Ewch i’r prif gynnwys
Dr Kerrie Thomas

Dr Kerrie Thomas

Ysgol y Biowyddorau

Email:
thomaskl5@cardiff.ac.uk
Telephone:
+44 (0)29 2068 8344
Location:
Adeilad Hadyn Ellis, Heol Maendy, Caerdydd, CF24 4HQ
Using contemporary techniques ranging from the genome-wide analysis of gene expression to the post-transcriptional gene silencing, my lab probes the molecular substrates of long-term memory. Focusing on hippocampal-dependent fear memory, we are particularly interested in understanding the cellular and neural processes supporting the formation of new memories and those supporting the maintenance of the memories after recall.

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Fresh memories need time to stabilise. The process of memory consolidation involves changes protein synthesis in a number of brain regions. These proteins contribute to the enduring synaptic and/or structural modifications that underlie the persistence of the memory trace in the face of an ever-changing brain. However, fully consolidated memories are far from being stable and resistant to disruption. When retrieved and reactivated, memories can be disrupted for a limited time and requirereconsolidation to be maintained long term. With repeated recall stable memories can also undergoextinction leading to a decline a learned behavioural response. Like consolidation, reconsolidation and extinction are protein synthesis-dependent memory processes. The brain regions supporting the memory trace can also undergo reorganisation with time.