Ewch i’r prif gynnwys
Dr Yi Jin

Dr Yi Jin

Research Fellow in Chemical Biology

Email:
jiny6@cardiff.ac.uk
Telephone:
+44 (0) 29 20870749
Location:
1.114, Y Prif Adeilad, Plas y Parc, Caerdydd, CF10 3AT
Ar gael fel goruchwyliwr ôl-raddedig

I enjoy using an interdisciplinary approach to studying protein structures and functions using X-ray crystallography, NMR, organic synthesis, in combination with biophysical and biochemical methods. This includes using suitable analogues to trap the multi-conformational enzymes in their relevant conformation to reveal the useful structural and chemical information. The ultimate goal of my research is to identify the catalytic mechanisms of key enzymes, such as phosphoryl transfer and carbohydrate processing enzymes, to develop novel compounds and proteins for medicinal purposes.

I am also actively involved in the International Student Exchange and Recruitment Scheme for the College

Education:

2008 - 2012:  PhD  University of Sheffield, UK  (with Prof. Jonathan Waltho and Prof. Mike Blackburn)

2005 - 2008:  MSc   Xiamen University, China (with Prof. Yufen Zhao)

2001 - 2005:  BSc  Xiamen University, China 

Career Overview:

2017 - present: University Research Fellow,  Cardiff University, School of Chemistry

2014 - 2017:  Postdoctoral Research Associate, University of York, UK (Prof. Gideon Davies, FRS, FMedSci)

2012 - 2014:  Postdoctoral Research Associate, University of Sheffield, UK (Prof. Jonathan Waltho)

Anrhydeddau a Dyfarniadau

2015 Young Observer for IUPAC World Chemistry Congress and General Assembly funded by RSC. 

Aelodaethau proffesiynol

Early career member of British Biochemical Society

AMRSC of Royal Society of Chemistry (RSC)

Ambassador of Science, Technology, Engineering and Mathematics Network (STEM)

2019

2018

2017

2016

2014

2012

2008

CH3405 Advanced Techniques in Organic and Biological Chemistry


Current major projects I am working on include:

* Structural studies on protein-protein interactions involved in sepsis.

* Structural and NMR studies of the catalysis of DNA-repairing enzymes.

* Catalytic mechanisms of small G proteins involving unnatural amino acid incorporation.

* Allosteric control of Alarmone (p)ppGpp synthetases and hydrolases involved in bacterial persistence. 

* Catalytic mechanisms of carbohydrate processing enzymes from gut microbiota involved in colon mucin degradation.