Ewch i’r prif gynnwys
Dr Selinda Orr

Dr Selinda Orr

Wellcome Trust Sir Henry Dale Fellow

Yr Ysgol Meddygaeth

Email:
orrs@cardiff.ac.uk
Telephone:
+44 (0)29 2068 7341
Location:
Tenovus Institute

Research Overview

I was awarded a PhD for my studies on the regulation of the inhibitory Sialic Acid Binding Ig-like Lectins (Siglecs) under the supervision of Prof. James Johnston (Queen’s University Belfast). During this time, I gained invaluable experience in studying cell signalling pathways and the regulatory mechanisms involved in these pathways.

I then spent 5yrs as an NIH Postdoctoral Visiting Fellow at the National Cancer Institute, Frederick in the laboratory of Dr. Daniel McVicar. While my PhD focused on the regulation of inhibitory receptor signaling, my postdoctoral training focused on the regulation of Immunoreceptor Tyrosine-Based Activation Motif (ITAM)-coupled receptors and how this affects cytokine production and inflammatory responses in various situations. From there my interest in the hemiITAM-containing or ITAM-coupled C-type lectin-like receptors developed.

I was awarded a Wellcome Trust VIP award in 2011 to relocate to Cardiff University to study the role of these C-type lectin-like receptors in host defence. I was awarded a Wellcome Trust and The Royal Society Sir Henry Dale Fellowship in 2012 to continue my research into C-type lectin-like receptor signalling and immune responses. As part of this fellowship I have developed novel models to facilitate this exciting research.

Education and Qualifications

2006: PhD, Immunology, Queens University Belfast.

2002: B.Sc. (Hons) Applied Biochemical Science, University of Ulster, Jordanstown.

2002: Diploma in Industrial Studies, University of Ulster, Jordanstown.

Career Overview

2013-Present: Sir Henry Dale Fellow, Cardiff University.

2011-2013: Wellcome VIP Fellow, Cardiff University.

2007-2011: Visiting Fellow, National Cancer Institute-Frederick.

Anrhydeddau a Dyfarniadau

Honours and awards

Centre for Cancer Research Fellows and Young Investigators Travel Award, 2011

Federal Technology Transfer Award, 2008

Dorothy Price Immunology Medal, 2005

Federation of Clinical Immunology Societies Travel Award, 2004

Aelodaethau proffesiynol

Professional memberships

British Society for Medical Mycology

2019

2018

2017

2016

2015

2014

2013

2012

2010

2009

2008

2007

2006

Collaborative and Redundant Roles of CLRs in Anti-Fungal Immunity

Myeloid cells such as macrophages, dendritic cells and neutrophils use cell surface receptors to recognize invading fungal pathogens. Various C-type lectin-like receptors including Dectin-1, Dectin-2, Mincle, Mannose receptor and DC-SIGN are involved in the recognition of various fungal cell-wall components such as beta-glucans and mannans. These receptors concurrently induce an inflammatory response upon recognition of fungal pathogens. Therefore, anti-fungal immune responses are complex, involving a highly co-ordinated response from multiple receptors.

We are working to determine how these receptors function individually and how they work together/collaborate to induce the co-ordinated anti-fungal immune response. We have generated novel models to fully dissect the role of these receptors during anti-fungal responses.