Timothy Pickles
Junior Statistician
- pickleste@cardiff.ac.uk
- +44 (0)29 2068 7259
- Neuadd Meirionnydd, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4YS
- Sylwebydd y cyfryngau
Trosolwg
Research Themes
I hold a BSc (Hons), a MSc (distinction), and have been working at Cardiff University since July 2009, currently in the Centre for Trials Research (CTR) and Cardiff Regional Experimental Arthritis Treatment and Evaluation (CREATE) Centre. I previously had a secondment in the School of Dentistry, which as well as research, involved teaching statistics and SPSS to BDS students, and providing statistical support to MOrth and PhD students.
My work in CTR principally involves being the statistician on multiple and differing clinical trials, across many varied disciplines. I have developed an interest in diabetes, urinary tract infections, rheumatology and skin conditions, as well as dental caries from my previous work in the School of Dentistry. The interventions I have focussed on are behaviour change counselling, shared decision making tools and devices/aids for appropriate antibiotic prescribing.
In my role within the CREATE centre, I am researching into the use of early phase clinical trial methodology in the field of rheumatology. I had already begun looking into techniques to explore the psychometric properties of various Quality of Life Instruments, and I was fortunate to spend my MSc dissertation learning about, and undertaking, Rasch analyses, which is a continuing research theme.
I have also undertaken meta-analyses and epidemiological research, and advised PhD students and relevant staff members. I am the statistical lead for CTR Standard Operating Procedures.
Further links:
publons: https://publons.com/author/1193132/timothy-pickles#profile
orcid: http://orcid.org/0000-0001-7743-0234
RSS StatsLife:
Bywgraffiad
Career Profile
2009 - 2014: Research Assistant, South East Wales Trials Unit and School of Dentistry, Cardiff University
2014 - present: Research Associate, Centre for Trials Research and Cardiff Regional Experimental Arthritis Treatment and Evaluation Centre
Education and Qualifications
2009: 1st Class BSc (Hons) Natural Sciences with Industrial Placement, University of Bath
2014: MSc (Distinction) Operational Research and Applied Statistics, Cardiff University
Teaching Profile
BDS Dental Public Health Statistics Lectures and SPSS Sessions
Anrhydeddau a Dyfarniadau
GradStat, Royal Statistical Society, 2016
Aelodaethau proffesiynol
Fellow of the Royal Statistical Society
Safleoedd academaidd blaenorol
Career Profile
2009 - 2014: Research Assistant, South East Wales Trials Unit and School of Dentistry, Cardiff University
2014 - present: Research Associate, Centre for Trials Research and Cardiff Regional Experimental Arthritis Treatment and Evaluation Centre
Ymrwymiadau siarad cyhoeddus
Pickles T, Playle R, Hood K, Gillard J. Rasch analysis of the PedsQLTM 3.0 Diabetes Module. Paper presented at: ISOQOL 2014. Proceedings of the 21st ISOQOL Annual conference; 2014 Oct 15-18; Berlin, Germany. Qual Life Res 2014;23(Suppl1):304.4.
Pickles T, Channon S, Gregory J, Lowes L. Development of the social activities and independence questionnaire in paediatric diabetes as part of the DECIDE randomised controlled trial. Poster Session presented at: ISOQOL 2014. Proceedings of the 21st ISOQOL Annual conference; 2014 Oct 15-18; Berlin, Germany. Qual Life Res 2014;23(Suppl1):2110.
Pickles T, Playle R, Hood K, Gillard J, Robling M. Rasch analysis of the PedsQLTM 3.0 Diabetes Module. Paper presented at: CTMC 2013. Proceedings of the 2nd Clinical Trial Methodology Conference; 2013 Nov 18-19; Edinburgh, UK. Trials 2013;13(Suppl1):O40.
Pickles T, Butler CC, Waldron CA, Thomas-Jones E, Hood K, O’Brien K, Hay AD. Presentation, Management and Outcomes of Preschool Children with UTI Presenting in UK Primary Care. Paper presented at: GRIN 2013. Proceedings of the 15th General Practice Research Infections Network Conference; 2013 Oct 4-5; Nice, France.
Pickles T, Blewitt N, Chestnutt IG. Determinants of Recall Intervals in Children. Poster Session Presented at: BSODR 2013. 60th Annual Scientific Meeting and Exhibition of the British Society of oral and Dental Research; 2013 Sep 9-11, Bath, UK.
Pickles T, Gillard J, Hood K, Playle R. Rasch analysis of the PedsQLTM 3.0 Diabetes Module. Paper presented at: YSM 2013. Proceedings of the 39th Young Statisticians’ Meeting; 2013 Jul 4-5; Imperial College London, UK.
Pickles T, Murangwa MY, Hood K, Butler CC. The Use of Composite Outcomes in Behaviour Change. Paper presented at: YSM 2012. Proceedings of the 38th Young Statisticians’ Meeting; 2012 Apr 2-3; Queen’s College, Cambridge, UK.
Pickles T, Gregory JW, Robling R. Cluster Randomised Controlled Trial of a Psychosocial Behavioural Change Intervention on children with type-1 Diabetes: Analysis of Baseline Questionnaire Score Data. Paper presented at: YSM 2010. Proceedings of the 36th Young Statisticians’ Meeting; 2010 Mar 30-31; University of Liverpool, UK.
Pwyllgorau ac adolygu
2016 - present: Member of the Cardiff University Time to Change Wales Committee
Cyhoeddiadau
2022
- Bisson, J. I. et al. 2022. Guided, internet based, cognitive behavioural therapy for post-traumatic stress disorder: pragmatic, multicentre, randomised controlled non-inferiority trial (RAPID). BMJ 377, article number: e069405. (10.1136/bmj-2021-069405)
- Pickles, T. et al. 2022. P089 Patient-reported outcome measures for rheumatoid arthritis disease activity: a systematic review following COSMIN guidelines. Presented at: British Society for Rheumatology Annual Conference 2022, Glasgow, Scotland, 25-27 April 2022Rheumatology Supplement 1, Vol. 61. pp. keac133.088., (10.1093/rheumatology/keac133.088)
- Pickles, T. et al. 2022. Patient reported outcome measures for rheumatoid arthritis disease activity: a systematic review following COSMIN guidelines. RMD Open 8(1), article number: e002093. (10.1136/rmdopen-2021-002093)
- Griffiths, C., Tollow, P., Cox, D., White, P., Pickles, T. and Harcourt, D. 2022. The CARe Burn Scale—Adult Form: Identifying the responsiveness and minimal important difference (MID) values of a Patient Reported Outcome Measure (PROM) to assess quality of life for adults with a burn injury. European Burn Journal 3(1), pp. 211-233. (10.3390/ebj3010019)
- Joshi, H. B. et al. 2022. Urinary stones and intervention quality of life (USIQoL): development and validation of a new core universal patient-reported outcome measure for urinary calculi. European Urology Focus 8(1), pp. 283-290. (10.1016/j.euf.2020.12.011)
- Pickering, D., Pickles, T. and Shiress, T. 2022. A study protocol to develop the domains of an observational well-being scale (WEBS) for non-verbal children and young people with cerebral palsy from using the Innowalk.. Presented at: National Patient Reported Outcome Measures, Online, 14 - 15 June 2022.
2021
- Griffiths, C., Tollow, P., Cox, D., White, P., Pickles, T. and Harcourt, D. 2021. Testing the responsiveness of and defining minimal important difference (MID) values for the CARe burn scales: patient-reported outcome measures to assess quality of life for children and young people affected by burn injuries, and their parents/caregivers. European Burn Journal 2(4), pp. 249-280. (10.3390/ebj2040019)
- Pattinson, R. L. et al. 2021. Patient-reported outcome measures in dermatology: a systematic review. Acta Dermato-Venereologica 101(9), article number: adv00559. (10.2340/00015555-3884)
- McCarroll, Z., Townson, J., Pickles, T., Gregory, J. W., Playle, R., Robling, M. and Hughes, D. 2021. Cost-effectiveness of home versus hospital management of children at onset of Type 1 Diabetes: The DECIDE randomised controlled trial. BMJ Open 11(5), article number: e043523. (10.1136/bmjopen-2020-043523)
- Abbott, R. A. et al. 2021. Observational study to estimate the proportion of surgical site infection following excision of ulcerated skin tumours (OASIS study). Clinical and Experimental Dermatology 47(5), pp. 882-888. (10.1111/ced.15037)
- Bartlett, R., Acton, J., Ryan, B., Man, R., Pickles, T. and Nollett, C. 2021. Training results in increased practitioner confidence and identification of depression in people with low vision: a mixed methods study. Ophthalmic and Physiological Optics 41(2), pp. 316-330. (10.1111/opo.12788)
- Griffiths, C., Guest, E., Pickles, T., Hollèn, L., Grzeda, M., Tollow, P. and Harcourt, D. 2021. The development and validation of the CARe Burn Scale: Child Form: a parent-proxy-reported outcome measure assessing quality of life for children aged 8 years and under living with a burn injury. Quality of Life Research 30, pp. 239-250. (10.1007/s11136-020-02627-x)
2020
- Lowe, J. et al. 2020. Study protocol: azithromycin therapy for chronic lung disease of prematurity (AZTEC) - a randomised, placebo-controlled trial of azithromycin for the prevention of chronic lung disease of prematurity in preterm infants. BMJ Open 10(10), article number: e041528. (10.1136/bmjopen-2020-041528)
- Bisson, J. I. et al. 2020. Randomised controlled trial of multi-modular motion-assisted memory desensitization and reconsolidation (3MDR) for male military veterans with treatment-resistant post-traumatic stress disorder. Acta Psychiatrica Scandinavica 142(2), pp. 141-151. (10.1111/acps.13200)
- Stampalija, T. et al. 2020. Fetal cerebral Doppler changes and outcome in late preterm fetal growth restriction: prospective cohort study. Ultrasound in Obstetrics and Gynecology 56(2), pp. 173-181. (10.1002/uog.22125)
- Nollett, C., Bartlett, R., Man, R., Pickles, T., Ryan, B. and Acton, J. H. 2020. Barriers to integrating routine depression screening into community low vision rehabilitation services: a mixed methods study. BMC Psychiatry 20, pp. 419. (10.1186/s12888-020-02805-8)
2019
- Nollett, C., Bartlett, R., Man, R., Pickles, T., Ryan, B. and Acton, J. H. 2019. How do community-based eye care practitioners approach depression in patients with low vision? A mixed methods study. BMC Psychiatry 19(1), article number: 426. (10.1186/s12888-019-2387-x)
- Gregory, J. W. et al. 2019. Effectiveness of home or hospital initiation of treatment at diagnosis for children with type 1 diabetes (DECIDE trial): a multicentre individually randomised controlled trial. BMJ Open 9, article number: e032317. (10.1136/bmjopen-2019-032317)
- Bosanquet, D. et al. 2019. Perineural local anaesthetic catheter after major lower limb amputation trial (PLACEMENT): results from a randomised controlled feasibility trial. BMJ Open 9(11), article number: e029233. (10.1136/bmjopen-2019-029233)
- Pickles, T. et al. 2019. Adaptive trial designs in rheumatology: Report from the OMERACT Special Interest Group. Journal of Rheumatology 46(10), pp. 1406-1408., article number: jrheum.181054. (10.3899/jrheum.181054)
- Griffiths, C. et al. 2019. The development and validation of the CARe Burn Scale - Adult Form: a Patient Reported Outcome Measure (PROM) to assess quality of life for adults living with a burn injury. Journal of Burn Care and Research 40(36), pp. 312-326. (10.1093/jbcr/irz021)
- Morgan-Trimmer, S. et al. 2019. The acceptability of fluoride varnish and fissure sealant treatments in children aged 6-9 delivered in a school setting. Community Dental Health 36(1), pp. 33-38. (10.1922/CDH_4263Morgan-Trimmer06)
2018
- Cooksey, R. et al. 2018. Cardiovascular risk factors predicting cardiac events are different in patients with rheumatoid arthritis, psoriatic arthritis, and psoriasis. Seminars in Arthritis and Rheumatism 48(3), pp. 367-373. (10.1016/j.semarthrit.2018.03.005)
- Bosanquet, D. C. et al. 2018. Major lower limb amputation audit – introduction and implementation of a multimodal perioperative pain management guideline. British Journal of Pain 12(4), pp. 257-258. (10.1177/2049463718800736)
- Pickles, T., Christensen, R., Tam, L., Simon, L. S. and Choy, E. H. 2018. Early phase and adaptive design clinical trials in rheumatoid arthritis: a systematic review of early phase trials. Rheumatology Advances in Practice 2(2), article number: rky045. (10.1093/rap/rky045)
- Butler, C. C. et al. 2018. Point-of-care urine culture for managing urinary tract infection in primary care: a randomised controlled trial of clinical and cost-effectiveness. British Journal of General Practice 68(669), pp. e268-e278. (10.3399/bjgp18X695285)
- Nollett, C. et al. 2018. Pragmatic RAndomised controlled trial of a trauma-focused guided self-help Programme versus InDividual trauma-focused cognitive Behavioural therapy for post-traumatic stress disorder (RAPID): trial protocol. BMC Psychiatry 18(1), article number: 77. (10.1186/s12888-018-1665-3)
- Ingram, J. et al. 2018. Levels of wound calprotectin and other inflammatory biomarkers aid in deciding which patients with a diabetic foot ulcer need antibiotic therapy (INDUCE study). Diabetic Medicine 35(2), pp. 255-261. (10.1111/dme.13431)
- Alhaidari, T. et al. 2018. Feasibility and acceptability of text messaging to support antenatal healthcare in Iraqi pregnant women: a pilot study. Journal of Perinatal Medicine 46(1), pp. 67-74. (10.1515/jpm-2016-0127)
2017
- Butler, C. C. et al. 2017. Variations in presentation, management, and patient outcomes of urinary tract infection: a prospective four-country primary care observational cohort study. British Journal of General Practice 67(665), pp. e830-e841. (10.3399/bjgp17X693641)
- Bosanquet, D. C. et al. 2017. Perineural local anaesthetic catheter after major lower limb amputation trial (PLACEMENT): study protocol for a randomised controlled pilot study. Trials 18, article number: 629. (10.1186/s13063-017-2357-x)
- White, J. et al. 2017. Adaptation of the ASSIST peer-led smoking intervention to deliver information from the Talk to FRANK drug education website (ASSIST+FRANK): a pilot cluster-randomised controlled trial. The Lancet 390(S3), pp. S1. (10.1016/S0140-6736(17)32936-7)
- White, J. et al. 2017. Adapting the ASSIST model of informal peer-led intervention delivery to the Talk to FRANK drug prevention programme in UK secondary schools (ASSIST?+FRANK): intervention development, refinement and a pilot cluster randomised controlled trial. Public Health Research 5(7), pp. 1-126. (10.3310/phr05070)
- Hullegie, S. et al. 2017. Clinicians' interpretations of point of care urine culture versus laboratory culture results: analysis from the four-country POETIC trial of diagnosis of uncomplicated urinary tract infection in primary care. Family Practice 34(4), pp. 392-399. (10.1093/fampra/cmx009)
- Chestnutt, I. G. et al. 2017. Fissure seal or fluoride varnish? A randomised trial of their relative effectiveness. Journal of Dental Research 96(7), pp. 754-761. (10.1177/0022034517702094)
- Chestnutt, I. G. et al. 2017. Seal or Varnish? A randomised controlled trial to determine the relative cost and effectiveness of pit and fissure sealant and fluoride varnish in preventing dental decay. Health Technology Assessment 21(21), pp. 1-256. (10.3310/hta21210)
- Chalumeau, M. et al. 2017. Comparison of microbiological diagnosis of urinary tract infection in young children by routine health service laboratories and a research laboratory: diagnostic cohort study. PLoS ONE 12(2), article number: e0171113. (10.1371/journal.pone.0171113)
2016
- Hay, A. D. et al. 2016. Improving the diagnosis and treatment of urinary tract infection in young children in primary care: results from the DUTY prospective diagnostic cohort study. Annals of Family Medicine 14(4), pp. 325-336. (10.1370/afm.1954)
- Hay, A. D. et al. 2016. The Diagnosis of Urinary Tract infection in Young children (DUTY): a diagnostic prospective observational study to derive and validate a clinical algorithm for the diagnosis of urinary tract infection in children presenting to primary care with an acute illness. Health Technology Assessment 20(51) (10.3310/hta20510)
- Butler, C. C. et al. 2016. Nappy pad urine samples for investigation and treatment of UTI in young children: the 'DUTY' prospective diagnostic cohort study. British Journal of General Practice 66(648), pp. e516-e524. (10.3399/bjgp16X685873)
- Elwyn, G. et al. 2016. Supporting shared decision making using an Option Grid for osteoarthritis of the knee in an interface musculoskeletal clinic: a stepped wedge trial. Patient Education and Counseling 99(4), pp. 571-577. (10.1016/j.pec.2015.10.011)
- Atwan, A., Ingram, J. R., Abbott, R., Kelson, M. J., Pickles, T. E., Bauer, A. and Piguet, V. 2016. Oral fumaric acid esters for psoriasis: abridged Cochrane systematic review including GRADE assessments. British Journal of Dermatology 175(5), pp. 873-881. (10.1111/bjd.14676)
- Butler, C. C. et al. 2016. Empiric antibiotic treatment for urinary tract infection in preschool children: susceptibilities of urine sample isolates. Family Practice 33(2), pp. 127-132. (10.1093/fampra/cmv104)
2015
- Randell, E., Pickles, T., Simpson, S. A., Spanou, C., McCambridge, J., Hood, K. and Butler, C. C. 2015. Eligibility for interventions, co-occurrence and risk factors for unhealthy behaviours in patients consulting for routine primary care: results from the Pre-Empt study. BMC Family Practice 16, article number: 133. (10.1186/s12875-015-0359-x)
- Gobat, N. H., Kinnersley, P., Gregory, J. W., Pickles, T. E., Hood, K. and Robling, M. R. 2015. Measuring clinical skills in agenda-mapping (EAGL-I). Patient Education and Counseling 98(10), pp. 1214-1221. (10.1016/j.pec.2015.06.018)
- Al Ali, A. et al. 2015. The influence of snoring, mouth breathing and apnoea on facial morphology in late childhood: a three-dimensional study. BMJ Open 5(9), article number: e009027. (10.1136/bmjopen-2015-009027)
- Atwan, A., Ingram, J., Abbott, R., Kelson, M., Pickles, T., Bauer, A. and Piguet, V. 2015. Oral fumaric acid esters for psoriasis. Cochrane Database of Systematic Reviews(8), article number: CD010497. (10.1002/14651858.CD010497.pub2)
- Butler, C. C. et al. 2015. Childhood urinary tract infection in primary care: a prospective observational study of prevalence, diagnosis, treatment, and recovery. British Journal of General Practice 65(633), pp. e217-e223. (10.3399/bjgp15X684361)
2014
- Bates, J. et al. 2014. Point of care testing for urinary tract infection in primary care (POETIC): protocol for a randomised controlled trial of the clinical and cost effectiveness of FLEXICULT (TM) informed management of uncomplicated UTI in primary care. BMC Family Practice 15, pp. -., article number: 187. (10.1186/s12875-014-0187-4)
- Al Ali, A. et al. 2014. A three-dimensional analysis of the effect of atopy on face shape. European Journal of Orthodontics 36(5), pp. 506-511. (10.1093/ejo/cjs107)
- Haddad, N. S. et al. 2014. A feasibility study of mobile phone text messaging to support education and management of type 2 diabetes in Iraq. Diabetes Technology & Therapeutics 16(7), pp. 454-459. (10.1089/dia.2013.0272)
- Lowes, L. M. et al. 2014. Late-breaking abstract. [LB1 Delivering early care in diabetes evaluation: the DECIDE Study. Hospital versus home management at diagnosis in childhood diabetes: a comparison of psychological, social, physical and economic outcomes]. Diabetic Medicine 31(s1), pp. 184. (10.1111/dme.12408)
- Lowes, L. M. et al. 2014. Delivering early care in diabetes evaluation: the DECIDE study. Hospital versus home management at diagnosis in childhood diabetes: a comparison of psychological, social, physical and economic outcomes. Presented at: Diabetes UK Professional Conference 2014, Liverpool, UK, 5-7 March 2014.
- Marrin, K. et al. 2014. Option Grids to facilitate shared decision making for patients with Osteoarthritis of the knee: protocol for a single site, efficacy trial. BMC Health Services Research 14, article number: 160. (10.1186/1472-6963-14-160)
2013
- Bates, J. et al. 2013. Effects of an optimised POCT guided diagnostic and treatment strategy for symptoms of uncomplicated UTI on use of appropriate antibiotics and uptake into primary care practice. [Abstract]. Trials 14(S1), pp. -., article number: P10. (10.1186/1745-6215-14-S1-P10)
- Pickles, T., Playle, R., Hood, K., Gillard, J. and Robling, M. 2013. Rasch analysis of the PedsQL 3.0 diabetes module. [Abstract]. Trials 14(S1), article number: 40. (10.1186/1745-6215-14-S1-O40)
- Butler, C. C. et al. 2013. Training practitioners to deliver opportunistic multiple behaviour change counselling in primary care: a cluster randomised trial. BMJ 346, article number: f1191. (10.1136/bmj.f1191)
- Edwards, A. G., Naik, G., Ahmed, H., Elwyn, G., Pickles, T. E., Hood, K. and Playle, R. A. 2013. Personalised risk communication for informed decision making about taking screening tests. Cochrane Database of Systematic Reviews 2013(2), article number: CD001865. (10.1002/14651858.CD001865.pub3)
- Waldron, C. et al. 2013. Recruitment to diagnosis of urinary tract infections in young children (DUTY) study: an evaluation of the successful methods used in a primary care, prospective cohort study. [Abstract]. Trials 14(S1), pp. -., article number: P37. (10.1186/1745-6215-14-S1-P37)
2012
- Chestnutt, I. G. et al. 2012. Protocol for 'Seal or Varnish' (SoV) trial: A randomised controlled trial to measure the relative cost and effectiveness of pit and fissure sealants and fluoride varnish in preventing dental decay. BMC Oral Health 12(1), pp. 51-62. (10.1186/1472-6831-12-51)
- Robling, M. R. et al. 2012. The effect of the Talking Diabetes consulting skills intervention on glycaemic control and quality of life in children with type 1 diabetes: cluster randomised controlled trial (DEPICTED study). British Medical Journal 344, article number: e2359. (10.1136/bmj.e2359)
2011
- Gregory, J. W. et al. 2011. Development and evaluation by a cluster randomised trial of a psychosocial intervention in children and teenagers experiencing diabetes: The DEPICTED study. Health Technology Assessment 15(29), pp. 1-202. (10.3310/hta15290)
2010
- Spanou, C. et al. 2010. Preventing disease through opportunistic, rapid engagement by primary care teams using behaviour change counselling (PRE-EMPT): protocol for a general practice-based cluster randomised trial. BMC Family Practice 11(1), pp. 69. (10.1186/1471-2296-11-69)