Yr Athro John Aggleton
FRS, FMedSci, BA MA Cantab, DPhil Oxon
Professor of Cognitive Neuroscience
I have been Professor of Cognitive Neuroscience in the School of Psychology since 1994 and my research helps to examine the architecture of the brain and how various brain structures cooperate to support different forms of memory.
These research activities bring to the Research Institute extensive experience in complementary methods including neuroanatomy, behavioural neuroscience, and neuropsychology, to help uncover contrasting pathways for recognition memory and episodic memory.
A specific area of my work has also focused on trying to understand the causes of 'diencephalic amnesia' - a severe form of memory loss associated with damage in the centre of the brain.
My work aims to bring a greater understanding of the functions of a specific brain structure called the amygdala and an understanding of how animals detect whether a stimulus is novel or familiar (recognition memory).
I am a former member of the Council of the Academy of Medical Sciences (2007-2009) and was the Chair of the Wellcome Trust's Neuroscience and Mental Health Committee(2007-2011).
I have published over 200 scientific papers, and am a former President of the European Brain and Behaviour Society (2004 -2006).
1965-72: Trinity School, Croydon 1973-6: B.A. University of Cambridge, Clare College; Natural Sciences
1980: D.Phil., Jesus College, University of Oxford, Thesis: Anatomical and Functional Subdivisions of the Amygdala. Supervisor: Dr. R.E. Passingham
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2002: Fellow of the Academy of Medical Sciences (FMedSci)
2004-6: President of the European Brain and Behaviour Society
2006: Experimental Psychology Society – 4th Mid Career Award Prize
2007-9: Council Member, Academy of Medical Sciences
2009-2014: Royal Society Wolfson Research Merit Award
2012: Fellow of the Royal Society
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1994-present: Professor of Cognitive Neuroscience, School of Psychology, University of Wales, Cardiff 1992-1994: Senior Lecturer, Department of Psychology, University of Durham 1983–1992: Lecturer, Department of Psychology, University of Durham 1980-1983: NIH Visiting Fellow, National Institute of Mental Health, Bethesda, Maryland. Laboratory of Neuropsychology (Head: Dr. M. Mishkin)
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Editorial Boards 1997-2000: European Journal of Neuroscience - Receiving Editor 1990-1993: Quarterly Journal of Experimental Psychology - Section B Associate Editor 1995-present: Brain Research Bulletin - Editorial Advisory Board 1995-present: Neuroscience and Biobehavioral Reviews - Editorial Advisory Board 1998-present: Behavioural Brain Research - Editorial Board 1998-present: Behavioral Neuroscience - Editorial Board 2000-present: European Journal of Neuroscience – Editorial Board 2001-present: Neuropsychologia –Board of Associate Editors
National Committees 1993-1995: MRC - NAHH (Neuroscience Approach to Human Health) Steering Committee 1996-2002: MRC - Neurosciences and Mental Health Studentships Allocation Panel 1997: MRC - Clinical Training and Career Development Panel 1997-2001: MRC - Neurosciences and Mental Health Board 1997-2002: MRC - Clinical Trials - Clinical Cross-Board subgroup 2003-2004: MRC – Cross Board 2008-present: MRC ad hoc committees
2004-2007: Wellcome Trust - Cognitive and Higher Systems Funding Committee 2004-2007: Wellcome Trust - Neuroscience and Mental Health (Joint) Committee 2007-present: Wellcome Trust - Chair of Cognitive and Higher Systems Funding Committee 2007-present: Wellcome Trust - Co Chair Neuroscience and Mental Health (Joint) Committee 2008-present: Wellcome Trust - Strategy Committee for Neuroscience and Mental Health 2009-present: British Neuroscience Association - Scientific Strategy Board
International Committees 2004-2006: President of the European Brain and Behaviour Society 2002-2004: Council member of the European Brain and Behaviour Society 2004-2006: Council member of FENS (Federation of European Neuroscience Societies) 2008: Programme committee member for FENS (Geneva) 2007: International Jury for Inaugural Evens Scientific Research Challenge
I lecture on a Year 3 module that examines the neuropsychology of memory (Memory Processes and Memory Disorders, PS3208).
My research examines how different brain regions interact to support different forms of memory. The focus of this research has largely been on two distinct regions within the brain, the medial temporal lobe and the medial diencephalon. These questions are being pursued at a variety of levels; anatomical, behavioural and clinical. My anatomical studies examine the nature of the interactions between the temporal lobe and medial diencephalic structures, i.e. their origin, the routes taken within the brain, and the degree to which single pathways link multiple regions (see below).
Fig. 1. Picture of the rat subiculum within the hippocampal formation showing the separate, but adjacent, populations of nerve cells that project to the mammillary bodies (green) and anterior thalamus (red) (Wright et al., Journal of Comparative Neurology, in press).
My behavioural studies examine animal models of amnesic conditions. For this reason I am very interested in refining learning tasks that tax the specific classes of cognitive problems found in amnesia. An important component has been the development of new tests of recognition memory, so enabling the study of the neural basis of recognition memory. I have proposed new models of how recognition memory and recall interact, and then tested these models with rodents and with clinical populations. My rodent studies seek to understand how the perirhinal cortex contributes to recognition and other forms of memory using a combination of lesion and gene imaging techniques. This research is in close collaboration with researchers at Bristol University, and is funded by a Wellcome Trust Programme Grant. At the same time, I am trying to tease apart the functional contributions of a series of parallel temporal – medial diencephalic pathways that conjointly support memory (Fig. 2).
Fig. 2. Schematic drawing of pathways running between the medial temporal lobe and the medial diencephalon that potentially support memory.
A further part of my research involves clinical studies of amnesia. An example of the latter was a survey of patients across the UK who received surgery to remove a colloid cyst in the third ventricle. We calculated the extent to which these patients suffer medial diencephalic damage and were directly able to relate these changes to their loss of episodic memory (Fig. 3). The results provided unusually strong evidence concerning, 1) the anatomical basis of diencephalic amnesia, 2) the relationship between mechanisms for recall and for recognition in the brain.
Fig. 3. Left: MRI analyses of colloid cyst patients. Right: positive correlation between mammillary body volume and memory (recall). (From Tsivilis et al., Nature Neuroscience, 2008)
2009: Royal Society Wolfson Research Merit Award, 2009-2014, £75,000
2009: International Investment Opportunities Fund New Zealand. 'Rescuing memory loss after brain injury'. P.I. John C. Dalrymple-Alford. 3 years $380,000 NZ
2009: Wellcome Trust 'Interleaving brain systems for recognition and episodic memory'. JPA Lead Applicant - with John Pearce, Malcolm Brown, Zafir Bashir, Clea Warburton, £1,569,168 for 5 years
2007: Wellcome Trust PhD Programme in Integrative Neuroscience 2008-2013– Lead Applicant and Deputy Directory. £4,000,000 over 6 years.
2006: Wellcome Trust. Why are there parallel hippocampal – diencephalic pathways for event memory? Lead applicant. £158,395 for 3 years.
2006: Wellcome Trust. Why are there parallel hippocampal – diencephalic pathways for event memory? Co-applicant with Erichsen, Vann, O'Mara. €203,428, for 3 years
UK based Professor Malcolm Brown, Bristol University Professory Zafir Bashir, Bristol University Dr Clea Warburton, Bristol University Dr Seralynne Vann, Cardiff University
International Dr Richard Saunders, NIMH, NIH Dr Mort Mishkin, NIMH, NIH Professor John Dalrymple-Alford, Christchurch, New Zealand Professor Shane O'Mara, Trinity College, Dublin