systemic bone loss. Bone 97, pp. 94-104. (10.1016/j.bone.2017.01.002)

2016

• Williams, A., Wang, E. C. Y., Thurner, L. and Liu, C. 2016. Novel insights into TNF receptor, DR3 and progranulin pathways in arthritis and bone remodeling. Arthritis & Rheumatology 68(12), pp. 2845-2856. (10.1002/art.39816)
• Perks, W. V. et al. 2016. Death Receptor 3 promotes chemokine directed leukocyte recruitment in acute resolving inflammation and is essential for pathological development of mesothelial fibrosis in chronic disease. American Journal of Pathology 186(11), pp. 2813-2823. (10.1016/j.ajpath.2016.07.021)
• Jia, L., Bamias, G., Burkly, L. C., Wang, E. C. Y., Gruszka, D., Pizarro, T. T. and Cominelli, F. 2016. A novel role for TL1A/DR3 in protection against intestinal injury and infection. Journal of Immunology 197(1), pp. 377-386. (10.4049/​jimmunol.1502466)
• Williams, J., Wang, E. C. Y., Lang, D. and Williams, A. S. 2016. Characterisation of Death Receptor 3 dependent aortic changes during inflammatory arthritis. Pharmacology Research & Perspectives 4(4), article number: e0024. (10.1002/prp2.240)

2015

• Wilkinson, G. W. G. et al. 2015. Human cytomegalovirus: taking the strain. Medical Microbiology and Immunology 204(3), pp. 273-284. (10.1007/s00430-015-0411-4)
• Collins, F. L., Williams, J., Bloom, A. C., Stone, M. D., Choy, E. H. S., Wang, E. C. Y. and Williams, A. S. 2015. Death Receptor 3 (TNFRSF25) Increases mineral apposition by osteoblasts and region specific new bone formation in the axial skeleton of male DBA/1 mice. Journal of Immunology Research 2015, pp. -., article number: 901679. (10.1155/2015/901679)

2014

• Wang, E. C. Y. et al. 2014. Regulation of early cartilage destruction in inflammatory arthritis by death receptor 3. Arthritis and Rheumatology 66(10), pp. 2762-2772. (10.1002/art.38770)
• Stanton, R. J. et al. 2014. HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells. Cell Host and Microbe 16(2), pp. 201-214. (10.1016/j.chom.2014.07.005)
• Weekes, M. et al. 2014. Quantitative temporal viromics: an approach to investigate host-pathogen interaction. Cell 157(6), pp. 1460-1472. (10.1016/j.cell.2014.04.028)
• Fielding, C. A. et al. 2014. Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation. PLoS Pathogens 10(5), article number: e1004058. (10.1371/journal.ppat.1004058)

2013

• Pembroke, T., Christian, A., Jones, E., Hills, R. K., Wang, E. C. Y., Gallimore, A. M. and Godkin, A. J. 2013. The paradox of NKp46+ natural killer cells: drivers of severe hepatitis C virus-induced pathology but in-vivo resistance to interferon treatment. Gut n/a (10.1136/gutjnl-2013-304472)
• Smith, W. et al. 2013. Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses. Cell Host & Microbe 13(3), pp. 324-335. (10.1016/j.chom.2013.02.003)

2012

• Collins, F., Stone, M. D., Goodfellow, R. M., Choy, E. H. S., Wang, E. C. Y. and Williams, A. S. 2012. TNF-like protein 1A/death receptor 3 pathway regulates osteoclastogenesis and is associated with erosive disease in rheumatoid arthritis. Arthritis and Rheumatism 64(10), pp. S768-S768.
• Coles, S., Hills, R. K., Wang, E. C. Y., Burnett, A. K., Man, S. T., Darley, R. L. and Tonks, A. 2012. Expression of CD200 on AML blasts directly suppresses memory T-cell function [Letter]. Leukemia 26(9), pp. 2148-2151. (10.1038/leu.2012.77)
• Coles, S., Hills, R. K., Wang, E. C. Y., Burnett, A. K., Man, S. T., Darley, R. L. and Tonks, A. 2012. Increased CD200 expression in acute myeloid leukemia is linked with an increased frequency of FoxP3+ regulatory T cells [Letter]. Leukemia 26(9), pp. 2146-2148. (10.1038/leu.2012.75)
• Pembroke, T. et al. 2012. Rapid early innate control of hepatitis C virus during IFN-α treatment compromises adaptive CD4+T-cell immunity. European Journal of Immunology 42(9), pp. 2383-2394. (10.1002/eji.201142072)
• Wang, E. C. Y. 2012. On death receptor 3 and its ligands... Immunology 137(1), pp. 114-116. (10.1111/j.1365-2567.2012.03606.x)
• Twohig, J. P. et al. 2012. The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4+ and CD8+ T-cell immunity. The FASEB Journal 26(8), pp. 3575-3586. (10.1096/fj.11-200618)
• Pembroke, T., Wang, E. C. Y., Gallimore, A. M. and Godkin, A. J. 2012. PMO-174 Intrahepatic natural killer cell phenotyping and functional analysis by fine needle aspiration in chronic HCV infection. Gut 61(S2), pp. A144-A145. (10.1136/gutjnl-2012-302514b.174)
• Collins, F., Stone, M., Wang, E. C. Y. and Williams, A. S. 2012. Death receptor 3 and tl1a: A regulatory pathway of bone turnover and target for osteoporosis therapy? [Abstract]. Osteoporosis International 23, pp. S528-S528.
• Calder, C. J. and Wang, E. C. Y. 2012. An essential role for death receptor 3 in experimental autoimmune uveoretinitis [Letter]. Ocular Immunology and Inflammation 20(3), pp. 212-214. (10.3109/09273948.2012.658135)
• Collins, F., Stone, M. D., Wang, E. C. Y. and Williams, A. S. 2012. Death receptor 3 and Tl1a: A driving force in osteoclast differentiation and potential target for rheumatoid arthritis therapy [Abstract]. Rheumatology 51(s3), pp. 140-140. (10.1093/rheumatology/kes108)
• Al-Lamki, R. S., Lu, W., Finlay, S., Twohig, J. P., Wang, E. C. Y., Tolkovsky, A. M. and Bradley, J. R. 2012. DR3 signaling protects against cisplatin nephrotoxicity mediated by tumor necrosis factor. American Journal of Pathology 180(4), pp. 1454-1464. (10.1016/j.ajpath.2012.01.003)
• Prod'homme, V. et al. 2012. Human cytomegalovirus UL40 signal peptide regulates cell surface expression of the NK cell ligands HLA-E and gpUL18. The Journal of Immunology 188(6), pp. 2794-2804. (10.4049/jimmunol.1102068)

2011

• Wang, E. C. Y. et al. 2011. Control of early cartilage destruction in inflammatory arthritis by death receptor 3 [Abstract]. Immunology 135(s1), pp. 153-153. (10.1111/j.1365-2567.2011.03534.x)
• Coles, S., Man, S. T., Hills, R. K., Wang, E. C. Y., Burnett, A. K., Darley, R. L. and Tonks, A. 2011. CD200 inhibits memory Th1 cell function in acute myeloid leukaemia (AML)[Abstract]. Immunology 135(S1), pp. 178. (10.1111/j.1365-2567.2011.03534.x)
• Stacey, M. A., Marsden, M., Wang, E. C. Y., Wilkinson, G. W. G. and Humphreys, I. R. 2011. IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection. The Journal of Immunology 187(6), pp. 2944-2952. (10.4049/jimmunol.1101021)
• Coles, S., Wang, E. C. Y., Man, S. T., Hills, R. K., Burnett, A. K., Tonks, A. and Darley, R. L. 2011. CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia. Leukemia 25(5), pp. 792-799. (10.1038/leu.2011.1)
• Jones, G. W. et al. 2011. Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. The FASEB Journal 25(1), pp. 409-419. (10.1096/fj.10-166843)
• Wang, E. C. Y. 2011. CD4+ T cells, human cytomegalovirus and end-stage renal disease. Nephrology Dialysis Transplantation 26(5), pp. 1467-1470. (10.1093/ndt/gfr167)

2010

• Williams, A. S., Collins, F., Newton, Z., Goodfellow, R. M., Rajak, R., Calder, C. J. and Wang, E. C. Y. 2010. Death Receptor 3 orchestrates erosive pathology in inflammatory arthritis [Poster Abstract]. Immunology 131(s1), pp. 53-53. (10.1111/j.1365-2567.2010.03390.x)
• Jones, G. W. et al. 2010. Differential responsiveness of naive and activated T cells to TL1A that affect Th17 generation, maintenance and proliferation [Abstract]. Immunology 131(s1), pp. 102-102. (10.1111/j.1365-2567.2010.03390.x)
• Coles, S., Man, S. T., Hills, R. K., Wang, E. C. Y., Burnett, A. K., Darley, R. L. and Tonks, A. 2010. Over-expression of CD200 un acute myeloid leukemia mediates the expansion of regulatory T-lymphocytes and directly inhibits natural killer cell tumor immunity [Abstract]. Blood 116(21), pp. 218-218.
• McLaren, J. E. et al. 2010. The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro. Journal of Immunology 184(10), pp. 5827-5834. (10.4049/jimmunol.0903782)
• Twohig, J. P. et al. 2010. Age-dependent maintenance of motor controland corticostriatal innervation by death receptor 3. Journal of Neuroscience 30(10), pp. 3782-3792. (10.1523/JNEUROSCI.1928-09.2010)
• Taraban, V. et al. 2010. Sustained TL1A expression modulates effector and regulatory T-cell responses and drives intestinal goblet cell hyperplasia. Mucosal Immunology 4(2), pp. 186-196. (10.1038/mi.2010.70)

2009

• Williams, A. S. et al. 2009. A functional role for death receptor-3 in arthritis [Abstract]. Cytokine 48(1-2), pp. 134-134. (10.1016/j.cyto.2009.07.568)
• Twohig, J. P. et al. 2009. Defective B cell ontogeny and humoral immune response in mice prematurely expressing human complement receptor 2 (CR2, CD21) is similar to that seen in aging wild type mice. Molecular Immunology 46(10), pp. 2002-2013. (10.1016/j.molimm.2009.03.007)
• Newton, Z., Bull, M., Wang, E. C. Y. and Williams, A. S. 2009. The role of dr3/tl1a in cartilage depletion caused by inflammatory arthritis [Abstract]. Rhuematology 48(s1), pp. I30-I30. (10.1093/rheumatology/kep713)
• Williams, A. S. et al. 2009. Functional role of dr3 in inflammatory arthritis: A novel target for therapy? [Abstract]. Rheumatology 48(s1), pp. I8-I8. (10.1093/rheumatology/kep704)

2008

• Jones, G. W. et al. 2008. TL1A/TNFSF15 promotes a STAT1-mediated suppression of IL-17-secreting T-helper cells [Abstract]. Immunology 125(s1), pp. 62-62. (10.1111/j.1365-2567.2008.02974.x)
• Williams, A. S. et al. 2008. The role of death receptor 3 in inflammatory arthritis [Abstract]. Immunology 125, pp. 34-34. (10.1111/j.1365-2567.2008.02974.x)
• Bull, M. J. et al. 2008. The Death Receptor 3-TNF-like protein 1A pathway drives adverse bone pathology in inflammatory arthritis. Journal of Experimental Medicine 205(11), pp. 2457-2464. (10.1084/jem.20072378)
• Meylan, F. et al. 2008. The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases. Immunity 29(1), pp. 79-89. (10.1016/j.immuni.2008.04.021)
• McSharry, B. P. et al. 2008. Adenovirus E3/19K promotes evasion of NK cell recognition by intracellular sequestration of the NKG2D ligands major histocompatibility complex class I chain-related proteins A and B. Journal of Virology 82(9), pp. 4585-4594. (10.1128/JVI.02251-07)
• Al-Lamki, R. S. et al. 2008. TL1A both promotes and protects from renal inflammation and injury. Journal of the American Society of Nephrology 19(5), pp. 953-960. (10.1681/ASN.2007060706)
• Chong, L. K., Aicheler, R., Llewellyn-Lacey, S., Tomasec, P., Brennan, P. and Wang, E. C. Y. 2008. Proliferation and interleukin 5 production by CD8hiCD57+ T cells. European Journal of Immunology 38(4), pp. 995-1000. (10.1002/eji.200737687)
• Jones, G. W. et al. 2008. TL1A negatively regulates development of T helper 17 cells [Abstract]. Rheumatology 47(S2), pp. II20-II20. (10.1093/rheumatology/kem509)
• Wilkinson, G. W. G. et al. 2008. Modulation of natural killer cells by human cytomegalovirus. Journal of Clinical Virology 41(3), pp. 206-212. (10.1016/j.jcv.2007.10.027)

2007

• Stanton, R. J., McSharry, B. P., Rickards, C. R., Wang, E. C. Y., Tomasec, P. and Wilkinson, G. W. G. 2007. Cytomegalovirus destruction of focal adhesions revealed in a high-throughput Western blot analysis of cellular protein expression. Journal of Virology 81(15), pp. 7860-7872. (10.1128/JVI.02247-06)
• Jones, G. W. et al. 2007. TL1A counteracts the IL-6 control of the STAT3-mediated development of T helper 17 cells [Abstract]. Cytokine 39(1), pp. 18-19.
• Prod'homme, V. et al. 2007. The Human Cytomegalovirus MHC Class I Homolog UL18 Inhibits LIR-1+ but Activates LIR-1- NK Cells. The Journal of Immunology 178(7), pp. 4473-4481.

2006

• Omidvar, N., Wang, E. C. Y., Brennan, P., Longhi, M. P., Smith, R. A. G. and Morgan, B. P. 2006. Expression of glycosylphosphatidylinositol-anchored CD59 on target cells enhances human NK cell-mediated cytotoxicity. Journal of immunology 176(5), pp. 2915-2923.
• Omidvar, N., Wang, E. C. Y., Brennan, P., Longhi, M. P., Smith, R. A. G. and Morgan, B. P. 2006. Expression of glycosylphosphatidylinositol-anchored CD59 on target cells enhances human NK cell-mediated cytotoxicity. The Journal of Immunology 176(5), pp. 2915-2923. (10.4049/jimmunol.176.5.2915)

2005

• Griffin, C., Wang, E. C. Y., McSharry, B. P., Rickards, C. R., Browne, H., Wilkinson, G. W. G. and Tomasec, P. 2005. Characterization of a highly glycosylated form of the human cytomegalovirus HLA class I homologue gpUL18. Journal of General Virology 86(11), pp. 2999-3008. (10.1099/vir.0.81126-0)
• Siebert, S., Amos, N., Fielding, C. A., Wang, E. C. Y., Aksentijevich, I., Williams, B. D. and Brennan, P. 2005. Reduced tumor necrosis factor signaling in primary human fibroblasts containing a tumor necrosis factor receptor superfamily 1A mutant. Arthritis & Rheumatism 52(4), pp. 1287-1282. (10.1002/art.20955)
• Tomasec, P. et al. 2005. Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141. Nature Immunology 6(2), pp. 181-188. (10.1038/ni1156)
• Vedhara, K. and Wang, E. C. Y. 2005. Assessment of the immune system in human psychoneuroimmunology. In: Vedhara, K. and Irwin, M. R. eds. Human Psychneuroimmunology. Oxford: Oxford University Press, pp. 53-80.

2002

• Wang, E. C. Y. et al. 2002. UL40-mediated NK evasion during productive infection with human cytomegalovirus. Proceedings of the National Academy of Sciences 99(11), pp. 7570-7575. (10.1073/pnas.112680099)

2001

• Wang, E. C. Y., Thern, A., Denzel, A., Kitson, J., Farrow, S. N. and Owen, M. J. 2001. DR3 regulates negative selection during thymocyte development. Molecular and cellular biology 21(10), pp. 3451-61. (10.1128/MCB.21.10.3451-3461.2001)
• Wang, E. C. Y., Kitson, J., Thern, A., Williamson, J., Farrow, S. N. and Owen, M. J. 2001. Genomic structure, expression, and chromosome mapping of the mouse homologue for the WSL-1 (DR3, Apo3, TRAMP, LARD, TR3, TNFRSF12) gene. Immunogenetics 53(1), pp. 59-63. (10.1007/s002510000290)
• Lawson, T. et al. 2001. Functional differences between influenza A-specific cytotoxic T lymphocyte clones expressing dominant and subdominant TCR. International Immunology 13(11), pp. 1383-1390. (10.1093/intimm/13.11.1383)

1998

• Wang, E. C. Y. 1998. Sorting of human peripheral blood T-cell subsets using immunomagnetic beads. In: Pound, J. D. ed. Immunochemical Protocols., Vol. 80. Methods in Molecular Biology Vol. 2. Humana Press, pp. 365-376., (10.1007/978-1-59259-257-9_37)

1992

• Wang, E. C. Y., Borysiewicz, L. K. and Weetman, A. P. 1992. Cell sorting using immunomagnetic beads. In: Manson, M. M. ed. Immunochemical Protocols. Methods in Molecular Biology Vol. 10. Totowa, NJ: Humana Press, pp. 347-358.