Ewch i’r prif gynnwys
 Marianne van den Bree

Marianne van den Bree

Professor, Division of Psychological Medicine and Clinical Neurosciences

Yr Ysgol Meddygaeth

+44 (0)29 2068 8433
2.16, Adeilad Hadyn Ellis, Heol Maendy, Caerdydd, CF24 4HQ

Professor van den Bree's research examines the developmental pathways of mental health. Her work focuses on the genetic and environmental factors that increase or decrease risk of the development of mental health problems in children and adolescents and the characterization of the underlying process.

She is interested in the manifestations associated with small chromosomal deletions and duplications. In addition to Velo-Cardio-Facial Syndrome (VCFS), which is also known as 22q11.2 Deletion Syndrome (22q11.2DS), her research also focuses on deletions and duplications in a number of other chromosomal regions.

Other research interests are the development of substance misuse in young people and factors contributing to, or exacerbating, risk of homelessness.

She also leads the effort to establish the impact on wider society of research conducted within her Institute of Psychological Medicine and Clinical Neurosciences at Cardiff University.


























Selected research projects:

ExperienCes of people witH cOpy number variants (ECHO Study)

Copy Number Variants (CNVs) are micro-deletions or -duplications of DNA sequence, which can be accompanied by physical, developmental, intellectual, behavioural and psychological problems. There is insufficient information on the manifestations of different CNVs to guide patients, their families, and health and other professionals. Furthermore, the changes occurring throughout childhood and into adolescence and adulthood remain poorly understood for individuals with chromosomal disorders.

The ECHO study ( ECHO Study ) aims to characterise the nature and prevalence of manifestations associated with CNVs in a number of different chromosomal regions. In addition to 22q11.2 deletion syndrome (22q11.2DS), the ECHO study also focuses on a number of other chromosomal regions, including 1q, 3q, 9q, 15q and 16p.

The ECHO study is part of The International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome and Professor van den Bree leads one of the five sites coordinating this Consortium (International Consortium ).

We also conduct studies to increase understanding of the service use experiences of families with a child with a chromosomal disorder.

Support: Bailey Thomas Charitable Trust, the Waterloo Foundation, HEFCW, Wellcome Trust, NIMH and MRF.

Intellectual Disability and Mental Health: Assessing Genomic Impact on Neurodevelopment (IMAGINE Study)

The IMAGINE study (IMAGINE) involves a collaboration between Cardiff and Cambridge University and University College London. Prof van den Bree of one of the lead researchers of the IMAGINE study, which aims to increase understanding of the links between intellectual disability and chromosomal disorder, with the ultimate aim to improve insight into the manifestations of chromosomal disorders in order to inform prognosis and management.

Support: MRC and MRF.

The Development of Substance Misuse in Adolescents

Studies based on twin and population-based samples have focused on the questions why young people start using alcohol, cigarettes or drugs, as well as which factors contribute to the development of heavy use and problem use over time.

Support: Wellcome Trust, ERAB, Mental Health Research Network Cymru, Children& Young People’s Research Network (CYPRN) for Wales.

Study of Experiences of Young Homeless People (SEYHOPE)

There is a dearth of longitudinal studies in which homeless people are followed over time. Conducting multiple interviews with young homeless people is improving our insights into their backgrounds, the problems they face and the changes that take place in their lives over time. Information is evaluated against service use and needs with the aim to foster more effective interventions.

Support: ESCR, Welsh Assembly Government. Knowledge Transfer Partnership with Llamau.