Yr Athro Valerie O'Donnell
Cyd-gyfarwyddwr Sefydliad Ymchwil Imiwnedd Systemau
- o-donnellvb@cardiff.ac.uk
- +44 (0)29 2068 7313
- Tenovus Institute
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwg
Overview
Our research uses mass spectrometry to discover and characterise new lipids (fats) made by circulating vascular cells that regulate immune defence and blood clotting.
Recently we showed that human blood platelets generate a large number of oxidized phospholipids several of which help clotting factors in plasma work more effectively. We also uncovered a new role for phospholipases in providing energy to the cell and how lipids in different people respond individually to aspirin (http://www.cardiff.ac.uk/news/view/264589-understanding-the-bodys-response-to-aspirin)
In 2016, the Wellcome Trust funded a £1.3M 5 yr initiative led by our group jointly with Babraham Institute, Cambridge, and University of California San Diego to fund continuation and further development of LIPID MAPS, the global online database and resource for lipid research (http://www.cardiff.ac.uk/news/view/380752-new-funding-boosts-lipidomics-research).
Our current research is focused on understanding the role of new lipids in vascular inflammation including cardiovascular disease, dementia and wound healing. Some lipids we discovered are being developed as the basis of new treatments for bleeding excess.
Research in our group is funded by grants from the European Research Council, Wellcome Trust, British Heart Foundation and Medical Research Council.
Bywgraffiad
Education:
1993 PhD Bristol University, Biochemistry
1990 BSc, University of Dublin, Trinity College, Human Nutrition and Dietetics
Anrhydeddau a Dyfarniadau
Royal Society Wolfson Research Merit Awardee (2017)
ERC Advanced Investigator (2015-)
Honorary Professor, Faculty of Medicine, University of the Republic, Montevideo, since 2008.
Marie Curie Excellence Award (EU), Brussels, March 2008
Wellcome Trust University Award, Cardiff University, 2002-2007
Iron Bolt Award, Gordon Research Conference on Oxygen Radicals, 2004
Wellcome Trust RCD Fellow, Cardiff University, 1999-2002
Parker B Francis Pulmonary Fellow, University of Alabama at Birmingham, 1997-1999
European Union Marie Curie Fellow, University of Berne, Switzerland, 1995-1996
Cyhoeddiadau
2022
- Brown, J. L. et al. 2022. Lipid hydroperoxides and oxylipins are mediators of denervation induced muscle atrophy. Redox Biology 57, article number: 102518. (10.1016/j.redox.2022.102518)
- McDonald, J. G. et al. 2022. Introducing the lipidomics minimal reporting checklist. Nature Metabolism 4(9), pp. 1086–1088. (10.1038/s42255-022-00628-3)
- Saud, Z. et al. 2022. The SARS-CoV2 envelope differs from host cells, exposes pro-coagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research 63(6), article number: 100208. (10.1016/j.jlr.2022.100208)
- Protty, M. B., Jenkins, P. V., Collins, P. W. and O'Donnell, V. B. 2022. The role of procoagulant phospholipids on the surface of circulating blood cells in thrombosis and haemostasis. Open Biology 12(4), article number: 210318. (10.1098/rsob.210318)
- Schebb, N. H. et al. 2022. Formation, signaling and occurrence of specialized pro-resolving lipid mediators - What is the evidence so far?. Frontiers in Pharmacology 13, article number: 838782. (10.3389/fphar.2022.838782)
- O'Donnell, V. B. 2022. New appreciation for an old pathway: the Lands Cycle moves into new arenas in health and disease. Biochemical Society Transactions 50(1), pp. 1-11. (10.1042/BST20210579)
- Misheva, M. et al. 2022. Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation. Nature Communications 13(1), article number: 139. (10.1038/s41467-021-27766-8)
2021
- Chakraborty, M. et al. 2021. nSeP: immune and metabolic biomarkers for early detection of neonatal sepsis-protocol for a prospective multicohort study. BMJ Open 11(12), article number: e050100. (10.1136/bmjopen-2021-050100)
- Diskin, C., Zotta, A., Corcoran, S. E., Tyrrell, V. J., Zaslona, Z., O'Donnell, V. B. and O'Neill, L. A. J. 2021. 4-Octyl-Itaconate and Dimethyl Fumarate Inhibit COX2 Expression and Prostaglandin Production in Macrophages. Journal of Immunology 207(10), pp. 2561-2569. (10.4049/jimmunol.2100488)
- Diskin, C. et al. 2021. The Trypanosome-derived metabolite indole-3-pyruvate inhibits prostaglandin production in macrophages by targeting COX2. Journal of Immunology 207(10), pp. 2551-2560. (10.4049/jimmunol.2100402)
- Köfeler, H. C. et al. 2021. Quality control requirements for the correct annotation of lipidomics data. Nature Communications 12(1), article number: 4771. (10.1038/s41467-021-24984-y)
- Chan, M. V. et al. 2021. Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function. Haematologica 106(5), pp. 1423-1432. (10.3324/haematol.2019.235895)
- Alvarez-Jarreta, J. et al. 2021. LipidFinder 2.0: advanced informatics pipeline for lipidomics discovery applications. Bioinformatics 37(10), pp. 1478-1479. (10.1093/bioinformatics/btaa856)
- Crittenden, S. et al. 2021. Prostaglandin E2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells. Science Advances 7(7), article number: eabd7954. (10.1126/sciadv.abd7954)
- Gaud, C. et al. 2021. BioPAN: a web-based tool to explore mammalian lipidome metabolic pathways on LIPID MAPS. F1000Research 10(4) (10.12688/f1000research.28022.1)
- Tyrrell, V. J. et al. 2021. Lipidomic and transcriptional analysis of the Linoleoyl-omega-Hydroxyceramide biosynthetic pathway in human psoriatic lesions. Journal of Lipid Research 62, article number: 100094. (10.1016/j.jlr.2021.100094)
2020
- Liebisch, G. et al. 2020. Update on LIPID MAPS classification, nomenclature and shorthand notation for MS-derived lipid structures. Journal of Lipid Research 61, pp. 1539-1555. (10.1194/jlr.S120001025)
- O'Donnell, V. B. et al. 2020. Steps Toward Minimal Reporting Standards for Lipidomics Mass Spectrometry in Biomedical Research Publications. Circulation: Genomic and Precision Medicine 13(6), article number: e003019. (10.1161/CIRCGEN.120.003019)
- Rosas, M. et al. 2020. The procoagulant activity of tissue factor expressed on fibroblasts is increased by tissue factor-negative extracellular vesicles. PLoS ONE 15(10), article number: e0240189. (10.1371/journal.pone.0240189)
- Ipseiz, N. et al. 2020. Tissue‐resident macrophages actively suppress IL‐1beta release via a reactive prostanoid/IL‐10 pathway. EMBO Journal 39(14), article number: e103454. (10.15252/embj.2019103454)
- Meckelmann, S. W. et al. 2020. Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274. Circulation: Genomic and Precision Medicine 13(3), pp. 149-164., article number: e002806. (10.1161/CIRCGEN.119.002806)
- O'Donnell, V. B. et al. 2020. Potential role of oral rinses targeting the viral lipid envelope in SARS-CoV-2 infection. Function 1(1), article number: zqaa002. (10.1093/function/zqaa002)
2019
- Doll, S. et al. 2019. FSP1 is a glutathione-independent ferroptosis suppressor. Nature 575, pp. 693-698. (10.1038/s41586-019-1707-0)
- Gallagher, H. et al. 2019. Dihimo-γ-linolenic acid inhibits several key cellular processes associated with atherosclerosis. BBA - Molecular Basis of Disease 1865(9), pp. 2538-2550. (10.1016/j.bbadis.2019.06.011)
- Hinz, C. et al. 2019. A comprehensive UHPLC ion mobility QTOF method for profiling and quantification of eicosanoids, other oxylipins and fatty acids. Analytical Chemistry 91(13), pp. 8025-8035. (10.1021/acs.analchem.8b04615)
- Kornilov, A. et al. 2019. Revising the structure of a new eicosanoid from human platelets to 8,9-11,12-diepoxy-13- hydroxy-eicosadienoic acid. Journal of Biological Chemistry 294, pp. 9225-9238. (10.1074/jbc.RA119.008915)
- Allen-Redpath, K. et al. 2019. Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity. Proceedings of the National Academy of Sciences 116(16), pp. 8038-8047. (10.1073/pnas.1814409116)
- Evans, R. J. et al. 2019. 15-keto-prostaglandin E₂ activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection. PLoS Pathogens 15(3), article number: e1007597. (10.1371/journal.ppat.1007597)
- O'Donnell, V., Aldrovandi, M., Murphy, R. C. and Kronke, G. 2019. Enzymatically-oxidized phospholipids assume center-stage as essential regulators of innate immunity and cell death. Science Signaling 12(574), article number: eaau2293. (10.1126/scisignal.aau2293)
- Fahy, E. et al. 2019. LipidFinder on LIPID MAPS: peak filtering, MS searching and statistical analysis for lipidomics. Bioinformatics 35(4), pp. 685-687. (10.1093/bioinformatics/bty679)
- O'Donnell, V., Dennis, E. A., Wakelam, M. J. O. and Subramaniam, S. 2019. LIPID MAP: Serving the next generation of lipid researchers with tools, resources, data and training. Science Signaling 12(563), article number: eaaw2964. (10.1126/scisignal.aaw2964)
2018
- Vliet, A. v. d. et al. 2018. Rust never sleeps: the continuing story of the Iron Bolt. Free Radical Biology and Medicine 124, pp. 353-357. (10.1016/j.freeradbiomed.2018.06.017)
- O'Donnell, V., Rossjohn, J. and Wakelam, M. J. O. 2018. Phospholipid signaling in innate immune cells. The Journal of Clinical Investigation 128(7), pp. 2670-2679. (10.1172/JCI97944)
- Freeman, B. A., O'Donnell, V. B. and Schopfer, F. J. 2018. The discovery of nitro-fatty acids as products of metabolic and inflammatory reactions and mediators of adaptive cell signaling. Nitric Oxide: Biology and Chemistry 77, pp. 106-111. (10.1016/j.niox.2018.05.002)
- Slatter, D. A. et al. 2018. Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies. JCI Insight 3(6), article number: e98459. (10.1172/jci.insight.98459)
- Walker, J. et al. 2018. Aspirin: 120 years of innovation. A report from the 2017 Scientific Conference of the International Aspirin Foundation, 14 September 2017, Charité, Berlin. ecancermedicalscience 12, article number: 813. (10.3332/ecancer.2018.813)
- Aldrovandi, M., Banthiya, S., Meckelmann, S., Zhou, Y., Heydeck, D., O'Donnell, V. B. and Kuhn, H. 2018. Specific oxygenation of plasma membrane phospholipids by Pseudomonas aeruginosa lipoxygenase induces structural and functional alterations in mammalian cells. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1863(2), pp. 152-164. (10.1016/j.bbalip.2017.11.005)
- O'Donnell, V. B. 2018. Gus Born: scientific reflections of later years, inspiring the next generation of blood researchers. Platelets 29(8), pp. 763-765. (10.1080/09537104.2018.1534948)
2017
- Zhao, J. et al. 2017. Preferential Generation of 15-HETE-PE Induced by IL-13 Regulates Goblet Cell Differentiation in Human Airway Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology 57(6) (10.1165/rcmb.2017-0031OC)
- Lauder, S. N. et al. 2017. Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis. Science Signaling 10(507), article number: eaan2787. (10.1126/scisignal.aan2787)
- Lue, H. et al. 2017. Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade. Genes and Development 31, pp. 2067-2084. (10.1101/gad.305292.117)
- Uderhardt, S. et al. 2017. Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis and thrombotic disease. Journal of Experimental Medicine 214(7), pp. 2121-2138. (10.1084/jem.20161070)
- O'Donnell, V. B. and Murphy, R. C. 2017. Directing eicosanoid esterification into phospholipids. Journal of Lipid Research 58(5), pp. 837-839. (10.1194/jlr.C075986)
- O'Connor, A., Brasher, C., Slatter, D., Meckelmann, S., Hawksworth, J., Allen, S. and O'Donnell, V. 2017. LipidFinder: a computational workflow for discovery of lipids identifies eicosanoid-phosphoinositides in platelets. JCI Insight 2(7), pp. e91634. (10.1172/jci.insight.91634)
- Aldrovandi, M. et al. 2017. DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil integrin expression. Redox Biology 11, pp. 663-672. (10.1016/j.redox.2017.01.001)
- Lauder, S. N. et al. 2017. Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels in vivo. Wellcome Open Research 2(1) (10.12688/wellcomeopenres.10308.1)
2016
- Liao, C. et al. 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46(9), pp. 2222-2232. (10.1002/eji.201646528)
- Heurich-Sevcenco, M., Preston, R., O'Donnell, V. B., Morgan, B. P. and Collins, P. W. 2016. Thrombomodulin enhances complement regulation through strong affinity interactions with factor H and C3b-Factor H complex. Thrombosis Research 145, pp. 84-92. (10.1016/j.thromres.2016.07.017)
- Stokes, C. A. et al. 2016. Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. Mucosal Immunology 9(5), pp. 1303-1316. (10.1038/mi.2015.137)
- Chiba, T., Thomas, C. P., Calcutt, M. W., Boeglin, W. E., O'Donnell, V. B. and Brash, A. R. 2016. The precise structures and stereochemistry of trihydroxy-linoleates esterified in human and porcine epidermis and their significance in skin barrier function: Implication of an epoxide hydrolase in the transformations of linoleate. Journal of Biological Chemistry 291(28), pp. 14540-14544. (10.1074/jbc.M115.711267)
- Bascoul-Colombo, C., Guschina, I. A., Maskrey, B. H., Good, M., O'Donnell, V. B. and Harwood, J. L. 2016. Dietary DHA supplementation causes selective changes in phospholipids from different brain regions in both wild type mice and the Tg2576 mouse model of Alzheimer's disease. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1861(6), pp. 524-537. (10.1016/j.bbalip.2016.03.005)
- Hinz, C. et al. 2016. Human platelets utilize cycloxygenase-1 to generate dioxolane A3, a neutrophil activating eicosanoid. Journal of Biological Chemistry 291(26), pp. 13448-13464. (10.1074/jbc.M115.700609)
- Slatter, D. A. et al. 2016. Mapping the human platelet lipidome reveals cytosolic phospholipase A2 as a regulator of mitochondrial bioenergetics during activation. Cell Metabolism 23(5), pp. 930-944. (10.1016/j.cmet.2016.04.001)
- Jones, V. et al. 2016. Role of Ep2 and Ep4 receptors in airway microvascular leak induced by prostaglandin E2. British Journal of Pharmacology 173(6), pp. 992-1004. (10.1111/bph.13400)
2015
- Freeman, P., Moschonas, K., Hinz, C., O'Donnell, V. B., Kinnaird, T. D., James, P. E. and Anderson, R. A. 2015. Changes in platelet function independent of pharmacotherapy following coronary intervention in non-ST-elevation myocardial infarction patients. Atherosclerosis 243(1), pp. 320-327. (10.1016/j.atherosclerosis.2015.09.024)
- McCully, M. L., Collins, P. J., Hughes, T. R., Thomas, C. P., Billen, J., O'Donnell, V. B. and Moser, B. 2015. Skin metabolites define a new paradigm in the localization of skin tropic memory T cells. Journal of Immunology 195(1), pp. 96-104. (10.4049/jimmunol.1402961)
- Percy, C. L. et al. 2015. Correcting thrombin generation ex vivo using different haemostatic agents following cardiac surgery requiring the use of cardiopulmonary bypass. Blood Coagulation and Fibrinolysis 26(4), pp. 357-367. (10.1097/MBC.0000000000000243)
- Ravi, S. et al. 2015. Metabolic plasticity in resting and thrombin activated platelets. PLoS ONE 10(4), article number: e0123597. (10.1371/journal.pone.0123597)
- Morgan, A. H. et al. 2015. A novel role for 12/15-lipoxygenase in regulating autophagy. Redox Biology 4, pp. 40-47. (10.1016/j.redox.2014.11.005)
2014
- Friedmann Angeli, J. P. et al. 2014. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nature Cell Biology 16, pp. 1180-1191. (10.1038/ncb3064)
- Mathie, S. A. et al. 2014. Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge. Allergy 70(1), pp. 80-89. (10.1111/all.12536)
- Rosas, M. et al. 2014. The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal. Science 344(6184), pp. 645-648. (10.1126/science.1251414)
- Fielding, C. A. et al. 2014. Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity 40(1), pp. 40-50. (10.1016/j.immuni.2013.10.022)
- Thomas, C. P., Clark, S. R., Hammond, V. J., Aldrovandi, M., Collins, P. W. and O'Donnell, V. B. 2014. Identification and quantification of aminophospholipid molecular species on the surface of apoptotic and activated cells. Nature Protocols 9(1), pp. 51-63. (10.1038/nprot.2013.163)
- O'Donnell, V., Murphy, R. C. and Watson, S. P. 2014. Platelet lipidomics: modern day perspective on lipid discovery and characterization in platelets. Circulation Research 114(7), pp. 1185-1203. (10.1161/CIRCRESAHA.114.301597)
2013
- Aldrovandi, M. et al. 2013. Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation. Journal of Lipid Research 54(11), pp. 3085-3097. (10.1194/jlr.M041533)
- Pauling, J. D., O'Donnell, V. B. and Mchugh, N. J. 2013. The contribution of platelets to the pathogenesis of Raynaud's phenomenon and systemic sclerosis. Platelets 24(7), pp. 503-515. (10.3109/09537104.2012.719090)
- Bonilla, L., O'Donnell, V. B., Clark, S. R., Rubbo, H. and Trostchansky, A. 2013. Regulation of protein kinase C by nitroarachidonic acid: impact on human platelet activation. Archives of Biochemistry and Biophysics 533(1-2), pp. 55-61. (10.1016/j.abb.2013.03.001)
- Clark, S. R. et al. 2013. Characterization of platelet aminophospholipid externalization reveals fatty acids as molecular determinants that regulate coagulation. Proceedings of the National Academy of Sciences of the United States of America 110(15), pp. 5875-5880. (10.1073/pnas.1222419110)
- Moideen, A. N. et al. 2013. Characterization of enzymes involved in nicotinamide adenine dinucleotide biosynthesis in rheumatoid arthritis synovium and cytokine-stimulated synovial fibroblasts [Abstracts]. Rhuematology 52(s1), pp. 138-139.
- Aldrovandi, M. and O'Donnell, V. B. 2013. Oxidized PLs and vascular inflammation. Current Atherosclerosis Reports 15(5), pp. 1989-1996., article number: 323. (10.1007/s11883-013-0323-y)
2012
- Hammond, V. J. et al. 2012. Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ. Journal of Biological Chemistry 287(50), pp. 41651-41666. (10.1074/jbc.M112.405407)
- Hammond, V. J. and O'Donnell, V. B. 2012. Esterified eicosanoids: generation, characterization and function. Biochimica et Biophysica Acta - Biomembranes 1818(10), pp. 2403-2412. (10.1016/j.bbamem.2011.12.013)
- Reynolds, S. L. et al. 2012. Contractile, but not endothelial, dysfunction in early inflammatory arthritis: a possible role for matrix metalloproteinase-9. British Journal of Pharmacology 167(3), pp. 505-514. (10.1111/j.1476-5381.2012.01988.x)
- O'Donnell, V. B. and Murphy, R. C. 2012. New families of bioactive oxidized phospholipids generated by immune cells: Identification and signaling actions. Blood 120(10), pp. 1985-1992. (10.1182/blood-2012-04-402826)
- Thomas, C. P. and O'Donnell, V. B. 2012. Oxidized phospholipid signaling in immune cells. Current Opinion in Pharmacology 12(4), pp. 471-477. (10.1016/j.coph.2012.02.013)
- Taylor, P. R. et al. 2012. Development of myeloproliferative disease in 12/15-lipoxygenase deficiency [Letter]. Blood 119(25), pp. 6173-6174. (10.1182/blood-2012-02-410928)
2011
- O'Donnell, V. B. 2011. Mass spectrometry analysis of oxidized phosphatidylcholine and phosphatidylethanolamine. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1811(11), pp. 818-826. (10.1016/j.bbalip.2011.07.018)
- Lauder, S. N. et al. 2011. Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity. Thorax 66(5), pp. 368-374. (10.1136/thx.2010.150318)
- Guschina, I., Millership, S., O'Donnell, V. B., Ninkina, N., Harwood, J. and Buchman, V. L. 2011. Lipid classes and fatty acid patterns are altered in the brain of γ-synuclein null mutant mice. Lipids 46(2), pp. 121-130. (10.1007/s11745-010-3486-0)
- Ruge, F. et al. 2011. Delineating immune-mediated mechanisms underlying hair follicle destruction in the mouse mutant defolliculated. Journal of Investigative Dermatology 131(3), pp. 572-579. (10.1038/jid.2010.379)
- Zhao, J., O'Donnell, V. B., Balzar, S., St. Croix, C. M., Trudeau, J. B. and Wenzel, S. E. 2011. 15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells. Proceedings of the National Academy of Sciences of the United States of America 108(34), pp. 14246-14251. (10.1073/pnas.1018075108)
- Trostchansky, A., Bonilla, L., Thomas, C. P., O'Donnell, V. B., Marnett, L. J., Radi, R. and Rubbo, H. 2011. Nitroarachidonic Acid, a Novel Peroxidase Inhibitor of Prostaglandin Endoperoxide H Synthases 1 and 2. Journal of Biological Chemistry 286(15), pp. 12891-12900. (10.1074/jbc.M110.154518)
- Clark, S. R. et al. 2011. Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. Blood 117(6), pp. 2033-2043. (10.1182/blood-2010-04-278887)
2010
- Thomas, C. P. et al. 2010. Phospholipid-esterified eicosanoids are generated in agonist-activated human platelets and enhance tissue factor-dependent thrombin generation. Journal of Biological Chemistry 285(10), pp. 6891-6903. (10.1074/jbc.M109.078428)
- Morgan, A. H. et al. 2010. Quantitative assays for esterified oxylipins generated by immune cells. Nature Protocols 5(12), pp. 1919-1931. (10.1038/nprot.2010.162)
- Ivanov, I., Heydeck, D., Hofheinz, K., Roffeis, J., O'Donnell, V. B., Kuhn, H. and Walther, M. 2010. Molecular enzymology of lipoxygenases. Archives of biochemistry and biophysics 503(2), pp. 161-174. (10.1016/j.abb.2010.08.016)
- Morgan, L. T., Thomas, C. P., Kühn, H. and O'Donnell, V. B. 2010. Thrombin-activated human platelets acutely generate oxidized docosahexaenoic-acid-containing phospholipids via 12-lipoxygenase. Biochemical Journal 431(1), pp. 141-148. (10.1042/BJ20100415)
2009
- Tull, S. P. et al. 2009. Omega-3 fatty acids and inflammation: novel interactions reveal a new step in neutrophil recruitment. PLoS Biology 7(8), article number: e1000177. (10.1371/journal.pbio.1000177)
- Rubbo, H., Trostchansky, A. and O'Donnell, V. B. 2009. Peroxynitrite-mediated lipid oxidation and nitration: mechanisms and consequences. Archives of Biochemistry and Biophysics 484(2), pp. 167-172. (10.1016/j.abb.2008.11.007)
- Ferreira, A. et al. 2009. Macrophage activation induces formation of the anti-inflammatory lipid cholesteryl-nitrolinoleate. Biochemical Journal 417(1), pp. 223-234. (10.1042/BJ20080701)
- Maskrey, B. H. et al. 2009. Activated platelets and monocytes generate four hydroxyphosphatidylethanolamines via lipoxygenase [Addition]. Journal of Biological Chemistry 284(37), pp. 25460. (10.1074/jbc.A611776200)
- Morgan, A. H. et al. 2009. Phosphatidylethanolamine-esterified eicosanoids in the mouse: tissue localization and inflammation-dependent formation in Th-2 disease. Journal of Biological Chemistry 284(32), pp. 21185-21191. (10.1074/jbc.M109.021634)
- Baker, P. R. S., Schopfer, F. J., O'Donnell, V. B. and Freeman, B. A. 2009. Convergence of nitric oxide and lipid signaling: anti-inflammatory nitro-fatty acids. Free Radical Biology & Medicine 46(8), pp. 989-1003. (10.1016/j.freeradbiomed.2008.11.021)
- Gregory, L. G. et al. 2009. Inhaled house dust mite induces pulmonary T helper 2 cytokine production. Clinical and Experimental Allergy 39(10), pp. 1597-1610. (10.1111/j.1365-2222.2009.03302.x)
- Zhao, J. et al. 2009. Interleukin-13-induced MUC5AC is regulated by 15-Lipoxygenase 1 pathway in human bronchial epithelial cells. American Journal of Respiratory and Critical Care Medicine 179(9), pp. 782-790. (10.1164/rccm.200811-1744OC)
2008
- Morton, J. et al. 2008. Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFN -dependent iNOS expression in the vasculature of healthy mice. Blood 111(10), pp. 5187-5194. (10.1182/blood-2007-10-117283)
- Dioszeghy, V. et al. 2008. 12/15-lipoxygenase regulates the inflammatory response to bacterial products in vivo. The Journal of Immunology 181(9), pp. 6514-6524.
2007
- Coles, B., Fielding, C. A., Rose-John, S., Scheller, J., Jones, S. A. and O'Donnell, V. B. 2007. Classic interleukin-6 receptor signaling and interleukin-6 trans-signaling differentially control angiotensin II-dependent hypertension, cardiac signal transducer and activator of transcription-3 activation, and vascular hypertrophy in vivo. American Journal of Pathology 171(1), pp. 315-325. (10.2353/ajpath.2007.061078)
2006
- Anning, P. B. et al. 2006. Nitric Oxide deficiency promotes vascular side effects of cyclooxygenase inhibitors. Blood 108(13), pp. 4059-4062. (10.1182/blood-2006-02-005330)
2005
- Williams, P. C. et al. 2005. In vivo aspirin supplementation inhibits nitric oxide consumption by human platelets. Blood 106(8), pp. 2737-2743. (10.1182/blood-2005-02-0664)
- Clark, S. R., Anning, P. B., Coffey, M. J., Roberts, A. G., Marnett, L. J. and O'Donnell, V. B. 2005. Depletion of iNOS-derived nitric oxide by prostaglandin H synthase-2 in inflammation-activated J774.2 macrophages through lipohydroperoxidase turnover. Biochemical Journal 385(3), pp. 815-821. (10.1042/BJ20041353)
2004
- Coffey, M. J., Coles, B., Locke, M., Bermudez-Fajardo, A., Williams, P. C., Jarvis, G. E. and O'Donnell, V. B. 2004. Interactions of 12-lipoxygenase with phospholipase A2 isoforms following platelet activation through the glycoprotein VI collagen receptor. FEBS Letters 576(1-2), pp. 165-168. (10.1016/j.febslet.2004.09.007)
- Coffey, M. J., Jarvis, G. E., Gibbins, J. M., Coles, B., Barrett, N. E., Wylie, O. R. and O'Donnell, V. B. 2004. Platelet 12-lipoxygenase activation via glycoprotein VI: involvement of multiple signaling pathways in agonist control of H(P)ETE synthesis. Circulation Research 94(12), pp. 1598-1605. (10.1161/01.RES.0000132281.78948.65)
2002
- Clark, S. R., Coffey, M. J., McLean, R. M., Collins, P. W., Lewis, M. J., Cross, A. R. and O'Donnell, V. B. 2002. Characterization of nitric oxide consumption pathways by normal, chronic granulomatous disease and myeloperoxidase-deficient human neutrophils. The Journal of Immunology 169(10), pp. 5889-5896.
- Coles, B., Bloodsworth, A., Clark, S. R., Lewis, M. J., Cross, A. R., Freeman, B. A. and O'Donnell, V. B. 2002. Nitrolinoleate inhibits superoxide generation, degranulation, and integrin expression by human neutrophils: novel antiinflammatory properties of nitric oxide-derived reactive species in vascular cells. Circulation Research 91(5), pp. 375-381. (10.1161/01.RES.0000032114.68919.EF)
2001
- Coffey, M. J. et al. 2001. Catalytic consumption of nitric oxide by 12/15- lipoxygenase: inhibition of monocyte soluble guanylate cyclase activation. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490 98(14), pp. 8006-8011. (10.1073/pnas.141136098)
Ymgysyllty
LIPID MAPS Database and Resource funded by Cardiff-led funding from Wellcome Trust
In 2016, the Wellcome Trust funded a £1.3M 5 yr initiative led by our group jointly with Babraham Institute, Cambridge, and University of California San Diego to fund continuation and further development of LIPID MAPS, the global online database and resource for lipid research (http://www.cardiff.ac.uk/news/view/380752-new-funding-boosts-lipidomics-research).
