Ewch i’r prif gynnwys
Dr Helen Pearson

Dr Helen Pearson

COFUND Fellow

Ysgol y Biowyddorau

Email:
pearsonh2@cardiff.ac.uk
Telephone:
+44 (0)29 2068 8517
Location:
Adeilad Hadyn Ellis, Heol Maendy, Caerdydd, CF24 4HQ

My lab is investigating the molecular mechanisms that underpin prostate cancer tumourigenesis, progression and resistance to current treatment approaches. This knowledge is applied to the preclinical development of novel, efficacious therapeutic approaches to treat prostate cancer.

Roles

2016 - present: Member of the School of Biosciences Research Ethics Committee (SREC)
2016 - present: Member of the Multidisciplinary Research Group (MDRG) for prostate cancer

Education and qualifications

2008: PhD (Cardiff University, Wales, UK)
2004: BSc (Biochemistry, University of East Anglia, UK + exchange year at Colorado University, Boulder, USA)

2019

2018

2017

2016

2015

2014

2013

2011

2009

2008

Focus

My research into prostate cancer integrates basic cancer biology, biomarker discovery and the preclinical assessment of novel therapeutic approaches with the ultimate goal improve upon the current standard of patient care. The research undertaken employs novel model systems to investigate genetic drivers of prostate cancer initiation and progression, and the preclinical development of innovative therapeutic strategies for prostate cancer.

My research is focused on prostate cancer and has two major themes: Oncogenic signalling and therapeutic resistance. My research group is closely linked to clinicians to facilitate translational research.

Current projects and/or themes within the lab

These include:

  • Establishing how loss of cellular polarity contributes to prostate cancer
  • Delineating molecular mechanisms of resistance to androgen-deprivation therapy
  • Enhancing the therapeutic efficacy of PARP inhibition for the treatment of prostate cancer
  • Ex-vivo models of prostate cancer
  • Prostate cancer stem cells