Yr Athro Monica Busse
- busseme@cardiff.ac.uk
- +44 (0)29 2068 7559
- Room 2F08, Cardigan House, Heath Park Campus, Cardiff, CF14 4XN, Cardigan House, Heath Park Campus, Cardiff, CF14 4XN
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwg
I have a specific interest in the development of exercise therapeutics in neurodegenerative conditions and extensive knowledge of the development and evaluation of complex interventions applied to neurodegeneration. I am interested more widely in the assessment and management of mobility problems and falls, methodologies for appropriate assessment of outcomes in complex health conditions and promotion of physical activity for health (along with behaviour change applications). I am currently developing and validating novel functional assessment methods and technologies to support patient monitoring to good clinical practice standards for application in ‘first-in-man’ clinical trials of ES derived stem cells in HD. I am a reviewer for a range of international peer reviewed journals in the field. I am also a member of the Scientific and Bioethics Advisory Committee (SBAC) of the European Huntington's Disease Network (EHDN) and the EHDN Physiotherapy working group. My ORCID-ID is 0000-0002-5331-5909.
Bywgraffiad
Qualifications
BSc Physiotherapy (University of Stellenbosch), December 1993
BSc (Med) Hons. Ergonomics (first class) (University of Cape Town), December 1996
MSc (Med) Biomedical Sciences (distinction) (University of Cape Town), December 2001
PhD (University of Wales College of Medicine), July 2005
Post Graduate Certificate in Teaching and Learning (Kingston University), July 2001
Diploma in Research Methods (University of Wales College of Medicine), May 2003
Certificate in Teaching Statistics in Higher Education (Royal Statistical Society), February 2005
I am in possession of both a Post Graduate Certificate in Teaching and Learning and a Certificate in Teaching Statistics in Higher Education (Royal Statistical Society). My teaching interests and professional development is aligned with my research work and has a clear focus on physiotherapy provision for people with Long Term Neurological Conditions (LTNCs). I also have a particular interest in innovative methods for teaching research and statistics and the use of reliability analyses and mixed methods in healthcare research which has developed as a direct result of application in my research area. I contribute to teaching on the Research Methods of Health and Social Care, Experimental Designs, Neuroscience and Neurorehabilitation modules. I also collaborate with clinicians and researchers based both in other schools within Cardiff University and other academic institutions in the United Kingdom and regularly review grants submitted for funding and manuscripts submitted for publication in the field of physiotherapy, neurology and rehabilitation.
Aelodaethau proffesiynol
Registered Physiotherapist Health Professions Council PH 53577 January 1998
Member of Chartered Society of Physiotherapy January 1998
Fellow of Higher Education Institute July 2001
Cyhoeddiadau
2023
- Fakolade, A. et al. 2023. Mapping two decades of multiple sclerosis rehabilitation trials: A systematic scoping review and call to action to advance the study of race and ethnicity in rehabilitation research. Multiple Sclerosis and Related Disorders, article number: 104606. (10.1016/j.msard.2023.104606)
- Potter, C. et al. 2023. Effectiveness and cost-effectiveness of a personalised self-management intervention for living with long covid: protocol for the listen randomised controlled trial. Trials 24, article number: 75. (10.1186/s13063-023-07090-w)
- Lemoine, L. et al. 2023. The striatum in time production: the model of Huntingtons's disease in longitudinal study. Neuropsychologia 179, article number: 108459. (10.1016/j.neuropsychologia.2022.108459)
2022
- Fahed, V. S., Doheny, E. P., Busse, M., Hoblyn, J. and Lowery, M. M. 2022. Comparison of acoustic voice features derived from mobile devices and studio microphone recordings. Journal of Voice (10.1016/j.jvoice.2022.10.006)
- Heaton-Shrestha, C., Torrens-Burton, A., Leggat, F., Islam, I., Busse, M. and Jones, F. 2022. Co-designing personalised self-management support for people living with long Covid: the LISTEN protocol. PLoS ONE 17(10), article number: e0274469. (10.1371/journal.pone.0274469)
- Metzler-Baddeley, C., Busse, M. E., Drew, C. J., Pallmann, P., Jones, D. K. and Rosser, A. 2022. HD-DRUM – a novel computerised drumming training for movement and cognitive abilities in people with Huntington’s disease – app development and protocol of a randomised controlled feasibility study. Presented at: EHDN 2022 Plenary Meeting, Bologna, Italy, 16-18 September 2022, Vol. 93. Vol. S1. pp. A100-A101., (10.1136/jnnp-2022-ehdn.267)
- Markoulidakis, A., Holmans, P., Pallmann, P., Busse, M. and Griffin, B. A. 2022. Covariate balancing & weighting web app (COBWEB): an online tool simplifying robust causal inference in observational studies. Journal of Neurology, Neurosurgery and Psychiatry 93(S1), article number: A44. (10.1136/jnnp-2022-ehdn.114)
- Markoulidakis, A., Busse, M., Doheny, E., Drew, C., Kirby, N. and Pallmann, P. 2022. Lifestyle index for individuals with HD (LifeHD): an aggregated measure that characterises the lifestyle habits of individuals with HD. Presented at: EHDN 2022 Plenary Meeting, Bologna, Italy, 16-18 September, Vol. 93. Vol. S1., (10.1136/jnnp-2022-ehdn.111)
- Quinn, L. et al. 2022. Physical activity and exercise outcomes in Huntington's disease (PACE-HD): results of a 12-month trial-within-cohort feasibility study of a physical activity intervention in people with Huntington's disease. Parkinsonism & Related Disorders 101, pp. 75-89. (10.1016/j.parkreldis.2022.06.013)
- Fritz, N. E., Busse, M., Muratori, L. M., Rao, A. K., Kloos, A., Kegelmeyer, D. and Quinn, L. 2022. An MDS evidence-based review on treatments for Huntington's disease [Letter]. Movement Disorders 37(7), pp. 1566-1567. (10.1002/mds.29059)
- Milosevic, S. et al. 2022. Understanding the support experiences of families of children with autism and sensory processing difficulties: A qualitative study.. Health Expectations 25(3), pp. 1118-1130. (10.1111/hex.13465)
- Morgan-Jones, P. et al. 2022. Monitoring and managing lifestyle behaviours using wearable activity trackers: a mixed methods study of views from the Huntington's disease community. JMIR Formative Research 6(6), article number: e36870. (10.2196/36870)
- Randell, E. et al. 2022. Sensory integration therapy for children with autism and sensory processing difficulties: the SenITA RCT. Health Technology Assessment 26(29) (10.3310/TQGE0020)
- Desai, R. et al. 2022. Postural control and gait measures derived from wearable inertial measurement unit devices in Huntington's disease: recommendations for clinical outcomes. Clinical Biomechanics 96, article number: 105658. (10.1016/j.clinbiomech.2022.105658)
- Rosser, A. E. et al. 2022. Translating cell therapies for neurodegenerative diseases: Huntington's disease as a model disorder. Brain 145(5), pp. 1584-1597. (10.1093/brain/awac086)
- Markoulidakis, A., Taiyari, K., Holmans, P., Pallmann, P., Busse, M., Godley, M. D. and Griffin, B. A. 2022. A tutorial comparing different covariate balancing methods with an application evaluating the causal effects of substance use treatment programs for adolescents. Health Services and Outcomes Research Methodology (10.1007/s10742-022-00280-0)
- Busse, M. et al. 2022. A web-based life-style, exercise and activity intervention for people with progressive multiple sclerosis results of a single-arm feasibility study. Multiple Sclerosis and Related Disorders 57, article number: 103388. (10.1016/j.msard.2021.103388)
- Drew, C. J. and Busse, M. 2022. Considerations for clinical trial design and conduct in the evaluation of novel advanced therapeutics in neurodegenerative disease. In: Current Challenges in Cell Therapy for Neurodegenerative Diseases. International Review of Neurobiology Elsevier, pp. 235-279., (10.1016/bs.irn.2022.09.006)
- Hare, E., Bachoud-Lévi, A., Reilmann, R., Craufurd, D., Busse, M., Rosser, A. and McLauchlan, D. 2022. Cognitive processes of apathy in Huntington's Disease show high sensitivity to disease progression. Clinical Parkinsonism & Related Disorders 7, article number: 100168. (10.1016/j.prdoa.2022.100168)
2021
- Muratori, L. M., Quinn, L., LI, X., Youdan, G., Busse, M. and Fritz, N. E. 2021. Measures of postural control and mobility during dual-tasking as candidate markers of instability in Huntington's Disease. Human Movement Science 80, article number: 102881. (10.1016/j.humov.2021.102881)
- Chopard, D., Treder, M., Corcoran, P., Johnson, C., Busse-Morris, M. and Spasic, I. 2021. Text mining of adverse events in clinical trials: Deep learning approach. JMIR Medical Informatics 9(12), article number: e28632. (10.2196/28632)
- Karen, K. et al. 2021. Quantification of daily-living gait quantity and quality using a wrist-worn accelerometer in Huntington's Disease. Frontiers in Neurology 12, article number: 719442. (10.3389/fneur.2021.719442)
- Simpson, S. et al. 2021. Healthy eating and lifestyle in pregnancy (HELP): a cluster randomised trial to evaluate the effectiveness of a weight management intervention for pregnant women with obesity on weight at 12 months postpartum. International Journal of Obesity 45, pp. 1728-1739. (10.1038/s41366-021-00835-0)
- Lunven, M. et al. 2021. Cognitive decline in Huntington's disease in the Digitalized Arithmetic Task (DAT). PLoS ONE 16(8), article number: e0253064. (10.1371/journal.pone.0253064)
- Woodgate, S. et al. 2021. Objectively characterizing Huntington’s disease using a novel upper limb dexterity test. Journal of Neurology 268, pp. 2550-2559. (10.1007/s00415-020-10375-8)
- Desai, R., Fritz, N. E., Muratori, L., Hausdorff, J. M., Busse, M. and Quinn, L. 2021. Evaluation of gait initiation parameters using inertial sensors in Huntington's Disease: insights into anticipatory postural adjustments and cognitive interference. Gait and Posture 87, pp. 117-122. (10.1016/j.gaitpost.2021.04.021)
- Latchem-Hastings, J. et al. 2021. Lifestyle, exercise and activity package for people living with progressive multiple sclerosis (LEAP-MS): protocol for a single-arm feasibility study. Pilot and Feasibility Studies 7, article number: 111. (10.1186/s40814-021-00852-w)
- Jones, U., Hamana, K., O'Hara, F. and Busse, M. 2021. The development of PAT‐HD: a co‐designed tool to promote physical activity in people with Huntington’s disease. Health Expectations 24(2), pp. 638-647. (10.1111/hex.13210)
- Lowe, R. et al. 2021. Lifestyle, exercise and activity package for people living with progressive Multiple Sclerosis (LEAP-MS): adaptions during the COVID-19 pandemic and remote delivery for improved efficiency. Trials 22, article number: 286. (10.1186/s13063-021-05245-1)
- Busse, M. et al. 2021. A web-based physical activity intervention for people with progressive Multiple Sclerosis: application of consensus-based intervention development guidance. BMJ Open 11(3), article number: e045378. (10.1136/bmjopen-2020-045378)
- Jones, L. et al. 2021. Can wearable technology be used to approximate cardiopulmonary exercise testing metrics?. Perioperative Medicine 10, article number: 9. (10.1186/s13741-021-00180-w)
- Griffin, B. A. et al. 2021. Estimating the causal effects of modifiable, non-genetic factors on Huntington Disease progression using propensity score weighting. Parkinsonism and Related Disorders 83, pp. 56-62. (10.1016/j.parkreldis.2021.01.010)
- Jones, A., Morgan-Jones, P., Busse, M., Shepherd, V. and Wood, F. 2021. Conducting focus groups in neurodegenerative disease populations: ethical and methodological considerations. BMJ Open 11(1), article number: e041869. (10.1136/bmjopen-2020-041869)
- Hamana, K., Quinn, L., Gambling, T. and Busse, M. 2021. An exploration of physical activity experiences throughout the Huntington's disease journey: supporting development of theoretically underpinned complex interventions. Disability and Rehabilitation 43(11), pp. 1565-1575. (10.1080/09638288.2019.1671501)
- Drew, C. et al. 2021. Protocol for an open label, phase I trial within a cohort of fetal cell transplants in people with Huntington’s disease. Brain Communications 3(1), article number: fcaa230. (10.1093/braincomms/fcaa230)
- Badin, R. A. et al. 2021. Stem cells for Huntington’s disease (SC4HD): an international consortium to facilitate stem cell-based therapy for Huntington’s disease. Journal of Huntington's Disease 10(2), pp. 221-226. (10.3233/JHD-210473)
2020
- Jones, U., Hamana, K. and Busse, M. 2020. Acceptability of a co-designed tool to promote physical activity in people with Huntington's disease [Abstract]. Neurotherapeutics 17(S), article number: 11. (10.1007/s13311-020-00945-z)
- Jones, U. and Busse, M. 2020. Navigating the challenges of COVID-19: staying active with HD [Abstract]. Neurotherapeutics 17(S), pp. 10-11. (10.1007/s13311-020-00945-z)
- Williams, N. et al. 2020. Protocol for a definitive randomised controlled trial and economic evaluation of a community-based rehabilitation programme following hip fracture: fracture in the elderly multidisciplinary rehabilitation—phase III (FEMuR III). BMJ Open 10, article number: e039791. (10.1136/bmjopen-2020-039791)
- Yhnell, E. et al. 2020. A randomised feasibility study of computerised cognitive training as a therapeutic intervention for people with Huntington's disease (CogTrainHD). Pilot and Feasibility Studies 6, article number: 88. (10.1186/s40814-020-00623-z)
- Busse, M. and Ramdharry, G. 2020. Targeting sedentary behaviour in neurological disease. Practical Neurology 20(3), pp. 187-188. (10.1136/practneurol-2019-002491)
- Steventon, J., Furby, H., Ralph, J., O'Callaghan, P., Wise, R., Busse, M. and Murphy, K. 2020. Altered cerebrovascular response to acute exercise in patients with Huntington’s Disease. Brain Communications 2(1), article number: fcaa044. (10.1093/braincomms/fcaa044)
- Quinn, L., Kegelmeyer, D., Kloos, A., Rao, A. K., Busse-Morris, M. and Fritza, N. E. 2020. Clinical recommendations to guide physical therapy practice for Huntington disease. Neurology 94(5), pp. 217-228. (10.1212/WNL.0000000000008887)
- Markoulidakis, A., Taiyari, K., Holmans, P., Pallmann, P., Busse-Morris, M. and Griffin, B. A. 2020. A tutorial comparing different covariate balancing methods with an application evaluating the causal effect of exercise on the progression of Huntington’s disease. [Online]. arXiv. Available at: https://arxiv.org/abs/2010.09563
2019
- Jones, U., Hamana, K., Vougioukalou, S., Jones, M. and Busse-Morris, M. 2019. Exploration of a co-production approach to developing a walking group with people with Huntington's Disease. Med One 4, article number: e190022. (10.20900/mo.20190022)
- Playle, R., Dimitropoulou, P., Kelson, M., Quinn, L. and Busse-Morris, M. 2019. Exercise interventions in Huntington's disease: An individual patient data meta-analysis. Movement Disorders Clinical Practice 6(7), pp. 567-575. (10.1002/mdc3.12809)
- Drew, C. J. G. et al. 2019. Physical activity and exercise outcomes in Huntington Disease (PACE-HD): Protocol for a 12-Month trial within cohort evaluation of a physical activity intervention in people with Huntington Disease. Physical Therapy 99(9), pp. 1201-1210. (10.1093/ptj/pzz075)
- Randell, E. et al. 2019. Sensory integration therapy versus usual care for sensory processing difficulties in autism spectrum disorder in children: study protocol for a pragmatic randomised controlled trial.. Trials 20, article number: 113. (10.1186/s13063-019-3205-y)
- Watt, F. E. et al. 2019. Towards prevention of post-traumatic osteoarthritis: report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury. Osteoarthritis and Cartilage 27(1), pp. 23-33. (10.1016/j.joca.2018.08.001)
- Clare, L. et al. 2019. Cognitive rehabilitation, self-management, psychotherapeutic and caregiver support interventions in progressive neurodegenerative conditions: A scoping review. NeuroRehabilitation 43(4), pp. 443-471. (10.3233/NRE-172353)
- Bachoud-Levi, A. et al. 2019. International guidelines for the treatment of Huntington's Disease. Frontiers in Neurology 10, article number: 710. (10.3389/fneur.2019.00710)
2018
- Jones, U., Hamana, K. and Busse-Morris, M. 2018. Working together to promote physical activity in people with huntington's disease. Journal of Neurology, Neurosurgery and Psychiatry 89(S1), pp. A81., article number: H41. (10.1136/jnnp-2018-EHDN.219)
- Busse, M. et al. 2018. J09 A new trial design for evaluating exercise outcomes in Huntington's Disease. Journal of Neurology, Neurosurgery and Psychiatry 89(Supp 1), pp. A100 - A101. (10.1136/jnnp-2018-EHDN.269)
- Bennasar, M., Hicks, Y. A., Clinch, S. P., Jones, P., Holt, C., Rosser, A. and Busse-Morris, M. 2018. Automated assessment of movement impairment in Huntington's disease. IEEE Transactions on Neural Systems and Rehabilitation Engineering 26(10), pp. 2062-2069. (10.1109/TNSRE.2018.2868170)
- Polgar, S., Karimi, L., Buultjens, M., Morris, M. E. and Busse-Morris, M. 2018. Assessing the efficacy of cell transplantation for Parkinson's Disease: a patient-centered approach. Journal of Parkinson's Disease 8(3), pp. 375-383. (10.3233/JPD-181309)
- Mestre, T. et al. 2018. Quality of life measures in Huntington’s Disease: critique and recommendations for measures assessing patient health‐related quality of life and caregiver quality of life. Movement Disorders 33(5), pp. 742-749. (10.1002/mds.27317)
- Yhnell, E. et al. 2018. Exploring computerised cognitive training as a therapeutic intervention for people with Huntington's disease (CogTrainHD): protocol for a randomised feasibility study. Pilot and Feasibility Studies 4, article number: 45. (10.1186/s40814-018-0237-0)
- Button, K., Nicholas, K., Busse-Morris, M., Collins, M. and Spasic, I. 2018. Integrating self-management support for knee injuries into routine clinical practice: TRAK intervention design and delivery. Musculoskeletal Science and Practice 33, pp. 53-60. (10.1016/j.msksp.2017.11.002)
- Button, K., Nicholas, K., Busse-Morris, M., Collins, M. and Spasic, I. 2018. An evaluation of TRAK physiotherapy self management intervention development and delivery for knee conditions. Presented at: OARSI 2018 World Congress on Osteoarthritis, Liverpool, 26-29 April 2018. pp. -.
2017
- Fritz, N. et al. 2017. Physical therapy and exercise interventions in Huntington's disease: a mixed methods systematic review. Journal of Huntington's Disease 6(3), pp. 217-235. (10.3233/JHD-170260)
- Quinn, L. and Busse, M. 2017. The role of rehabilitation therapy in Huntington disease. In: Feigen, A. S. and Anderson, K. E. eds. Handbook of Clinical Neurology: Huntington Disease., Vol. 144. Elsevier: Monograph Series, pp. 151-165., (10.1016/B978-0-12-801893-4.00013-4)
- Fritz, N., Busse-Morris, M., Jones, K., Khalil, H. and Quinn, L. 2017. A classification system to guide physical therapy management in Huntington’s disease: a case series. Journal of Neurologic Physical Therapy 41(3), pp. 156-163. (10.1097/NPT.0000000000000188)
- Quinn, L. et al. 2017. Physical therapy and exercise interventions in Huntington's disease: a mixed methods systematic review protocol. JBI Database of Systematic Reviews and Implementation Reports 15(7), pp. 1783-4433. (10.11124/JBISRIR-2016-003274)
- Busse, M. et al. 2017. Physical activity self-management and coaching compared to social interaction in Huntington’s disease: Results from the ENGAGE-HD randomized, controlled, pilot feasibility trial. Physical Therapy 97(6), pp. 625-639. (10.1093/ptj/pzx031)
- Khalil, H., Busse-Morris, M. and Quinn, L. 2017. A pilot study of a minimally supervised home exercise and walking program for people with Parkinson’s disease in Jordan. Neurodegenerative Disease Management 7(1) (10.2217/nmt-2016-0041)
- Clinch, S., Busse-Morris, M., Döbrössy, M. D. and Dunnett, S. B. 2017. Rehabilitation training in neural restitution. In: Progress in Brain Research., Vol. 230. Elsevier, pp. 305-329., (10.1016/bs.pbr.2016.12.006)
2016
- Drew, C. et al. 2016. Integrating technology into complex intervention trial processes: a case study. Trials 17(1), article number: 551. (10.1186/s13063-016-1674-9)
- Mestre, T. A. et al. 2016. Rating scales for behavioural symptoms in Huntington's Disease: critique and recommendations. Movement Disorders 31(10), pp. 1466-1478. (10.1002/mds.26675)
- Jones, C. et al. 2016. The societal cost of Huntington’s disease: are we underestimating the burden?. European Journal of Neurology 23(10), pp. 1588-1590. (10.1111/ene.13107)
- Jones, U. F., Busse, M., Enright, S. and Rosser, A. E. 2016. Respiratory decline is integral to disease progression in Huntington's disease [Letter]. European Respiratory Journal 48(2), pp. 585-588. (10.1183/13993003.02215-2015)
- Townhill, J. et al. 2016. Using Actiwatch to monitor circadian rhythm disturbance in Huntington' disease: A cautionary note. Journal of Neuroscience Methods 265, pp. 13-18. (10.1016/j.jneumeth.2016.01.009)
- Quinn, L. et al. 2016. Development and delivery of a physical activity intervention for people with Huntington Disease. Journal of Neurologic Physical Therapy 40(2), pp. 71-80. (10.1097/NPT.0000000000000119)
- Bennasar, M., Hicks, Y. A., Clinch, S., Jones, P., Rosser, A. E., Busse, M. and Holt, C. A. 2016. Huntington's Disease assessment using tri axis accelerometers. Procedia Computer Science 96, pp. 1193-1201. (10.1016/j.procs.2016.08.163)
2015
- Dawes, H. et al. 2015. Exercise testing and training in people with Huntington's diseas. Clinical Rehabilitation 29(2), pp. 196-206. (10.1177/0269215514540921)
2014
- Busse, M., Quinn, L., Khalil, H. and McEwan, K. 2014. Optimising mobility outcome measures in Huntington's disease. Journal of Huntington's Disease 3(2), pp. 175-188. (10.3233/JHD-140091)
- Jones, U. F., Busse, M., Enright, S. and Rosser, A. E. 2014. Respiratory function decreases with progression of Huntington's Disease. Journal of Neurology, Neurosurgery & Psychiatry 85(Suppl), pp. A61-A62. (10.1136/jnnp-2014-309032.173)
- Jones, K., Hamana, K., Quinn, L., Rosser, A. and Busse, M. 2014. Physiotherapy task orientated approach: A case report. Journal of neurology, neurosurgery and psychiatry 85(1), article number: A68. (10.1136/jnnp-2014-309032.192)
- Busse, M. et al. 2014. Supporting physical activity engagement in people with Huntington's disease (ENGAGE-HD): study protocol for a randomized controlled feasibility trial. Trials 15(1), article number: 487. (10.1186/1745-6215-15-487)
2013
- Busse, M. et al. 2013. A randomized feasibility study of a 12-week community-based exercise program for people with Huntington's Disease. Journal of Neurologic Physical Therapy 37(4), pp. 149-158., article number: 1557-0576/13/3704-0149. (10.1097/NPT.0000000000000016)
- Khalil, H., Quinn, L., Van Deursen, R. W. M., Dawes, H., Playle, R. A., Rosser, A. E. and Busse, M. 2013. What effect does a structured home-based exercise programme have on people with Huntington's disease? A randomized, controlled pilot study. Clinical Rehabilitation 27(7), pp. 646-658. (10.1177/0269215512473762)
- Quinn, L. et al. 2013. Reliability and minimal detectable change of physical performance measures in individuals with pre-manifest and manifest Huntington disease. Physical Therapy 93(7), pp. 942-956. (10.2522/ptj.20130032)
- Dalton, A., Khalil, H., Busse, M., Rosser, A. E., Van Deursen, R. W. M. and ÓLaighin, G. 2013. Analysis of gait and balance through a single triaxial accelerometer in presymptomatic and symptomatic Huntington's disease. Gait & Posture 37(1), pp. 49-64. (10.1016/j.gaitpost.2012.05.028)
- Quinn, L., Busse, M. and Dal Bello-Haas, V. 2013. Management of upper extremity dysfunction in people with Parkinson disease and Huntington disease: facilitating outcomes across the disease lifespan. Journal of Hand Therapy 26(2), pp. 148-155. (10.1016/j.jht.2012.11.001)
- Harrison, D. J., Busse, M., Openshaw, R., Rosser, A. E., Dunnett, S. B. and Brooks, S. P. 2013. Exercise attenuates neuropathology and has greater benefit on cognitive than motor deficits in the R6/1 Huntington's disease mouse model. Experimental Neurology 248, pp. 457-469. (10.1016/j.expneurol.2013.07.014)
- Quinn, L., Busse, M. and Rosser, A. E. 2013. Critical features in the development of exercise-based interventions for people with Huntington's disease. European Neurological Review 8(1), pp. 10-13.
2012
- Griffiths, A., Busse, M. and Sarin, B. 2012. Do the understanding, knowledge and fears of the caregivers of first time stroke survivors accurately reflect the difficulties faced after discharge from hospital?. Presented at: Welsh Stroke Conference 2012, Newport, Wales, 22nd June 2012.
- Quinn, L. and Busse, M. 2012. Physiotherapy clinical guidelines for Huntington’s disease. Neurodegenerative Disease Management 2(1), pp. 21-31. (10.2217/nmt.11.86)
- Jones, U. F., Enright, S. and Busse, M. 2012. Management of respiratory problems in people with neurodegenerative conditions: a narrative review. Physiotherapy 98(1), pp. 1-12. (10.1016/j.physio.2011.03.002)
- Busse, M. et al. 2012. Q12 A randomised feasibility study of a 12-week exercise programme in Huntington's disease (HD) [Abstract]. Journal of Neurology, Neurosurgery & Psychiatry 83(S1), pp. A58-A59. (10.1136/jnnp-2012-303524.182)
- Hamana, K. et al. 2012. Q13 Perspectives of participating in a 12-week exercise programme for people with early -mid stage Huntington's disease [Abstract]. Journal of Neurology, Neurosurgery & Psychiatry 83(S1), pp. A59. (10.1136/jnnp-2012-303524.183)
- Khalil, H., Quinn, L., Van Deursen, R. W. M., Dawes, H., Playle, R., Rosser, A. E. and Busse, M. 2012. Q15 A pilot study of an exercise intervention to improve motor function in people with Huntington's disease (HD) [Abstract]. Journal of Neurology, Neurosurgery and Psychiatry 83(S1), pp. A59. (10.1136/jnnp-2012-303524.185)
- Read, J. et al. 2012. I03 Evaluation of life time physical activity levels in Huntington's disease [Abstract]. Journal of Neurology, Neurosurgery and Psychiatry 83(S1), pp. A33. (10.1136/jnnp-2012-303524.102)
- Jones, K. et al. 2012. Q14 Sub maximal exercise testing in people with early stage Huntington's disease [Abstract]. Journal of Neurology, Neurosurgery and Psychiatry 83(S1), pp. A59. (10.1136/jnnp-2012-303524.184)
- Busse, M., Khalil, H., Quinn, L., Brooks, S. P. and Rosser, A. E. 2012. Practice, progress and future directions for physical therapies in Huntington's Disease. Journal of Huntington's Disease 1(2), pp. 175-185. (10.3233/JHD-120025)
- Jones, K. et al. 2012. Sub maximal exercise testing in people with early stage Huntington’s Disease [Abstract]. Journal of Neurology, Neurosurgery and Psychiatry 83(S. 1), article number: A59. (10.1136/jnnp-2012-303524.184)
2011
- Pickering, D. and Busse, M. 2011. What value does the MPOC-SP have for physiotherapists working with children? Focus group results about family centred care.. Presented at: World Confederation of Physical Therapy, Amsterdam, The Netherlands, 21-24 June 2011.
- Jones, U. F., Busse, M., Enright, S. and Rosser, A. E. 2011. A pilot study of influences on physical activity level and exercise capacity in people with Huntington's disease [Abstract]. Physiotherapy 97(s1), pp. eS570., article number: RR-PL-1276. (10.1016/j.physio.2011.04.002)
2010
- Sheeran, L., Sparkes, V., Busse-Morris, M. and Van Deursen, R. 2010. Preliminary study: reliability of the spinal wheel. A novel device to measure spinal postures applied to sitting and standing. European Spine Journal 19(6), pp. 995-1003. (10.1007/s00586-009-1241-0)
- Sheeran, L., Sparkes, V., Busse, M. and Van Deursen, R. W. M. 2010. Preliminary study: reliability of the spinal wheel. A novel device to measure spinal postures applied to sitting and standing. European Spine Journal 19(6), pp. 995-1003. (10.1007/s00586-009-1241-0)
- Pickering, D. and Busse, M. 2010. An Audit of disabled children’s services – what value is MPOC-SP?. Clinical Audit 2010(2), pp. 13-22. (10.2147/CA.S8073)
- Pickering, D. and Busse, M. 2010. Disabled children's services: how do we measure family-centred care?. Journal of Child Health Care 14(2), pp. 200-207. (10.1177/1367493509360207)
- Busse, M., Al-Madfai, H., Kenkre, J., Landwehrmeyer, G. B., Bentivoglio, A. and Rosser, A. E. 2010. Utilisation of Healthcare and Associated Services in Huntington's disease: a data mining study. PLoS Currents 3, article number: RRN1206. (10.1371/currents.RRN1206)
2009
- Cooper, A., Alghamdi, G. A., Alghamdi, M. A., Busse, M. and Richardson, S. 2009. The relationship of lower limb muscle strength and joint kinematics during the stance phase of gait in hemiparetic stroke patients [Abstract]. International Journal of Stroke 4(S2), pp. 36-36. (10.1111/j.1747-4949.2009.00354.x)
- Tyson, S. F., Connell, L., Busse, M. and Lennon, S. 2009. What do acute stroke physiotherapists do to treat postural control and mobility? An exploration of the content of therapy in the UK. Clinical Rehabilitation 23(11), pp. 1051-1055. (10.1177/0269215509334837)
- Busse, M., Wiles, C. M. and Rosser, A. E. 2009. Mobility and falls in people with Huntington's disease. Journal of Neurology Neurosurgery and Psychiatry 80(1), pp. 88-90. (10.1136/jnnp.2008.147793)
- Busse, M. and Tyson, S. F. 2009. How many body locations need to be tested when assessing sensation after stroke? An investigation of redundancy in the Rivermead Assessment of Somatosensory Performance. Clinical Rehabilitation 23(1), pp. 91-95. (10.1177/0269215508097296)
- Busse, M., Van Deursen, R. W. M. and Wiles, C. M. 2009. Real-life step and activity measurement: reliability and validity. Journal of Medical Engineering & Technology 33(1), pp. 33-41. (10.1080/03091900701682606)
- Tyson, S. F., Connell, L. A., Busse, M. and Lennon, S. 2009. What is Bobath? A survey of UK stroke physiotherapists' perceptions of the content of the Bobath concept to treat postural control and mobility problems after stroke. Disability & Rehabilitation 31(6), pp. 448-457. (10.1080/09638280802103621)
- Tyson, S. F., Connell, L. A., Lennon, S. and Busse, M. 2009. What treatment packages do UK physiotherapists use to treat postural control and mobility problems after stroke?. Disability & Rehabilitation 31(18), pp. 1494-1500. (10.1080/09638280802627686)
2008
- Busse, M., Khalil, H., Quinn, L. and Rosser, A. E. 2008. Physical therapy intervention for people with Huntington disease. Physical Therapy 88(7), pp. 820-31. (10.2522/ptj.20070346)
- Meaney, A., Busse, M., Dawes, H. and Rosser, A. E. 2008. Response to a structured exercise programme for Huntington's Disease [Abstract]. Journal of Sport Science 26(S2), pp. 125-126. (10.1080/02640410802306202)
2007
- Busse, M. and Tyson, S. F. 2007. Functional balance and mobility tests in healthy participants: reliability, error and influencing factors. Physiotherapy Research International 12(4), pp. 242-250. (10.1002/pri.383)
- Sparkes, V., Smith, M. and Busse, M. 2007. Scapular taping in the therapeutic management of subacromial impingement symptoms - exploration of a clinical theory. Physiotherapy Research International 12(4), pp. 203-204. (10.1002/pri.387)
2006
- Busse, M., Wiles, C. M. and Van Deursen, R. W. M. 2006. Co-activation: its association with weakness and specific neurological pathology. Journal of NeuroEngineering and Rehabilitation 3(1), pp. 26-33. (10.1186/1743-0003-3-26)
- Busse, M., Wiles, C. M. and Van Deursen, R. W. M. 2006. Community walking activity in neurological disorders with leg weakness. Journal of Neurology Neurosurgery & Psychiatry 77(3), pp. 359-362. (10.1136/jnnp.2005.074294)
2005
- Wiles, C. M., Busse, M., Sampson, C. M. A., Rogers, M., Fenton-May, J. M. and Van Deursen, R. W. M. 2005. Falls and stumbles in myotonic dystrophy. Journal of Neurology, Neurosurgery and Psychiatry 77(3), pp. 393-396. (10.1136/jnnp.2005.066258)
- Busse, M., Wiles, C. M. and Van Deursen, R. W. M. 2005. Muscle co-activation in neurological conditions. Physical Therapy Reviews 10(4), pp. 247-253. (10.1179/108331905X78915)
2004
- Busse, M., Pearson, O. R., Van Deursen, R. W. M. and Wiles, C. M. 2004. Quantified measurement of activity provides insight into motor function and recovery in neurological disease. Journal of Neurology Neurosurgery & Psychiatry 75(6), pp. 884-8. (10.1136/jnnp.2003.020180)
- Pearson, O. R., Busse, M., Van Deursen, R. W. M. and Wiles, C. M. 2004. Quantification of walking mobility in neurological disorders. QJM: An International Journal of Medicine 97(8), pp. 463-475. (10.1093/qjmed/hch084)
1998
- Vaughan, C. L., Subramanian, N. and Busse, M. 1998. Selective dorsal rhizotomy as a treatment option for children with spastic cerebral palsy. Gait and Posture 8(1), pp. 43-59.
Addysgu
I am in possession of a Post Graduate Certificate in Teaching and Learning in Higher Education, a Certificate in Teaching Statistics in Higher Education (Royal Statistical Society) and a Post Graduate Diploma in Clinical Trials (LSHTM). My research has a clear focus on physical activity and development and evaluation of complex interventions for people with Long Term Neurological Conditions (LTNCs). I collaborate closely with colleagues working in engineering and biosciences to achieve a translational focus to my work. I also have a particular interest in innovative methods for teaching research and statistics and the use of reliability analyses and mixed methods in healthcare research that has developed as a direct result of application in my research area.
My research has mainly focused on developing evidence and guidelines for targeted physical interventions in Huntington's disease (HD) and Parkinson's disease (PD). Such interventions are complex, and involve many components. It is therefore essential that the main "active components" within the intervention are defined and benefits evaluated in terms of relevant outcomes. We have adopted the Medical Research Council (MRC) Framework for design and evaluating complex interventions to provide a structure that should ultimately lead to full scale, robust controlled clinical trials.
Working closely with people with HD and their families as part of the research process is very important to us. We established the Wales HD Involving People Group in 2010 (now BRAIN Involve) with a view to ensuring that our work is always relevant and applicable to the needs of the HD community. We have successfully conducted and published data from the first randomised and controlled multi-centre studies investigating different physiotherapy and exercise interventions for HD (MOVE TO EXERCISE, TRAIN-HD and COMMET-HD). This work has led to further funding for exercise intervention trials related in HD (ENGAGE-HD and ExERT-HD). The growing recognition of the importance of physical activity and mobility in HD is further evidenced by the FP-7 funded programme of work being conducted in REPAIR-HD (http://www.repair-hd.eu/) where I am a principle investigator along with a consortia of researchers based in Germany, France and Italy. I am also a principle investigator in the Wales BRAIN Unit where I lead the patient monitoring and patient and public involvement work-packages.
Research grants
2017
- Jacques and Gloria Gossweiler Foundation Research Grants in the field of Neurology "Physical Activity and Exercise Outcomes in Huntington's Disease." £411 00.00.
- Huntington's Disease Association of England and Wales. "Promotion of physical activity in Huntington's Disease clinics." £10 300.00.
2016
MRC Confidence in Concept "Using wearable technology to predict perioperative high-risk patient outcomes." £39,490.
MRC Confidence in Concept "Developing clinical applications for a novel multi-task functional assessment." £49,902.00.
Wellcome Trust ISSF Cross disciplinary awards “Pilot study of motor coordination disorder in 22q11.2 deletion syndrome.“ £8,935.
Wellcome Trust ISSF Cross disciplinary awards “Automated assessment of timing and movement signatures in Huntington’s Disease.” £47,945
- Wellcome Trust ISSF ISSF populations pilot awards “Feasibility of using consumer-targeted activity monitors in collecting physical activity data within the HealthWise Wales cohort: a pragmatic pilot study.” £28,414
- Jacques and Gloria Gossweiler Foundation Research Grants in the field of Neurology “Exploring cognitive training as a non-pharmaceutical intervention for people with Huntingtons disease.” £94,071
2015
- Division of Health and Care Research Wales (DHCRW); Brain Repair And Intracranial Neurotherapeutics- Wales BRAIN Unit. £1.2m; lead applicant Professor W. Grey.
2013
- FP7-HEALTH-2013-INNOVATION-1 "REPAIR-HD Human pluripotent stem cell differentiation, safety and preparation for therapeutic transplantation in Huntington's disease". £1,705,800
- Jacques and Gloria Gossweiler Foundation "ExeRT-HD Exercise Rehabilitation Trial in Huntington's Disease". £172,805
- National Institute of Social Care and Health Research/ National Institute of Health Research "Move to Exercise: Home based exercise for people with Huntington's Disease". £687,362
2012
- Linden. Morris, Subramanian, Busse Wellcome Trust ISSF Seedcorn "Real Time fMRI neurofeedback as a treatment for Parkinson's Disease". £45,000
2011
- Neil Glendinning Research Grant Huntington's Disease Association: Task Training in Huntington's Disease £99,230
- European Huntington's Disease Network. Feasibility and benefit of inspiratory muscle training in people with Huntington's disease. (co-applicant; £38,384)
2010
- National Institute for Social Care and Health Research Health Research Funding Scheme: Can community supported exercise benefit subjective wellbeing, physical activity levels and abilities in people with Huntington's disease? A randomised feasibility study and process evaluation (COMMET-HD) £122,720
- Medical Research Council. National Prevention Research Initiative. Health Eating and Lifestyle in Pregnancy Study (HELP) (collaboration with South East Wales Trials Unit) (co-applicant; £1,041,422)
2009
- European Huntington's Disease Network. Reliability and minimal detectable change of measures of participation, functional activities and impairments in individuals with Huntington's disease ( £36,000)
- Physiotherapy Research Foundation Scheme B. Respiratory Function in people with Huntington's disease: a cross sectional study (co-applicant; £6,500)
- Research Capacity Building Consortium Wales PhD studentship. Respiratory Function in people with Huntington's disease: a cross sectional study (co-applicant; £51,558)
2008
- Chief Medical Officer for Wales Research Budget. Development and evaluation of a DVD resource for people with a neurodegenerative disease who may be at risk of falls. £9,938.
- Paul Jeffries Waters Bequest Fund to support research in Huntington' disease £2,820.
2007
Physiotherapy Research Society. Mobility and Falls in Huntington's Disease. £500
