Dr Andreia De Almeida

2021

• de Almeida, A., Parthimos, D., Dew, H., Smart, O., Wiltshire, M. and Errington, R. J. 2021. Aquaglyceroporin-3’s expression and cellular localization is differentially modulated by hypoxia in prostate cancer cell lines. Cells 10(4), article number: 838. (10.3390/cells10040838)

2019

• Wragg, D., de Almeida, A., Casini, A. and Leoni, S. 2019. Unveiling the mechanisms of aquaglyceroporin-3 water and glycerol permeation by metadynamics. Chemistry - A European Journal 25(37), pp. 8713-8718. (10.1002/chem.201902121)
• Wenzel, M. N. et al. 2019. Insights into the mechanisms of aquaporin-3 inhibition by gold(III) complexes: the importance of non-coordinative adduct formation. Inorganic Chemistry 58(3), pp. -. (10.1021/acs.inorgchem.8b03233)

2018

• Aikman, B. et al. 2018. Gold(III) pyridine-benzimidazole complexes as aquaglyceroporin inhibitors and antiproliferative agents. Inorganics 6(4), article number: 123. (10.3390/inorganics6040123)
• Mósca, A. F. et al. 2018. Molecular basis of Aquaporin-7 permeability regulation by pH. Cells 7(11), article number: 207. (10.3390/cells7110207)
• Wragg, D., De Almeida, A., Bonsignore, R., Kühn, F. E., Leoni, S. and Casini, A. 2018. On the mechanism of Gold/NHC compounds binding to DNA G-quadruplexes: combined metadynamics and biophysical methods. Angewandte Chemie International Edition 57(44), pp. 14524-14528. (10.1002/anie.201805727)
• Aikman, B., De Almeida, A., Meier-Menches, S. M. and Casini, A. 2018. Aquaporins in cancer development: opportunities for bioinorganic chemistry to contribute novel chemical probes and therapeutic agents. Metallomics 10(5), pp. 696-712. (10.1039/C8MT00072G)

2017

• Boorsma, C. E. et al. 2017. A potent tartrate resistant acid phosphatase inhibitor to study the function of TRAP in alveolar macrophages. Scientific Reports 7(1), article number: 12570. (10.1038/s41598-017-12623-w)
• De Almeida, A. et al. 2017. The mechanism of aquaporin inhibition by gold compounds elucidated by biophysical and computational methods. Chemical Communications 53(27), pp. 3830-3833. (10.1039/C7CC00318H)

2016

• Khan, R. A., De Almeida, A., Al-Farhan, K., Alsalme, A., Casini, A., Ghazzali, M. and Reedijk, J. 2016. Transition-metal norharmane compounds as possible cytotoxic agents: new insights based on a coordination chemistry perspective. Journal of Inorganic Biochemistry 165, pp. 128-135. (10.1016/j.jinorgbio.2016.07.001)
• Spinello, A., De Almeida, A., Casini, A. and Barone, G. 2016. The inhibition of glycerol permeation through aquaglyceroporin-3 induced by mercury (II): A molecular dynamics study. Journal of Inorganic Biochemistry 160, pp. 78-84. (10.1016/j.jinorgbio.2015.11.027)
• De Almeida, A., Martins, A. P., Mósca, A. F., Wijma, H. J., Prista, C., Soveral, G. and Casini, A. 2016. Exploring the gating mechanisms of aquaporin-3: new clues for the design of inhibitors?. Molecular BioSystems 12, pp. 1564-1573. (10.1039/C6MB00013D)
• Wenzel, M. et al. 2016. New luminescent polynuclear metal complexes with anticancer properties: toward structure-activity relationships. Inorganic Chemistry 55(5), pp. 2544-2557. (10.1021/acs.inorgchem.5b02910)
• Tsitsa, I. et al. 2016. Structure and biological activities of metal complexes of flumequine. RSC Advances 6(23), pp. 19555-19570. (10.1039/C5RA25776J)

2014

• Khan, R. A., Al-Farhan, K., De Almeida, A., Alsalme, A., Casini, A., Ghazzali, M. and Reedijk, J. 2014. Light-stable bis(norharmane)silver(I) compounds: synthesis, characterization and antiproliferative effects in cancer cells. Journal of Inorganic Biochemistry 140, pp. 1-5. (10.1016/j.jinorgbio.2014.06.019)
• De Almeida, A., Soveral, G. and Casini, A. 2014. Gold compounds as aquaporin inhibitors: new opportunities for therapy and imaging. MedChemComm 5, pp. 1444-1453. (10.1039/C4MD00265B)
• Khan, R. A., Khalid, A., De Almeida, A., Alsalme, A., Casini, A., Ghazzali, M. and Reedijk, J. 2014. Silver(I) bis(norharmane) compounds: synthesis, 3D structures and cytostatic properties. Journal of Biological Inorganic Chemistry 19, pp. S799.
• Bertrand, B. et al. 2014. Fluorescent organometallic gold(I) N-heterocyclic carbene complexes: synthesis and biological activities. Journal of Biological Inorganic Chemistry 19, pp. S792.
• Madeira, A. et al. 2014. A gold coordination compound as a chemical probe to unravel aquaporin-7 function. ChemBioChem 15(10), pp. 1487-1494. (10.1002/cbic.201402103)
• Rubbiani, R., Salassa, L., De Almeida, A., Casini, A. and Ott, I. 2014. Cytotoxic gold(I) N-heterocyclic carbene complexes with phosphane ligands as potent enzyme inhibitors. ChemMedChem 9(6), pp. 1205-1210. (10.1002/cmdc.201400056)
• Frik, M. et al. 2014. Luminescent iminophosphorane gold, palladium and platinum complexes as potential anticancer agents. Inorganic Chemistry Frontiers 1(3), pp. 231-241. (10.1039/c4qi00003j)

2013

• De Almeida, A., Oliveira, B. L., Correia, J. D., Soveral, G. and Casini, A. 2013. Emerging protein targets for metal-based pharmaceutical agents: an update. Coordination Chemistry Reviews 257(19-20), pp. 2689-2704. (10.1016/j.ccr.2013.01.031)
• Martins, A. P., Ciancetta, A., De Almeida, A., Marrone, A., Re, N., Soveral, G. and Casini, A. 2013. Aquaporin inhibition by gold(III) compounds: new insights. ChemMedChem 8(7), pp. 1086-1092. (10.1002/cmdc.201300107)
• Lease, N. et al. 2013. Potential anticancer heterometallic Fe-Au and Fe-Pd agents: initial mechanistic insights. Journal of Medicinal Chemistry 56(14), pp. 5806-5818. (10.1021/jm4007615)
• Contel, M. et al. 2013. Iminophosphorane d(8) transition metal complexes as potential anticancer agents via a non-cisplatin mode of action. Abstracts of Papers of the American Chemical Society 245