Ewch i’r prif gynnwys
Dr Wayne Nishio Ayre

Dr Wayne Nishio Ayre

Darlithydd mewn Bioddeunyddiau

Ysgol Deintyddiaeth

Email:
ayrewn@cardiff.ac.uk
Telephone:
+44(0) 292 2510 660
Location:
Ysbyty Deintyddol y Brifysgol, Parc y Mynydd Bychan, Caerdydd, CF14 4XY
Ar gael fel goruchwyliwr ôl-raddedig

Career overview

  • September 2016 – Present: Lecturer in Biomaterials – Cardiff School of Dentistry.
  • November 2014 – September 2016: Research fellow – Cardiff School of Dentistry, Tissue Engineering & Reparative Dentistry.  Life Sciences Research Network Wales: Delivery of osteogenic molecules from acrylic bone cement to encourage regenerative bone repair around cemented joint replacements.
  • September 2014 – November 2014: Research associate – Cardiff School of Pharmacy and Pharmaceutical Sciences.  SATRTE Bio-E Pilot Project: Phosphonate-tethered lysophosphatidic acid-functionalised titanium: a novel surface finish for bone regenerative applications.
  • June 2014 – August 2014: Research associate – Cardiff School of Pharmacy and Pharmaceutical Sciences.  SATRTE Health Technology Challenge Pilot Project: Liposomal antimicrobial delivery system for PMMA bone cement
  • December 2013 – May 2014: Research associate – Cardiff School of Dentistry, Tissue Engineering & Reparative Dentistry.  Dunhill Medical Trust: Preventing dental pain, abscess and tooth loss in older adults: development of antimicrobial restorative materials to manage dental disease in older adults
  • September 2013 – November 2013: Research assistant – Cardiff School of Engineering, Institute of Mechanical and Manufacturing Engineering.  Clean Sky/EU Commission: Developing, manufacturing and testing composite materials for aerospace applications.

Education and qualification

  • 2009 – 2013: Doctor of Philosophy (Ph.D.) in Mechanical Engineering, Cardiff University/Arthritis Research UK Biomechanics and Bioengineering Centre. Inter-disciplinary research project between the schools of Engineering and Pharmacy, developing and testing novel formulations of PMMA bone cements to enhance mechanical, drug delivery and osseointegrative properties.
  • 2006 – 2009: Bachelor of Engineering (B.Eng. First Class Hons) in Medical Engineering, School of Engineering, Cardiff University

Ymrwymiadau siarad cyhoeddus

  • Ayre WN,  Scott T, Hallam K, Blom AW, Denyer SP, Bone H, Mansell JP. 2016. Phosphonate-tethered lysophosphatidic acid-functionalised titanium: a novel surface finish for cementless orthopaedic implants. British Orthopaedic Research Society Annual Meeting, Glasgow.
  • Ayre WN, Waddington RJ, Evans SL, Mason DJ, Evans B, Birchall JC, Morgan-Jones R, Denyer SP, Sloan AJ. 2016. Delivery of osteogenic liposomal bone morphogenetic protein-2 from poly(methyl methacrylate) bone cement.  Tissue and Cell Engineering Society Meeting, UCL, London.
  • Ayre WN, Evans B, Mason DJ, Birchall JC, Evans SL, Denyer SP, Morgan-Jones R, Waddington RJ and Sloan AJ.  2015.  Delivery of osteogenic molecules from acrylic bone cement to encourage regenerative bone repair around cemented joint replacements. Southwest Regional Regenerative Medicine Meeting, Bristol.
  • Ayre, WN, Roberts, J, Marsh, LL, Evans, SL, Maillard, J, Denyer, SP, Lynch, CD and Sloan, AJ. 2014.  Novel Ex vivo Models for Endodontic Infection and Antimicrobial Assessment. IADR/PER Congress, Dubrovnik, Croatia.
  • Ayre, WN, Birchall, JC, Evans, SL and Denyer, SP.  2013. Liposomal therapeutic delivery system for poly(methyl methacrylate) bone cement.  APS PharmSci, Edinburgh, UK.
  • Ayre, WN, Birchall, JC, Evans, SL and Denyer, SP.  2013. Development of a novel liposomal therapeutic delivery system for poly(methyl methacrylate) bone cement.  British Orthopaedic Research Society and Bone Research Society Joint Meeting, Oxford, UK.
  • Ayre, WN, Madete, JK, Jones, DK and Holt, CA. 2010. Quantifying manual and bi-manual tasks using motion capture for brain imaging. Proceedings of the 9th International Conference on Computer Methods in Biomechanics and Biomedical Engineering, Valencia, Spain.

2018

2017

2016

2015

2014

2013

2012

I am currently co-supervising two PhD student at the School of Dentistry and have previously supervised 3 MSc, 8 undergraduate and 3 ERASMUS student projects.  I deliver lectures, practical sessions and set examination questions on the Biomaterials undergraduate module at the Cardiff School of Dentistry, participate in microbiology practicals at the Cardiff School of Pharmacy and Pharmaceutical Sciences including marking of manuscripts and have demonstrated in undergraduate lectures, laboratory practicals and UCAS tours on mechanical engineering for the School of Engineering.

Research funding

2017 – MRC Confidence in Concept- “Robust and facile lipid coating to enhance lubrication and reduce biofilm formation on urinary catheters”. £62,427.  August 2017.  Principal applicant.

2017 – Cardiff University Research Infrastructure Fund “Spark Plasma Sintering (SPS) system”.  £179,000.  April 2017.  Co-applicant

2016 – NHS R&D Equipment bid “3D Printer”.  £8,000 February 2016.  Principal applicant.

2016 – Life Sciences Bridging Fund “Optimisation and toxicity testing of the liposomal drug delivery system for orthopaedic bone cement”.  £71,114. January 2017.  Principal applicant.

2016 – Wellcome Trust ISSF “Enhancing wear properties of CRF-PEEK and UHMWPE acetabular cups using a novel lipid bilayer surface functionalization.” £23,067.00 July 2016.  Principal applicant.

2016 – NHS R&D Equipment bid “Rotary evaporator”.  £5737.50 February 2016.  Principal applicant.

2015 Dunhill Medical Trust – “Preventing aseptic loosening of cemented joint replacements in older adults: delivery of osteogenic molecules from PMMA bone cement to encourage bone repair and implant osseointegration”. £86,104 February 2015 – August 2016.  Co-applicant.

2015 – NIHR i4i – “Fluorophosphonate biofunctionalisation of biomaterials for orthopaedic applications”.  £500,000 September 2015 – August 2017. Co-applicant.

2015 – MRC Proximity to Discover Scheme – “Novel biomimetic, antimicrobial and bioactive dentine scaffolds for vital pulp therapies”.  £20,000 October 2015 – December 2015. Principal applicant.

2014 – Renishaw PhD Studentship – “Bacterial adhesion and inhibition at dental implant and abutment surfaces”.  £50,000 October 2015 – 2018. Co-applicant.

2014 – Life Sciences Research Network Wales Research Project – “Delivery of osteogenic molecules from acrylic bone cement to encourage regenerative bone repair around cemented joint replacements”. £49,929 February 2015 – 2016. Principal applicant.

2014 – SARTRE Health Technology Challenge Scheme – “Liposomal antimicrobial delivery system for PMMA bone cement”.  £19,635 July – September 2014. Principal applicant.

Patents

  • Denyer S, Evans S, Ayre W.  Liposomal drug delivery system for bone cements.  International Patent number: WO 2015004450 A1.

Goruchwyliaeth gyfredol

Peter Hansal

Peter Hansal

Research student