Dr Kirsten Bentley
Cydymaith Ymchwil Ôl-ddoethurol
- BentleyK@caerdydd.ac.uk
- Adeilad Henry Wellcome ar gyfer Ymchwil Biofeddygol, Ystafell 3F08, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
Trosolwyg
Rwy'n postdoc o fewn yr is-adran Heintiau ac Imiwnedd, ar hyn o bryd yn gweithio ar brosiectau sy'n gysylltiedig â SARS-CoV-2. Fy niddordebau ymchwil yw deall y mecanweithiau sylfaenol sy'n sail i ddyblygu firysau RNA llinyn cadarnhaol, yn enwedig y broses o ailgyfuno a sut mae'n cyfrannu at esblygiad firws.
Cyhoeddiad
2023
- Duggan, K., Bentley, K., Stanton, R. J. and Maillard, J. 2023. Evaluating the antimicrobial efficacy of long-lasting hand sanitisers on skin. Journal of Hospital Infection (10.1016/j.jhin.2023.08.020)
- Grant, M. D. et al. 2023. Combined anti-S1 and anti-S2 antibodies from hybrid immunity elicit potent cross-variant ADCC against SARS-CoV-2. JCI Insight 8(15), article number: e170681. (10.1172/jci.insight.170681)
- Meredith, R. T. et al. 2023. Differential cellular and humoral immune responses in immunocompromised individuals following multiple SARS-CoV-2 vaccinations. Frontiers in Cellular and Infection Microbiology 13 (10.3389/fcimb.2023.1207313)
2022
- Dangi, T. et al. 2022. Improved control of SARS-CoV-2 by treatment with nucleocapsid-specific monoclonal antibody. Journal of Clinical Investigation 132(23), article number: e162282. (10.1172/JCI162282)
- Scurr, M. J. et al. 2022. Magnitude of venous or capillary blood-derived SARS-CoV-2-specific T cell response determines COVID-19 immunity. Nature Communications 13, article number: 5422. (10.1038/s41467-022-32985-8)
- Saud, Z. et al. 2022. Mechanically ventilated patients shed high titre live SARS-CoV2 for extended periods from both the upper and lower respiratory tract. Clinical Infectious Diseases 75(1), pp. e82-e88., article number: ciac170. (10.1093/cid/ciac170)
- Saud, Z. et al. 2022. The SARS-CoV2 envelope differs from host cells, exposes pro-coagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research 63(6), article number: 100208. (10.1016/j.jlr.2022.100208)
- Alnaji, F. G. et al. 2022. Generated randomly and selected functionally? The nature of enterovirus recombination. Viruses 14(5), article number: 916. (10.3390/v14050916)
2021
- Bentley, K. and Stanton, R. J. 2021. Hydroxypropyl methylcellulose-based nasal sprays effectively inhibit in vitro SARS-CoV-2 infection and spread. Viruses 13(12), article number: 2345. (10.3390/v13122345)
- Bentley, K. et al. 2021. Isolation and identification of inter-species Enterovirus recombinant genomes. Viruses 13(12), article number: 2390. (10.3390/v13122390)
- Bentley, K., Alnaji, F. G., Woodford, L., Jones, S., Woodman, A. and Evans, D. J. 2021. Imprecise recombinant viruses evolve via a fitness-driven, iterative process of polymerase template-switching events. PLoS Pathogens 17(8), article number: e1009676. (10.1371/journal.ppat.1009676)
2020
- Keep, S. et al. 2020. Multiple novel non-canonically transcribed sub-genomic mRNAs produced by avian coronavirus infectious bronchitis virus. Journal of General Virology 101(10), pp. 1103-1118. (10.1099/jgv.0.001474)
2019
- Herod, M. R., Adeyemi, O. O., Ward, J., Bentley, K., Harris, M., Stonehouse, N. J. and Polyak, S. J. 2019. The broad-spectrum antiviral drug arbidol inhibits foot-and-mouth disease virus genome replication. Journal of General Virology 100(9), pp. 1293-1302. (10.1099/jgv.0.001283)
2018
- Bentley, K., Cook, J. P., Tuplin, A. K. and Evans, D. J. 2018. Structural and functional analysis of the roles of the HCV 5' NCR miR122-dependent long-range association and SLVI in genome translation and replication. PeerJ 6, article number: e5870. (10.7717/peerj.5870)
- Bentley, K. and Evans, D. J. 2018. Mechanisms and consequences of positive-strand RNA virus recombination. Journal of General Virology 99(10), article number: 1345. (10.1099/jgv.0.001142)
2017
- Meng, B., Bentley, K., Marriott, A. C., Scott, P. D., Dimmock, N. J. and Easton, A. J. 2017. Unexpected complexity in the interference activity of a cloned influenza defective interfering RNA. Virology Journal 14(1), article number: 138. (10.1186/s12985-017-0805-6)
2015
- Tuplin, A., Struthers, M., Cook, J., Bentley, K. and Evans, D. J. 2015. Inhibition of HCV translation by disrupting the structure and interactions of the viral CRE and 3' X-tail. Nucleic Acids Research 43(5), pp. 2914-2926. (10.1093/nar/gkv142)
2013
- Bentley, K., Armesto, M. and Britton, P. 2013. Infectious Bronchitis Virus as a Vector for the Expression of Heterologous Genes. PLoS ONE 8(6), pp. e67875. (10.1371/journal.pone.0067875)
- Bentley, K., Keep, S. M., Armesto, M. and Britton, P. 2013. Identification of a noncanonically transcribed subgenomic mRNA of infectious bronchitis virus and other gammacoronaviruses. Journal of Virology 87(4), pp. 2128-2136. (10.1128/JVI.02967-12)
2012
- Armesto, M., Bentley, K., Bickerton, E., Keep, S. and Britton, P. Bridgen, A. ed. 2012. Coronavirus reverse genetics. [Reverse Genetics of RNA Viruses: Applications and Perspectives]. Wiley.
- Bentley, K., Dove, B. K., Parks, S. R., Walker, J. T. and Bennett, A. M. 2012. Hydrogen peroxide vapour decontamination of surfaces artificially contaminated with norovirus surrogate feline calicivirus. Journal of Hospital Infection 80(2), pp. 116-121. (10.1016/j.jhin.2011.10.010)
Articles
- Duggan, K., Bentley, K., Stanton, R. J. and Maillard, J. 2023. Evaluating the antimicrobial efficacy of long-lasting hand sanitisers on skin. Journal of Hospital Infection (10.1016/j.jhin.2023.08.020)
- Grant, M. D. et al. 2023. Combined anti-S1 and anti-S2 antibodies from hybrid immunity elicit potent cross-variant ADCC against SARS-CoV-2. JCI Insight 8(15), article number: e170681. (10.1172/jci.insight.170681)
- Meredith, R. T. et al. 2023. Differential cellular and humoral immune responses in immunocompromised individuals following multiple SARS-CoV-2 vaccinations. Frontiers in Cellular and Infection Microbiology 13 (10.3389/fcimb.2023.1207313)
- Dangi, T. et al. 2022. Improved control of SARS-CoV-2 by treatment with nucleocapsid-specific monoclonal antibody. Journal of Clinical Investigation 132(23), article number: e162282. (10.1172/JCI162282)
- Scurr, M. J. et al. 2022. Magnitude of venous or capillary blood-derived SARS-CoV-2-specific T cell response determines COVID-19 immunity. Nature Communications 13, article number: 5422. (10.1038/s41467-022-32985-8)
- Saud, Z. et al. 2022. Mechanically ventilated patients shed high titre live SARS-CoV2 for extended periods from both the upper and lower respiratory tract. Clinical Infectious Diseases 75(1), pp. e82-e88., article number: ciac170. (10.1093/cid/ciac170)
- Saud, Z. et al. 2022. The SARS-CoV2 envelope differs from host cells, exposes pro-coagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research 63(6), article number: 100208. (10.1016/j.jlr.2022.100208)
- Alnaji, F. G. et al. 2022. Generated randomly and selected functionally? The nature of enterovirus recombination. Viruses 14(5), article number: 916. (10.3390/v14050916)
- Bentley, K. and Stanton, R. J. 2021. Hydroxypropyl methylcellulose-based nasal sprays effectively inhibit in vitro SARS-CoV-2 infection and spread. Viruses 13(12), article number: 2345. (10.3390/v13122345)
- Bentley, K. et al. 2021. Isolation and identification of inter-species Enterovirus recombinant genomes. Viruses 13(12), article number: 2390. (10.3390/v13122390)
- Bentley, K., Alnaji, F. G., Woodford, L., Jones, S., Woodman, A. and Evans, D. J. 2021. Imprecise recombinant viruses evolve via a fitness-driven, iterative process of polymerase template-switching events. PLoS Pathogens 17(8), article number: e1009676. (10.1371/journal.ppat.1009676)
- Keep, S. et al. 2020. Multiple novel non-canonically transcribed sub-genomic mRNAs produced by avian coronavirus infectious bronchitis virus. Journal of General Virology 101(10), pp. 1103-1118. (10.1099/jgv.0.001474)
- Herod, M. R., Adeyemi, O. O., Ward, J., Bentley, K., Harris, M., Stonehouse, N. J. and Polyak, S. J. 2019. The broad-spectrum antiviral drug arbidol inhibits foot-and-mouth disease virus genome replication. Journal of General Virology 100(9), pp. 1293-1302. (10.1099/jgv.0.001283)
- Bentley, K., Cook, J. P., Tuplin, A. K. and Evans, D. J. 2018. Structural and functional analysis of the roles of the HCV 5' NCR miR122-dependent long-range association and SLVI in genome translation and replication. PeerJ 6, article number: e5870. (10.7717/peerj.5870)
- Bentley, K. and Evans, D. J. 2018. Mechanisms and consequences of positive-strand RNA virus recombination. Journal of General Virology 99(10), article number: 1345. (10.1099/jgv.0.001142)
- Meng, B., Bentley, K., Marriott, A. C., Scott, P. D., Dimmock, N. J. and Easton, A. J. 2017. Unexpected complexity in the interference activity of a cloned influenza defective interfering RNA. Virology Journal 14(1), article number: 138. (10.1186/s12985-017-0805-6)
- Tuplin, A., Struthers, M., Cook, J., Bentley, K. and Evans, D. J. 2015. Inhibition of HCV translation by disrupting the structure and interactions of the viral CRE and 3' X-tail. Nucleic Acids Research 43(5), pp. 2914-2926. (10.1093/nar/gkv142)
- Bentley, K., Armesto, M. and Britton, P. 2013. Infectious Bronchitis Virus as a Vector for the Expression of Heterologous Genes. PLoS ONE 8(6), pp. e67875. (10.1371/journal.pone.0067875)
- Bentley, K., Keep, S. M., Armesto, M. and Britton, P. 2013. Identification of a noncanonically transcribed subgenomic mRNA of infectious bronchitis virus and other gammacoronaviruses. Journal of Virology 87(4), pp. 2128-2136. (10.1128/JVI.02967-12)
- Bentley, K., Dove, B. K., Parks, S. R., Walker, J. T. and Bennett, A. M. 2012. Hydrogen peroxide vapour decontamination of surfaces artificially contaminated with norovirus surrogate feline calicivirus. Journal of Hospital Infection 80(2), pp. 116-121. (10.1016/j.jhin.2011.10.010)
Books
- Armesto, M., Bentley, K., Bickerton, E., Keep, S. and Britton, P. Bridgen, A. ed. 2012. Coronavirus reverse genetics. [Reverse Genetics of RNA Viruses: Applications and Perspectives]. Wiley.
Bywgraffiad
2021-presennol: Ymchwilydd ôl-ddoethurol, Prifysgol Caerdydd, Ysgol Meddygaeth
2015-2020: ymchwilydd ôl-ddoethurol, Prifysgol St Andrews, Ysgol Bioleg
2013-2015: ymchwilydd ôl-ddoethurol, Prifysgol Warwick, Ysgol Bioleg
2006-2008: Gwyddonydd Ymchwil, Iechyd Cyhoeddus Lloegr, Porton Down
Addysg:
2008-2012: Firoleg PhD, Sefydliad Pirbright/Prifysgol Warwick
2005-2006: MSc Bioleg Foleciwlaidd a Patholeg Firysau: Coleg Imperial Llundain.
1999-2002: BSc (Anrh) Microbioleg a Firoleg, Prifysgol Warwick
Aelodaethau proffesiynol
Cymdeithas Microbioleg