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Dr Daniel Turnham
Cydymaith Ymchwil
Ysgol y Biowyddorau
- TurnhamD@caerdydd.ac.uk
- Adeilad Hadyn Ellis, Ystafell ECSCRI, Heol Maendy, Caerdydd, CF24 4HQ
Trosolwyg
Mae fy ymchwil yn canolbwyntio ar ddatblygu strategaethau therapiwtig newydd i drin canserau ymosodol, anodd eu trin.
Yn y DU, bydd tua 1 o bob 8 dyn yn datblygu canser y prostad yn ystod eu hoes. Bydd cyfran uchel o'r dynion hyn yn cyflwyno clefyd lleol ac yn byw allan o'u canser heb yr angen am therapi ymledol, ond i'r rhai sydd â chanser y prostad cyfnod hwyr sydd wedi lledaenu y tu hwnt i'r prostad mae'r prognosis yn wael ac nid yw'r clefyd bellach yn welladwy.
Trwy fy ngwaith rwy'n gobeithio gwella ein dealltwriaeth o ganser y prostad cam hwyr a datblygu therapïau newydd wedi'u targedu y gellir eu defnyddio yn y clinig ryw ddydd i wella rhagolygon ar gyfer dynion â'r clefyd hwn.
Cyhoeddiad
2024
- Turnham, D. J., Smith, H. and Clarkson, R. W. E. 2024. Suppression of Bcl3 disrupts viability of breast cancer cells through both p53-dependent and p53-independent mechanisms via loss of NF-κB signalling. Biomedicines 12(1), article number: 143. (10.3390/biomedicines12010143)
2023
- Chessa, T. A. et al. 2023. PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate. Molecular Cell 83(16), pp. 2991-3009., article number: E13. (10.1016/j.molcel.2023.07.015)
2021
- Soukupova, J. et al. 2021. The discovery of a novel anti-metastatic Bcl3 inhibitor. Molecular Cancer Therapeutics 10(5), pp. 775-786. (10.1158/1535-7163.MCT-20-0283)
2020
- Turnham, D. J., Yang, W. W., Davies, J., Varnava, A., Ridley, A. J., Conlan, R. S. and Clarkson, R. W. E. 2020. Bcl-3 promotes multi-modal tumour cell migration via NF-kB1 mediated regulation of Cdc42. Carcinogenesis 41(10), pp. 1432-1443. (10.1093/carcin/bgaa005)
- Turnham, D. J., Bullock, N., Dass, M. S., Staffurth, J. N. and Pearson, H. B. 2020. The PTEN conundrum: how to target PTEN-deficient prostate cancer. Cells 9(11), article number: 2342. (10.3390/cells9112342)
- Kiraga, L. et al. 2020. Biodistribution PET/CT study of hemoglobin-DFO-89Zr complex in healthy and lung tumor-bearing mice. International Journal of Molecular Sciences 21(14), article number: 4991. (10.3390/ijms21144991)
2017
- Turnham, D. 2017. Understanding the role of Bcl-3 in breast cancer metastasis. PhD Thesis, Cardiff University.
Erthyglau
- Turnham, D. J., Smith, H. and Clarkson, R. W. E. 2024. Suppression of Bcl3 disrupts viability of breast cancer cells through both p53-dependent and p53-independent mechanisms via loss of NF-κB signalling. Biomedicines 12(1), article number: 143. (10.3390/biomedicines12010143)
- Chessa, T. A. et al. 2023. PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate. Molecular Cell 83(16), pp. 2991-3009., article number: E13. (10.1016/j.molcel.2023.07.015)
- Soukupova, J. et al. 2021. The discovery of a novel anti-metastatic Bcl3 inhibitor. Molecular Cancer Therapeutics 10(5), pp. 775-786. (10.1158/1535-7163.MCT-20-0283)
- Turnham, D. J., Yang, W. W., Davies, J., Varnava, A., Ridley, A. J., Conlan, R. S. and Clarkson, R. W. E. 2020. Bcl-3 promotes multi-modal tumour cell migration via NF-kB1 mediated regulation of Cdc42. Carcinogenesis 41(10), pp. 1432-1443. (10.1093/carcin/bgaa005)
- Turnham, D. J., Bullock, N., Dass, M. S., Staffurth, J. N. and Pearson, H. B. 2020. The PTEN conundrum: how to target PTEN-deficient prostate cancer. Cells 9(11), article number: 2342. (10.3390/cells9112342)
- Kiraga, L. et al. 2020. Biodistribution PET/CT study of hemoglobin-DFO-89Zr complex in healthy and lung tumor-bearing mice. International Journal of Molecular Sciences 21(14), article number: 4991. (10.3390/ijms21144991)
Gosodiad
- Turnham, D. 2017. Understanding the role of Bcl-3 in breast cancer metastasis. PhD Thesis, Cardiff University.
