Dr Matthew Locke
Uwch-ddarlithydd Clinigol/ Cyfarwyddwr Rhaglen Therapi ac Hylendid
- lockem1@cardiff.ac.uk
- +44 2922510641
- Ysbyty Deintyddol y Brifysgol, Parc y Mynydd Bychan, Caerdydd, CF14 4XY
Research Interests
Oral mucosa derived progenitor cell populations
Periodontal disease initiation and progression
Career aspirations of recently qualified dental clinicians
Selected Projects
- Oral mucosa derived progenitor cell populations
- Role of fibroblast extracellular matrix in regulation of epithelial cells in health and disease
Career Profile
Academic Qualifications
- BDS - Bachelor of Dental Surgery with Merit University of Wales, College of Medicine, July 1996.
- Diploma in Biomedical Methods University of Wales, College of Medicine, February 2001.
- ECDL - European Computer Driving Licence University of Wales, College of Medicine, January 2002.
- PhD - Doctor of Philosophy Cardiff University, February 2005.
Professional Qualifications
- MFDS RCS - Member of the Faculty of Dental Surgery Royal College of Surgeons of England, September 1999.
- FDS RCS (Restorative Dentistry) - Fellowship in Dental Surgery in Restorative Dentistry Intercollegiate Royal College of Surgeons, Royal College of Surgeons and Physicians, Glasgow, May 2008.
- CCST - Certificate of Completion of Specialist Training in Restorative Dentistry Wales Denary, October 2008.
Memberships / External Activities
- British Society for Dental Research (International Association for Dental Research)
- British Society for Restorative Dentistry Member.
- British Society of Periodontology Membership
Aelodaethau proffesiynol
Fellow of the Faculty of Dental Surgeons (Royal College of Surgeons of England)
2018
- Chin, J. S.et al. 2018. Teaching of implant dentistry in undergraduate dental schools in the UK and Ireland. British Dental Journal 225(8), pp. 763-768. (10.1038/sj.bdj.2018.867)
2016
- Locke, M., Davies, L. C. and Stephens, P. 2016. Oral mucosal progenitor cell clones resist In Vitro myogenic differentiation. Archives of Oral Biology 70, pp. 100-110. (10.1016/j.archoralbio.2016.06.013)
2013
- Locke, M., Thomas, M. B. M. and Dummer, P. 2013. A survey of adoption of endodontic Nickel-Titanium rotary instrumentation Part 1: General Dental practitioners in Wales. British Dental Journal 214(3), article number: E6. (10.1038/sj.bdj.2013.108)
- Thomas, M. B. M., Locke, M. and Dummer, P. M. H. 2013. A survey of adoption of endodontic Nickel-Titanium rotary instrumentation Part 2: Community and Hospital Dental Practitioners in Wales. British Dental Journal 214(3), article number: E7. (10.1038/sj.bdj.2013.109)
2012
- Davies, L. C.et al. 2012. Oral mucosal progenitor cells are potently immunosuppressive in a dose-independent manner. Stem Cells and Development 21(9), pp. 1478-1487. (10.1089/scd.2011.0434)
2010
- Smith, E.et al. 2010. An ex vivo rodent mandible culture model for bone repair. Tissue Engineering Part C: Methods 16(6), pp. 1287-1296. (10.1089/ten.tec.2009.0698)
- Davies, L. C.et al. 2010. A multipotent neural crest derived progenitor cell population is resident within the oral mucosa lamina propria. Stem Cells and Development 19(6), pp. 819-830. (10.1089/scd.2009.0089)
2009
- Borg, K.et al. 2009. Intragenic deletion of TRIM32 in compound heterozygotes with sarcotubular myopathy/LGMD2H. Human Mutation 30(10), pp. E831-E844. (10.1002/humu.21063)
- Locke, M.et al. 2009. TRIM32 is an E3 ubiquitin ligase for dysbindin. Human Molecular Genetics 18(13), pp. 2344-2358. (10.1093/hmg/ddp167)
- Waite, A. J.et al. 2009. The neurobiology of the dystrophin-associated glycoprotein complex. Annals of Medicine 41(5), pp. 344-359. (10.1080/07853890802668522)
2008
- Addy, L. D.et al. 2008. The teaching of implant dentistry in undergraduate dental schools in the United Kingdom and Ireland. British Dental Journal 205(11), pp. 609-614. (10.1038/sj.bdj.2008.1027)
- Al-Ahmar, A. O.et al. 2008. Quality of master impressions and related materials for fabrication of complete dentures in the UK. Journal of Oral Rehabilitation 35(2), pp. 111-115. (10.1111/j.1365-2842.2007.01796.x)
- Locke, M.et al. 2008. Modulation of gingival epithelial phenotypes by interactions with regionally defined populations of fibroblasts. Journal of Periodontal Research 43(3), pp. 279-289. (10.1111/j.1600-0765.2007.01028.x)
2007
- Esapa, C. T.et al. 2007. SGCE missense mutations that cause myoclonus-dystonia syndrome impair epsilon-sarcoglycan trafficking to the plasma membrane: modulation by ubiquitination and torsinA. Human Molecular Genetics 16(3), pp. 327-342. (10.1093/hmg/ddl472)
2006
- Britt-Compton, B.et al. 2006. Structural stability and chromosome-specific telomere length is governed by cis-acting determinants in humans. Human Molecular Genetics 15(5), pp. 725-733. (10.1093/hmg/ddi486)
2005
- Locke, M.et al. 2005. Retention of intrinsic stem cell hierarchies in carcinoma-derived cell lines. Cancer Research 65(19), pp. 8944-8950. (10.1158/0008-5472.CAN-05-0931)
- Locke, M. 2005. Epithelial regulation by regionally defined populations of oral fibroblasts. PhD Thesis, Cardiff University.
2004
- Coffey, M. J.et al. 2004. Interactions of 12-lipoxygenase with phospholipase A2 isoforms following platelet activation through the glycoprotein VI collagen receptor. FEBS Letters 576(1-2), pp. 165-168. (10.1016/j.febslet.2004.09.007)
From 2016 Director of Dental Hygiene & Therapy Programmes
Research Projects
- Predominately interested in studying pluripotent stem cell induction from the readily accessible oral mucosal tissues.