Dr Vera Knauper
Uwch Ddarlithydd, Clefydau Microbaidd
- KnauperV@caerdydd.ac.uk
- +44 29225 10645
- Ysbyty Deintyddol y Brifysgol, Llawr 4, Ystafell 411, Parc y Mynydd Bychan, Caerdydd, CF14 4XY
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
Thema Ymchwil
Gwyddorau llafar a biofeddygol
Grŵp Ymchwil
Matrics Bioleg a Thrwsio Meinwe
Diddordebau Ymchwil
Mae diddordebau ymchwil mawr yn fy ngrŵp yn canolbwyntio ar ddeall swyddogaeth metalloproteinase mewn llid a chanser. Prif ffocws y grwpiau yw deall rôl metalloproteinases mewn signalau cellog ar lefel foleciwlaidd a dylunio cyfundrefnau therapiwtig newydd i reoli llid a chanser. Mae gennym ddiddordeb hefyd yn y dadansoddiad proteomic a secretomig o lwybrau signalau cellog a reoleiddir gan proteolysis.
Prosiectau PhD cyfredol
- Mae cyffur canser newydd yn rheoleiddio gweithgarwch disintegrin a metalloproteinase (ADAM) mewn canser y pen a'r gwddf.
- Frank Antwi
- Rheoleiddio imiwnedd amddiffynnol i firysau trwy fasnachu celloedd T effaithor.
- Abdullah Alanazi
- Penderfynu ar rôl ADAM15 yn y pen a'r gwddf a chanserau eraill.
- Tufaha Awad
Gwybodaeth Ychwanegol
- Arweinydd grŵp ymchwil Matrix metalloproteinase
Cyhoeddiad
2024
- Bauer, L., Edwards, J., Heil, A., Dewitt, S., Biebermann, H., Aeschlimann, D. and Knauper, V. 2024. Mesenchymal transglutaminase 2 activates epithelial ADAM17: link to G-protein coupled receptor 56 (ADGRG1) signalling. International Journal of Molecular Sciences 25(4), article number: 2329. (10.3390/ijms25042329)
- Owens, H. A. et al. 2024. Alzheimer’s disease-associated P460L variant of EphA1 dysregulates receptor activity and blood brain barrier function. Alzheimer's & Dementia: The Journal of the Alzheimer's Association (10.1002/alz.13603)
2022
- Ganesh, R. A. et al. 2022. Multi-omics analysis of glioblastoma and glioblastoma cell line: Molecular insights into the functional role of GPR56 in mesenchymal transition. Frontiers in Oncology 12, article number: 841890. (10.3389/fonc.2022.841890)
2020
- Howes, J., Knauper, V., Malcor, J. and Farndale, R. W. 2020. Cleavage by MMP-13 renders VWF unable to bind to collagen but increases its platelet-reactivity. Journal of Thrombosis and Haemostatis 18(4), pp. 942-954. (10.1111/jth.14729)
2019
- Mohammed, R. N. et al. 2019. ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells. Scientific Reports 9, article number: 5487. (10.1038/s41598-019-41811-z)
- Mattern, J., Roghi, C. S., Hurtz, M., Knauper, V., Edwards, D. R. and Poghosyan, Z. 2019. ADAM15 mediates upregulation of Claudin-1 expression in breast cancer cells. Scientific Reports 9(1), article number: 12540. (10.1038/s41598-019-49021-3)
2018
- Howes, J., Pugh, N., Hamaia, S. W., Jung, S. M., Knauper, V., Malcor, J. and Farndale, R. W. 2018. MMP-13 binds to platelet receptors αIIbβ3 and GPVI and impairs aggregation and thrombus formation. Research and Practice in Thrombosis and Haemostasis 2(2), pp. 370-379. (10.1002/rth2.12088)
- Gaweł-Bęben, K., Ali, N., Ellis, V., Velasco, G., Poghosyan, Z., Ager, A. and Knauper, V. 2018. TMEFF2 shedding is regulated by oxidative stress and mediated by ADAMs and transmembrane serine proteases implicated in prostate cancer. Cell Biology International 42(3), pp. 273-280. (10.1002/cbin.10832)
2017
- Aeschlimann, D. and Knauper, V. 2017. P2X7 receptor-mediated TG2 externalization: a link to inflammatory arthritis?. Amino Acids 49(3), pp. 453-460. (10.1007/s00726-016-2319-8)
2016
- Chang, G. et al. 2016. The adhesion G protein-coupled receptor GPR56/ADGRG1 is an inhibitory receptor on human NK cells. Cell Reports 15(8), pp. 1757-1770. (10.1016/j.celrep.2016.04.053)
2015
- Adamczyk, M., Griffiths, R., Dewitt, S., Knauper, V. and Aeschlimann, D. 2015. P2X7 receptor activation regulates rapid unconventional export of transglutaminase-2. Journal of Cell Science 128(24), pp. 4615-4628. (10.1242/jcs.175968)
- Howes, J., Pugh, N., Knauper, V. and Farndale, R. W. 2015. Modified platelet deposition on MMP-13 digested collagen I. Journal of Thrombosis and Haemostatis 13(12), pp. 2253-2259. (10.1111/jth.13166)
- Wanger, T. M., Dewitt, S., Collins, A., Maitland, N. J., Poghosyan, Z. and Knauper, V. 2015. Differential regulation of TROP2 release by PKC isoforms through vesicles and ADAM17. Cellular Signalling 27(7), pp. 1325-1335. (10.1016/j.cellsig.2015.03.017)
2014
- Muller, A. et al. 2014. The extracellular N-terminal domain of G-protein coupled receptor 83 regulates signaling properties and is an intramolecular inverse agonist. BMC Research Notes 7, article number: 913. (10.1186/1756-0500-7-913)
- Howes, J. et al. 2014. The recognition of collagen and triple-helical toolkit peptides by MMP-13: sequence specificity for binding and cleavage. Journal of Biological Chemistry 289, pp. 24091-24101. (10.1074/jbc.M114.583443)
2013
- Qi, J. H. et al. 2013. Tissue inhibitor of metalloproteinases-3 peptides inhibit angiogenesis and choroidal neovascularization in mice. PLoS ONE 8(3), article number: e55667. (10.1371/journal.pone.0055667)
2010
- Knauper, V. and Murphy, G. 2010. Methods for studying activation of matrix metalloproteinases. Methods Mol Biol 622, pp. 233-43. (10.1007/978-1-60327-299-5_14)
2009
- Ali, N., Fiedler, L. and Knauper, V. L. F. 2009. ADAMTS4 mediated signalling alters cell morphology and motility. International Journal of Experimental Pathology 90(1), pp. A60-A61.
2007
- Ali, N. and Knauper, V. 2007. Phorbol Ester-induced shedding of the prostate cancer marker transmembrane protein with epidermal growth factor and two follistatin motifs 2 is mediated by the disintegrin and metalloproteinase-17*. Journal of Biological Chemistry 282(52), pp. 37378-37388. (10.1074/jbc.M702170200)
2005
- Singh, R. J. et al. 2005. Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3. Cardiovascular Research 67(1), pp. 39-49. (10.1016/j.cardiores.2005.02.020)
2004
- Lee, M., Rapti, M., Knauper, V. and Murphy, G. 2004. Threonine 98, the pivotal residue of tissue inhibitor of metalloproteinases (TIMP)-1 in metalloproteinase recognition. Journal of Biological Chemistry 279(17), pp. 17562-17569. (10.1074/jbc.M312589200)
2003
- Murphy, G. et al. 2003. Role of TIMPs (tissue inhibitors of metalloproteinases) in pericellular proteolysis:tThe specificity is in the detail. Biochemical Society Symposia 70, pp. 65-80. (10.1042/bss0700065)
- Worley, J. R. et al. 2003. Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP). Biochemical Journal 372(3), pp. 799-809. (10.1042/BJ20021573)
- Lee, M., Dodds, P., Verma, V., Maskos, K., Knauper, V. and Murphy, G. 2003. Tailoring tissue inhibitor of metalloproteinases-3 to overcome the weakening effects of the cysteine-rich domains of tumour necrosis factor-α converting enzyme. Biochemical Journal 371(2), pp. 369-376. (10.1042/bj20021538)
2002
- Knauper, V., Bailey, L., Worley, J. R., Soloway, P., Patterson, M. L. and Murphy, G. 2002. Cellular activation of proMMP-13 by MT1-MMP depends on the C-terminal domain of MMP-13. FEBS Letters 532(1-2), pp. 127-130. (10.1016/S0014-5793(02)03654-2)
- Lee, M., Maskos, K., Knauper, V., Dodds, P. and Murphy, G. 2002. Mapping and characterization of the functional epitopes of tissue inhibitor of metalloproteinases (TIMP)-3 using TIMP-1 as the scaffold: a new frontier in TIMP engineering. Protein Science 11(10), pp. 2493-2503. (10.1110/ps.0216202)
- Lafleur, M. A., Handsley, M. M., Knauper, V., Murphy, G. and Edwards, D. R. 2002. Endothelial tubulogenesis within fibrin gels specifically requires the activity of membrane-type-matrix metalloproteinases (MT-MMPs). Journal of Cell Science 115(17), pp. 3427-3438.
- Amour, A. et al. 2002. The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs. FEBS Letters 524(1-3), pp. 154-158. (10.1016/S0014-5793(02)03047-8)
- Lee, M. et al. 2002. The C-terminal domains of TACE weaken the inhibitory action of N-TIMP-3. FEBS Letters 520(1-3), pp. 102-106. (10.1016/S0014-5793(02)02776-X)
- Lee, M. et al. 2002. Engineering N-terminal domain of tissue inhibitor of metalloproteinase (TIMP)-3 to be a better inhibitor against tumour necrosis factor-a-converting enzyme. Biochemical Journal -London- 364, pp. 227-234.
- Rodriguez-Manzaneque, J. C. et al. 2002. ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors. Biochemical and Biophysical Research Communications 293(1), pp. 501-508. (10.1016/S0006-291X(02)00254-1)
- Bailey, L., Wienke, D., Howard, M., Knauper, V., Isacke, C. M. and Murphy, G. 2002. Investigation of the role of Endo180/urokinase-type plasminogen activator receptor-associated protein as a collagenase 3 (matrix metalloproteinase 13) receptor. Biochemical Journal -London- 363(1), pp. 67-72.
- Stringa, E., White, D., Tuan, R. S., Knauper, V. and Gavrilovic, J. 2002. Role of newly synthesized fibronectin in vascular smooth muscle cell migration on matrix-metalloproteinase-degraded collagen. Biochemical Society Transactions 30, pp. 102-111.
2001
- English, W. R., Holtz, B., Vogt, G., Knauper, V. and Murphy, G. 2001. Characterization of the role of the "MT-loop" - an eight-amino acid insertion specific to progelatinase A (MMP2) activating membrane-type matrix metalloproteinases. Journal of Biological Chemistry 276(45), pp. 42018-42026. (10.1074/jbc.M107783200)
- Patterson, M. L., Atkinson, S. J., Knauper, V. and Murphy, G. 2001. Specific collagenolysis by gelatinase A, MMP-2, is determined by the hemopexin domain and not the fibronectin-like domain. FEBS Letters 503(2-3), pp. 158-162. (10.1016/S0014-5793(01)02723-5)
- Williamson, R. A., Hutton, M., Vogt, G., Rapti, M., Knauper, V., Carr, M. D. and Murphy, G. 2001. Tyrosine 36 plays a critical role in the interaction of the AB loop of tissue inhibitor of metalloproteinases-2 with matrix metalloproteinase-14. Journal of Biological Chemistry 276(35), pp. 32966-32970. (10.1074/jbc.M101843200)
- Groft, L. L., Muzik, H., Johnston, R. N., Knauper, V., Lafleur, M. A., Forsyth, P. A. and Edwards, D. R. 2001. Differential expression and localization of TIMP-1 and TIMP-4 in human gliomas. British Journal of Cancer 85(1), pp. 55-63. (10.1054/bjoc.2001.1854)
- Lafleur, M. A., Hollenberg, M. D., Atkinson, S. J., Knauper, V., Murphy, G. and Edwards, D. R. 2001. Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species. Biochemical Journal 357(1), pp. 107-115. (10.1042/bj3570107)
- Knauper, V., Balbin, M., Fueyo, A. and Lopez-Otin, C. 2001. Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation. Journal of Biological Chemistry 276(13), pp. 10253-10262.
- Knauper, V., Patterson, M. L., Gomis-Ruth, F. X., Smith, B., Lyons, A., Docherty, A. J. and Murphy, G. 2001. The role of exon 5 in fibroblast collagenase (MMP-1) substrate specificity and inhibitor selectivity. European Journal of Biochemistry 268(6), pp. 1888-1896. (10.1046/j.1432-1327.2001.02062.x)
- Lee, M., Knauper, V., Becherer, J. and Murphy, G. 2001. Full-length and N-TIMP-3 display equal inhibitory activities toward TNF-α convertase. Biochemical and Biophysical Research Communications 280(3), pp. 945-950. (10.1006/bbrc.2000.4192)
2000
- Bond, M., Murphy, G., Bennett, M. R., Amour, A., Knauper, V., Newby, A. C. and Baker, A. H. 2000. Localization of the death domain of tissue inhibitor of metalloproteinase-3 to the N terminus: Metalloproteinase inhibition is associated with proapoptotic activity. Journal of Biological Chemistry 275(52), pp. 41358-41363. (10.1074/jbc.M007929200)
- Wang, T. et al. 2000. One-step sandwich enzyme immunoassay using monoclonal antibodies for detection of human enamelysin (MMP-20). European Journal of Oral Sciences 108(6), pp. 530-537. (10.1034/j.1600-0722.2000.00922.x)
- Stracke, J. O. et al. 2000. Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP). FEBS Letters 478(1-2), pp. 52-56. (10.1016/S0014-5793(00)01819-6)
- Hardern, I. M., Knauper, V., Ernill, R. J., Taylor, I. W., Cooper, K. L. and Abbott, W. 2000. An analysis of two refolding routes for a C-terminally truncated human collagenase-3 expressed in Escherichia coli. Protein Expression and Purification 19(2), pp. 246-252. (10.1006/prep.2000.1244)
- Stringa, E., Knauper, V., Murphy, G. and Gavrilovic, J. 2000. Collagen degradation and platelet-derived growth factor stimulate the migration of vascular smooth muscle cells. Journal of Cell Science 113(11), pp. 2055-2064. (10.1242/jcs.113.11.2055)
- Amour, A. et al. 2000. The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3. FEBS Letters 473(3), pp. 275-279. (10.1016/S0014-5793(00)01528-3)
- Stracke, J. O. et al. 2000. Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme. Journal of Biological Chemistry 275(20), pp. 14809-14816. (10.1074/jbc.275.20.14809)
- English, W. R. et al. 2000. Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-α convertase activity but does not activate pro-MMP2. Journal of Biological Chemistry 275(19), pp. 14046-14055. (10.1074/jbc.275.19.14046)
- Murphy, G., Knauper, V., Atkinson, S., Gavrilovic, J. and Edwards, D. 2000. Cellular mechanisms for focal proteolysis and the regulation of the microenvironment. Fibrinolysis and Proteolysis 14(2-3), pp. 165-174. (10.1054/fipr.2000.0068)
- Ottl, J. et al. 2000. Recognition and catabolism of synthetic heterotrimeric collagen peptides by matrix metalloproteinases. Chemistry and Biology 7(2), pp. 119-132. (10.1016/S1074-5521(00)00077-6)
1999
- Butler, G. S., Hutton, M., Wattam, B. A., Williamson, R. A., Knauper, V., Willenbrock, F. and Murphy, G. 1999. The specificity of TIMP-2 for matrix metalloproteinases can be modified by single amino acid mutations. Journal of Biological Chemistry 274(29), pp. 20391-20396. (10.1074/jbc.274.29.20391)
- Vassiliou, S. et al. 1999. Phosphinic pseudo-tripeptides as potent inhibitors of matrix metalloproteinases: a structure-activity study. Journal of Medicinal Chemistry 42(14), pp. 2610-2620. (10.1021/jm9900164)
- Amour, A. et al. 1999. Inhibition of the metalloproteinase domain of mouse TACE. Annals of the New York Academy of Sciences 878(1), pp. 728-731. (10.1111/j.1749-6632.1999.tb07774.x)
- Murphy, G. et al. 1999. Evaluation of some newer matrix metalloproteinases. Annals of the New York Academy of Sciences 878(1), pp. 25-39. (10.1111/j.1749-6632.1999.tb07672.x)
- Llano, E., Pendás, A. M., Freije, J. P., Nakano, A., Knauper, V., Murphy, G. and López-Otin, C. 1999. Identification and characterization of human MT5-MMP, a new membrane- bound activator of progelatinase A overexpressed in brain tumors. Cancer Research 59(11), pp. 2570-2576.
- Murphy, G., Stanton, H., Cowell, S., Butler, G., Knauper, V., Susan, A. and Gavrilovic, J. 1999. Mechanisms for pro matrix metalloproteinase activation. APMIS 107(1-6), pp. 38-44. (10.1111/j.1699-0463.1999.tb01524.x)
1998
- Amour, A. et al. 1998. TNF-α converting enzyme (TACE) is inhibited by TIMP-3. FEBS Letters 435(1), pp. 39-44. (10.1016/S0014-5793(98)01031-X)
- Cowell, S. et al. 1998. Induction of matrix metalloproteinase activation cascades based on membrane-type 1 matrix metalloproteinase: Associated activation of gelatinase A, gelatinase B and collagenase 3. Biochemical Journal 331(2), pp. 453-458. (10.1042/bj3310453)
- Messent, A. J., Tuckwell, D. S., Knauper, V., Humphries, M. J., Murphy, G. and Gavrilovic, J. 1998. Effects of collagenase-cleavage of type I collagen on α2β1 integrin-mediated cell adhesion. Journal of Cell Science 111(8), pp. 1127-1135. (10.1242/jcs.111.8.1127)
1997
- Llano, E. et al. 1997. Identification and structural and functional characterization of human enamelysin (MMP-20). Biochemistry 36(49), pp. 15101-15108. (10.1021/bi972120y)
- Knauper, V., Smith, B., López-Otin, C. and Murphy, G. 1997. Activation of progelatinase B (proMMP-9) by active collagenase-3 (MMP-13). European Journal of Biochemistry 248(2), pp. 369-373. (10.1111/j.1432-1033.1997.00369.x)
- Sasaki, T. et al. 1997. Limited cleavage of extracellular matrix protein BM-40 by matrix metalloproteinases increases its affinity for collagens. Journal of Biological Chemistry 272(14), pp. 9237-9243. (10.1074/jbc.272.14.9237)
- Murphy, G. and Knauper, V. 1997. Relating matrix metalloproteinase structure to function: Why the 'Hemopexin' domain?. Matrix Biology 15(8-9), pp. 511-518. (10.1016/S0945-053X(97)90025-1)
- Knauper, V. et al. 1997. The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction. Journal of Biological Chemistry 272(12), pp. 7608-7616. (10.1074/jbc.272.12.7608)
- Knauper, V., Docherty, A. J., Smith, B., Tschesche, H. and Murphy, G. 1997. Analysis of the contribution of the hinge region of human neutrophil collagenase (HNC, MMP-8) to stability and collagenolytic activity by alanine scanning mutagenesis. FEBS Letters 405(1), pp. 60-64. (10.1016/S0014-5793(97)00158-0)
- Pendás, A. M. et al. 1997. Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location, and tissue distribution. Journal of Biological Chemistry 272(7), pp. 4281-4286. (10.1074/jbc.272.7.4281)
1996
- Gomis-Rüth, F., Gohlke, U., Betz, M., Knauper, V., Murphy, G., López-Otı́n, C. and Bode, W. 1996. The helping hand of collagenase-3 (MMP-13): 2.7 Å crystal structure of its C-terminal haemopexin-like domain. Journal of Molecular Biology 264(3), pp. 556-566. (10.1006/jmbi.1996.0661)
- Fosang, A. J., Last, K., Knauper, V., Murphy, G. and Neame, P. J. 1996. Degradation of cartilage aggrecan by collagenase-3 (MMP-13). FEBS Letters 380(1-2), pp. 17-20. (10.1016/0014-5793(95)01539-6)
- Matsuki, H., Fujimoto, N., Iwata, K., Knauper, V., Okada, Y. and Hayakawa, T. 1996. A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 8 (neutrophil collagenase) using monoclonal antibodies. Clinica Chimica Acta 244(2), pp. 129-143. (10.1016/0009-8981(95)06197-5)
- Knauper, V., López-Otin, C., Smith, B., Knight, G. and Murphy, G. 1996. Biochemical characterization of human collagenase-3. Journal of Biological Chemistry 271(3), pp. 1544-1550. (10.1074/jbc.271.3.1544)
- Knauper, V., Murphy, G. and Tschesche, H. 1996. Activation of human neutrophil procollagenase by stromelysin 2. European Journal of Biochemistry 235(1-2), pp. 187-191. (10.1111/j.1432-1033.1996.00187.x)
1995
- Siri, A., Knauper, V., Veirana, N., Caocci, F., Murphy, G. and Zardi, L. 1995. Different susceptibility of small and large human tenascin-C isoforms to degradation by matrix metalloproteinases. Journal of Biological Chemistry 270(15), pp. 8650-8654. (10.1074/jbc.270.15.8650)
1994
- Fosang, A. J. et al. 1994. Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A(374) in the interglobular domain of cartilage aggrecan. Biochemical Journal 304(2), pp. 347-351. (10.1042/bj3040347)
- Knauper, V., Murphy, G. and Tschesche, H. 1994. Neutrophil procollagenase can be activated by stromelysin-2. Annals of the New York Academy of Sciences 732(1), pp. 367-368. (10.1111/j.1749-6632.1994.tb24755.x)
- Barnes Jr., E. M. et al. 1994. MPSA short communications. Journal of Protein Chemistry 13(5), pp. 431-512. (10.1007/BF01898855)
- Tschesche, H., Knauper, V., Kleine, T., Reinemer, P., Schnierer, S., Grams, F. and Bode, W. 1994. Function and structure of human leucocyte collagenase. Protein Journal 13(5), pp. 460-461. (10.1007/978-1-4899-1031-8_34)
1993
- Knauper, V., Wilhelm, S., Seperack, P. K., DeClerck, Y. A., Langley, K. E., Osthues, A. and Tschesche, H. 1993. Direct activation of human neutrophil procollagenase by recombinant stromelysin. Biochemical Journal 295(2), pp. 581-586. (10.1042/bj2950581)
- Fosang, A. J. et al. 1993. Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain. Biochemical Journal 295(1), pp. 273-276. (10.1042/bj2950273)
- Knauper, V., Osthues, A., DeClerck, Y. A., Langley, K. E., Bläser, J. and Tschesche, H. 1993. Fragmentation of human polymorphonuclear-leucocyte collagenase. Biochemical Journal 291(3), pp. 847-854. (10.1042/bj2910847)
- Schnierer, S., Kleine, T., Gote, T., Hillemann, A., Knauper, V. and Tschesche, H. 1993. The recombinant catalytic domain of human neutrophil collagenase lacks type I collagen substrate specificity. Biochemical and Biophysical Research Communications 191(2), pp. 319-326. (10.1006/bbrc.1993.1220)
1992
- Triebel, S., Bläser, J., Reinke, H., Knauper, V. and Tschesche, H. 1992. Mercurial activation of human PMN leucocyte type IV procollagenase (gelatinase). FEBS Letters 298(2-3), pp. 280-284. (10.1016/0014-5793(92)80077-T)
- Osthues, A., Knauper, V., Oberhoff, R., Reinke, H. and Tschesche, H. 1992. Isolation and characterization of tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) from human rheumatoid synovial fluid. FEBS Letters 296(1), pp. 16-20. (10.1016/0014-5793(92)80393-U)
- Tschesche, H., Knauper, V., Krämer, S., Michaelis, J., Oberhoff, R. and Reinke, H. 1992. Latent collagenase and gelatinase from human neutrophils and their activation.. Matrix (Stuttgart, Germany). Supplement 1, pp. 245-255.
1991
- Blaser, J., Knauper, V., Osthues, A., Reinke, H. and Tschesche, H. 1991. Mercurial activation of human polymorphonuclear leucocyte procollagenase. European Journal of Biochemistry 202(3), pp. 1223-1230. (10.1111/j.1432-1033.1991.tb16494.x)
- Knauper, V., Triebel, S., Reinke, H. and Tschesche, H. 1991. Inactivation of human plasma C1-inhibitor by human PMN leucocyte matrix metalloproteinases. FEBS Letters 290(1-2), pp. 99-102. (10.1016/0014-5793(91)81235-Z)
1990
- Knauper, V., Kramer, S., Reinke, H. and Tschesche, H. 1990. Partial amino acid sequence of human PMN leukocyte procollagenase. Biological Chemistry Hoppe-Seyler 371(5 SUPP), pp. 295-304. (10.1515/bchm3.1990.371.2.733)
- Knauper, V., Kramer, S., Reinke, H. and Tschesche, H. 1990. Partial amino-acid sequence of human PMN leukocyte procollagenase.. Biological Chemistry Hoppe Seyler 371(8), pp. 733.
- Knauper, V., Kramer, S., Reinke, H. and Tscheche, H. 1990. Characterization and activation of procollagenase from human polymorphonuclear leucocytes. N-terminal sequence determination of the proenzyme and various proteolytically activated forms. European Journal of Biochemistry 189(2), pp. 295-300. (10.1111/j.1432-1033.1990.tb15489.x)
- Knauper, V., Reinke, H. and Tschesche, H. 1990. Inactivation of human plasma α1-proteinase inhibitor by human PMN leucocyte collagenase. FEBS Letters 263(2), pp. 355-357. (10.1016/0014-5793(90)81412-H)
- Wize, J., Knauper, V. and Tschesche, H. 1990. Some properties of latent collagenase from human synovial fluid. Acta Biochimica Polonica 37(1), pp. 201-206.
1989
- Bergmann, U., Michaelis, J., Oberhoff, R., Knauper, V., Beckmann, R. and Tschesche, H. 1989. Enzyme linked immunosorbent assays (ELISA) for the quantitative determination of human leukocyte collagenase and gelatinase. Journal Of Clinical Chemistry And Clinical Biochemistry 27(6), pp. 351-359. (10.1515/cclm.1989.27.6.351)
Articles
- Bauer, L., Edwards, J., Heil, A., Dewitt, S., Biebermann, H., Aeschlimann, D. and Knauper, V. 2024. Mesenchymal transglutaminase 2 activates epithelial ADAM17: link to G-protein coupled receptor 56 (ADGRG1) signalling. International Journal of Molecular Sciences 25(4), article number: 2329. (10.3390/ijms25042329)
- Owens, H. A. et al. 2024. Alzheimer’s disease-associated P460L variant of EphA1 dysregulates receptor activity and blood brain barrier function. Alzheimer's & Dementia: The Journal of the Alzheimer's Association (10.1002/alz.13603)
- Ganesh, R. A. et al. 2022. Multi-omics analysis of glioblastoma and glioblastoma cell line: Molecular insights into the functional role of GPR56 in mesenchymal transition. Frontiers in Oncology 12, article number: 841890. (10.3389/fonc.2022.841890)
- Howes, J., Knauper, V., Malcor, J. and Farndale, R. W. 2020. Cleavage by MMP-13 renders VWF unable to bind to collagen but increases its platelet-reactivity. Journal of Thrombosis and Haemostatis 18(4), pp. 942-954. (10.1111/jth.14729)
- Mohammed, R. N. et al. 2019. ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells. Scientific Reports 9, article number: 5487. (10.1038/s41598-019-41811-z)
- Mattern, J., Roghi, C. S., Hurtz, M., Knauper, V., Edwards, D. R. and Poghosyan, Z. 2019. ADAM15 mediates upregulation of Claudin-1 expression in breast cancer cells. Scientific Reports 9(1), article number: 12540. (10.1038/s41598-019-49021-3)
- Howes, J., Pugh, N., Hamaia, S. W., Jung, S. M., Knauper, V., Malcor, J. and Farndale, R. W. 2018. MMP-13 binds to platelet receptors αIIbβ3 and GPVI and impairs aggregation and thrombus formation. Research and Practice in Thrombosis and Haemostasis 2(2), pp. 370-379. (10.1002/rth2.12088)
- Gaweł-Bęben, K., Ali, N., Ellis, V., Velasco, G., Poghosyan, Z., Ager, A. and Knauper, V. 2018. TMEFF2 shedding is regulated by oxidative stress and mediated by ADAMs and transmembrane serine proteases implicated in prostate cancer. Cell Biology International 42(3), pp. 273-280. (10.1002/cbin.10832)
- Aeschlimann, D. and Knauper, V. 2017. P2X7 receptor-mediated TG2 externalization: a link to inflammatory arthritis?. Amino Acids 49(3), pp. 453-460. (10.1007/s00726-016-2319-8)
- Chang, G. et al. 2016. The adhesion G protein-coupled receptor GPR56/ADGRG1 is an inhibitory receptor on human NK cells. Cell Reports 15(8), pp. 1757-1770. (10.1016/j.celrep.2016.04.053)
- Adamczyk, M., Griffiths, R., Dewitt, S., Knauper, V. and Aeschlimann, D. 2015. P2X7 receptor activation regulates rapid unconventional export of transglutaminase-2. Journal of Cell Science 128(24), pp. 4615-4628. (10.1242/jcs.175968)
- Howes, J., Pugh, N., Knauper, V. and Farndale, R. W. 2015. Modified platelet deposition on MMP-13 digested collagen I. Journal of Thrombosis and Haemostatis 13(12), pp. 2253-2259. (10.1111/jth.13166)
- Wanger, T. M., Dewitt, S., Collins, A., Maitland, N. J., Poghosyan, Z. and Knauper, V. 2015. Differential regulation of TROP2 release by PKC isoforms through vesicles and ADAM17. Cellular Signalling 27(7), pp. 1325-1335. (10.1016/j.cellsig.2015.03.017)
- Muller, A. et al. 2014. The extracellular N-terminal domain of G-protein coupled receptor 83 regulates signaling properties and is an intramolecular inverse agonist. BMC Research Notes 7, article number: 913. (10.1186/1756-0500-7-913)
- Howes, J. et al. 2014. The recognition of collagen and triple-helical toolkit peptides by MMP-13: sequence specificity for binding and cleavage. Journal of Biological Chemistry 289, pp. 24091-24101. (10.1074/jbc.M114.583443)
- Qi, J. H. et al. 2013. Tissue inhibitor of metalloproteinases-3 peptides inhibit angiogenesis and choroidal neovascularization in mice. PLoS ONE 8(3), article number: e55667. (10.1371/journal.pone.0055667)
- Knauper, V. and Murphy, G. 2010. Methods for studying activation of matrix metalloproteinases. Methods Mol Biol 622, pp. 233-43. (10.1007/978-1-60327-299-5_14)
- Ali, N., Fiedler, L. and Knauper, V. L. F. 2009. ADAMTS4 mediated signalling alters cell morphology and motility. International Journal of Experimental Pathology 90(1), pp. A60-A61.
- Ali, N. and Knauper, V. 2007. Phorbol Ester-induced shedding of the prostate cancer marker transmembrane protein with epidermal growth factor and two follistatin motifs 2 is mediated by the disintegrin and metalloproteinase-17*. Journal of Biological Chemistry 282(52), pp. 37378-37388. (10.1074/jbc.M702170200)
- Singh, R. J. et al. 2005. Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3. Cardiovascular Research 67(1), pp. 39-49. (10.1016/j.cardiores.2005.02.020)
- Lee, M., Rapti, M., Knauper, V. and Murphy, G. 2004. Threonine 98, the pivotal residue of tissue inhibitor of metalloproteinases (TIMP)-1 in metalloproteinase recognition. Journal of Biological Chemistry 279(17), pp. 17562-17569. (10.1074/jbc.M312589200)
- Murphy, G. et al. 2003. Role of TIMPs (tissue inhibitors of metalloproteinases) in pericellular proteolysis:tThe specificity is in the detail. Biochemical Society Symposia 70, pp. 65-80. (10.1042/bss0700065)
- Worley, J. R. et al. 2003. Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP). Biochemical Journal 372(3), pp. 799-809. (10.1042/BJ20021573)
- Lee, M., Dodds, P., Verma, V., Maskos, K., Knauper, V. and Murphy, G. 2003. Tailoring tissue inhibitor of metalloproteinases-3 to overcome the weakening effects of the cysteine-rich domains of tumour necrosis factor-α converting enzyme. Biochemical Journal 371(2), pp. 369-376. (10.1042/bj20021538)
- Knauper, V., Bailey, L., Worley, J. R., Soloway, P., Patterson, M. L. and Murphy, G. 2002. Cellular activation of proMMP-13 by MT1-MMP depends on the C-terminal domain of MMP-13. FEBS Letters 532(1-2), pp. 127-130. (10.1016/S0014-5793(02)03654-2)
- Lee, M., Maskos, K., Knauper, V., Dodds, P. and Murphy, G. 2002. Mapping and characterization of the functional epitopes of tissue inhibitor of metalloproteinases (TIMP)-3 using TIMP-1 as the scaffold: a new frontier in TIMP engineering. Protein Science 11(10), pp. 2493-2503. (10.1110/ps.0216202)
- Lafleur, M. A., Handsley, M. M., Knauper, V., Murphy, G. and Edwards, D. R. 2002. Endothelial tubulogenesis within fibrin gels specifically requires the activity of membrane-type-matrix metalloproteinases (MT-MMPs). Journal of Cell Science 115(17), pp. 3427-3438.
- Amour, A. et al. 2002. The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs. FEBS Letters 524(1-3), pp. 154-158. (10.1016/S0014-5793(02)03047-8)
- Lee, M. et al. 2002. The C-terminal domains of TACE weaken the inhibitory action of N-TIMP-3. FEBS Letters 520(1-3), pp. 102-106. (10.1016/S0014-5793(02)02776-X)
- Lee, M. et al. 2002. Engineering N-terminal domain of tissue inhibitor of metalloproteinase (TIMP)-3 to be a better inhibitor against tumour necrosis factor-a-converting enzyme. Biochemical Journal -London- 364, pp. 227-234.
- Rodriguez-Manzaneque, J. C. et al. 2002. ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors. Biochemical and Biophysical Research Communications 293(1), pp. 501-508. (10.1016/S0006-291X(02)00254-1)
- Bailey, L., Wienke, D., Howard, M., Knauper, V., Isacke, C. M. and Murphy, G. 2002. Investigation of the role of Endo180/urokinase-type plasminogen activator receptor-associated protein as a collagenase 3 (matrix metalloproteinase 13) receptor. Biochemical Journal -London- 363(1), pp. 67-72.
- Stringa, E., White, D., Tuan, R. S., Knauper, V. and Gavrilovic, J. 2002. Role of newly synthesized fibronectin in vascular smooth muscle cell migration on matrix-metalloproteinase-degraded collagen. Biochemical Society Transactions 30, pp. 102-111.
- English, W. R., Holtz, B., Vogt, G., Knauper, V. and Murphy, G. 2001. Characterization of the role of the "MT-loop" - an eight-amino acid insertion specific to progelatinase A (MMP2) activating membrane-type matrix metalloproteinases. Journal of Biological Chemistry 276(45), pp. 42018-42026. (10.1074/jbc.M107783200)
- Patterson, M. L., Atkinson, S. J., Knauper, V. and Murphy, G. 2001. Specific collagenolysis by gelatinase A, MMP-2, is determined by the hemopexin domain and not the fibronectin-like domain. FEBS Letters 503(2-3), pp. 158-162. (10.1016/S0014-5793(01)02723-5)
- Williamson, R. A., Hutton, M., Vogt, G., Rapti, M., Knauper, V., Carr, M. D. and Murphy, G. 2001. Tyrosine 36 plays a critical role in the interaction of the AB loop of tissue inhibitor of metalloproteinases-2 with matrix metalloproteinase-14. Journal of Biological Chemistry 276(35), pp. 32966-32970. (10.1074/jbc.M101843200)
- Groft, L. L., Muzik, H., Johnston, R. N., Knauper, V., Lafleur, M. A., Forsyth, P. A. and Edwards, D. R. 2001. Differential expression and localization of TIMP-1 and TIMP-4 in human gliomas. British Journal of Cancer 85(1), pp. 55-63. (10.1054/bjoc.2001.1854)
- Lafleur, M. A., Hollenberg, M. D., Atkinson, S. J., Knauper, V., Murphy, G. and Edwards, D. R. 2001. Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species. Biochemical Journal 357(1), pp. 107-115. (10.1042/bj3570107)
- Knauper, V., Balbin, M., Fueyo, A. and Lopez-Otin, C. 2001. Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation. Journal of Biological Chemistry 276(13), pp. 10253-10262.
- Knauper, V., Patterson, M. L., Gomis-Ruth, F. X., Smith, B., Lyons, A., Docherty, A. J. and Murphy, G. 2001. The role of exon 5 in fibroblast collagenase (MMP-1) substrate specificity and inhibitor selectivity. European Journal of Biochemistry 268(6), pp. 1888-1896. (10.1046/j.1432-1327.2001.02062.x)
- Lee, M., Knauper, V., Becherer, J. and Murphy, G. 2001. Full-length and N-TIMP-3 display equal inhibitory activities toward TNF-α convertase. Biochemical and Biophysical Research Communications 280(3), pp. 945-950. (10.1006/bbrc.2000.4192)
- Bond, M., Murphy, G., Bennett, M. R., Amour, A., Knauper, V., Newby, A. C. and Baker, A. H. 2000. Localization of the death domain of tissue inhibitor of metalloproteinase-3 to the N terminus: Metalloproteinase inhibition is associated with proapoptotic activity. Journal of Biological Chemistry 275(52), pp. 41358-41363. (10.1074/jbc.M007929200)
- Wang, T. et al. 2000. One-step sandwich enzyme immunoassay using monoclonal antibodies for detection of human enamelysin (MMP-20). European Journal of Oral Sciences 108(6), pp. 530-537. (10.1034/j.1600-0722.2000.00922.x)
- Stracke, J. O. et al. 2000. Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP). FEBS Letters 478(1-2), pp. 52-56. (10.1016/S0014-5793(00)01819-6)
- Hardern, I. M., Knauper, V., Ernill, R. J., Taylor, I. W., Cooper, K. L. and Abbott, W. 2000. An analysis of two refolding routes for a C-terminally truncated human collagenase-3 expressed in Escherichia coli. Protein Expression and Purification 19(2), pp. 246-252. (10.1006/prep.2000.1244)
- Stringa, E., Knauper, V., Murphy, G. and Gavrilovic, J. 2000. Collagen degradation and platelet-derived growth factor stimulate the migration of vascular smooth muscle cells. Journal of Cell Science 113(11), pp. 2055-2064. (10.1242/jcs.113.11.2055)
- Amour, A. et al. 2000. The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3. FEBS Letters 473(3), pp. 275-279. (10.1016/S0014-5793(00)01528-3)
- Stracke, J. O. et al. 2000. Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme. Journal of Biological Chemistry 275(20), pp. 14809-14816. (10.1074/jbc.275.20.14809)
- English, W. R. et al. 2000. Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-α convertase activity but does not activate pro-MMP2. Journal of Biological Chemistry 275(19), pp. 14046-14055. (10.1074/jbc.275.19.14046)
- Murphy, G., Knauper, V., Atkinson, S., Gavrilovic, J. and Edwards, D. 2000. Cellular mechanisms for focal proteolysis and the regulation of the microenvironment. Fibrinolysis and Proteolysis 14(2-3), pp. 165-174. (10.1054/fipr.2000.0068)
- Ottl, J. et al. 2000. Recognition and catabolism of synthetic heterotrimeric collagen peptides by matrix metalloproteinases. Chemistry and Biology 7(2), pp. 119-132. (10.1016/S1074-5521(00)00077-6)
- Butler, G. S., Hutton, M., Wattam, B. A., Williamson, R. A., Knauper, V., Willenbrock, F. and Murphy, G. 1999. The specificity of TIMP-2 for matrix metalloproteinases can be modified by single amino acid mutations. Journal of Biological Chemistry 274(29), pp. 20391-20396. (10.1074/jbc.274.29.20391)
- Vassiliou, S. et al. 1999. Phosphinic pseudo-tripeptides as potent inhibitors of matrix metalloproteinases: a structure-activity study. Journal of Medicinal Chemistry 42(14), pp. 2610-2620. (10.1021/jm9900164)
- Amour, A. et al. 1999. Inhibition of the metalloproteinase domain of mouse TACE. Annals of the New York Academy of Sciences 878(1), pp. 728-731. (10.1111/j.1749-6632.1999.tb07774.x)
- Murphy, G. et al. 1999. Evaluation of some newer matrix metalloproteinases. Annals of the New York Academy of Sciences 878(1), pp. 25-39. (10.1111/j.1749-6632.1999.tb07672.x)
- Llano, E., Pendás, A. M., Freije, J. P., Nakano, A., Knauper, V., Murphy, G. and López-Otin, C. 1999. Identification and characterization of human MT5-MMP, a new membrane- bound activator of progelatinase A overexpressed in brain tumors. Cancer Research 59(11), pp. 2570-2576.
- Murphy, G., Stanton, H., Cowell, S., Butler, G., Knauper, V., Susan, A. and Gavrilovic, J. 1999. Mechanisms for pro matrix metalloproteinase activation. APMIS 107(1-6), pp. 38-44. (10.1111/j.1699-0463.1999.tb01524.x)
- Amour, A. et al. 1998. TNF-α converting enzyme (TACE) is inhibited by TIMP-3. FEBS Letters 435(1), pp. 39-44. (10.1016/S0014-5793(98)01031-X)
- Cowell, S. et al. 1998. Induction of matrix metalloproteinase activation cascades based on membrane-type 1 matrix metalloproteinase: Associated activation of gelatinase A, gelatinase B and collagenase 3. Biochemical Journal 331(2), pp. 453-458. (10.1042/bj3310453)
- Messent, A. J., Tuckwell, D. S., Knauper, V., Humphries, M. J., Murphy, G. and Gavrilovic, J. 1998. Effects of collagenase-cleavage of type I collagen on α2β1 integrin-mediated cell adhesion. Journal of Cell Science 111(8), pp. 1127-1135. (10.1242/jcs.111.8.1127)
- Llano, E. et al. 1997. Identification and structural and functional characterization of human enamelysin (MMP-20). Biochemistry 36(49), pp. 15101-15108. (10.1021/bi972120y)
- Knauper, V., Smith, B., López-Otin, C. and Murphy, G. 1997. Activation of progelatinase B (proMMP-9) by active collagenase-3 (MMP-13). European Journal of Biochemistry 248(2), pp. 369-373. (10.1111/j.1432-1033.1997.00369.x)
- Sasaki, T. et al. 1997. Limited cleavage of extracellular matrix protein BM-40 by matrix metalloproteinases increases its affinity for collagens. Journal of Biological Chemistry 272(14), pp. 9237-9243. (10.1074/jbc.272.14.9237)
- Murphy, G. and Knauper, V. 1997. Relating matrix metalloproteinase structure to function: Why the 'Hemopexin' domain?. Matrix Biology 15(8-9), pp. 511-518. (10.1016/S0945-053X(97)90025-1)
- Knauper, V. et al. 1997. The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction. Journal of Biological Chemistry 272(12), pp. 7608-7616. (10.1074/jbc.272.12.7608)
- Knauper, V., Docherty, A. J., Smith, B., Tschesche, H. and Murphy, G. 1997. Analysis of the contribution of the hinge region of human neutrophil collagenase (HNC, MMP-8) to stability and collagenolytic activity by alanine scanning mutagenesis. FEBS Letters 405(1), pp. 60-64. (10.1016/S0014-5793(97)00158-0)
- Pendás, A. M. et al. 1997. Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location, and tissue distribution. Journal of Biological Chemistry 272(7), pp. 4281-4286. (10.1074/jbc.272.7.4281)
- Gomis-Rüth, F., Gohlke, U., Betz, M., Knauper, V., Murphy, G., López-Otı́n, C. and Bode, W. 1996. The helping hand of collagenase-3 (MMP-13): 2.7 Å crystal structure of its C-terminal haemopexin-like domain. Journal of Molecular Biology 264(3), pp. 556-566. (10.1006/jmbi.1996.0661)
- Fosang, A. J., Last, K., Knauper, V., Murphy, G. and Neame, P. J. 1996. Degradation of cartilage aggrecan by collagenase-3 (MMP-13). FEBS Letters 380(1-2), pp. 17-20. (10.1016/0014-5793(95)01539-6)
- Matsuki, H., Fujimoto, N., Iwata, K., Knauper, V., Okada, Y. and Hayakawa, T. 1996. A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 8 (neutrophil collagenase) using monoclonal antibodies. Clinica Chimica Acta 244(2), pp. 129-143. (10.1016/0009-8981(95)06197-5)
- Knauper, V., López-Otin, C., Smith, B., Knight, G. and Murphy, G. 1996. Biochemical characterization of human collagenase-3. Journal of Biological Chemistry 271(3), pp. 1544-1550. (10.1074/jbc.271.3.1544)
- Knauper, V., Murphy, G. and Tschesche, H. 1996. Activation of human neutrophil procollagenase by stromelysin 2. European Journal of Biochemistry 235(1-2), pp. 187-191. (10.1111/j.1432-1033.1996.00187.x)
- Siri, A., Knauper, V., Veirana, N., Caocci, F., Murphy, G. and Zardi, L. 1995. Different susceptibility of small and large human tenascin-C isoforms to degradation by matrix metalloproteinases. Journal of Biological Chemistry 270(15), pp. 8650-8654. (10.1074/jbc.270.15.8650)
- Fosang, A. J. et al. 1994. Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A(374) in the interglobular domain of cartilage aggrecan. Biochemical Journal 304(2), pp. 347-351. (10.1042/bj3040347)
- Knauper, V., Murphy, G. and Tschesche, H. 1994. Neutrophil procollagenase can be activated by stromelysin-2. Annals of the New York Academy of Sciences 732(1), pp. 367-368. (10.1111/j.1749-6632.1994.tb24755.x)
- Barnes Jr., E. M. et al. 1994. MPSA short communications. Journal of Protein Chemistry 13(5), pp. 431-512. (10.1007/BF01898855)
- Tschesche, H., Knauper, V., Kleine, T., Reinemer, P., Schnierer, S., Grams, F. and Bode, W. 1994. Function and structure of human leucocyte collagenase. Protein Journal 13(5), pp. 460-461. (10.1007/978-1-4899-1031-8_34)
- Knauper, V., Wilhelm, S., Seperack, P. K., DeClerck, Y. A., Langley, K. E., Osthues, A. and Tschesche, H. 1993. Direct activation of human neutrophil procollagenase by recombinant stromelysin. Biochemical Journal 295(2), pp. 581-586. (10.1042/bj2950581)
- Fosang, A. J. et al. 1993. Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain. Biochemical Journal 295(1), pp. 273-276. (10.1042/bj2950273)
- Knauper, V., Osthues, A., DeClerck, Y. A., Langley, K. E., Bläser, J. and Tschesche, H. 1993. Fragmentation of human polymorphonuclear-leucocyte collagenase. Biochemical Journal 291(3), pp. 847-854. (10.1042/bj2910847)
- Schnierer, S., Kleine, T., Gote, T., Hillemann, A., Knauper, V. and Tschesche, H. 1993. The recombinant catalytic domain of human neutrophil collagenase lacks type I collagen substrate specificity. Biochemical and Biophysical Research Communications 191(2), pp. 319-326. (10.1006/bbrc.1993.1220)
- Triebel, S., Bläser, J., Reinke, H., Knauper, V. and Tschesche, H. 1992. Mercurial activation of human PMN leucocyte type IV procollagenase (gelatinase). FEBS Letters 298(2-3), pp. 280-284. (10.1016/0014-5793(92)80077-T)
- Osthues, A., Knauper, V., Oberhoff, R., Reinke, H. and Tschesche, H. 1992. Isolation and characterization of tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) from human rheumatoid synovial fluid. FEBS Letters 296(1), pp. 16-20. (10.1016/0014-5793(92)80393-U)
- Tschesche, H., Knauper, V., Krämer, S., Michaelis, J., Oberhoff, R. and Reinke, H. 1992. Latent collagenase and gelatinase from human neutrophils and their activation.. Matrix (Stuttgart, Germany). Supplement 1, pp. 245-255.
- Blaser, J., Knauper, V., Osthues, A., Reinke, H. and Tschesche, H. 1991. Mercurial activation of human polymorphonuclear leucocyte procollagenase. European Journal of Biochemistry 202(3), pp. 1223-1230. (10.1111/j.1432-1033.1991.tb16494.x)
- Knauper, V., Triebel, S., Reinke, H. and Tschesche, H. 1991. Inactivation of human plasma C1-inhibitor by human PMN leucocyte matrix metalloproteinases. FEBS Letters 290(1-2), pp. 99-102. (10.1016/0014-5793(91)81235-Z)
- Knauper, V., Kramer, S., Reinke, H. and Tschesche, H. 1990. Partial amino acid sequence of human PMN leukocyte procollagenase. Biological Chemistry Hoppe-Seyler 371(5 SUPP), pp. 295-304. (10.1515/bchm3.1990.371.2.733)
- Knauper, V., Kramer, S., Reinke, H. and Tschesche, H. 1990. Partial amino-acid sequence of human PMN leukocyte procollagenase.. Biological Chemistry Hoppe Seyler 371(8), pp. 733.
- Knauper, V., Kramer, S., Reinke, H. and Tscheche, H. 1990. Characterization and activation of procollagenase from human polymorphonuclear leucocytes. N-terminal sequence determination of the proenzyme and various proteolytically activated forms. European Journal of Biochemistry 189(2), pp. 295-300. (10.1111/j.1432-1033.1990.tb15489.x)
- Knauper, V., Reinke, H. and Tschesche, H. 1990. Inactivation of human plasma α1-proteinase inhibitor by human PMN leucocyte collagenase. FEBS Letters 263(2), pp. 355-357. (10.1016/0014-5793(90)81412-H)
- Wize, J., Knauper, V. and Tschesche, H. 1990. Some properties of latent collagenase from human synovial fluid. Acta Biochimica Polonica 37(1), pp. 201-206.
- Bergmann, U., Michaelis, J., Oberhoff, R., Knauper, V., Beckmann, R. and Tschesche, H. 1989. Enzyme linked immunosorbent assays (ELISA) for the quantitative determination of human leukocyte collagenase and gelatinase. Journal Of Clinical Chemistry And Clinical Biochemistry 27(6), pp. 351-359. (10.1515/cclm.1989.27.6.351)
Ymchwil
Prosiectau Ymchwil Cyfredol:
- Rheoleiddio imiwnedd amddiffynnol i firysau trwy fasnachu celloedd T effaithor. Llywodraeth Saudi Arabia, Cyd-oruchwyliwr, 2017-2022, £153,000
- Abdullah Alanazi
- Mae cyffur canser newydd yn rheoleiddio gweithgarwch disintegrin a metalloproteinase (ADAM) mewn canser y pen a'r gwddf. Reseach Rhagoriaeth Studenthip. Prifysgol Caerdydd, Prif oruchwyliwr, 2018-2022, £129,973.
- Frank Antwi
- Penderfynu ar rôl ADAM15 yn y pen a'r gwddf a chanserau eraill. Prifysgol Caerdydd, Prif oruchwyliwr, 2021-2024, £143,500
- Tufaha Awad
- Rheoleiddio imiwnedd amddiffynnol i firysau gan L-selectin. Grant prosiect BBSRC Rhif 514650, Cyd-PI Ionawr 2019 – Rhagfyr 2023, £ 548,955
- Gwerthuso anactifadu rhwydweithiau signalau gan EBC-46 mewn canser y pen a'r gwddf. Gwobr MRC-CiC, PI Medi 2022 - Mawrth 2023, £34,031
- Meghan Larin
Addysgu
Mae Dr Knauper yn dysgu ar gwrs BDS ail flwyddyn. Yn y modiwl ecosystemau Llafar mae hi'n trafod rheoleiddio mecanwaith llif poer. Addysgir agweddau ar sut mae meddyginiaeth a gymerir ar gyfer cyflyrau eraill yn ymyrryd â llif a swyddogaeth poer a phydredd dannedd dilynol. Mae hi hefyd yn dysgu mecanweithiau ffurfio cyfanrif, gan arwain at lynu micro-organebau geneuol i'r arwynebau enamel a ffurfio bioffilm ddilynol.
Dr Knauper yw cydlynydd modiwl DET034 ar gyfer MSC mewn Bioleg Lafar. Mae'n dysgu agweddau ar ddiraddio matrics a datblygu canser y geg, yn ogystal â methodoleg wyddonol.
Bywgraffiad
Proffil Gyrfa
1985 Diploma mewn Cemeg Prifysgol Bielefeld Yr Almaen
1989 - Dr. Rer. Nat. (PhD mewn Biocemeg) Prifysgol Bielefeld Yr Almaen
1993-1995 Wellcome Trust Travelling Fellow Strangeways Research Laboratory Cambridge UK
1995-2000 Cydymaith Ymchwil Ôl-ddoethurol gyda'r Athro Gillian Murphy Strangeways Research Laboratory a Phrifysgol East Anglia Norwich
2001-2006 Darlithydd ym Mhrifysgol Efrog (Adran Fioleg)
O 2006 ymlaen Uwch Ddarlithydd ym Mhrifysgol Caerdydd (Ysgol Ddeintyddiaeth)
Aelodaeth / Gweithgareddau Allanol
Aelod BSMB
Aelod ASMB
Meysydd goruchwyliaeth
Mae gen i ddiddordeb mewn goruchwylio myfyrwyr ymchwil yn y meysydd canlynol:
- Atgyweirio ac adfywio meinwe
- Canser y geg
- Rheoleiddio signalau gan proteolysis
- Marcwyr bôn-gelloedd
- peirianneg protein