
Dr Xiao-Qing Wei
Uwch-ddarlithydd mewn Imiwnoleg, Ysgol Deintyddiaeth
- Ar gael fel goruchwyliwr ôl-raddedig
Bywgraffiad
Cyhoeddiadau
2020
- Jiang, L.et al. 2020. Liposomes loaded with transforming growth factor β1 promote odontogenic differentiation of dental pulp stem cells. Journal of Dentistry 103, article number: 103501. (10.1016/j.jdent.2020.103501)
- Rong, X.et al. 2020. IL-35 is critical in suppressing superantigenic Staphylococcus aureus-driven inflammatory Th17 responses in human nasopharynx-associated lymphoid tissue. Mucosal Immunology 13, pp. 460-470. (10.1038/s41385-019-0246-1)
2019
- Williams, A.et al. 2019. Immunohistochemical expression patterns of inflammatory cells involved in Chronic Hyperplastic Candidosis. Pathogens 8(4), article number: 232. (10.3390/pathogens8040232)
- Wang, X.et al. 2019. A generic coordination assembly-enabled nanocoating of individual tumor cells for personalized immunotherapy. Advanced Healthcare Materials 8(17), article number: 1900474. (10.1002/adhm.201900474)
- Morse, D. J.et al. 2019. Molecular community profiling of the bacterial microbiota associated with denture-related stomatitis. Scientific Reports 9, article number: 10228. (10.1038/s41598-019-46494-0)
- Koshy, B.et al. 2019. Array analysis for T-cell associated cytokines in gingival crevicular fluid: Identifying altered profiles associated with periodontal disease status. Journal of Dentistry 85, pp. 39-46. (10.1016/j.jdent.2019.04.009)
- Morse, D.et al. 2019. Modulation of Candida albicans virulence in in vitro biofilms by oral bacteria. Letters in Applied Microbiology 68(4), pp. 337-343. (10.1111/lam.13145)
2018
- Morse, D.et al. 2018. Denture-associated biofilm infection in 3-dimensional 1 oral mucosal tissue models. Journal of Medical Microbiology 67(3), pp. 364-375. (10.1099/jmm.0.000677)
2017
- Shi, G.et al. 2017. Enhanced antitumor immunity by targeting dendritic cells with tumor cell lysate-loaded chitosan nanoparticles vaccine. Biomaterials 113, pp. 191-202. (10.1016/j.biomaterials.2016.10.047)
2016
- Li, P.et al. 2016. PLGA nano/micro particles encapsulated with pertussis toxoid (PTd) enhances Th1/Th17 immune response in a murine model. International Journal of Pharmaceutics 513(1-2), pp. 183-190. (10.1016/j.ijpharm.2016.08.059)
- Zhang, G.et al. 2016. The role of Kv1.2 channel in electrotaxis cell migration. Journal of Cellular Physiology 231(6), pp. 1375-1384. (10.1002/jcp.25259)
- Zhang, S.et al. 2016. Decreased interleukin-35 is associated with higher risk of pregnancy morbidity in patients with antiphospholipid syndrome. Clinical and Experimental Rheumatology 34(3), pp. PI 0562-PF 0563.
- Zhang, S. L.et al. 2016. Decreased interleukin-35 levels are associated with higher risk of pregnancy morbidity in patients with antiphospholipid syndrome. Clinical and Experimental Rheumatology 34(3), pp. 562-563.
- Song, B.et al. 2016. Bladder smooth muscle cells differentiation from dental pulp stem cells: future potential for bladder tissue engineering. Stem Cells International 2016, article number: 6979368. (10.1155/2016/6979368)
2015
- Eastwood, S. E.et al. 2015. Osteoclastogenesis-related cytokines and peri-prosthetic osteolysis in revision metal-on-metal total hip replacements. Hip International 25(4), pp. 355-360. (10.5301/hipint.5000241)
- Boros-Majewska, J.et al. 2015. A novel in vitro assay for assessing efficacy and toxicity of antifungals using human leukemic cells infected with Candida albicans. Journal of Applied Microbiology 119(1), pp. 177-187. (10.1111/jam.12817)
- Haan, N.et al. 2015. Crosstalk between macrophages and astrocytes affects proliferation, reactive phenotype and inflammatory response, suggesting a role during reactive gliosis following spinal cord injury. Journal of Neuroinflammation 12, article number: 109. (10.1186/s12974-015-0327-3)
- Cavalcanti, Y. W.et al. 2015. Virulence and pathogenicity of Candida albicans is enhanced in biofilms containing oral bacteria. Biofouling 31(1), pp. 27-38. (10.1080/08927014.2014.996143)
- Liu, J.et al. 2015. Electric signals regulate directional migration of ventral midbrain derived dopaminergic neural progenitor cells via Wnt/GSK3β signaling. Experimental Neurology 263, pp. 113-121. (10.1016/j.expneurol.2014.09.014)
- Xia, T.et al. 2015. Plasma Interleukin-37 is elevated in patients with rheumatoid arthritis: Its correlation with disease activity and Th1/Th2/Th17-related cytokines. Disease Markers 2015, article number: 795043. (10.1155/2015/795043)
- Xu, R.et al. 2015. IL-34 suppresses 'Candida albicans' induced TNFα production in M1 macrophages by downregulating expression of Dectin-1 and TLR2. Journal of Immunology Research 2015, article number: 328146. (10.1155/2015/328146)
2014
- Alves, C. T.et al. 2014. Candida albicans promotes invasion and colonisation of Candida glabrata in a reconstituted human vaginal epithelium. Journal of Infection 69(4), pp. 396-407. (10.1016/j.jinf.2014.06.002)
- Boros-Majewska, J.et al. 2014. Novel Nystatin A1 derivatives exhibiting low host cell toxicity and antifungal activity in an in vitro model of oral candidosis. Medical Microbiology and Immunology 203(5), pp. 341-355. (10.1007/s00430-014-0343-4)
2013
- Rogers, H.et al. 2013. Immune response and candidal colonisation in denture associated stomatitis. Journal of Clinical & Cellular Immunology 4(6), article number: 178. (10.4172/2155-9899.1000178)
- Williams, D. W.et al. 2013. Interactions of Candida albicans with host epithelial surfaces. Journal of Oral Microbiology 5, article number: 22434. (10.3402/jom.v5i0.22434)
- Zheng, X. F.et al. 2013. Lipopolysaccharide-induced M2 to M1 macrophage transformation for IL-12p70 production is blocked by Candida albicans mediated up-regulation of EBI3 expression. PLoS ONE 8(5), article number: e63967. (10.1371/journal.pone.0063967)
- Yang, J.et al. 2013. The prevention of restenosis in vivo with a VEGF gene and paclitaxel co-eluting stent. Biomaterials 34(6), pp. 1635-1643. (10.1016/j.biomaterials.2012.11.006)
- Long, J.et al. 2013. IL-35 over-expression increases apoptosis sensitivity and suppresses cell growth in human cancer cells. Biochemical and Biophysical Research Communications 430(1), pp. 364-369. (10.1016/j.bbrc.2012.11.004)
- Rogers, H.et al. 2013. Role of bacterial lipopolysaccharide in enhancing host immune response to Candida albicans. Clinical and Developmental Immunology 2013, article number: 320168. (10.1155/2013/320168)
2012
- Feng, G. J.et al. 2012. Conditional disruption of Axin1 leads to development of liver tumors in mice. Gastroenterology 143(6), pp. 1650-1659. (10.1053/j.gastro.2012.08.047)
- Do, D. V.et al. 2012. Interleukin-18 system plays an important role in keloid pathogenesis via epithelial-mesenchymal interactions. British Journal of Dermatology 166(6), pp. 1275-1288. (10.1111/j.1365-2133.2011.10721.x)
- Van Belle, T. L.et al. 2012. IL-15 augments TCR-Induced CD4+ T Cell Expansion In Vitro by Inhibiting the Suppressive Function of CD25High CD4+ T Cells. Plos One 7(9), article number: e45299. (10.1371/journal.pone.0045299)
2011
- Wei, X.et al. 2011. The Role of the IL-12 Cytokine Family in Directing T-Cell Responses in Oral Candidosis. Clinical & Developmental Immunology, article number: 697340. (10.1155/2011/697340)
2010
- Koutoulaki, A.et al. 2010. TNF alpha and TGF-beta 1 influence IL-18-induced IFN gamma production through regulation of IL-18 receptor and T-bet expression. Cytokine 49(2), pp. 177-184. (10.1016/j.cyto.2009.09.015)
2009
- Bo, H.et al. 2009. Elevated expression of transmembrane IL-15 in immune cells correlates with the development of murine lupus: A potential target for immunotherapy against SLE. Scandinavian Journal of Immunology 69(2), pp. 119-129. (10.111/j.1365.3083.2008.02197.x)
2008
- Chen, L.et al. 2008. IL-23 promotes osteoclast formation by up-regulation of receptor activator of NF-kappa B (RANK) expression in myeloid precursor cells. European Journal of Immunology 38(10), pp. 2845-2854. (10.1002/eji.200838192)
- Niedbala, W.et al. 2008. Interleukin 27 attenuates collagen-induced arthritis. Annals of the Rheumatic Diseases 67(10), pp. 1474-1479. (10.1136/ard.2007.083360)
- Antonopoulos, C.et al. 2008. IL-18 is a key proximal mediator of contact hypersensitivity and allergen-induced Langerhans cell migration in murine epidermis. Journal of Leukocyte Biology 83(2), pp. 361-367. (10.1189/jlb.0604352)
- Anderson, I. E.et al. 2008. Production and Utilization of Interleukin-15 in Malignant Catarrhal Fever. Journal of Comparative Pathology 138(2-3), pp. 131-144. (10.1016/j.jcpa.2008.01.002)
- Bryson, K. J., Wei, X. and Alexander, J. 2008. Interleukin-18 enhances a Th2 biased response and susceptibility to Leishmania mexicana in BALB/c mice. Microbes and Infection 10(7), pp. 834-839. (10.1016/j.micinf.2008.03.009)
- Phan, T. T.et al. 2008. Interleukin-18 system plays an important role in keloid pathogenesis via epithelial-mesenchymal interactions. Tissue Engineering Part A 14(5), pp. 749-749.
2007
- Niedbala, W.et al. 2007. IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells [Erratum]. European Journal of Immunology 37(11), pp. 3293-3293.
- Niedbala, W.et al. 2007. IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells. European Journal of Immunology 37(11), pp. 3021-3029. (10.1002/eji.200737810)
2006
- Mullen, A. B.et al. 2006. Endogenous interleukin-18 is involved in immunity to Leishmania donovani but its absence does not adversely influence the therapeutic activity of sodium stibogluconate. Immunology 119(3), pp. 348-354. (10.1111/j.1365-2567.2006.02438.x)
- Verri Jr, W. A.et al. 2006. IL-15 mediates immune inflammatory hypernociception by triggering a sequential release of IFN-γ, endothelin, and prostaglandin. Proceedings of the National Academy of Sciences 103(25), pp. 9721-9725. (10.1073/pnas.0603286103)
2005
- McInnes, I. B.et al. 2005. Septic arthritis in inducible NO synthase knockout mice. Arthritis and Rheumatism : Supplement 39(S9), pp. S115. (10.1002/art.1780391402)
2004
- Wei, X.et al. 2004. Host genetic background determines whether IL-18 deficiency results in increased susceptibility or resistance to murine Leishmania major infection. Immunology Letters 94(1-2), pp. 35-37. (10.1016/j.imlet.2004.04.001)
- Kerr, A. R.et al. 2004. Nitric oxide exerts distinct effects in local and systemic infections with Streptococcus pneumoniae. Microbial Pathogenesis 36(6), pp. 303-310. (10.1016/j.micpath.2004.02.001)
- Millington, O. R.et al. 2004. Interleukin-15 is not required for the induction or maintenance of orally induced peripheral tolerance. Immunology 113(3), pp. 304-309. (10.1111/j.1365-2567.2004.01965.x)
2003
- Liew, F. Y., Wei, X. and McInnes, I. B. 2003. Role of interleukin 18 in rheumatoid arthritis. Annals Of The Rheumatic Diseases 62, pp. 48-50. (10.1136/ard.62.suppl_2.ii48)
- Kuffova, L.et al. 2003. The effect of local and systemic administration of soluble IL-15 receptor alpha-chain in experimental corneal transplantation [Abstract]. Investigative Ophthalmology & Visual Science 44, pp. U620-U620.
- Komai-Koma, M.et al. 2003. Chemoattraction of human T cells by IL-18. The Journal of Immunology 170(2), pp. 1084-1090.
- Pollock, K. G. J.et al. 2003. Interleukin-18 plays a role in both the alum-induced T helper 2 response and the T helper 1 response induced by alum-adsorbed interleukin-12. Immunology 108(2), pp. 137-143. (10.1046/j.1365-2567.2003.01581.x)
- McInnes, I.et al. 2003. Innate response cytokines in inflammatory synovitis: novel targets and strategies. Arthritis Research & Therapy 5(S3), pp. 68-68. (10.1186/ar869)
2002
- Niedbala, W.et al. 2002. Nitric oxide preferentially induces type 1 T cell differentiation by selectively up-regulating IL-12 receptor beta 2 expression via cGMP. Proceedings of the National Academy of Sciences 99(25), pp. 16186-16191. (10.1073/pnas.252464599)
- Nguyen, K. B.et al. 2002. Coordinated and distinct roles for IFN-alpha beta, IL-12, and IL-15 regulation of NK cell responses to viral infection. The Journal of Immunology 169(8), pp. 4279-4287.
- Mulero, V.et al. 2002. Regulation of phagosomal iron release from murine macrophages by nitric oxide. Biochemical Journal 365(1), pp. 127-132.
- Khan, I. A.et al. 2002. Treatment with soluble interleukin-15 Ralpha exacerbates intracellular parasitic infection by blocking the development of memory CD8+T cell response. Journal of Experimental Medicine 195(11), pp. 1463-1470. (10.1084/jem.20011915)
- Nguyen, K. B.et al. 2002. Multiple signaling mechanisms for IFN-alpha/beta regulation of natural killer and memory CD8 T cell responses during viral infections.. Faseb Journal 16(4), pp. A287-A287.
- Canthaboo, C.et al. 2002. Investigation of role of nitric oxide in protection from Bordetella pertussis respiratory challenge. Infection and Immunity 70(2), pp. 679-684. (10.1128/IAI.70.2.679-684.2002)
- Niedbala, W., Wei, X. and Liew, F. Y. 2002. IL-15 induces type 1 and type 2 CD4(+) and CD8(+) T cells proliferation but is unable to drive cytokine production in the absence of TCR activation or IL-12/IL-4 simulation in vitro. European Journal of Immunology 32(2), pp. 341-347.
2001
- Armour, K. J.et al. 2001. Activation of the inducible nitric oxide synthase pathway contributes to inflammation-induced osteoporosis by suppressing bone formation and causing osteoblast apoptosis. Arthritis and Rheumatism 44(12), pp. 2790-2796. (10.1002/1529-0131(200112)44:12<2790::AID-ART466>3.0.CO;2-X)
- Esfandiari, E.et al. 2001. A proinflammatory role of IL-18 in the development of spontaneous autoimmune disease. The Journal of Immunology 167(9), pp. 5338-5347.
- Wei, X.et al. 2001. The sushi domain of soluble IL-15 receptor alpha is essential for binding IL-15 and inhibiting inflammatory and allogenic responses in vitro and in vivo. The Journal of Immunology 167(1), pp. 277-282.
- Wei, X.et al. 2001. Reduced incidence and severity of collagen-induced arthritis in mice lacking IL-18. The Journal of Immunology 166(1), pp. 517-521.
2000
- Leung, B. P.et al. 2000. Reduced incidence and severity of collagen-induced arthritis in mice lacking interleukin-18 (IL-18)[Abstract]. Arthritis and Rheumatism 43(S9), pp. S176-S176., article number: 657. (10.1002/art.1780432008)
- Smith, X. G.et al. 2000. Selective blockade of IL-15 by soluble IL-15 receptor alpha-chain enhances cardiac allograft survival. The Journal of Immunology 165(6), pp. 3444-3450.
- McInnes, I. B.et al. 2000. Interleukin 18: a pleiotropic participant in chronic inflammation. Immunology Today 21(7), pp. 312-315. (10.1016/S0167-5699(00)01648-0)
- van't Hof, R. J.et al. 2000. Requirement of the inducible nitric oxide synthase pathway for IL-1-induced osteoclastic bone resorption. Proceedings of the National Academy of Sciences of the United States of America 97(14), pp. 7993-7998. (10.1073/pnas.130511497)
- Leung, B. P.et al. 2000. Combined effects of IL-12 and IL-18 on the induction of collagen-induced arthritis. The Journal of Immunology 164(12), pp. 6495-6502.
- Feng, G. J.et al. 2000. Erk and p38 MAP kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and interleukin-12 in macrophages: Leishmania phosphoglycans subvert macrophage interleukin-12 production by targetting Erk MAP kinase. Presented at: 6th International Meeting on the Biology of Nitric Oxide, Stockholm, Sweden, 5-8 September 1999 Presented at Moncada, S. ed.The Biology of Nitric Oxide Part 7: Proceedings of the 6th International Meeting on the Biology of Nitric Oxide, held in Stockholm, Sweden, in September 1999. Portland Press Proceedings Vol. 16. London: Portland Press pp. 222.
- Lawrence, C. E.et al. 2000. Nitric oxide mediates intestinal pathology but not immune expulsion during Trichinella spiralis infection in mice. The Journal of Immunology 164(8), pp. 4229-4234.
- Duffield, J. S.et al. 2000. Activated macrophages direct apoptosis and suppress mitosis of mesangial cells. The Journal of Immunology 164(4), pp. 2110-2119.
1999
- Wei, X.et al. 1999. Altered immune responses and susceptibility to Leishmania major and Staphylococcus aureus infection in IL-18-deficient mice. The Journal of Immunology 163(5), pp. 2821-2828.
- McInnes, I. B.et al. 1999. Soluble interleukin-15 alpha chain administration during murine infectious arthritis defines a role for IL-15 in regulating T helper 1 responses.. Arthritis and Rheumatism 42(9), pp. S337-S337.
- Millar, A. E.et al. 1999. T-cell responses during Trypanosoma brucei infections in mice deficient in inducible nitric oxide synthase. Infection and Immunity 67(7), pp. 3334-3338.
- Niedbala, W.et al. 1999. Effects of nitric oxide on the induction and differentiation of Th1 cells. European Journal of Immunology 29(8), pp. 2498-2505. (10.1002/(SICI)1521-4141(199908)29:08<2498::AID-IMMU2498>3.0.CO;2-M)
- Feng, G.et al. 1999. Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase. The Journal of Immunology 163(12), pp. 6403-6412.
1998
- Ruchatz, H.et al. 1998. Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: A role for IL-15 in development of antigen-induced immunopathology. The Journal of Immunology 160(11), pp. 5654-5660.
- Huang, F.et al. 1998. Mice defective in fas are highly susceptible to Leishmania major infection despite elevated IL-12 synthesis, strong Th1 responses, and enhanced nitric oxide production. The Journal of Immunology 160(9), pp. 4143-4147.
- Cattell, V.et al. 1998. Anti-GBM glomerulonephritis in mice lacking nitric oxide synthase type 2. Kidney International 53(4), pp. 932-936.
- MacLean, A.et al. 1998. Mice lacking inducible nitric-oxide synthase are more susceptible to herpes simplex virus infection despite enhanced Th1 cell responses. Journal of General Virology 79(4), pp. 825-830.
- Zaragoza, C.et al. 1998. The role of inducible nitric oxide synthase in the host response to Coxsackievirus myocarditis. Proceedings of the National Academy of Sciences of the United States of America 95(5), pp. 2469-2474.
- McInnes, I. B.et al. 1998. Septic arthritis following Staphylococcus aureus infection in mice lacking inducible nitric oxide synthase. The Journal of Immunology 160(1), pp. 308-315.
- Huang, F.et al. 1998. Nitric oxide regulates Th1 cell development through the inhibition of IL-12 synthesis by macrophages. European Journal of Immunology 28(12), pp. 4062-4070. (10.1002/(SICI)1521-4141(199812)28:12<4062::AID-IMMU4062>3.0.CO;2-K)
1997
- Liew, F. Y., Wei, X. and Proudfoot, L. 1997. Cytokines and nitric oxide as effector molecules against parasitic infections. Philosophical Transactions Of The Royal Society B-Biological Sciences 352(1359), pp. 1311-1315.
- Casey, J. J.et al. 1997. Skin allograft rejection in mice lacking inducible nitric oxide synthase. Transplantation 64(4), pp. 589-593. (10.1097/00007890-199708270-00007)
1996
- Casey, J. J.et al. 1996. Allograft rejection by mice lacking inducible nitric oxide synthase. Immunology 89, pp. ORI24-ORI24.
- Proudfoot, L.et al. 1996. Regulation of the expression of nitric oxide synthase and leishmanicidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine macrophages. Proceedings Of The National Academy Of Sciences Of The United States Of America 93(20), pp. 10984-10989.
- McInnes, I. B.et al. 1996. Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients. Journal Of Experimental Medicine 184(4), pp. 1519-1524.
- Baylis, S. A.et al. 1996. Expression of inducible nitric oxide synthase in the developing mouse placenta.. Biology Of Nitric Oxide, Pt 5 10, pp. 237-237.
1995
- Wei, X.et al. 1995. Altered immune responses in mice lacking inducible nitric oxide synthase [Letter]. Nature 375(6530), pp. 408-411. (10.1038/375408a0)
- Moss, D. W.et al. 1995. Enzymatic characterization of recombinant murine inducible nitric-oxide synthase. European Journal Of Pharmacology-Molecular Pharmacology Section 289(1), pp. 41-48. (10.1016/0922-4106(95)90166-3)
Cytokines play a pivotal role in controlling the outcome of infectious and inflammatory diseases by regulation of host innate and adaptive immune responses. My research has focused on understanding the role of some important pro-inflammatory cytokines, such as IL-15, IL-18 and IL-12 family cytokines (IL-23, 27) in the disease process in order to find practical ways to regulate the function of those cytokines for disease treatment. I have studied the role of IL-15 and IL-18 in rheumatoid arthritis (RA) and have identified IL-18 as a potential target for RA treatment. Since commencing my dental research work in 2004, my interest has advanced to the area of periodontal inflammation, in an attempt to understand the mechanism of bone loss in periodontal disease and RA. Periodontal disease is a chronic inflammatory disease triggered by bacterial infection. Host immune responses lead to bone resorption similar to the joint destruction in rheumatoid arthritis. In order to understand the consequences of host responses in periodontal tissue damage, we have considered the following:Research Projects