Ewch i’r prif gynnwys
Yr Athro Meng Li

Yr Athro Meng Li

Chair in Stem Cell Neurobiology, Institute of Psychological Medicine and Clinical Neurosciences

Yr Ysgol Meddygaeth

Email:
lim26@cardiff.ac.uk
Telephone:
+44(0) 29 2068 8345
Location:
Room 3.40, Adeilad Hadyn Ellis, Heol Maendy, Caerdydd, CF24 4HQ

Meng Li's group is interested in elucidating the molecular mechanisms underlining neural fate specification and the subsequent differentiation of neuroectoderm cells into defined neuronal subtypes. 

We aim to exploit iPSC-derived neurons for elucidating the cellular basis of neuropsychiatric diseases and developing better strategies for cell therapies. 

We employ an integrated experimental approach involving in vitro neural development of human and mouse embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), as well as contemporary genetic manipulation in model organisms. 

We apply the resulting knowledge to devise novel strategies that drive pluripotent stem cells into clinically important neurons, such as midbrain dopamine neuron, striatal GABAergic neurons and cortical interneurons.

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The primary research interest of our laboratory is to uncover the molecular mechanisms underlying neuronal subtype specification of pluripotent stem cells and during mammalian development. Our research over the years has contributed to the advance in understanding pluripotent stem cell (PSC) neural fate conversion and dopaminergic fate specification of PSCs and during normal mammalian development. These studies led to the establishment of valuable 'tool boxes' for lineage-specific marking of defined stem/progenitors and mature dopamine neurons, and efficient novel methods for directed neuronal differentiation.  Recently, we have extended our interest into GABAergic cortical interneurons, a complex group of cells which dysfunction has been implicated in neuropsychiatric diseases and epilepsy.