Yr Athro Karl Swann

2019

• Bradley, J.et al. 2019. Dynamic label-free imaging of lipid droplets and their link to fatty acid and pyruvate oxidation in mouse eggs. Journal of Cell Science 132(13), article number: jcs228999. (10.1242/jcs.228999)
• Bradley, J. and Swann, K. 2019. Mitochondria and lipid metabolism in mammalian oocytes and early embryos. International Journal of Developmental Biology 63(3-4-5), pp. 93-103. (10.1387/ijdb.180355ks)
• Borri, P.et al. 2019. Imaging lipids in living mammalian oocytes and early embryos by coherent Raman scattering microscopy. Presented at: SPIE BIOS, San Francisco, CA, USA, 2-7 February 2019Proceedings Volume 10890, Label-free Biomedical Imaging and Sensing (LBIS) 2019, Vol. 108900. Society of Photo-Optical Instrumentation Engineers (SPIE) pp. 3., (10.1117/12.2506248)

2018

• Swann, K. 2018. The role of Ca 2+ in oocyte activation during In Vitro fertilization: Insights into potential therapies for rescuing failed fertilization. BBA - Molecular Cell Research 1865(11), pp. 1830-1837. (10.1016/j.bbamcr.2018.05.003)
• Pope, I.et al. 2018. Coherent Raman Scattering microscopy: technology developments and biological applications. Presented at: 20th International Conference on Transparent Optical Networks (ICTON), Bucharest, Romania, 1-5 Jul 201820th International Conference on Transparent Optical Networks (ICTON). IEEE, (10.1109/ICTON.2018.8473706)
• FitzHarris, G., Carroll, J. and Swann, K. 2018. Electrical-assisted microinjection for analysis of fertilization and cell division in mammalian oocytes and early embryos. Methods in Cell Biology 144, pp. 431-440. (10.1016/bs.mcb.2018.03.036)
• Sanders, J.et al. 2018. PLCz induced Ca2+ oscillations in mouse eggs involve a positive feedback cycle of Ca2+ induced InsP3 formation from cytoplasmic PIP2. Frontiers in Cell and Developmental Biology 6, article number: 36. (10.3389/fcell.2018.00036)

2017

• Nomikos, M., Swann, K. and Lai, F. A. 2017. Fundamental role for sperm phospholipase C ζ in mammalian fertilization. In: De Jonge, C. J. and Barratt, C. L. R. eds. The Sperm Cell. Cambridge: Cambridge University Press, pp. 177-192., (10.1017/9781316411124.014)
• Nomikos, M.et al. 2017. Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLCζ. Biochemical Journal 474(6), pp. 1003-1016. (10.1042/BCJ20161057)
• Kashir, J.et al. 2017. Antigen unmasking enhances visualization efficacy of the oocyte activation factor, phospholipase C zeta, in mammalian sperm. Molecular Human Reproduction 23(1), pp. 54-67. (10.1093/molehr/gaw073)

2016

• Sanders, J. R. and Swann, K. 2016. Molecular triggers of egg activation at fertilization in mammals. Reproduction 152(2), article number: R41. (10.1530/REP-16-0123)
• Bradley, J.et al. 2016. Quantitative imaging of lipids in live mouse oocytes and early embryos using CARS microscopy. Development 143, pp. 2238-2247. (10.1242/dev.129908)
• Swann, K. and Lai, F. A. 2016. The sperm phospholipase C-ζ and Ca2+ signalling at fertilization in mammals. Biochemical Society Transactions 44(1), pp. 267-272. (10.1042/BST20150221)
• Haverfield, J.et al. 2016. Ca2+ dynamics in oocytes from naturally-aged mice. Scientific Reports 6, article number: 19357. (10.1038/srep19357)
• Swann, K. and Lai, F. A. 2016. Egg activation at fertilization by a soluble sperm protein. Physiological Reviews 96(1), pp. 127-149. (10.1152/physrev.00012.2015)

2015

• Nomikos, M.et al. 2015. Essential role of the EF-hand domain in targeting sperm phospholipase Cζ to membrane phosphatidylinositol 4,5-bisphosphate (PIP2). Journal of Biological Chemistry 290(49), pp. 29519-29530. (10.1074/jbc.M115.658443)
• Sanusi, R.et al. 2015. Rescue of failed oocyte activation after ICSI in a mouse model of male factor infertility by recombinant phospholipase Cζ. Molecular Human Reproduction 21(10), pp. 783-791. (10.1093/molehr/gav042)
• Nomikos, M.et al. 2015. Functional disparity between human PAWP and PLCζ in the generation of Ca2+ oscillations for oocyte activation. Molecular Human Reproduction 21(9), pp. 702-710. (10.1093/molehr/gav034)
• Kashir, J.et al. 2015. PLCζ or PAWP: revisiting the putative mammalian sperm factor that triggers egg activation and embryogenesis. Molecular Human Reproduction 21(5), pp. 383-388. (10.1093/molehr/gav009)
• Nomikos, M., Swann, K. and Lai, F. A. 2015. Is PAWP the 'real' sperm factor?. Asian Journal of Andrology 17(3), pp. 444-446. (10.4103/1008-682X.142145)

2014

• Nomikos, M.et al. 2014. Sperm-specific post-acrosomal WW-domain binding protein (PAWP) does not cause Ca2+ release in mouse oocytes. Molecular Human Reproduction 20(10), pp. 938-947. (10.1093/molehr/gau056)
• Kashir, J.et al. 2014. Sperm-induced Ca2+ release during egg activation in mammals. Biochemical and Biophysical Research Communications 450(3), pp. 1204-1211. (10.1016/j.bbrc.2014.04.078)
• Nomikos, M.et al. 2014. Human PLCζ exhibits superior fertilization potency over mouse PLCζ in triggering the Ca2+ oscillations required for mammalian oocyte activation. Molecular Human Reproduction 20(6), pp. 489-498. (10.1093/molehr/gau011)
• Gonzalez-Garcia, J. R.et al. 2014. The dynamics of MAPK inactivation at fertilization in mouse eggs. Journal of Cell Science 127(12), pp. 2749-2760. (10.1242/jcs.145045)
• Fourrage, C.et al. 2014. An endogenous green fluorescent protein-photoprotein pair in Clytia hemisphaerica eggs shows co-targeting to mitochondria and efficient bioluminescence energy transfer. Open Biology 4(4), pp. 130206. (10.1098/rsob.130206)

2013

• Theodoridou, M.et al. 2013. Chimeras of sperm PLCζ reveal disparate protein domain functions in the generation of intracellular Ca2+ oscillations in mammalian eggs at fertilization. Molecular Human Reproduction 19(12), pp. 852-864. (10.1093/molehr/gat070)
• Swann, K. and Lai, F. A. 2013. PLCζ and the initiation of Ca2+ oscillations in fertilizing mammalian eggs. Cell Calcium 53(1), pp. 55-62. (10.1016/j.ceca.2012.11.001)
• Gonzalez Garcia, J.et al. 2013. The dynamics of PKC-induced phosphorylation triggered by Ca2+oscillations in mouse eggs. Journal of Cellular Physiology 228(1), pp. 110-119. (10.1002/jcp.24110)
• Nomikos, M.et al. 2013. Phospholipase Cζ rescues failed oocyte activation in a prototype of male factor infertility. Fertility and Sterility 99(1), pp. 76-85. (10.1016/j.fertnstert.2012.08.035)
• Swann, K. 2013. Measuring Ca2+ Oscillations in Mammalian Eggs. In: Homer, H. A. ed. Mammalian Oocyte Regulation., Vol. 957. Methods in Molecular Biology Humana Press, pp. 231-248., (10.1007/978-1-62703-191-2_16)

2012

• Swann, K.et al. 2012. Phospholipase C-ζ-induced Ca2+ oscillations cause coincident cytoplasmic movements in human oocytes that failed to fertilize after intracytoplasmic sperm injection. Fertility and Sterility 97(3), pp. 742-747. (10.1016/j.fertnstert.2011.12.013)
• Yu, Y.et al. 2012. PLCζ causes Ca2+ oscillations in mouse eggs by targeting intracellular and not plasma membrane PI(4,5)P2. Molecular Biology of the Cell 23(2), pp. 371-380. (10.1091/mbc.E11-08-0687)

2011

• Nomikos, M.et al. 2011. Phospholipase C binding to PtdIns(4,5)P2 requires the XY-linker region. Journal of Cell Science 124(15), pp. 2582-2590. (10.1242/jcs.083485)
• Ajduk, A.et al. 2011. Rhythmic actomyosin-driven contractions induced by sperm entry predict mammalian embryo viability. Nature Communications 2, article number: 417. (10.1038/ncomms1424)
• Nomikos, M.et al. 2011. Male infertility-linked point mutation disrupts the Ca2+oscillation-inducing and PIP2hydrolysis activity of sperm PLCζ. Biochemical Journal 434(2), pp. 211-217. (10.1042/BJ20101772)
• Nomikos, M.et al. 2011. Male infertility-linked point mutation disrupts the Ca2+ oscillation-inducing and PIP2 hydrolysis activity of sperm PLCζ [Erratum]. The Biochemical Journal 435(3), pp. 791.
• Phillips, S. V.et al. 2011. Divergent effect of mammalian PLC-zeta in generating Ca2+ oscillations in somatic cells versus eggs. Biochemical Journal 438, pp. 545-533. (10.1042/BJ20101581)
• Nomikos, M., Swann, K. and Lai, F. A. 2011. Starting a new life: Sperm PLC-zeta mobilizes the Ca2+ signal that induces egg activation and embryo development. BioEssays 34(2), pp. 126-134. (10.1002/bies.201100127)
• Nomikos, M.et al. 2011. Novel regulation of PLCζ activity via its XY-linker. Biochemical Journal 438, pp. 427-432. (10.1042/BJ20110953)

2010

• Yu, Y.et al. 2010. Redistribution of mitochondria leads to bursts of ATP production during spontaneous mouse oocyte maturation. Journal of Cellular Physiology 224(3), pp. 672-680. (10.1002/jcp.22171)

2009

• Dumollard, R.et al. 2009. Mitochondrial function and redox state in mammalian embryos. Seminars in Cell and Developmental Biology 20(3), pp. 346-353. (10.1016/j.semcdb.2008.12.013)

2008

• Ajduk, A. M.et al. 2008. Fertilization differently affects the levels of cyclin B1 and M-phase promoting factor activity in maturing and metaphase II mouse oocytes. Reproduction 136(6), pp. 741-752. (10.1530/REP-08-0271)
• Yu, Y.et al. 2008. Regulation of diacylglycerol production and protein kinase C stimulation during sperm- and PLCζ-mediated mouse egg activation. Biology of the Cell 100(11), pp. 633-643. (10.1042/BC20080033)
• Dumollard, R.et al. 2008. Regulation of cytosolic and mitochondrial ATP levels in mouse eggs and zygotes. Developmental Biology 316(2), pp. 431-440. (10.1016/j.ydbio.2008.02.004)
• Yu, Y.et al. 2008. Preimplantation development of mouse oocytes activated by different levels of human phospholipase C zeta. Human Reproduction 23(2), pp. 365-373. (10.1093/humrep/dem350)

2006

• Campbell, K. and Swann, K. 2006. Ca2+ oscillations stimulate an ATP increase during fertilization of mouse eggs. Developmental Biology 298(1), pp. 225-233. (10.1016/j.ydbio.2006.06.032)

2005

• Nomikos, M.et al. 2005. Role of phospholipase C-zeta domains in Ca2+-dependent phosphatidylinositol 4,5-bisphosphate hydrolysis and cytoplasmic Ca2+ oscillations. Journal of biological chemistry 280(35), pp. 31011-31018. (10.1074/jbc.M500629200)

2004

• Rogers, N. T.et al. 2004. Phospholipase Cζ causes Ca2+ oscillations and parthenogenetic activation of human oocytes. Reproduction 128(6), pp. 697-702. (10.1530/rep.1.00484)
• Larman, M. G.et al. 2004. Cell cycle-dependent Ca2+ oscillations in mouse embryos are regulated by nuclear targeting of PLCzeta. Journal of cell science 117(12), pp. 2513-2521. (10.1242/jcs.01109)

2002

• Saunders, C. M.et al. 2002. PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development. Development 129(15), pp. 3533-3544.