Dr Wayne Nishio Ayre
Darlithydd mewn Bioddeunyddiau
- ayrewn@cardiff.ac.uk
- +44(0) 292 2510 660
- Ysbyty Deintyddol y Brifysgol, Parc y Mynydd Bychan, Caerdydd, CF14 4XY
- Ar gael fel goruchwyliwr ôl-raddedig
Bywgraffiad
Career overview
- September 2016 – Present: Lecturer in Biomaterials – Cardiff School of Dentistry.
- November 2014 – September 2016: Research fellow – Cardiff School of Dentistry, Tissue Engineering & Reparative Dentistry. Life Sciences Research Network Wales: Delivery of osteogenic molecules from acrylic bone cement to encourage regenerative bone repair around cemented joint replacements.
- September 2014 – November 2014: Research associate – Cardiff School of Pharmacy and Pharmaceutical Sciences. SATRTE Bio-E Pilot Project: Phosphonate-tethered lysophosphatidic acid-functionalised titanium: a novel surface finish for bone regenerative applications.
- June 2014 – August 2014: Research associate – Cardiff School of Pharmacy and Pharmaceutical Sciences. SATRTE Health Technology Challenge Pilot Project: Liposomal antimicrobial delivery system for PMMA bone cement
- December 2013 – May 2014: Research associate – Cardiff School of Dentistry, Tissue Engineering & Reparative Dentistry. Dunhill Medical Trust: Preventing dental pain, abscess and tooth loss in older adults: development of antimicrobial restorative materials to manage dental disease in older adults
- September 2013 – November 2013: Research assistant – Cardiff School of Engineering, Institute of Mechanical and Manufacturing Engineering. Clean Sky/EU Commission: Developing, manufacturing and testing composite materials for aerospace applications.
Education and qualification
- 2009 – 2013: Doctor of Philosophy (Ph.D.) in Mechanical Engineering, Cardiff University/Arthritis Research UK Biomechanics and Bioengineering Centre. Inter-disciplinary research project between the schools of Engineering and Pharmacy, developing and testing novel formulations of PMMA bone cements to enhance mechanical, drug delivery and osseointegrative properties.
- 2006 – 2009: Bachelor of Engineering (B.Eng. First Class Hons) in Medical Engineering, School of Engineering, Cardiff University
Ymrwymiadau siarad cyhoeddus
- Ayre WN, Scott T, Hallam K, Blom AW, Denyer SP, Bone H, Mansell JP. 2016. Phosphonate-tethered lysophosphatidic acid-functionalised titanium: a novel surface finish for cementless orthopaedic implants. British Orthopaedic Research Society Annual Meeting, Glasgow.
- Ayre WN, Waddington RJ, Evans SL, Mason DJ, Evans B, Birchall JC, Morgan-Jones R, Denyer SP, Sloan AJ. 2016. Delivery of osteogenic liposomal bone morphogenetic protein-2 from poly(methyl methacrylate) bone cement. Tissue and Cell Engineering Society Meeting, UCL, London.
- Ayre WN, Evans B, Mason DJ, Birchall JC, Evans SL, Denyer SP, Morgan-Jones R, Waddington RJ and Sloan AJ. 2015. Delivery of osteogenic molecules from acrylic bone cement to encourage regenerative bone repair around cemented joint replacements. Southwest Regional Regenerative Medicine Meeting, Bristol.
- Ayre, WN, Roberts, J, Marsh, LL, Evans, SL, Maillard, J, Denyer, SP, Lynch, CD and Sloan, AJ. 2014. Novel Ex vivo Models for Endodontic Infection and Antimicrobial Assessment. IADR/PER Congress, Dubrovnik, Croatia.
- Ayre, WN, Birchall, JC, Evans, SL and Denyer, SP. 2013. Liposomal therapeutic delivery system for poly(methyl methacrylate) bone cement. APS PharmSci, Edinburgh, UK.
- Ayre, WN, Birchall, JC, Evans, SL and Denyer, SP. 2013. Development of a novel liposomal therapeutic delivery system for poly(methyl methacrylate) bone cement. British Orthopaedic Research Society and Bone Research Society Joint Meeting, Oxford, UK.
- Ayre, WN, Madete, JK, Jones, DK and Holt, CA. 2010. Quantifying manual and bi-manual tasks using motion capture for brain imaging. Proceedings of the 9th International Conference on Computer Methods in Biomechanics and Biomedical Engineering, Valencia, Spain.
Cyhoeddiadau
2022
- Azizova, L. et al. 2022. Parameters controlling octadecyl phosphonic acid self-assembled monolayers on titanium dioxide for anti-fouling biomedical applications. Applied Surface Science 604, article number: 154462. (10.1016/j.apsusc.2022.154462)
- Sadaghiani, L., Alshumrani, A. M., Gleeson, H., Nishio Ayre, W. and Sloan, A. 2022. Growth Factor release and dental pulp stem cell attachment following dentine conditioning- an in vitro study. International Endodontic Journal (10.1111/iej.13781)
- Hawi, S., Goel, S., Kumar, V., Pearce, O., Nishio Ayre, W. and Ivanova, E. P. 2022. Critical review of nanopillar-Based mechanobactericidal systems. ACS Applied Nano Material 5(1), pp. 1-17. (10.1021/acsanm.1c03045)
2021
- Larrañaga-Altuna, M. et al. 2021. Bactericidal surfaces: an emerging 21st century ultra-precision manufacturing and materials puzzle. Applied Physics Reviews 8(2), article number: 21303. (10.1063/5.0028844)
- Nishio Ayre, W. et al. 2021. Alternative radiopacifiers for polymethyl methacrylate bone cements: Silane-treated anatase titanium dioxide and yttria-stabilised zirconium dioxide. Journal of Biomaterials Applications 35(10), pp. 1235-1252. (10.1177/0885328220983797)
- Jiao, Y. et al. 2021. In vitro cytocompatibility of a Zr-based metallic glass modified by laser surface texturing for potential implant applications. Applied Surface Science 547, article number: 149194. (10.1016/j.apsusc.2021.149194)
- Song, B. et al. 2021. Electric signals counterbalanced posterior vs anterior PTEN signaling in directed migration of Dictyostelium. Cell and Bioscience 11, article number: 111. (10.1186/s13578-021-00580-x)
2020
- Jiang, L., Nishio Ayre, W., Melling, G. E., Song, B., Wei, X., Sloan, A. and Chen, X. 2020. Liposomes loaded with transforming growth factor β1 promote odontogenic differentiation of dental pulp stem cells. Journal of Dentistry 103, article number: 103501. (10.1016/j.jdent.2020.103501)
- Farnell, D. J. J., Khor, C., Nishio Ayre, W., Doyle, Z. and Chadwick, E. 2020. Initial Investigations of the cranial size and shape of adult Eurasian otters (Lutra lutra) in Great Britain. Journal of Imaging 6(10), article number: 106. (10.3390/jimaging6100106)
- Sheil, A. I. et al. 2020. Development of a facile fluorophosphonate-functionalised titanium surface for potential orthopaedic applications. Journal of Orthopaedic Translation 23, pp. 140-151. (10.1016/j.jot.2020.02.002)
- Avery, S. J., Ayre, W. N., Sloan, A. J. and Waddington, R. J. 2020. Interrogating the osteogenic potential of implant surfaces in vitro: a review of current assays. Tissue Engineering Part B: Reviews 26(3), pp. 217-229. (10.1089/ten.teb.2019.0312)
2019
- Beamish, R., Ayre, W. N. and Evans, S. 2019. Prosthetic joint infection and aseptic loosening: could liposomes be the solution?. Presented at: International Society for Technology in Arthroplasty (ISTA) 31st Annual Congress, London, England, 10-13 October 2018, Vol. 101-B. Vol. Supple. British Editorial Society of Bone and Joint Surgery, (10.1302/1358-992X.2019.5.111)
2018
- Blaikie, P., Nishio Ayre, W., Thomas, D., Begum, T., Eaton, M., Harwood, C. and Crivelli, D. 2018. A smart surgical tool for optimal dental implant fixation. Presented at: 96th General Session of the IADR, London, UK, 25-28 Jul 2018.
- Melling, G., Colombo, J. S., Avery, S., Nishio Ayre, W., Evans, S. L., Waddington, R. and Sloan, A. 2018. Liposomal delivery of demineralised dentine matrix for dental tissue regeneration. Journal of Tissue Engineering 24(13-14), pp. 1057-1065. (10.1089/ten.TEA.2017.0419)
- Nishio Ayre, W. et al. 2018. Enterococcus faecalis demonstrates pathogenicity through increased attachment in an ex vivo polymicrobial pulpal infection. Infection and Immunity 86(5), article number: e00871-17. (10.1128/IAI.00871-17)
- Williams, R., Khan, W., Williams, H., Abbas, A., Mehta, A., Ayre, W. and Morgan-Jones, R. 2018. Chemical debridement using acetic acid during revision arthroplasty. Presented at: European Bone And Joint Infection Society 34th Annual Meeting, Estoril, Portugal, 10-12 September 2015, Vol. 97-B. Vol. SUPP_1., (10.1302/1358-992X.97BSUPP_15.EBJIS2015-051)
2017
- Quiney, D., Ayre, W. N. and Milward, P. 2017. The effectiveness of adhesives on the retention of mandibular free end saddle partial dentures: an in vitro study. Journal of Dentistry 62, pp. 64-71. (10.1016/j.jdent.2017.05.008)
- Williams, R. L., Nishio Ayre, W., Khan, W. S., Mehta, A. and Morgan-Jones, R. 2017. Acetic acid as part of a debridement protocol during revision total knee arthroplasty. The Journal of Arthroplasty 32(3), pp. 953-957. (10.1016/j.arth.2016.09.010)
2016
- Nishio Ayre, W., Birchall, J. C., Evans, S. L. and Denyer, S. P. 2016. A novel liposomal drug delivery system for PMMA bone cements. Journal of Biomedical Materials Research Part B: Applied Biomaterials 104(8), pp. 1510-1524. (10.1002/jbm.b.33488)
- Sloan, A., Colombo, J., Roberts, J., Waddington, R. and Nishio Ayre, W. 2016. Tissue culture models and approaches for dental tissue regeneration. In: Waddington, R. and Sloan, A. eds. Tissue Engineering and Regeneration in Dentistry: Current Strategies. West Sussex: John Wiley & Sons, pp. 96-109., (10.1002/9781119282181.ch5)
- Jordan, R. P. C. et al. 2016. An assessment of early colonisation of implant-abutment metal surfaces by single species and co-cultured bacterial periodontal pathogens. Journal of Dentistry 53, pp. 64-72. (10.1016/j.jdent.2016.07.013)
- Nishio Ayre, W., Scott, T., Hallam, K., Blom, A. W., Denyer, S., Bone, H. K. and Mansell, J. P. 2016. Fluorophosphonate-functionalised titanium via a pre-adsorbed alkane phosphonic acid: a novel dual action surface finish for bone regenerative applications. Journal of Materials Science: Materials in Medicine 27, article number: 36. (10.1007/s10856-015-5644-7)
2015
- Lee, C. P., Colombo, J. S., Nishio Ayre, W., Sloan, A. J. and Waddington, R. J. 2015. Elucidating the cellular actions of demineralised dentine matrix extract on a clonal dental pulp stem cell population in orchestrating dental tissue repair. Journal of Tissue Engineering 6, pp. 1-13. (10.1177/2041731415586318)
2014
- Nishio Ayre, W., Denyer, S. P. and Evans, S. L. 2014. Ageing and moisture uptake in polymethyl methacrylate (PMMA) bone cements. Journal of the Mechanical Behavior of Biomedical Materials 32, pp. 76-88. (10.1016/j.jmbbm.2013.12.010)
2013
- Ayre, W. N. 2013. Novel approaches to the development of PMMA bone cement. PhD Thesis, Cardiff University.
2012
- Ayre, W. N. and Evans, S. L. 2012. Fatigue crack propagation in poly (methyl methacrylate) bone cement under different loading frequencies and stress intensities [Abstract]. Orthopaedic Proceedings: a supplement of Journal of Bone and Joint Surgery (British) 94-B(SXVIII), pp. 63-63.
2010
- Ayre, W., Howell, M., Madete, J. K., Jones, D. K. and Holt, C. A. 2010. Quantifying manual and bi-manual tasks using motion capture for brain imaging. Presented at: 9th International Conference on Computer Methods in Biomechanics and Biomedical Engineering, Valencia, Spain.
Addysgu
I am currently co-supervising two PhD student at the School of Dentistry and have previously supervised 3 MSc, 8 undergraduate and 3 ERASMUS student projects. I deliver lectures, practical sessions and set examination questions on the Biomaterials undergraduate module at the Cardiff School of Dentistry, participate in microbiology practicals at the Cardiff School of Pharmacy and Pharmaceutical Sciences including marking of manuscripts and have demonstrated in undergraduate lectures, laboratory practicals and UCAS tours on mechanical engineering for the School of Engineering.
Research funding
2017 – MRC Confidence in Concept- “Robust and facile lipid coating to enhance lubrication and reduce biofilm formation on urinary catheters”. £62,427. August 2017. Principal applicant.
2017 – Cardiff University Research Infrastructure Fund “Spark Plasma Sintering (SPS) system”. £179,000. April 2017. Co-applicant
2016 – NHS R&D Equipment bid “3D Printer”. £8,000 February 2016. Principal applicant.
2016 – Life Sciences Bridging Fund “Optimisation and toxicity testing of the liposomal drug delivery system for orthopaedic bone cement”. £71,114. January 2017. Principal applicant.
2016 – Wellcome Trust ISSF “Enhancing wear properties of CRF-PEEK and UHMWPE acetabular cups using a novel lipid bilayer surface functionalization.” £23,067.00 July 2016. Principal applicant.
2016 – NHS R&D Equipment bid “Rotary evaporator”. £5737.50 February 2016. Principal applicant.
2015 – Dunhill Medical Trust – “Preventing aseptic loosening of cemented joint replacements in older adults: delivery of osteogenic molecules from PMMA bone cement to encourage bone repair and implant osseointegration”. £86,104 February 2015 – August 2016. Co-applicant.
2015 – NIHR i4i – “Fluorophosphonate biofunctionalisation of biomaterials for orthopaedic applications”. £500,000 September 2015 – August 2017. Co-applicant.
2015 – MRC Proximity to Discover Scheme – “Novel biomimetic, antimicrobial and bioactive dentine scaffolds for vital pulp therapies”. £20,000 October 2015 – December 2015. Principal applicant.
2014 – Renishaw PhD Studentship – “Bacterial adhesion and inhibition at dental implant and abutment surfaces”. £50,000 October 2015 – 2018. Co-applicant.
2014 – Life Sciences Research Network Wales Research Project – “Delivery of osteogenic molecules from acrylic bone cement to encourage regenerative bone repair around cemented joint replacements”. £49,929 February 2015 – 2016. Principal applicant.
2014 – SARTRE Health Technology Challenge Scheme – “Liposomal antimicrobial delivery system for PMMA bone cement”. £19,635 July – September 2014. Principal applicant.
Patents
- Denyer S, Evans S, Ayre W. Liposomal drug delivery system for bone cements. International Patent number: WO 2015004450 A1.