Yr Athro Alastair J Sloan
BSc (Hons), PhD, FHEA
Pennaeth yr Ysgol
- Sylwebydd y cyfryngau
Bywgraffiad
Alastair Sloan is the Head of School in the School of Dentistry and began his tenure in this role in August 2017. He holds a substantive post as Professor of Bone Biology and Tissue Engineering in the School of Dentistry and is a member of the Cardiff Institute for Tissue Engineering and Repair (CITER) at Cardiff University. Alongside his role as Head of School, he co-leads the MIneralised Tissue Research Group.
He obtained his BSc in Biomedical Sciences from the University of Wales in 1993 and his PhD in Oral Cell Biology from The University of Birmingham, UK in 1997 in the Faculty of Medicine and Dentistry. Following postdoctoral research he was appointed to a Lectureship in Oral Biology at the School of Dentistry in The University of Birmingham in 2000. In 2005, he moved to the School of Dentistry and was awarded his personal chair in 2012. He is a Fellow of the Higher Education Academy.
Professor Sloan's research is multi-disciplinary and focussed on the repair and regeneration of mineralised tissues and the behaviour and therapeutic use of dental pulp stem cells. He is interested in the cellular and molecular responses of these cells to natural biomatrices and compromised biological environments to understand their functional behaviour during tissue injury and developing methods to mediate natural repair processes in bone trauma. Complimentary to this work, he is also interested in understanding the heterogeneity within dental pulp progenitor populations and their function in 3D environments. His research is also focussed on understanding bacterial invasion and attachment in dental and bone infections and development of novel delivery mechanisms for antimicrobial agents to control infection within these tissues. In support of these studies, he has significant interest in the development of 3D organotypic culture models to provide high throughput model systems with high reproducibiilty and address the 3Rs in this field of bioengineering.
With a background in biosciences and oral biology, Professor Sloan has teaching responsibilities on the BDS programme where he contributes to the Oral Ecosystems course (year 2). In addition he teaches on the MSc Tissue Engineering and MClinDent programmes and also will be contributing to the new MSc Oral Biology programme.
Professor Sloan is the recipient of several awards and honours. In 1998 he was awarded the IADR, British Division's Mineralised Tissue Research Prize and several of his students have won national research prizes including the IADR British Division Mineralised Tissue Prize in 2008, 2013, 2014, the British Division Unilever Poster Prize in 2012 and the TCES Poster Prize in 2014. Professor Sloan was the President of the Pulp Biology and Regeneration Group of the IADR in 2010-2011. In 2011 he was awarded the IADR Distinguished Scientist Award, the Young Investigators Award, in recognition of his research to date. He holds a Visiting Chair at the Fourth Military Medical University in Xi'an, China since 2013, Dalian Medical University since 2015 and China Medical University since 2016.
From 2015-2017 Professor Sloan was Chair of the Cardiff Insitute for Tissue Engineering and Repair (CITER). He currently sits on the Management Committee of the British Society for Oral and Dental Research (BSODR), the Executive Committee of the Tissue and Cell Engineering Society (UK) and the Grant Assessment Panel of the NC3Rs. He acts a reviewer for all RCUK funding bodies and the EU. He has attracted research funding from the NC3Rs, Health and Care Research Wales, MRC, EPSRC, Dr Hadwen Trust and Dunhill Medical Research Trust along with those from the industrial sector (Philips, Renishaw plc). He has been an active member of the Cardiff Institute for Tissue Engineering and Repair (CITER) since 2005 and was Chair of CITER from 2015 - 2017.
Education / Qualifications
1993 - BSc (Hons) Biomedical Sciences (Wales)
1997 - PhD (Bham)
2003 - PGCert Teaching in Higher Education (Bham)
Anrhydeddau a Dyfarniadau
1998 - British Society for Oral and Dental Research (BSODR) MIneralised Tissue Prize
2011 - IADR Distinguished Scientist Award, Young Investigators Award
Aelodaethau proffesiynol
Higher Education Academy
International Association for Dental Research (IADR)
British Society for Oral and Dental Research (BSODR)
Tissue and Cell Engineering Society (TCES)
Tissue Engineering and Regenerative Medicine International Society (TERMIS)
International Sociery for the Advancement of Cytometry (IASC)
Pwyllgorau ac adolygu
University Committees
- Cardiff University Senate
- College Board (College of Biomedical and Life Sciences)
- Biological Standards Committee
External Committees
- Management Committee of the British Society for Oral and Dental Research (BSODR)
- Management Committee of the Tissue and Cell Engineering Society (TCES)
- Committee Member, Association of Basic Science Teachers in Dentistry (ABSTD)
- NC3Rs Grant Assessment Panel
Cyhoeddiadau
2020
- Jiang, L.et al. 2020. Liposomes loaded with transforming growth factor β1 promote odontogenic differentiation of dental pulp stem cells. Journal of Dentistry 103, article number: 103501. (10.1016/j.jdent.2020.103501)
- Alraies, A.et al. 2020. Evaluation of dental pulp stem cell heterogeneity and behaviour in 3D type I collagen gels. BioMed Research International (10.1155/2020/3034727)
- Avery, S. J.et al. 2020. Interrogating the osteogenic potential of implant surfaces in vitro: a review of current assays. Tissue Engineering Part B: Reviews 26(3), pp. 217-229. (10.1089/ten.teb.2019.0312)
- Bender, L.et al. 2020. A novel dual action monolithic thermosetting hydrogel loaded with lidocaine and metronidazole as a potential treatment for alveolar osteitis. European Journal of Pharmaceutics and Biopharmaceutics 149, pp. 85-94. (10.1016/j.ejpb.2020.01.007)
- Serra, E.et al. 2020. Methylcellulose hydrogel with melissa officinalis essential oil as a potential treatment for oral candidiasis. Microorganisms 8(2), article number: 215. (10.3390/microorganisms8020215)
- Yee Lim, S.et al. 2020. Mucoadhesive thin films for the simultaneous delivery of microbicide and anti-inflammatory drugs in the treatment of periodontal diseases. International Journal of Pharmaceutics 573, article number: 118860. (10.1016/j.ijpharm.2019.118860)
2019
- Alraies, A.et al. 2019. Discrimination of dental pulp stem cell regenerative heterogeneity by single cell raman spectroscopy. Tissue Engineering Part C Methods 25(8), pp. 489-499. (10.1089/ten.TEC.2019.0129)
- Rivera, M.et al. 2019. Anti-inflammatory drug-eluting implant model system to prevent wear particles induced periprosthetic osteolysis. International Journal of Nanomedicine 14, pp. 1069-1084. (10.2147/IJN.S188193)
- Jiang, W.et al. 2019. Wnt-GSK3ß/ß-catenin regulates the differentiation of dental pulp stem cells into bladder smooth muscle cells. Stem Cells International 2019, article number: 8907570. (10.1155/2019/8907570)
- Alraies, A.et al. 2019. Real-time binding kinetic analyses of the interaction of the dietary stain Orange II with dentin matrix. Journal of Dentistry 80, pp. 80-88. (10.1016/j.jdent.2018.06.001)
- Munir, A.et al. 2019. Efficacy of copolymer scaffolds delivering human demineralised dentine matrix for bone regeneration. Journal of Tissue Engineering 10, pp. 204173141985270. (10.1177/2041731419852703)
2018
- Lynch, C. D.et al. 2018. An ex-vivo model to determine dental pulp responses to heat and light-curing of dental restorative materials. Journal of Dentistry 79, pp. 11-18. (10.1016/j.jdent.2018.08.014)
- Melling, G.et al. 2018. Liposomal delivery of demineralised dentine matrix for dental tissue regeneration. Journal of Tissue Engineering 24(13-14), pp. 1057-1065. (10.1089/ten.TEA.2017.0419)
- Nishio Ayre, W.et al. 2018. Enterococcus faecalis demonstrates pathogenicity through increased attachment in an ex vivo polymicrobial pulpal infection. Infection and Immunity 86(5), article number: e00871-17. (10.1128/IAI.00871-17)
- Yusop, N.et al. 2018. Isolation and characterisation of mesenchymal stem cells from rat bone marrow and the endosteal niche: A comparative study. Stem Cells International, article number: 6869128. (10.1155/2018/6869128)
2017
- Avery, S.et al. 2017. Analysing the bioactive makeup of demineralised dentine matrix on bone marrow mesenchymal stem cells for enhanced bone repair. European Cells and Materials 34, pp. 1-14. (10.22203/eCM.v034a01)
- Alraies, A.et al. 2017. Variation in human dental pulp stem cell ageing profiles reflect contrasting proliferative and regenerative capabilities. BMC Cell Biology 18, article number: 12. (10.1186/s12860-017-0128-x)
2016
- Sloan, A.et al. 2016. Tissue culture models and approaches for dental tissue regeneration. In: Waddington, R. and Sloan, A. eds. Tissue Engineering and Regeneration in Dentistry: Current Strategies. West Sussex: John Wiley & Sons, pp. 96-109., (10.1002/9781119282181.ch5)
- Sadaghiani, L.et al. 2016. Growth factor liberation and DPSCs response following dentine conditioning. Journal of Dental Research 95(11), pp. 1298-1307. (10.1177/0022034516653568)
- Jordan, R. P. C.et al. 2016. An assessment of early colonisation of implant-abutment metal surfaces by single species and co-cultured bacterial periodontal pathogens. Journal of Dentistry 53, pp. 64-72. (10.1016/j.jdent.2016.07.013)
- Young, F. I.et al. 2016. Clonal heterogeneity in the neuronal and glial differentiation of dental pulp stem/progenitor cells. Stem Cells International, article number: 1290561. (10.1155/2016/1290561)
- Song, B.et al. 2016. Bladder smooth muscle cells differentiation from dental pulp stem cells: future potential for bladder tissue engineering. Stem Cells International 2016, article number: 6979368. (10.1155/2016/6979368)
2015
- Board-Davies, E.et al. 2015. Oral mucosal lamina propria-progenitor cells exert antibacterial properties via the secretion of osteoprotegerin and haptoglobin. Stem Cells Translational Medicine 4(11), pp. 1283-1293. (10.5966/sctm.2015-0043)
- Colombo, J. S.et al. 2015. A 3D ex vivo mandible slice system for longitudinal culturing of transplanted dental pulp progenitor cells. Cytometry Part A 87(10), pp. 921-928. (10.1002/cyto.a.22680)
- Lee, C. P.et al. 2015. Elucidating the cellular actions of demineralised dentine matrix extract on a clonal dental pulp stem cell population in orchestrating dental tissue repair. Journal of Tissue Engineering 6, pp. 1-13. (10.1177/2041731415586318)
2014
- Harrington, J., Sloan, A. J. and Waddington, R. J. 2014. Quantification of clonal heterogeneity of mesenchymal progenitor cells in dental pulp and bone marrow. Connective Tissue Research 55(S1), pp. 62-67. (10.3109/03008207.2014.923859)
2013
- Young, F., Sloan, A. J. and Song, B. 2013. Dental pulp stem cells and their potential roles in central nervous system regeneration and repair. Journal of Neuroscience Research 91(11), pp. 1383-1393. (10.1002/jnr.23250)
- Chen, X.et al. 2013. Ex vivo antimicrobial efficacy of strong acid electrolytic water against Enterococcus faecalis biofilm. International Endodontic Journal 46(10), pp. 938-946. (10.1111/iej.12084)
- Roberts, J. L.et al. 2013. Development of an ex vivo coculture system to model pulpal infection by Streptococcus anginosus group bacteria. Journal of Endodontics 39(1), pp. 49-56. (10.1016/j.joen.2012.09.005)
- Sloan, A. J.et al. 2013. A novel ex vivo culture model for inflammatory bone destruction. Journal of Dental Research 92(8), pp. 728-734. (10.1177/0022034513495240)
2012
- Sloan, A. J. and Lynch, C. D. 2012. Dental tissue repair: Novel models for tissue regeneration strategies. The Open Dentistry Journal 6(1), pp. 214-219. (10.2174/1874210601206010214)
- Colombo, J. S.et al. 2012. Osteogenic potential of bone marrow stromal cells on smooth, roughened, and tricalcium phosphate-modified titanium alloy surfaces. Internation Journal of Oral and Maxillofacial Implants 27(5), pp. 1029-1042.
- Al-Daghree, S.et al. 2012. Longterm effect of low intensity pulsed ultrasound on a human tooth slice organ culture. Archives of Oral Biology 57(6), pp. 760-768. (10.1016/j.archoralbio.2011.11.010)
- Colombo, J. S.et al. 2012. In vivo monitoring of the bone healing process around different titanium alloy implant surfaces placed into fresh extraction sockets. Journal of Dentistry 40(4), pp. 338-346. (10.1016/j.jdent.2012.01.010)
- Waddington, R. J. and Sloan, A. J. 2012. Is there anything to be gained by augmenting the implant surface?. Faculty Dental Journal 3(1), pp. 28-33. (10.1308/204268512X13207759526292)
- Waddington, R. J. and Sloan, A. J. 2012. Is there anything to be gained by augmenting the implant surface?. Faculty Dental Journal 3(1), pp. 28-33. (10.1308/204268512X13207759526292)
- Wan Hassan, W. N.et al. 2012. An ex vivo culture model for orthodontically induced root resorption. Journal of dentistry 40(5), pp. 406-416. (10.1016/j.jdent.2012.02.002)
2011
- Waddington, R. J.et al. 2011. Characterization of oxidative stress status during diabetic bone healing. Cells Tissues Organs 194(2-4), pp. 307-312. (10.1159/000324251)
- Colombo, J. S.et al. 2011. Delayed osteoblast differentiation and altered inflammatory response around implants placed in incisor sockets of type 2 diabetic rats. Clinical Oral Implants Research 22(6), pp. 578-586. (10.1111/j.1600-0501.2010.01992.x)
- Smith, E.et al. 2011. TGF-beta1 exposure from bone surfaces by chemical treatment modalities. European Cells & Materials 21, pp. 193-201.
- Berkovitz, B. K. B.et al. 2011. Master Dentistry. Volume 3: Oral Biology. London: Churchill Livingstone.
- Lynch, C. D.et al. 2011. Hunter-Schreger Band patterns and their implications for clinical dentistry. Journal of Oral Rehabilitation 38(5), pp. 359-365. (10.1111/j.1365-2842.2010.02162.x)
- El-Bialy, T.et al. 2011. The effect of low intensity pulsed ultrasound in a 3D ex vivo orthodontic model. Journal of Dentistry 39(10), pp. 693-699. (10.1016/j.jdent.2011.08.001)
2010
- Smith, E.et al. 2010. An ex vivo rodent mandible culture model for bone repair. Tissue Engineering Part C: Methods 16(6), pp. 1287-1296. (10.1089/ten.tec.2009.0698)
- Lynch, C. D.et al. 2010. Hunter-Schreger Band patterns in human tooth enamel. Journal of Anatomy 217(2), pp. 106-115. (10.1111/j.1469-7580.2010.01255.x)
- Musson, D. S.et al. 2010. Adrenomedullin is expressed during rodent dental tissue development and promotes cell growth and mineralization. Biology of the Cell 102(3), pp. 145-157. (10.1042/bc20090122)
- Koutoulaki, A.et al. 2010. TNF alpha and TGF-beta 1 influence IL-18-induced IFN gamma production through regulation of IL-18 receptor and T-bet expression. Cytokine 49(2), pp. 177-184. (10.1016/j.cyto.2009.09.015)
- Lynch, C. D.et al. 2010. Gabriel-Philippe de la Hire and the discovery of Hunter-Schreger bands. British Dental Journal 209(9), pp. 461-465. (10.1038/sj.bdj.2010.980)
- Kilfeather, G. P.et al. 2010. Quality of communication and master impressions for the fabrication of cobalt chromium removable partial dentures in general dental practice in England, Ireland and Wales in 2009. Journal of Oral Rehabilitation 37(4), pp. 300-305. (10.1111/j.1365-2842.2009.02055.x)
- Patel, P. M.et al. 2010. Treatment planning for replacing missing teeth in UK general dental practice: current trends. Journal of Oral Rehabilitation 37(7), pp. 509-517. (10.1111/j.1365-2842.2010.02077.x)
- Singhrao, S. K.et al. 2010. Technical advances in the sectioning of dental tissue and of on-section cross-linked collagen detection in mineralized teeth. Microscopy Research and Technique 73(8), pp. 741-745. (10.1002/jemt.20815)
2009
- Waddington, R. J.et al. 2009. Isolation of distinct progenitor stem cell populations from dental pulp. Cells Tissues Organs 189(1-4), pp. 268-274. (10.1159/000151447)
- Baker, S. M.et al. 2009. TGF-β/extracellular matrix interactions in dentin matrix: a role in regulating sequestration and protection of bioactivity. Calcified Tissue International 85(1), pp. 66-74. (10.1007/s00223-009-9248-4)
- Jenkins, S.et al. 2009. Quality of prescription and fabrication of single-unit crowns by general dental practitioners in Wales. Journal of Oral Rehabilitation 36(2), pp. 150-156. (10.1111/j.1365-2842.2008.01916.x)
- Patel, M.et al. 2009. Phenotype and behaviour of dental pulp cells during expansion culture. Archives of Oral Biology 54(10), pp. 898-908. (10.1016/j.archoralbio.2009.06.008)
- Sloan, A. J. and Waddington, R. J. 2009. Dental pulp stem cells: what, where, how?. International Journal of Paediatric Dentistry 19(1), pp. 61-70. (10.1111/j.1365-263X.2008.00964.x)
2008
- Roberts, H. C.et al. 2008. Lipopolysaccharide alters decorin and biglycan synthesis in rat alveolar bone osteoblasts: Consequences for bone repair during periodontal disease. European Journal of Oral Sciences 116(3), pp. 207-216. (10.1111/j.1600-0722.2008.00535.x)
- Fleming, G. J. P.et al. 2008. The potential of a resin-composite to be cured to a 4 mm depth. Dental Materials 24(4), pp. 522-529. (10.1016/j.dental.2007.05.016)
- Lam, B.et al. 2008. Histomorphometric analysis of the effect of therapeutic ultrasound on the dentoalveolar structures during orthodontic force application in-vitro. Canadian Acoustics - Acoustique Canadienne 36(3), pp. 36-37.
2007
- Stringer, B.et al. 2007. Serum from Postmenopausal Women Directs Differentiation of Human Clonal Osteoprogenitor Cells from an Osteoblastic toward an Adipocytic Phenotype. Calcified Tissue International 80(4), pp. 233-243. (10.1007/s00223-007-9016-2)
- Sloan, A.et al. 2007. Bone matrix formation in osteogenic cultures derived from human embryonic stem cells in vitro. Stem Cells and Development 16(1), pp. 39-52. (10.1089/scd.2006.0010)
- Stringer, B.et al. 2007. Bespoke Human Hypertrophic Chondrocytic Cell Lines Provide the Osteoinductive Signals Required for Vascularized Bone Formation. Tissue Engineering 13(1), pp. 133-145. (10.1089/ten.2006.0111)
2006
- Graham, L.et al. 2006. The effect of calcium hydroxide on solubilisation of bio-active dentine matrix components. Biomaterials 27(14), pp. 2865-2873. (10.1016/j.biomaterials.2005.12.020)
2005
- Dhopatkar, A.et al. 2005. A novel in vitro culture model to investigate the reaction of the dentine-pulp complex to orthodontic force. Journal of Orthodontics 32(2), pp. 122-132. (10.1179/146531205225020979)
2004
- McLachlan, J. L.et al. 2004. S100 and cytokine expression in caries. Infection and Immunity 72(7), pp. 4102-4108. (10.1128/IAI.72.7.4102-4108.2004)
- Waddington, R. J.et al. 2004. Fluoride-induced changes to proteoglycan structure synthesised within the dentine-pulp complex in vitro. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1689(2), pp. 142-151. (10.1016/j.bbadis.2004.03.003)
2003
- Moseley, R.et al. 2003. The influence of fluoride exposure on dentin mineralization using an in vitro organ culture model. Calcified Tissue International 73(5), pp. 470-475. (10.1007/s00223-003-0022-8)
- Moseley, R.et al. 2003. The influence of fluoride on the cellular morphology and synthetic activity of the rat dentine-pulp complex in vitro. Archives of Oral Biology 48(1), pp. 39-46. (10.1016/S0003-9969(02)00160-7)
2002
- Sloan, A. J.et al. 2002. TGF-beta latency-associated peptides (LAPs) in human dentin matrix and pulp. Connective Tissue Research 43(2-3), pp. 381-386. (10.1080/03008200290000916)
Addysgu
BDS: Oral Ecosystems (Dental Anatomy, Oral Physiology, Developmental Biology, and Oral and Craniofacial biology).
MSc Tissue Engineering (Stem Cell Biology and Bioengineering)
MSc Oral Biology (Cell and Tissue Structure/Histology, Mineralised Tissue Biology, Stem Cell Biology)
Recent Grants
Philips - Development of an epithelial tissue culture model to assess direct Contact of H2O2 and light on cell responses. AJ Sloan (PI), RJ Waddington, WN Ayre. 2017-2018; £120,471
Research Network Wales Life Sciences Bridging Fund - Towards the Commercialization of Dual Action Mucoadhesive Patches to Treat Periodontal Diseases. C Heard, AJ Sloan. 2017-2018; £75,000
Philips – Effect of light activated peroxide agents on gingival tissue. RJ Waddington, AJ Sloan, WN Ayre. 2016-2017; £75,000
Philips - Effect of staining on Dental Tissue and Direct Contact of H202 on dental pulp cells. AJ Sloan (PI), RJ Waddington, WN Ayre. 2016-2017; £114,536
Dunhill Medical Research Trust - Preventing aseptic loosening of cemented joint replacements in older adults: delivery of osteogenic molecules from PMMA bone cement to encourage bone repair and implant osseointegration. AJ Sloan (PI), W Ayre, RJ Waddington, D Mason, B Evans, S Evans, SP Denyer, S Evans, RM Jones 2016-2017; £84,104
MRC P2D – Bioactive materials to manage dental tissue regeneration. W Ayre, AJ Sloan, RJ Waddington, CD Lynch, S Evans. 2016; £20,000
MRC CiC – Delivery of Antimicrobials from dental cements for Dental Tissue Repair. AJ Sloan (PI), JY Maillard, RJ Waddington, CD Lynch. 2016; £50,000
Renishaw Ltd – Antimicrobial coatings of implantable devices. AJ Sloan (PI), RJ Waddington, WN Ayre, Q Jones. 2015-2018; £50,000
Philips – Effect of novel antimicrobial agent on oral epithelial tissues. RJ Waddington, AJ Sloan, W Ayre. 2015-2015; £25,000
Petplan Charitable Trust - Development of novel in vitro models to investigate the role of pathogens in the aetiology of feline chronic gingivostomatitis and test therapeutic interventions. MP Riggio (Glasgow), D Bennett (Glasgow), DF Lapping (Glasgow), C Nile (Glasgow), AJ Sloan, SP Denyer (Brighton). 2015-2018; £89942
Philips – Effect of whitening agents on dental pulp functional behaviour AJ Sloan (PI), RJ Waddington, J Rees. 2015-2016; £105,785
Philips – Effect of ultrasound mediated CPC on 3D oral mucosa tissue cultures. RJ Waddington, AJ Sloan, W Ayre. 2014-2015; £27,000
UKRMP Partnership Award– Novel Bioactive Delivery Materials for Mineralised Tissue Repair. AJ Sloan (PI), RJ Waddington, S Evans. 2015; £50,000
NISCHR – Novel Antimicrobial Restorative Materials to Manage Dental Disease. AJ Sloan (PI), A Paul (CHEMY), RJ Waddington. 2014-2017; £66,000
Current Projects
Novel Antimicrobial Restorative Materials to Manage Dental Disease
Delivery of osteogenic molecules ffor bone repair and implant osseointegration
Antimicrobial coatings of implantable devices
Understanding heterogeneity of dental pulp progenitor cells through lineage tacking and biophotonic labelling
Effect of whitening agents on dental pulp functional behaviour
Dental material directed tissue regeneration
Ex vivo modelling of antimicrobial measures in pulpal disease
Ex vivo modelling of bone regeneration
