Dr Owen B. Spiller
Senior Lecturer
- spillerb@cardiff.ac.uk
- +44 (0)29 2074 2394
- UHW Main Building
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwg
I lead the U.K. site for the international reference laboratory in Ureaplasma and Mycoplasma pathogenicity and antimicrobial resistance testing. Aside from a long standing productive collaboration with Public Health England, developing new clinical diagnostic and microbial typing schemes, I am also an adjunct associate professor with the Univeristy of Western Australia, the elected Secretary-General for the International Organisation of Mycoplasmology and the current elected Treasurer for the European Society for Clinical Microbiology and Infectious Disease Mycoplasma study group. My expertise is in determining underlying mechanisms of bacterial antimicrobial resistance, primarily in Mycoplasmas and Ureaplasmas, but expanding into Streptococcus agalactiae and Legionella pneumophilia. I am currently located on the 6th floor of the University Hospital of Wales, Department of Medical Microbiology which also includes the adjacent laboratories of Prof. Timothy Walsh and Dr. Mark Toleman.
Bywgraffiad
Originally a Canadian Microbiologist from Vancouver, I initially came to the U.K. to examine innate immune evasion of microbes. From 2000 to 2005 I established an independed research group through the Wellcome Trust Career Development Fellowship Program, before joining the Department of Child Health at University Hosptial of Wales in 2005 to develop a new research theme examining antimicrobial resistance in bacterial infections of premature neonates. This led to my establishing the leading U.K. reference laboratory for investigations of Mycoplasma and Ureaplasma infections. These cell wall-less bacteria are inherently resistant to most antimicrobials and are the leading cause of preterm birth and are emerging as respiratory pathogens. I am in my second elected term as the Secretary-General of the International Organisation of Mycoplasmology (http://iom-online.org) and have just completed 2 elected terms as the mycoplasma antimicrobial resistance officer for the European Society of Clinical Microbiology and Infectious Diseases (https://www.escmid.org/research_projects/study_groups/mycoplasma_infections/executive_committee/).
In 2012, I began a Royal Society funded collaboration with the University of Western Australia to investigate intrauterine microbial pathology and develop new antibiotics that were safe and effective for use in pregnant women. These collaborations resulted in my being awarded an adjunct associate professorship at the University of Western Australia's School of Women's and Infant's Health, Perth, Australia in 2015.
Also in 2015, I joined the All Wales Antimicrobial Resistance Engagement unit, headed by Prof. Timothy Walsh, and have been expanding my research of antimicrobial resistance to other bacteria. As a result in 2017, I have new research projects characterising Group B Streptococcus strains isolated from U.K. sepsis patients and characterisation of Legionella pnuemophilia isolates from U.K. outbreaks of Legionnaires' disease, also known as legionellosis.
Education and qualifications:
1995: PhD (Pathology), University of British Columbia, Vancouver, B.C. Canada
Anrhydeddau a Dyfarniadau
- 2000 Wellcome Trust Research Career Development Fellowship
- 2015 awarded honorary adjunct Associate Professorship at the University of Western Australia
Cyhoeddiadau
2023
- Khan, U. B., Portal, E. A. R., Sands, K., Lo, S., Chalker, V. J., Jauneikaite, E. and Spiller, O. B. 2023. Genomic analysis reveals new integrative conjugal elements and transposons in GBS conferring antimicrobial resistance. Antibiotics 12(3), article number: 544. (10.3390/antibiotics12030544)
2022
- van Gorp, C. et al. 2022. Antenatal Ureaplasma infection induces ovine small intestinal goblet cell defects: a strong link with NEC pathology. Tissue Barriers, article number: 2158016. (10.1080/21688370.2022.2158016)
- Day, J. et al. 2022. Phenotypic and genotypic antimicrobial susceptibility patterns of the emerging human respiratory pathogen Mycoplasma amphoriforme isolated from the UK and Denmark. Journal of Antimicrobial Chemotherapy 77(11), pp. 3126-3129. (10.1093/jac/dkac293)
- Dakorah, M. P. et al. 2022. Utilising cumulative antibiogram data to enhance antibiotic stewardship capacity in the Cape Coast Teaching Hospital, Ghana. Antimicrobial Resistance and Infection Control 11, article number: 122. (10.1186/s13756-022-01160-5)
- Dolton, G. et al. 2022. Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope. Cell 185(16), pp. 2936-2951. (10.1016/j.cell.2022.07.002)
- Sands, K. et al. 2022. Characterisation of Staphylococci species from neonatal blood cultures in low- and middle-income countries. BMC Infectious Diseases 22(1), article number: 593. (10.1186/s12879-022-07541-w)
- Khan, U. B., Jauneikaite, E., Andrews, R., Chalker, V. J. and Spiller, O. B. 2022. Identifying large-scale recombination and capsular switching events in Streptococcus agalactiae strains causing disease in adults in the UK between 2014 and 2015. Microbial Genomics 8(3), article number: 783. (10.1099/mgen.0.000783)
- Silwedel, C. et al. 2022. Ureaplasma-driven neonatal neuroinflammation: novel insights from an ovine model. Cellular and Molecular Neurobiology 43, pp. 785-795. (10.1007/s10571-022-01213-8)
- Acolatse, J. E. E. et al. 2022. Environmental surveillance of ESBL and carbapenemase-producing gram-negative bacteria in a Ghanaian Tertiary Hospital. Antimicrobial Resistance and Infection Control 11(1), article number: 49. (10.1186/s13756-022-01090-2)
- Sands, K., Spiller, O. B., Thomson, K., Portal, E. A. R., Iregbu, K. C. and Walsh, T. R. 2022. Early-onset neonatal sepsis in low- and middle-income countries: current challenges and future opportunities. Infection and Drug Resistance 2022, pp. 933—946. (10.2147/IDR.S294156)
- Boostrom, I., Portal, E. A. R., Spiller, O. B., Walsh, T. R. and Sands, K. 2022. Comparing long-read assemblers to explore the potential of a sustainable low-cost, low-infrastructure approach to sequence antimicrobial resistant bacteria with Oxford nanopore sequencing. Frontiers in Microbiology 13, article number: 796465. (10.3389/fmicb.2022.796465)
- Preval, N. M. R., Spiller, O. B., Mondeja Rodríguez, B. A., Morales, R. S., Cintra, Y. R. and Rivera-Tapia, J. A. 2022. Antibiotic resistance among clinical Ureaplasma isolates from Cuban individuals between 2013 and 2018. Journal of Medical Microbiology 71(2), article number: 1477. (10.1099/jmm.0.001477)
2021
- Boostrom, I. et al. 2021. Evaluation of the MYCOPLASMA IST3 urogenital mycoplasma assay in an international multicentre trial. Journal of Antimicrobial Chemotherapy 76(12), pp. 3175-3182. (10.1093/jac/dkab320)
- Rowlands, R., Kragh, K., Sahu, S., Maddocks, S., Bolhuis, A., Spiller, O. and Beeton, M. 2021. A requirement for flow to enable the development of Ureaplasma parvum biofilms in vitro. Journal of Applied Microbiology 131(5), pp. 2579-2585. (10.1111/jam.15120)
- Sharratt, M. et al. 2021. Defining fluoroquinolone resistance-mediating mutations from non-resistance polymorphisms in Mycoplasma hominis Topoisomerases. Antibiotics 10(11), article number: 1379. (10.3390/antibiotics10111379)
- Spiller-Boulter, O., Paukner, S., Boostrom, I., Sands, K., Portal, E. A. R. and Spiller, O. B. 2021. Determination of in vitro antimicrobial susceptibility for Lefamulin (Pleuromutilin) for Ureaplasma Spp. and Mycoplasma hominis. Antibiotics 10(11), article number: 1370. (10.3390/antibiotics10111370)
- Goedicke-Fritz, S. et al. 2021. Detection of volatile organic compounds as potential novel biomarkers for chorioamnionitis - proof of experimental models. Frontiers in Pediatrics 9, article number: 698489. (10.3389/fped.2021.698489)
- Portal, E., Sands, K., Portnojs, A., Chalker, V. . J. and Spiller, O. B. 2021. Legionella antimicrobial sensitivity testing: comparison of microbroth dilution with BCYE and LASARUS solid media. Journal of Antimicrobial Chemotherapy 76(5), pp. 1197-1204. (10.1093/jac/dkaa535)
- Portal, E. et al. 2021. Legionella antibiotic susceptibility testing: is it time for international standardization and evidence-based guidance?. Journal of Antimicrobial Chemotherapy 76(5), pp. 1113-1116. (10.1093/jac/dkab027)
- Ophelders, D. R. M. G. et al. 2021. Screening of chorioamnionitis using volatile organic compound detection in exhaled breath: a pre-clinical proof of concept study. Frontiers in Pediatrics 9, article number: 617906. (10.3389/fped.2021.617906)
- Chalker, V. J. et al. 2021. Tetracycline resistance mediated by tet(M) has variable integrative conjugative element composition in Mycoplasma hominis isolated in the United Kingdom from 2005-2015.. Antimicrobial Agents and Chemotherapy 65, article number: e02513-20. (10.1128/AAC.02513-20)
2020
- Morris, D. J., Jones, L. C., Davies, R. L., Sands, K., Portal, E. and Spiller, O. B. 2020. MYCO WELL D-ONE detection of Ureaplasma spp. and Mycoplasma hominis in sexual health patients in Wales. European Journal of Clinical Microbiology and Infectious Diseases 39, pp. 2427-2440. (10.1007/s10096-020-03993-7)
- Heymans, C. et al. 2020. Prophylactic intra-uterine β-cyclodextrin administration during intra-uterine Ureaplasma parvum infection partly prevents liver inflammation without interfering with the enterohepatic circulation of the fetal sheep. Nutrients 12(5), article number: 1312. (10.3390/nu12051312)
- Yang, Q. E. et al. 2020. Compensatory mutations modulate the competitiveness and dynamics of plasmid-mediated colistin resistance in Escherichia coli clones. ISME Journal 14, pp. 861-865. (10.1038/s41396-019-0578-6)
- Heymans, C. et al. 2020. Chronic intra-uterine ureaplasma parvum infection induces injury of the enteric nervous system in ovine fetuses. Frontiers in Immunology 11(189) (10.3389/fimmu.2020.00189)
- Spiller, O. B., Rees, C. L., Morris, D. J., Davies, R. L. and Jones, L. C. 2020. Mycoplasma genitalium prevalence in Welsh sexual health patients: low antimicrobial resistance markers and no association of symptoms to bacterial load. Microbial Pathogenesis 139, article number: 103872. (10.1016/j.micpath.2019.103872)
- Beeton, M. L. et al. 2020. Mycoplasma pneumoniae infections, 11 countries in Europe and Israel, 2011 to 2016. Eurosurveillance 25(2), article number: pii=1900112. (10.2807/1560-7917.ES.2020.25.2.1900112)
- Pavlidis, I., Spiller, O. B., Sammut Demarco, G., MacPherson, H., Howie, S. E. M., Norman, J. E. and Stock, S. J. 2020. Cervical epithelial damage promotes Ureaplasma parvum ascending infection, intrauterine inflammation and preterm birth induction in mice. Nature Communications 11, article number: 199. (10.1038/s41467-019-14089-y)
2019
- Hütten, M. C. et al. 2019. Detrimental effects of an inhaled phosphodiesterase-4 inhibitor on lung inflammation in ventilated preterm lambs exposed to chorioamnionitis are dose dependent. Journal of Aerosol Medicine and Pulmonary Drug Delivery 32(6), pp. 396-404. (10.1089/jamp.2019.1528)
- van Gorp, C. et al. 2019. Protection of the ovine fetal gut against ureaplasma-induced chorioamnionitis: a potential role for plant sterols. Nutrients 11(5), pp. -., article number: 968. (10.3390/nu11050968)
2017
- Yang, Q. et al. 2017. Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms. Nature Communications 8, article number: 2054. (10.1038/s41467-017-02149-0)
- Gussenhoven, R. et al. 2017. The paradoxical effects of chronic intra-amniotic Ureaplasma exposure on ovine fetal brain development. Developmental Neuroscience 39(6), pp. 472-486. (10.1159/000479021)
- Willems, M. G. M. et al. 2017. Pulmonary vascular changes in extremely preterm sheep after intra-amniotic exposure to Ureaplasma parvum and lipopolysaccharide. PLoS ONE 12(6), article number: e0180114. (10.1371/journal.pone.0180114)
- Spiller, O. B. 2017. Emerging pathogenic respiratory mycoplasma hominis infections in lung transplant patients: time to reassesses it's role as a pathogen?. EBioMedicine 19, pp. 8-9. (10.1016/j.ebiom.2017.05.002)
- Hillitt, K. L., Jenkins, R. E., Spiller, O. B. and Beeton, M. L. 2017. Antimicrobial activity of Manuka honey against antibiotic resistant strains of the cell wall free bacteria ureaplasma parvum and Ureaplasma urealyticum. Letters In Applied Microbiology 64(3), pp. 198-202. (10.1111/lam.12707)
- Beeton, M. and Spiller, O. B. 2017. Antibiotic resistance among Ureaplasma spp isolates: cause for concern?. Journal of Antimicrobial Chemotherapy 72(2), pp. 330-337. (10.1093/jac/dkw425)
- Kemp, M. W. et al. 2017. Fetal Ureaplasma parvum bacteraemia as a function of gestation-dependent complement insufficiency: evidence from a sheep model of pregnancy. American Journal of Reproductive Immunology 77(1), article number: e12599. (10.1111/aji.12599)
- Stock, S. J. et al. 2017. Intrauterine Candida albicans infection causes systemic fetal candidiasis with progressive cardiac dysfunction in a sheep model of early pregnancy. Reproductive Sciences 24(1), pp. 77-84. (10.1177/1933719116649697)
2016
- Jironkin, A., Brown, R. J., Underwood, A., Chalker, V. J. and Spiller, O. B. 2016. Genomic determination of minimum multi-locus sequence typing schemas to represent the genomic phylogeny of Mycoplasma hominis.. BMC Genomics 17, article number: 964. (10.1186/s12864-016-3284-z)
- Beeton, M. L., Maxwell, N. C., Chalker, V. J., Brown, R. J., Aboklaish, A. F. and Spiller, O. B. 2016. Isolation of separate Ureaplasma species from endotracheal secretions of twin patients. Pediatrics 138(2), article number: e20160565. (10.1542/peds.2016-0565)
- Aboklaish, A., Ahmed, S., McAllister, D., Cassell, G., Zheng, X. and Spiller, O. B. 2016. Differential recognition of the Multiple Banded Antigen isoforms across Ureaplasma parvum and Ureaplasma urealyticum species by monoclonal antibodies. Journal of Microbiological Methods 127, pp. 13-19. (10.1016/j.mimet.2016.05.015)
- Brown, R., Nguipdop-Djomo, P., Zhao, H., Stanford, E., Spiller, O. B. and Chalker, V. J. 2016. Mycoplasma pneumoniae epidemiology in England and Wales: a national perspective. Frontiers in Microbiology 7, article number: 157. (10.3389/fmicb.2016.00157)
- Kemp, M. W. et al. 2016. Outside-in? Acute fetal systemic inflammation in very preterm chronically catheterized sheep fetuses is not driven by cells in the fetal blood. American Journal of Obstetrics and Gynecology 214(2), pp. 281.e1-281.e10. (10.1016/j.ajog.2015.09.076)
- Beeton, M. L., Chalker, V. J., Jones, L. C., Maxwell, N. C. and Spiller, O. B. 2016. Antibiotic resistance among clinical Ureaplasma Isolates Recovered from Neonates in England and Wales between 2007 and 2013. Antimicrobial Agents and Chemotherapy 60(1), pp. 52-56. (10.1128/AAC.00889-15)
2015
- Brown, R., Spiller, O. B. and Chalker, V. J. 2015. Molecular typing of mycoplasma pneumoniae: where do we stand?. Future Microbiology 10(11), pp. 1793-1795. (10.2217/fmb.15.96)
- Nesargikar, P., Pino-Chavez, G., Spiller, O. B., Fraser, D. J., Jenkins, R. H. and Chavez, R. 2015. Single dose sCR1 attenuates renal ischemia reperfusion injury in rats despite early reconstitution of the complement system [Abstract]. Transplant International 28(S4), pp. 62-62. (10.1111/tri.12700)
- Brown, R., Holden, M. T. G., Spiller, O. B., Chalker, V. J. and Ledeboer, N. A. 2015. Development of a multilocus sequence typing scheme for molecular typing of mycoplasma pneumoniae. Journal of Clinical Microbiology 53(10), pp. 3195-3203. (10.1128/JCM.01301-15)
- Furfaro, L. L., Spiller, O. B., Keelan, J. A. and Payne, M. S. 2015. In vitro activity of solithromycin and its metabolites, CEM-214 and N-acetyl-CEM-101, against 100 clinical Ureaplasma spp. isolates compared with azithromycin. International Journal of Antimicrobial Agents 46(3), pp. 319-324. (10.1016/j.ijantimicag.2015.04.015)
- Ahmed, S. et al. 2015. Comparison of complement activity in adult and preterm sheep serum. American Journal of Reproductive Immunology 73(3), pp. 232-241. (10.1111/aji.12299)
2014
- Aboklaish, A., Dordet-Frisoni, E., Citti, C., Toleman, M. A., Glass, J. I. and Spiller, O. B. 2014. Random insertion and gene disruption via transposon mutagenesis of Ureaplasma parvum using a mini-transposon plasmid. International Journal of Medical Microbiology 304(8), pp. 1218-1225. (10.1016/j.ijmm.2014.09.003)
- Kemp, M. W. et al. 2014. Maternal intravenous administration of azithromycin results in significant fetal uptake in a sheep model of second trimester pregnancy. Antimicrobial Agents and Chemotherapy 58(11), pp. 6581-6591. (10.1128/AAC.03721-14)
- Kemp, M. W. et al. 2014. Repeated maternal intramuscular or intraamniotic erythromycin incompletely resolves intrauterine Ureaplasma parvum infection in a sheep model of pregnancy. American Journal of Obstetrics and Gynecology 211(2), pp. 134.e1-134.e9. (10.1016/j.ajog.2014.02.025)
- Lowe, J., Watkins, W., Edwards, M., Spiller, O., Jacqz-Aigrain, E., Kotecha, S. and Kotecha, S. 2014. Association between pulmonary Ureaplasma colonization and bronchopulmonary dysplasia in preterm infants: updated systematic review and meta-analysis. The Pediatric Infectious Disease Journal 33(7), pp. 697-702. (10.1097/INF.0000000000000239)
- Miura, Y. et al. 2014. Maternal intravenous treatment with either azithromycin or solithromycin clears Ureaplasma parvum from the amniotic fluid in an ovine model of intrauterine infection. Antimicrobial Agents and Chemotherapy 58(9), pp. 5413-5420. (10.1128/AAC.03187-14)
- Van Den Berg, C., Tambourgi, D. V., Clark, H. W., Hoong, S. J., Spiller, O. and McGreal, E. 2014. Mechanism of neutrophil dysfunction: neutrophil serine proteases cleave and inactivate the C5a receptor. The Journal of Immunology 192(4), pp. 1787-1795. (10.4049/jimmunol.1301920)
- Brown, R., Chalker, V. J. and Spiller, O. B. 2014. Mycoplasma hominis variable adherence-associated antigen: A major adhesin and highly variable surface membrane protein. Advances in Microbiology 4(11), pp. 736-746. (10.4236/aim.2014.411080)
2013
- Payne, M. S., Tabone, T., Kemp, M. W., Keelan, J. A., Spiller, O. B., Newnham, J. P. and Carroll, K. C. 2013. High-resolution melt PCR analysis for genotyping of Ureaplasma parvum isolates directly from clinical samples. Journal of Clinical Microbiology 52(2), pp. 599-606. (10.1128/JCM.03036-13)
- Triantafilou, M., De Glanville, B., Aboklaish, A. F., Spiller, O. B., Kotecha, S. and Triantafilou, K. 2013. Synergic activation of Toll-Like Receptor (TLR) 2/6 and 9 in response to ureaplasma parvum & urealyticum in human amniotic epithelial cells. PLoS ONE 8(4), article number: e61199. (10.1371/journal.pone.0061199)
2012
- Beeton, M. L., Daha, M. R., El-Shanawany, T., Jolles, S., Kotecha, S. and Spiller, O. B. 2012. Serum killing of 'ureaplasma parvum' shows serovar-determined susceptibility for normal individuals and common variable immuno-deficiency patients. Immunobiology 217(2), pp. 187-194. (10.1016/j.imbio.2011.07.009)
- McGreal, E. P., Hearne, K. and Spiller, O. B. 2012. Off to a slow start: under-development of the complement system in term newborns is more substantial following premature birth. Immunobiology 217(2), pp. 176-186. (10.1016/j.imbio.2011.07.027)
2011
- Pinkert, S., Klingel, K., Lindig, V., Dorner, A., Zeichhardt, H., Spiller, O. B. and Fechner, H. 2011. Virus-host coevolution in a persistently coxsackievirus B3-infected cardiomyocyte cell line. Journal of Virology 85(24), pp. 13409-13419. (10.1128/JVI.00621-11)
- Beeton, M. L. et al. 2011. Role of pulmonary infection in the development of chronic lung disease of prematurity. European Respiratory Journal 37(6), pp. 1424-1430. (10.1183/09031936.00037810)
2010
- McGreal, E. P. et al. 2010. Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis. Biochimica et Biophysica Acta - Molecular Basis of Disease 1802(7-8), pp. 649-658. (10.1016/j.bbadis.2010.04.005)
- Davies, P. L., Spiller, O. B., Beeton, M. L., Maxwell, N. C., Remold-O'Donnell, E. and Kotecha, S. 2010. Relationship of proteinases and proteinase inhibitors with microbial presence in chronic lung disease of prematurity. Thorax 65(3), pp. 246-251. (10.1136/thx.2009.116061)
2009
- Beeton, M. L., Chalker, V. J., Maxwell, N. C., Kotecha, S. and Spiller, O. B. 2009. Concurrent titration and determination of antibiotic resistance in 'ureaplasma' species with identification of novel point mutations in genes associated with resistance. Antimicrobial Agents and Chemotherapy 53(5), pp. 2020-2027. (10.1128/AAC.01349-08)
- Wall, S. R., Wat, D., Spiller, O. B., Gelder, C. M., Kotecha, S. and Doull, I. J. M. 2009. The viral aetiology of croup and recurrent croup. Archives of Disease in Childhood 94(5), pp. 359-360. (10.1136/adc.2008.142984)
- Okroj, M. et al. 2009. Characterization of the complement inhibitory function of rhesus rhadinovirus complement control protein (RCP). Journal of Biological Chemistry 284(1), pp. 505-514. (10.1074/jbc.M806669200)
- Beeton, M. L., Chalker, V. J., Kotecha, S. and Spiller, O. B. 2009. Comparison of full gyrA, gyrB, parC and parE gene sequences between all Ureaplasma parvum and Ureaplasma urealyticum serovars to separate true fluoroquinolone antibiotic resistance mutations from non-resistance polymorphism. Journal of Antimicrobial Chemotherapy 64(3), pp. 529-538. (10.1093/jac/dkp218)
- Pinkert, S. et al. 2009. Prevention of cardiac dysfunction in acute coxsackievirus B3 cardiomyopathy by inducible expression of a soluble coxsackievirus-adenovirus receptor. Circulation 120(23), pp. 2358-2366. (10.1161/CIRCULATIONAHA.108.845339)
2008
- Griesche, N. et al. 2008. Growth characteristics of human adenoviruses on porcine cell lines. Virology 373(2), pp. 400-410. (10.1016/j.virol.2007.12.015)
- Mark, L., Proctor, D. G., Blackbourn, D. J., Blom, A. M. and Spiller, O. B. 2008. Separation of decay-accelerating and cofactor functional activities of Kaposi's sarcoma-associated herpesvirus complement control protein using monoclonal antibodies. Immunology 123(2), pp. 228-238. (10.1111/j.1365-2567.2007.02692.x)
- Davies, P. L., Maxwell, N. C., Kotecha, S. and Spiller, O. B. 2008. Monoclonal anti-neutrophil elastase antibody characterisation: ability to block function, detect free versus serpin-complexed enzyme and stain intracellular granules. Journal of Immunological Methods 336(2), pp. 175-182. (10.1016/j.jim.2008.04.010)
2006
- Spiller, O. B., Mark, L., Blue, C. E., Proctor, D. G., Aitken, J. A., Blom, A. M. and Blackbourn, D. J. 2006. Dissecting the regions of virion-associated Kaposi's sarcoma-associated herpesvirus complement control protein required for complement regulation and cell binding. Journal of Virology 80(8), pp. 4068-4078. (10.1128/JVI.80.8.4068-4078.2006)
2005
- Spiller, O. B., Goodfellow, I. G., Evans, D. and Blom, A. M. 2005. Inhibition of coxsackie B virus infection by soluble forms of its receptors: binding affinities, altered particle formation, and competition with cellular receptors. Journal of Virology 79(18), pp. 12016-12024. (10.1128/JVI.79.18.12016-12024.2005)
2003
- Spiller, O. B., Blackbourn, D. J., Mark, L., Proctor, D. G. and Blom, A. M. 2003. Functional activity of the complement regulator encoded by Kaposi's sarcoma-associated herpesvirus. Journal of Biological Chemistry 278(11), pp. 9283-9289. (10.1074/jbc.M211579200)
- Spiller, O. B., Robinson, M., O'Donnell, E., Milligan, S., Morgan, B. P., Davison, A. J. and Blackbourn, D. J. 2003. Complement regulation by Kaposi's sarcoma-associated herpesvirus ORF4 protein. Journal of Virology 77(1), pp. 592-599. (10.1128/JVI.77.1.592-599.2003)
