Dr Yasir Ahmed Syed
CMU Research Fellow
- syedy@cardiff.ac.uk
- +44 (0)29 2068 8314
- Adeilad Hadyn Ellis, Heol Maendy, Caerdydd, CF24 4HQ
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwg
The overarching goal of my lab is to define the key molecular pathways in the pathogenesis of neuropsychiatric disorders and neurodegenerative disorders. To gain insight into pathogenesis of neuropsychiatric and neurological disorder, such as mood disorders, schizophrenia and Alzheimer disease, we use patient derived pluripotent stem cells and differentiate them into neural linage cells in vitro. We employ combination of cellular, genetic, electrophysiological, behavioural and material science approaches to understand the mechanisms of disease initiation and progression, as to ultimately develop novel and reliable drug targets.
Complementary projects focuses on role of neuroinflammation in the pathogenesis of neurodevelopmental disorders and glioblastoma multiforme (GBM)
Bywgraffiad
Research Fellow/ Group Leader (2017- present), Neuroscience and Mental Health Institute, Cardiff University, Cardiff
Postdoctoral Research Associate (2010 – 2016), Welcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, UK
PhD(2005 – 2009) Max-Planck Institute for Experimental Medicine, Germany and Medical University of Vienna, Austria.
Cyhoeddiadau
2022
- Robinson, J. et al. 2022. The association of neurodevelopmental abnormalities, congenital heart and renal defects in a Tuberous Sclerosis Complex patient cohort. BMC Medicine 20, article number: 123. (10.1186/s12916-022-02325-0)
- Dash, S., Syed, Y. A. and Khan, M. R. 2022. Understanding the role of the gut microbiome in brain development and its association with neurodevelopmental psychiatric disorders. Frontiers in Cell and Developmental Biology 10, article number: 880544. (10.3389/fcell.2022.880544)
- Chapman, G. et al. 2022. Using induced pluripotent stem cells to investigate human neuronal phenotypes in 1q21.1 deletion and duplication syndrome. Molecular Psychiatry 27, pp. 819-830. (10.1038/s41380-021-01182-2)
2021
- Dowden, L., Tucker, D., Morgan, S., Uzun, O. and Syed, Y. A. 2021. Contribution of congenital heart disorders associated with copy number variants in mediating risk for brain developmental disorders; evidence from 20-year retrospective cohort study. Frontiers in Cardiovascular Medicine 8, article number: 655463. (10.3389/fcvm.2021.655463)
2020
- Akter, F., Yu, X., Qin, X., Yao, S., Nikrouz, P., Syed, Y. A. and Kotter, M. 2020. Corrigendum: The pathophysiology of degenerative cervical myelopathy and the physiology of recovery following decompression. Frontiers in Neuroscience 14, pp. 628. (10.3389/fnins.2020.00628)
- Drakulic, D. et al. 2020. Copy number variants (CNVs): a powerful tool for iPSC-based modelling of ASD. Molecular Autism 11(1), article number: 42. (10.1186/s13229-020-00343-4)
- Akter, F., Yu, X., Qin, X., Yao, S., Nikrouz, P., Syed, Y. and Kotter, M. 2020. The pathophysiology of degenerative cervical myelopathy and the physiology of recovery following decompression. Frontiers in Neuroscience 14, article number: 138. (10.3389/fnins.2020.00138)
- Savory, K., Manivannan, S., Zaben, M., Uzun, O. and Syed, Y. A. 2020. Impact of copy number variation on human neurocognitive deficits and congenital heart defects: a systematic review. Neuroscience and Biobehavioral Reviews 108, pp. 83-93. (10.1016/j.neubiorev.2019.10.020)
- Savory, K. and Syed, Y. A. 2020. Advances in the understanding of cellular pathogenesis associated with Autism Spectrum Disorder. Journal for ReAttach Therapy and Developmental Diversities 2(2), pp. 96-118.
2019
- Silva, A. I. et al. 2019. Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility. Nature Communications 10, article number: 3455. (10.1038/s41467-019-11119-7)
2017
- Radtke, F., Chapman, G., Hall, J. and Syed, Y. A. 2017. Modulating neuroinflammation to treat neuropsychiatric disorders. BioMed Research International, article number: 5071786.
2016
- Syed, Y. A., Abdulla, S. A. and Kotter, M. R. N. 2016. Studying the effects of semaphorins on oligodendrocyte lineage cells. In: Terman, J. R. ed. Semaphorin Signaling., Vol. 1493. Methods in Molecular Biology New York, NY: Humana Press, pp. 363-378., (10.1007/978-1-4939-6448-2_26)
- Gonzalez, G. A. et al. 2016. Tamoxifen accelerates the repair of demyelinated lesions in the central nervous system. Scientific Reports 6, article number: 31599. (10.1038/srep31599)
- Dhillon, R. S. et al. 2016. Axonal plasticity underpins the functional recovery following surgical decompression in a rat model of cervical spondylotic myelopathy. Acta Neuropathologica Communications 4, article number: 89. (10.1186/s40478-016-0359-7)
- Syed, Y. A. et al. 2016. Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination. Acta Neuropathologica 131(2), pp. 281-298. (10.1007/s00401-015-1521-1)
2013
- Syed, Y. A. et al. 2013. Inhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination. EMBO Molecular Medicine 5(12), pp. 1918-1934. (10.1002/emmm.201303123)
- Hannan, N. et al. 2013. Generation of multipotent foregut stem cells from human pluripotent stem cells. Stem Cell Reports 1(4), pp. 293-306. (10.1016/j.stemcr.2013.09.003)
2011
- Syed, Y. A., Hand, E., Mobius, W., Zhao, C., Hofer, M., Nave, K. A. and Kotter, M. R. 2011. Inhibition of CNS remyelination by the presence of semaphorin 3A. Journal of Neuroscience 31(10), pp. 3719-3728. (10.1523/JNEUROSCI.4930-10.2011)
2009
- Baer, A. S. et al. 2009. Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling. Brain 132(2), pp. 465-481. (10.1093/brain/awn334)
2008
- Syed, Y. A., Baer, A. S., Lubec, G., Hoeger, H., Widhalm, G. and Kotter, M. R. 2008. Inhibition of oligodendrocyte precursor cell differentiation by myelin-associated proteins. Neurosurgical Focus 24(3-4), article number: E5. (10.3171/FOC/2008/24/3-4/E4)