![Eamon McGreal BSc (Hons), PhD, PgCUTL](https://profiles-cardiff.imgix.net/attachments/5271?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Eamon McGreal
(e/fe)
BSc (Hons), PhD, PgCUTL
Uwch Ddarlithydd
Trosolwyg
Rwy'n gweithio yn y Ganolfan Addysg Feddygol yma yn Ysgol Meddygaeth Prifysgol Caerdydd. Rwyf wedi cael amrywiaeth o rolau ym maes addysg feddygol ac ar hyn o bryd rwy'n Gyfarwyddwr ar gyfer Blwyddyn 3 y MBBCh. Dyma flwyddyn gyntaf Cam 2 y cwricwlwm meddygaeth israddedig lle mae myfyrwyr yn treulio cyfran fawr o'u hamser yn dysgu tra ar leoliad mewn amgylcheddau clinigol.
Rwy'n wyddonydd sydd â chefndir ymchwil a diddordeb arbennig yn y system imiwnedd a'i chynnwys mewn clefyd llidiol cronig. Roedd llawer o'm hymchwil flaenorol yn canolbwyntio ar rôl celloedd gwyn y gwaed (niwtroffiliaid a macroffagau) mewn clefydau llwybr anadlu fel Fibrosis Systig. Mae fy angerdd am imiwnoleg a'i gysylltiad â chlefyd dynol yn parhau yn fy rolau amrywiol yn y Ganolfan Addysg Feddygol.
Rwy'n arwain ar gyfer yr Achos Meddygaeth Anadlol ar gyfer ein myfyrwyr Blwyddyn 1.
Yn ogystal â'r rolau hyn, rwy'n ymgymryd ag ystod o weithgareddau addysgu ac asesu ar draws y cwricwlwm MBBCh 5 mlynedd a'r BSc mewn Ffarmacoleg Feddygol.
Cyhoeddiad
2018
- Griffiths, J. S. et al. 2018. Differential susceptibility of Dectin-1 isoforms to functional inactivation by neutrophil and fungal proteases. FASEB Journal 32(6), pp. 3385-3397. (10.1096/fj.201701145R)
2017
- Stott, M., van den Berg, C., Forton, J., Monk, P., Morgan, B. P. and McGreal, E. 2017. Post-translational modification of complement anaphylatoxins during chronic neutrophilic inflammation. Molecular Immunology 89, pp. 167., article number: 103. (10.1016/j.molimm.2017.06.141)
2014
- Chakraborty, M. et al. 2014. Role of serine proteases in the regulation of interleukin-877 during the development of bronchopulmonary dysplasia in preterm ventilated infants. PLoS ONE 9(12), article number: e114524. (10.1371/journal.pone.0114524)
- Prince, L. R. et al. 2014. Macrophage phenotype is associated with disease severity in preterm infants with chronic lung dsease. PLoS ONE 9(8), article number: e103059. (10.1371/journal.pone.0103059)
- Van Den Berg, C., Tambourgi, D. V., Clark, H. W., Hoong, S. J., Spiller, O. and McGreal, E. 2014. Mechanism of neutrophil dysfunction: neutrophil serine proteases cleave and inactivate the C5a receptor. The Journal of Immunology 192(4), pp. 1787-1795. (10.4049/jimmunol.1301920)
2013
- Kotecha, S., Doull, I. J. M., Davies, P. L., McKenzie, Z., Madsen, J., Clark, H. W. and McGreal, E. P. 2013. Functional heterogeneity of pulmonary surfactant protein-D in cystic fibrosis. Biochimica et Biophysica Acta - Molecular Basis of Disease 1832(12), pp. 2391-2400. (10.1016/j.bbadis.2013.10.002)
- Kotecha, S., Davies, P. L., Clark, H. W. and McGreal, E. P. 2013. Increased prevalence of low oligomeric state surfactant protein D with restricted lectin activity in bronchoalveolar lavage fluid from preterm infants. Thorax 68(5), pp. 460-467. (10.1136/thoraxjnl-2012-202729)
- Chakraborty, M., McGreal, E. P., Davies, P. L., Nowell, M. A., Jones, S. A. and Kotecha, S. 2013. Role of interleukin-6, its receptor and soluble gp130 in chronic lung disease of prematurity. Neonatology 104(3), pp. 161-167. (10.1159/000351015)
2012
- McGreal, E. P., Hearne, K. and Spiller, O. B. 2012. Off to a slow start: under-development of the complement system in term newborns is more substantial following premature birth. Immunobiology 217(2), pp. 176-186. (10.1016/j.imbio.2011.07.027)
2011
- Beeton, M. L. et al. 2011. Role of pulmonary infection in the development of chronic lung disease of prematurity. European Respiratory Journal 37(6), pp. 1424-1430. (10.1183/09031936.00037810)
- Duvoix, A., Mackay, R., Henderson, N., McGreal, E. P., Postle, A., Reid, K. and Clark, H. 2011. Physiological concentration of calcium inhibits elastase-induced cleavage of a functional recombinant fragment of surfactant protein D. Immunobiology 216(1-2), pp. 72-79. (10.1016/j.imbio.2010.03.006)
- McGreal, E. P., Chakraborty, M., Winter, V. T., Jones, S. A., Coalson, J. J. and Kotecha, S. 2011. Dynamic expression of IL-6 trans-signalling molecules in the lungs of preterm baboons undergoing mechanical ventilation. Neonatology 100(2), pp. 130-138. (10.1159/000322148)
2010
- Chakraborty, M., McGreal, E. P. and Kotecha, S. 2010. Acute lung injury in preterm newborn infants: mechanisms and management. Paediatric Respiratory Reviews 11(3), pp. 162-170. (10.1016/j.prrv.2010.03.002)
- McGreal, E. P. et al. 2010. Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis. Biochimica et Biophysica Acta - Molecular Basis of Disease 1802(7-8), pp. 649-658. (10.1016/j.bbadis.2010.04.005)
2009
- Jones, H. E., Taylor, P. R., McGreal, E. P., Zamze, S. and Wong, S. Y. C. 2009. The contribution of naturally occurring IgM antibodies, IgM cross-reactivity and complement dependency in murine humoral responses to pneumococcal capsular polysaccharides. Vaccine 27(42), pp. 5806-5815. (10.1016/j.vaccine.2009.07.063)
- McGreal, E. P. 2009. Structural basis of pattern recognition by innate immune molecules. In: Kishore, U. ed. Target Pattern Recognition in Innate Immunity. Advances in Experimental Medicine and Biology Vol. 653. New York: Springer, pp. 139-161.
2006
- McGreal, E. P., Wienke, D., McKenzie, E. J. and Gordon, R. 2006. Carbohydrate-independent recognition of collagens by the macrophage mannose receptor. European Journal of Immunology 36(5), pp. 1074-82. (10.1002/eji.200535685)
- McGreal, E. P. et al. 2006. The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose. Glycobiology 16(5), pp. 422-30. (10.1093/glycob/cwj077)
2005
- McGreal, E. P., Miller, J. L. and Gordon, S. 2005. Ligand recognition by antigen-presenting cell C-type lectin receptors. Current Opinion in Immunology 17(1), pp. 18-24. (10.1016/j.coi.2004.12.001)
2004
- McGreal, E. P., Martinez-Pomares, L. and Gordon, S. 2004. Divergent roles for C-type lectins expressed by cells of the innate immune system. Molecular Immunology 41(11), pp. 1109-1121. (10.1016/j.molimm.2004.06.013)
2002
- McGreal, E. P., Ikawaki, N., Akatsu, H., Morgan, B. P. and Gasque, P. 2002. Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q. Journal of Immunology 168, pp. 5222-5232.
- McGreal, E. P. and Gasque, P. 2002. Structure-function studies of the receptors for complement C1q. Biochemical Society Transactions 30(6), pp. 1010-1014. (10.1042/BST0301010)
2001
- McGreal, E. P., Gasque, P. and Dean, Y. D. 2001. Endothelial cells, megakaryoblasts, platelets and alveolar epithelial cells express abundant levels of the mouse AA4 antigen, a C-type lectin-like receptor involved in homing activities and innate immune host defense. European Journal of Immunology 31(5), pp. 1370-81. (10.1002/1521-4141(200105)31:5<1370::AID-IMMU1370>3.0.CO;2-B)
2000
- Dean, Y., McGreal, E. P., Akatsu, H. and Gasque, P. 2000. Molecular and cellular properties of the rat AA4 antigen, a C-type lectin-like receptor with structural homology to thrombomodulin. Journal of Biological Chemistry 275(44), pp. 34382-34392. (10.1074/jbc.M006229200)
- Gasque, P., Dean, Y. D., McGreal, E. P., VanBeek, J. and Morgan, B. P. 2000. Complement components of the innate immune system in health and disease in the CNS. Immunopharmacology 49(1-2), pp. 171-186. (10.1016/S0162-3109(00)80302-1)
Adrannau llyfrau
- McGreal, E. P. 2009. Structural basis of pattern recognition by innate immune molecules. In: Kishore, U. ed. Target Pattern Recognition in Innate Immunity. Advances in Experimental Medicine and Biology Vol. 653. New York: Springer, pp. 139-161.
Erthyglau
- Griffiths, J. S. et al. 2018. Differential susceptibility of Dectin-1 isoforms to functional inactivation by neutrophil and fungal proteases. FASEB Journal 32(6), pp. 3385-3397. (10.1096/fj.201701145R)
- Stott, M., van den Berg, C., Forton, J., Monk, P., Morgan, B. P. and McGreal, E. 2017. Post-translational modification of complement anaphylatoxins during chronic neutrophilic inflammation. Molecular Immunology 89, pp. 167., article number: 103. (10.1016/j.molimm.2017.06.141)
- Chakraborty, M. et al. 2014. Role of serine proteases in the regulation of interleukin-877 during the development of bronchopulmonary dysplasia in preterm ventilated infants. PLoS ONE 9(12), article number: e114524. (10.1371/journal.pone.0114524)
- Prince, L. R. et al. 2014. Macrophage phenotype is associated with disease severity in preterm infants with chronic lung dsease. PLoS ONE 9(8), article number: e103059. (10.1371/journal.pone.0103059)
- Van Den Berg, C., Tambourgi, D. V., Clark, H. W., Hoong, S. J., Spiller, O. and McGreal, E. 2014. Mechanism of neutrophil dysfunction: neutrophil serine proteases cleave and inactivate the C5a receptor. The Journal of Immunology 192(4), pp. 1787-1795. (10.4049/jimmunol.1301920)
- Kotecha, S., Doull, I. J. M., Davies, P. L., McKenzie, Z., Madsen, J., Clark, H. W. and McGreal, E. P. 2013. Functional heterogeneity of pulmonary surfactant protein-D in cystic fibrosis. Biochimica et Biophysica Acta - Molecular Basis of Disease 1832(12), pp. 2391-2400. (10.1016/j.bbadis.2013.10.002)
- Kotecha, S., Davies, P. L., Clark, H. W. and McGreal, E. P. 2013. Increased prevalence of low oligomeric state surfactant protein D with restricted lectin activity in bronchoalveolar lavage fluid from preterm infants. Thorax 68(5), pp. 460-467. (10.1136/thoraxjnl-2012-202729)
- Chakraborty, M., McGreal, E. P., Davies, P. L., Nowell, M. A., Jones, S. A. and Kotecha, S. 2013. Role of interleukin-6, its receptor and soluble gp130 in chronic lung disease of prematurity. Neonatology 104(3), pp. 161-167. (10.1159/000351015)
- McGreal, E. P., Hearne, K. and Spiller, O. B. 2012. Off to a slow start: under-development of the complement system in term newborns is more substantial following premature birth. Immunobiology 217(2), pp. 176-186. (10.1016/j.imbio.2011.07.027)
- Beeton, M. L. et al. 2011. Role of pulmonary infection in the development of chronic lung disease of prematurity. European Respiratory Journal 37(6), pp. 1424-1430. (10.1183/09031936.00037810)
- Duvoix, A., Mackay, R., Henderson, N., McGreal, E. P., Postle, A., Reid, K. and Clark, H. 2011. Physiological concentration of calcium inhibits elastase-induced cleavage of a functional recombinant fragment of surfactant protein D. Immunobiology 216(1-2), pp. 72-79. (10.1016/j.imbio.2010.03.006)
- McGreal, E. P., Chakraborty, M., Winter, V. T., Jones, S. A., Coalson, J. J. and Kotecha, S. 2011. Dynamic expression of IL-6 trans-signalling molecules in the lungs of preterm baboons undergoing mechanical ventilation. Neonatology 100(2), pp. 130-138. (10.1159/000322148)
- Chakraborty, M., McGreal, E. P. and Kotecha, S. 2010. Acute lung injury in preterm newborn infants: mechanisms and management. Paediatric Respiratory Reviews 11(3), pp. 162-170. (10.1016/j.prrv.2010.03.002)
- McGreal, E. P. et al. 2010. Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis. Biochimica et Biophysica Acta - Molecular Basis of Disease 1802(7-8), pp. 649-658. (10.1016/j.bbadis.2010.04.005)
- Jones, H. E., Taylor, P. R., McGreal, E. P., Zamze, S. and Wong, S. Y. C. 2009. The contribution of naturally occurring IgM antibodies, IgM cross-reactivity and complement dependency in murine humoral responses to pneumococcal capsular polysaccharides. Vaccine 27(42), pp. 5806-5815. (10.1016/j.vaccine.2009.07.063)
- McGreal, E. P., Wienke, D., McKenzie, E. J. and Gordon, R. 2006. Carbohydrate-independent recognition of collagens by the macrophage mannose receptor. European Journal of Immunology 36(5), pp. 1074-82. (10.1002/eji.200535685)
- McGreal, E. P. et al. 2006. The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose. Glycobiology 16(5), pp. 422-30. (10.1093/glycob/cwj077)
- McGreal, E. P., Miller, J. L. and Gordon, S. 2005. Ligand recognition by antigen-presenting cell C-type lectin receptors. Current Opinion in Immunology 17(1), pp. 18-24. (10.1016/j.coi.2004.12.001)
- McGreal, E. P., Martinez-Pomares, L. and Gordon, S. 2004. Divergent roles for C-type lectins expressed by cells of the innate immune system. Molecular Immunology 41(11), pp. 1109-1121. (10.1016/j.molimm.2004.06.013)
- McGreal, E. P., Ikawaki, N., Akatsu, H., Morgan, B. P. and Gasque, P. 2002. Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q. Journal of Immunology 168, pp. 5222-5232.
- McGreal, E. P. and Gasque, P. 2002. Structure-function studies of the receptors for complement C1q. Biochemical Society Transactions 30(6), pp. 1010-1014. (10.1042/BST0301010)
- McGreal, E. P., Gasque, P. and Dean, Y. D. 2001. Endothelial cells, megakaryoblasts, platelets and alveolar epithelial cells express abundant levels of the mouse AA4 antigen, a C-type lectin-like receptor involved in homing activities and innate immune host defense. European Journal of Immunology 31(5), pp. 1370-81. (10.1002/1521-4141(200105)31:5<1370::AID-IMMU1370>3.0.CO;2-B)
- Dean, Y., McGreal, E. P., Akatsu, H. and Gasque, P. 2000. Molecular and cellular properties of the rat AA4 antigen, a C-type lectin-like receptor with structural homology to thrombomodulin. Journal of Biological Chemistry 275(44), pp. 34382-34392. (10.1074/jbc.M006229200)
- Gasque, P., Dean, Y. D., McGreal, E. P., VanBeek, J. and Morgan, B. P. 2000. Complement components of the innate immune system in health and disease in the CNS. Immunopharmacology 49(1-2), pp. 171-186. (10.1016/S0162-3109(00)80302-1)
Bywgraffiad
2023-presennol: Cyfarwyddwr Blwyddyn 3, Canolfan Addysg Feddygol, Ysgol Meddygaeth Prifysgol Caerdydd.
2016-2023: Dirprwy Gyfarwyddwr Blwyddyn 3, Dirprwy Gyfarwyddwr SSCs, Canolfan Addysg Feddygol, Ysgol Meddygaeth Prifysgol Caerdydd.
Hydref 2005-2016: Darlithydd mewn Bioleg Anadlol Bediatreg, Ysgol Meddygaeth Prifysgol Caerdydd.
2008: Cymrawd yr Academi Addysg Uwch.
2008: Tystysgrif Ôl-raddedig mewn Addysgu a Dysgu Prifysgol, Prifysgol Caerdydd.
Ionawr 2005-Oct 2005: Wellcome Trust Gwerth mewn Pobl Gwobr Cymrawd Ymchwil Ôl-ddoethurol, Adran Biocemeg ac Imiwnoleg Feddygol, Ysgol Meddygaeth Prifysgol Caerdydd.
Ebrill 2002-Rhagfyr 2004: Ymchwilydd Ôl-ddoethurol, Ysgol Patholeg Syr William Dunn, Prifysgol Rhydychen.
1998-2002: Ysgoloriaeth PhD, Adran Biocemeg Feddygol, Coleg Meddygaeth Prifysgol Cymru, Caerdydd.
1998-1999: Diploma mewn Dulliau Biofeddygol, Coleg Meddygaeth Prifysgol Cymru, Caerdydd.
1993-1997: BSc (Anrh) Dosbarth1af , Biocemeg, Prifysgol Genedlaethol Iwerddon, Galway.
Anrhydeddau a dyfarniadau
Arbenigeddau
- Imiwnoleg cellog
- Imiwnedd cynhenid
- Afiechydon anadlol
- Addysg feddygol