Ewch i’r prif gynnwys
Yr Athro Valerie O'Donnell

Yr Athro Valerie O'Donnell

Cyd-gyfarwyddwr Sefydliad Ymchwil Imiwnedd Systemau

Yr Ysgol Meddygaeth

Email
o-donnellvb@cardiff.ac.uk
Telephone
+44 (0)29 2068 7313
Campuses
Tenovus Institute
Users
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Trosolwg

Overview

Our research uses mass spectrometry to discover and characterise new lipids (fats) made by circulating vascular cells that regulate immune defence and blood clotting.

Recently we showed that human blood platelets generate a large number of oxidized phospholipids several of which help clotting factors in plasma work more effectively.  We also uncovered a new role for phospholipases in providing energy to the cell and how lipids in different people respond individually to aspirin (http://www.cardiff.ac.uk/news/view/264589-understanding-the-bodys-response-to-aspirin)

In 2016, the Wellcome Trust funded a £1.3M 5 yr initiative led by our group jointly with Babraham Institute, Cambridge, and University of California San Diego to fund continuation and further development of LIPID MAPS, the global online database and resource for lipid research (http://www.cardiff.ac.uk/news/view/380752-new-funding-boosts-lipidomics-research).

Our current research is focused on understanding the role of new lipids in vascular inflammation including cardiovascular disease, dementia and wound healing.  Some lipids we discovered are being developed as the basis of new treatments for bleeding excess.

Research in our group is funded by grants from the European Research Council, Wellcome Trust, British Heart Foundation and Medical Research Council.

Bywgraffiad

Education:

1993 PhD Bristol University, Biochemistry

1990 BSc, University of Dublin, Trinity College, Human Nutrition and Dietetics

Anrhydeddau a Dyfarniadau

Royal Society Wolfson Research Merit Awardee (2017)

ERC Advanced Investigator (2015-)

Honorary Professor, Faculty of Medicine, University of the Republic, Montevideo, since 2008.

Marie Curie Excellence Award (EU), Brussels, March 2008

Wellcome Trust University Award, Cardiff University, 2002-2007

Iron Bolt Award, Gordon Research Conference on Oxygen Radicals, 2004

Wellcome Trust RCD Fellow, Cardiff University, 1999-2002

Parker B Francis Pulmonary Fellow, University of Alabama at Birmingham, 1997-1999

European Union Marie Curie Fellow, University of Berne, Switzerland, 1995-1996

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LIPID MAPS Database and Resource funded by Cardiff-led funding from Wellcome Trust

In 2016, the Wellcome Trust funded a £1.3M 5 yr initiative led by our group jointly with Babraham Institute, Cambridge, and University of California San Diego to fund continuation and further development of LIPID MAPS, the global online database and resource for lipid research (http://www.cardiff.ac.uk/news/view/380752-new-funding-boosts-lipidomics-research).

LIPID MAPS Database and Resource funded by Cardiff-led funding from Wellcome Trust

In 2016, the Wellcome Trust funded a £1.3M 5 yr initiative led by our group jointly with Babraham Institute, Cambridge, and University of California San Diego to fund continuation and further development of LIPID MAPS, the global online database and resource for lipid research (http://www.cardiff.ac.uk/news/view/380752-new-funding-boosts-lipidomics-research).