
Yr Athro Judith Hall
OBE
Professor of Anaesthetics, Intensive Care and Pain Medicine. Phoenix Project Lead
- hallje@cardiff.ac.uk
- +44 (0)29 2074 3110
- UHW Main Building
Cyhoeddiadau
2019
- Saxena, N.et al. 2019. Mild propofol sedation reduces frontal lobe and thalamic cerebral blood flow: An arterial spin labeling study. Frontiers in Physiology 10, article number: 1541. (10.3389/fphys.2019.01541)
2018
- Slatter, D. A.et al. 2018. Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies. JCI Insight 3(6), article number: e98459. (10.1172/jci.insight.98459)
- Szakmany, T.et al. 2018. Defining sepsis on the wards: results of a multi-centre point-prevalence study comparing two sepsis definitions. Anaesthesia 73(2), pp. 195-204. (10.1111/anae.14062)
- Hadfield, A.et al. 2018. Perception of simulation training in emergencies for dental sedation practitioners. Clinical Teacher 15(1), pp. 52-56. (10.1111/tct.12626)
2017
- Collins, P. W.et al. 2017. Viscoelastometry guided fresh frozen plasma infusion for postpartum haemorrhage: OBS2, an observational study. British Journal of Anaesthesia 119(3), pp. 422-434. (10.1093/bja/aex245)
- Collins, P. W.et al. 2017. Viscoelastometric-guided early fibrinogen concentrate replacement during postpartum haemorrhage: OBS2, a double-blind randomized controlled trial. British Journal of Anaesthesia 119(3), pp. 411-421. (10.1093/bja/aex181)
- Merola, A.et al. 2017. Mapping the pharmacological modulation of brain oxygen metabolism: the effects of caffeine on absolute CMRO2 measured using dual calibrated fMRI. NeuroImage 155, pp. 331-343. (10.1016/j.neuroimage.2017.03.028)
- Watkins, C.et al. 2017. Improving aid through good design: a case study in rural Zambia. In: Chakrabarti, A. and Chakrabarti, D. eds. Research into Design for Communities, Volume 1., Vol. 65. Smart Innovation, Systems and Technologies Singapore: Springer, pp. 881-892., (10.1007/978-981-10-3518-0_76)
- Holst, B.et al. 2017. Soluble toll-like receptor 2 is a biomarker for sepsis in critically ill patients with multi-organ failure within 12 h of ICU admission. Intensive Care Medicine Experimental 5(1) (10.1186/s40635-016-0116-z)
- Paul, A.et al. 2017. Laboratory evaluation of a novel anaesthesia delivery device. Anaesthesia 72(1), pp. 63-72. (10.1111/anae.13625)
2016
- Szakmany, T.et al. 2016. Sepsis prevalence and outcome on the general wards and emergency departments in Wales: Results of a multi-centre, observational, point prevalence study. PLOS ONE 11(12), article number: e0167230. (10.1371/journal.pone.0167230)
- Germuska, M.et al. 2016. A forward modelling approach for the estimation of oxygen extraction fraction by calibrated fMRI. NeuroImage 139, pp. 313-323. (10.1016/j.neuroimage.2016.06.004)
- Warnert, E. A. H.et al. 2016. The major cerebral arteries proximal to the Circle of Willis contribute to cerebrovascular resistance in humans. Journal of Cerebral Blood Flow and Metabolism 36(8), pp. 1384-1395. (10.1177/0271678X15617952)
- Sharif, B.et al. 2016. Developing a digital data collection platform to measure the prevalence of sepsis in Wales. Journal of the American Medical Informatics Assocation 23(6), pp. 1185-1189. (10.1093/jamia/ocv208)
- Morgan, M.et al. 2016. Sepsis patients with first and second-hit infections show different outcomes depending on the causative organism. Frontiers in Microbiology 7, article number: 207. (10.3389/fmicb.2016.00207)
- Harris, A. P.et al. 2016. The role of brain derived neurotrophic factor in learned fear processing: an awake rat fMRI study. Genes, Brain and Behavior 15(2), pp. 221-230. (10.1111/gbb.12277)
- Taylor, A. M.et al. 2016. Neural responses to a modified Stroop paradigm in patients with complex chronic musculoskeletal pain compared to matched controls: an experimental functional magnetic resonance imaging study. BMC Psychology 4(5), pp. 1-13. (10.1186/s40359-016-0109-4)
- Bruynseels, D.et al. 2016. Commentary on reconstituting fibrinogen concentrate to maintain blinding in a double-blind, randomized trial in an emergency Setting. Journal of Emergency Medicine 28(1), pp. 104-107.e.1. (10.1016/j.jemermed.2015.09.017)
2015
- Taylor, A. M.et al. 2015. A functional magnetic resonance imaging study to investigate the utility of a picture imagination task in investigating neural responses in patients with chronic musculoskeletal pain to daily physical activity photographs. PLoS ONE 10(10), article number: e0141133. (10.1371/journal.pone.0141133)
- Shaw, A. D.et al. 2015. Ketamine amplifies induced gamma frequency oscillations in the human cerebral cortex. European Neuropsychopharmacology 25(8), pp. 1136-1146. (10.1016/j.euroneuro.2015.04.012)
- Percy, C. L.et al. 2015. Correcting thrombin generation ex vivo using different haemostatic agents following cardiac surgery requiring the use of cardiopulmonary bypass. Blood Coagulation and Fibrinolysis 26(4), pp. 357-367. (10.1097/MBC.0000000000000243)
- Aawar, N.et al. 2015. Fibrinogen concentrate versus placebo for treatment of postpartum haemorrhage: study protocol for a randomised controlled trial. Trials 16(1), pp. 1-11. (10.1186/s13063-015-0670-9)
- Szakmany, T.et al. 2015. Effect of early tracheostomy on resource utilization and clinical outcomes in critically ill patients: meta-analysis of randomized controlled trials. British Journal of Anaesthesia 114(3), pp. 396-405. (10.1093/bja/aeu440)
- Warnert, E. A.et al. 2015. Noninvasive assessment of arterial compliance of human cerebral arteries with short inversion time arterial spin labeling. Journal of Cerebral Blood Flow and Metabolism 35(3), pp. 461-468. (10.1038/jcbfm.2014.219)
- Salama, I. E.et al. 2015. Volatile fluorinated nanoemulsions: a chemical route to controlled delivery of inhalation anesthesia. Journal of Colloid and Interface Science 440, pp. 78-83. (10.1016/j.jcis.2014.10.021)
- Lilley, G.et al. 2015. Measurement of blood loss during postpartum haemorrhage. International Journal of Obstetric Anesthesia 24(1), pp. 8-14. (10.1016/j.ijoa.2014.07.009)
2014
- Davey, M. S.et al. 2014. Microbe-specific unconventional T cells induce human neutrophil differentiation into antigen cross-presenting cells. Journal of Immunology 193(7), pp. 3704-3716. (10.4049/jimmunol.1401018)
- Collins, P. W.et al. 2014. Fibrin-based clot formation as an early and rapid biomarker for progression of postpartum hemorrhage: a prospective study. Blood 124(11), pp. 1727-1736. (10.1182/blood-2014-04-567891)
- Warnert, E. A.et al. 2014. In vivo assessment of human brainstem cerebrovascular function: a multi-inversion time pulsed arterial spin labelling study. Journal of Cerebral Blood Flow and Metabolism 34(6), pp. 956-963. (10.1038/jcbfm.2014.39)
2013
- Morgan, M.et al. 2013. Gamma-delta t cell activation by hmb-pp in early sepsis is associated with higher risk of death on the icu [Abstract]. Intensive Care Medicine 39(Supp 2), pp. S451-S452.
- Raby, A.et al. 2013. Targeting the TLR co-receptor CD14 with TLR2-derived peptides modulates immune responses to pathogens. Science Translational Medicine 5(185), article number: 185ra64. (10.1126/scitranslmed.3005544)
- Morgan, M.et al. 2013. Human gamma delta T cells in severe bacterial sepsis [Abstract]. British Journal of Anaesthesia 110(5), pp. 876-877. (10.1093/bja/aes490)
- Morton, W.et al. 2013. Investigation of phthalate release from tracheal tubes. Anaesthesia 68(4), pp. 377-381. (10.1111/anae.12083)
- Saxena, N.et al. 2013. Enhanced stimulus-induced gamma activity in humans during propofol-induced sedation. PLoS ONE 8(3), article number: e57685. (10.1371/journal.pone.0057685)
- Harris, A. D.et al. 2013. Temporal dynamics of lactate concentration in the human brain during acute inspiratory hypoxia. Journal of Magnetic Resonance Imaging 37(3), pp. 739-745. (10.1002/jmri.23815)
- Tailor, N.et al. 2013. Non-invasive measurement of brainstem blood flow [Abstract]. Anaesthesia 68(3), pp. 322. (10.1111/anae.12097)
- Gili, T.et al. 2013. The thalamus and brainstem act as key hubs in alterations of human brain network connectivity induced by mild propofol sedation. The Journal of Neuroscience 33(9), pp. 4024-4031. (10.1523/JNEUROSCI.3480-12.2013)
- Harris, A. D.et al. 2013. Cerebral blood flow response to acute hypoxic hypoxia. NMR in Biomedicine 26(12), pp. 1844-1852. (10.1002/nbm.3026)
2012
- Durno, K.et al. 2012. STLR-2 levels can discriminate between infective and non-infective origins of multi-organ dysfunction on ICU admission: a pilot study. Critical Care Medicine 40(12), pp. U138-U139. (10.1097/01.ccm.0000424713.57752.27)
- Tailor, N.et al. 2012. Non-invasive measurement of brainstem blood flow in normocapnia and hypercapnia using arterial spin labelling MRI [Abstract]. Anaesthesia 67(S2), pp. 18. (10.1111/anae.12032)
- Sheraton, T. E., Wilkes, A. R. and Hall, J. E. 2012. Mobile phones and the developing world. Anaesthesia 67(9), pp. 945-950. (10.1111/j.1365-2044.2012.07298.x)
- Holst, B.et al. 2012. Complement takes its Toll: an inflammatory crosstalk between Toll-like receptors and the receptors for the complement anaphylatoxin C5a. Anaesthesia 67(1), pp. 60-64. (10.1111/j.1365-2044.2011.07011.x)
2011
- Taylor, A. M.et al. 2011. Imaging neural responses to affective and pain-related stimuli in chronic non-malignant pain patients vs healthy controls [Abstract]. British Journal of Anaesthesia 107(5), pp. 830-831. (10.1093/bja/aer234)
- Coakley, M.et al. 2011. Assessment of thrombin generation measured before and after cardiopulmonary bypass surgery and its association with postoperative bleeding. Journal of Thrombosis and Haemostatis 9(2), pp. 282-292. (10.1111/j.1538-7836.2010.04146.x)
- Raby, A.et al. 2011. TLR activation enhances C5a-induced pro-inflammatory responses by negatively modulating the second C5a receptor, C5L2. European Journal of Immunology 41(9), pp. 2741-2752. (10.1002/eji.201041350)
2010
- Edden, R. A. E.et al. 2010. Edited MRS is sensitive to changes in lactate concentration during inspiratory hypoxia. Journal of Magnetic Resonance Imaging 32(2), pp. 320-325. (10.1002/jmri.22233)
- Poonawala, Y.et al. 2010. The effect of desflurane on filtration performance of breathing system filters. Anaesthesia 65(8), pp. 831-835. (10.1111/j.1365-2044.2010.06419.x)
- Cann, C.et al. 2010. Are we using our brains? Diagnosis of postoperative cognitive dysfunction [Editorial]. Anaesthesia 65(12), pp. 1166-1169. (10.1111/j.1365-2044.2010.06531.x)
2009
- McPherson, D.et al. 2009. Fluid flow through intravenous cannulae in a clinical model. Anesthesia and Analgesia 108(4), pp. 1198-1202. (10.1213/ane.0b013e3181966451)
- Lewis, E.et al. 2009. Laryngoscope light output. Anaesthesia 64(6), pp. 688-689. (10.1111/j.1365-2044.2009.05948.x)
2008
- Wilkes, A. R.et al. 2008. Can force be used as a surrogate measure for difficult laryngoscopy? A reply. Anaesthesia 63(3), pp. 319-319. (10.1111/j.1365-2044.2008.05462_1.x)
- Froom, S. R.et al. 2008. The effect of volatile anaesthetic agents on the filtration performance of paediatric breathing system filters. Anaesthesia 63(1), pp. 77-81. (10.1111/j.1365-2044.2007.05277.x)
- Froom, S. R.et al. 2008. Bispectral index asymmetry and COMFORT score in paediatric intensive care patients. BJA: British Journal of Anaesthesia 100(5), pp. 690-696. (10.1093/bja/aen035)
- Malan, C. A.et al. 2008. Minimum and optimum light requirements for laryngoscopy in paediatric anaesthesia: a manikin study. Anaesthesia 63(1), pp. 65-70. (10.1111/j.1365-2044.2007.05259.x)
- Sandby-Thomas, M., Sullivan, G. and Hall, J. E. 2008. A national survey into the peri-operative anaesthetic management of patients presenting for surgical correction of a fractured neck of femur - a reply. Anaesthesia 63(9), pp. 1015. (10.1111/j.1365-2044.2008.05663_2.x)
2007
- Malan, C. A.et al. 2007. An evaluation of the filtration performance of paediatric breathing system filters at low flows. Anaesthesia -London- 62(5), pp. 504-508.
- Harvey, K.et al. 2007. A comparison of the use of Trachlight and Eschmann multiple-use introducer in simulated difficult intubation. European Journal of Anaesthesiology 24(1), pp. 76-81. (10.1017/s0265021506001177)
- Rees, L. M.et al. 2007. Assessing the efficacy of HME filters at preventing contamination of breathing systems. Anaesthesia -London- 62(1), pp. 67-71. (10.1111/j.1365-2044.2006.04867.x)
- Sheraton, T. E., Gildersleve, C. and Hall, J. E. 2007. The use of nitrous oxide in paediatric anaesthetic practice in the United Kingdom: a questionnaire survey. Anaesthesia -London- 62(1), pp. 62-66. (10.1111/j.1365-2044.2006.04857.x)
- Wilkes, A. R., Malan, C. A. and Hall, J. E. 2007. The effect of flow on the filtration performance of paediatric breathing system filters. Anaesthesia -London- 63(1), pp. 71-76. (10.1111/j.1365-2044.2007.05276.x)
- Kumar, R. A.et al. 2007. Predictive value of IL-18 and SC5b-9 for neurocognitive dysfunction after cardiopulmonary bypass. British Journal of Anaesthesia 98(3), pp. 317-322. (10.1093/bja/ael366)
- Cann, C., Wilkes, A. R. and Hall, J. E. 2007. A reply [Letter]. Anaesthesia 62(2), pp. 193-193. (10.1111/j.1365-2044.2007.04958_2.x)
2006
- Absolom, M.et al. 2006. The use of impedance respirometry to confirm tracheal intubation in children. Anaesthesia -London- 61(12), pp. 1145-1148. (10.1111/j.1365-2044.2006.04838.x)
- Evans, A.et al. 2006. A comparison of the Seeing Optical Stylet and the gum elastic bougie in simulated difficult tracheal intubation: a manikin study. Anaesthesia -London- 61(5), pp. 478-481. (10.1111/j.1365-2044.2006.04539.x)
- Sudheer, P.et al. 2006. Haemodynamic effects of the prone position: a comparison of propofol total intravenous and inhalation anaesthesia. Anaesthesia -London- 61(2), pp. 138-141. (10.1111/j.1365-2044.2005.04464.x)
- Stacey, M. R.et al. 2006. Cardiovascular responses following laryngoscope-assisted fibreoptic orotracheal intubation [letter]. Anaesthesia -London- 61(2), pp. 196-197. (10.1111/j.1365-2044.2005.04522_1.x)
- Cann, C.et al. 2006. The pressure required to force liquid through breathing system filters. Anaesthesia 61(5), pp. 492-497. (10.1111/j.1365-2044.2006.04581.x)
2005
- Henderson, K. A., Raj, N. and Hall, J. E. 2005. The use of nitrous oxide in anaesthetic practice: a questionnaire survey. Anaesthesia -London- 57(12), pp. 1155-1158. (10.1046/j.1365-2044.2002.02790.x)
- Rassam, S.et al. 2005. Airway management before, during and after extubation: a survey of practice in the United Kingdom and Ireland. Anaesthesia -London- 60(10), pp. 995-1001. (10.1111/j.1365-2044.2005.04235.x)
- Goodwin, N.et al. 2005. Effect of breathing low concentrations of volatile anaesthetic agents on incidence of adverse airway events. Anaesthesia -London- 60(10), pp. 955-959. (10.1111/j.1365-2044.2005.04279.x)
- Hall, J. E. and Diaz-Navarro, C. 2005. Living with the European Clinical Trials Directive: one year on [editorial]. Anaesthesia -London- 60(10), pp. 949-951. (10.1111/j.1365-2044.2005.04406.x)
- Jones, R. M.et al. 2005. The Cardiff paediatric laryngoscope and its "non-conforming" siblings [letter]. Anaesthesia -London- 60(7), pp. 721-722. (10.1111/j.1365-2044.2005.04271.x)
- Chawathe, M.et al. 2005. Sevoflurane (12% and 8%) inhalational induction in children. Pediatric Anesthesia 15(6), pp. 470-475. (10.1111/j.1460-9592.2005.01478.x)
- Goodwin, N., Wilkes, A. and Hall, J. E. 2005. Strength of disposable laryngoscope blades [letter]. Anaesthesia -London- 60(6), pp. 630-631. (10.1111/j.1365-2044.2005.04253.x)
- Sudheer, P.et al. 2005. Flow cytometric investigation of peri-anaesthetic anaphylaxis using CD63 and CD203c. Anaesthesia -London- 60(3), pp. 251-256. (10.1111/j.1365-2044.2004.04086.x)
- Evans, A., Wilkes, A. R. and Hall, J. E. 2005. Strength requirements for laryngoscope blades[letter]. Anaesthesia -London- 60(3), pp. 289-290. (10.1111/j.1365-2044.2005.04127.x)
- Cann, C.et al. 2005. Is ethical approval necessary for manikin studies?. Anaesthesia 60(1), pp. 94-96. (10.1111/j.1365-2044.2004.04046.x)
2004
- Jones, R. M.et al. 2004. The Cardiff paediatric laryngoscope blade: a comparison with the Miller size 1 and Macintosh size 2 laryngoscope blades. Anaesthesia -London- 59(10), pp. 1016-1019. (10.1111/j.1365-2044.2004.03839.x)
- Garrard, A.et al. 2004. The effect of mechanically-induced cricoid force on lower oesophageal sphincter pressure in anaesthetised patients. Anaesthesia -London- 59(5), pp. 435-439. (10.1111/j.1365-2044.2004.03682.x)
- Goodwin, N.et al. 2004. A comparison of 8% and 12% sevoflurane for inhalation induction in adults. Anaesthesia -London- 59(1), pp. 15-19. (10.1111/j.1365-2044.2004.03481.x)
2003
- Evans, A.et al. 2003. A comparison of the forces exerted during laryngoscopy using disposable and non-disposable laryngoscope blades. Anaesthesia -London- 58(9), pp. 869-873. (10.1046/j.1365-2044.2003.03340.x)
- Stacey, M. R.et al. 2003. Mechanical closure of the vocal cords with the Airway Management Device [letter]. British Journal of Anaesthesia 91(2), pp. 299. (10.1093/bja/aeg590)
- Raj, N.et al. 2003. Evaluation of personal, environmental and biological exposure of paediatric anaesthetists to nitrous oxide and sevoflurane. Anaesthesia -London- 58(7), pp. 630-636. (10.1046/j.1365-2044.2003.03235.x)
- Goodwin, N.et al. 2003. The rigid nasendoscope as a tool for difficult tracheal intubation: a manikin study. Anaesthesia -London- 58(7), pp. 675-679. (10.1046/j.1365-2044.2003.03203.x)
- Sivasankar, R.et al. 2003. An evaluation of the modified Airway Management Device. Anaesthesia -London- 58(6), pp. 558-561. (10.1046/j.1365-2044.2003.03185.x)
- Henderson, K., Raj, N. and Hall, J. E. 2003. The use of nitrous oxide in anaesthetic practice: a second questionnaire survey [letter]. Anaesthesia -London- 58(3), pp. 294. (10.1046/j.1365-2044.2003.306923.x)
- Campbell, A. E.et al. 2003. Cricoid yoke: the effect of surface area and applied force on discomfort experienced by conscious volunteers. European Journal of Anaesthesiology 20(1), pp. 52-55. (10.1017/s0265021503000097)
2002
- Sehgal, A. and Hall, J. E. 2002. Herbal medicines--harmless or harmful? [editorial]. Anaesthesia -London- 57(10), pp. 947-948. (10.1046/j.1365-2044.2002.02907.x)
- Jeffs, S. A., Hall, J. E. and Morris, S. 2002. Comparison of morphine alone with morphine plus clonidine for postoperative patient-controlled analgesia. British Journal of Anaesthesia 89(3), pp. 424-427. (10.1093/bja/aef216)
2001
- Zatman, T. F., Hall, J. E. and Harmer, M. 2001. Gastric residual volume in children: a study comparing efficiency of erythromycin and metoclopramide as prokinetic agents. British Journal of Anaesthesia 86(6), pp. 869-871. (10.1093/bja/86.6.869)
- Hall, J. E., Uhrich, T. D. and Ebert, T. J. 2001. Sedative, analgesic and cognitive effects of clonidine infusions in humans. British Journal of Anaesthesia 86(1), pp. 5-11. (10.1093/bja/86.1.5)
2000
- Mallinder, P. A.et al. 2000. A comparison of opiate- and epidural-induced alterations in splanchnic blood flow using intra-operative gastric tonometry. Anaesthesia -London- 55(7), pp. 659-665. (10.1046/j.1365-2044.2000.01475.x)
- Wilkes, A. R.et al. 2000. The effect of humidification and smoking habit on the incidence of adverse airway events during deepening of anaesthesia with desflurane. Anaesthesia -London- 55(7), pp. 685-689. (10.1046/j.1365-2044.2000.01469.x)
- Hall, J. E., Ebert, T. J. and Harmer, M. 2000. Induction characteristics with 3% and 8% sevoflurane in adults: an evaluation of the second stage of anaesthesia and its haemodynamic consequences. Anaesthesia -London- 55(6), pp. 545-550. (10.1046/j.1365-2044.2000.01476.x)
- Plastow, S. E., Hall, J. E. and Pugh, S. C. 2000. Fentanyl supplementation of sevoflurane induction of anasthesia. Anaesthesia -London- 55(5), pp. 475-478. (10.1046/j.1365-2044.2000.01268.x)
- Hall, J. E.et al. 2000. Sedative, amnestic, and analgesic properties of small-dose dexmedetomidine infusions. Anesthesia and Analgesia 90(3), pp. 699-705. (10.1097/00000539-200003000-00035)
1997
- Hall, J. E.et al. 1997. Comparison between halothane and sevoflurane for adult vital capacity induction. British Journal of Anaesthesia 79(3), pp. 285-288. (10.1093/bja/79.3.285)
- Hall, J. E.et al. 1997. Environmental monitoring during gaseous induction with sevoflurane. British Journal of Anaesthesia 79(3), pp. 342-345. (10.1093/bja/79.3.342)
- Hall, J. E., Stewart, J. I. and Harmer, M. 1997. Single-breath inhalation induction of sevoflurane anaesthesia with and without nitrous oxide: a feasibility study in adults and comparison with an intravenous bolus of propofol. Anaesthesia -London- 52(5), pp. 410-415. (10.1111/j.1365-2044.1997.091-az0086.x)
- Hall, J. E., Ng, W. S. and Smith, S. 1997. Blood loss during first trimester termination of pregnancy: comparison of two anaesthetic techniques. British Journal of Anaesthesia 78(2), pp. 172-174. (10.1093/bja/78.2.172)
1996
- Hall, J. E., Stewart, J. I. and Harmer, M. 1996. Tachypnoea following vital capacity induction with sevoflurane [letter]. Anaesthesia -London- 51(9), pp. 890. (10.1111/j.1365-2044.1996.tb12635.x)
- Hall, J. E. and Harmer, M. 1996. Erythromycin as a prokinetic agent in children [letter]. Anaesthesia -London- 51(5), pp. 503-504. (10.1111/j.1365-2044.1996.tb07810.x)
0
- Fayaz, K. M.et al. . Histamine release during adult cardiopulmonary bypass. Anaesthesia -London- 60(12), pp. 1179-1184. (10.1111/j.1365-2044.2005.04368.x)
- Bowrey, S.et al. . A comparison of 0.2 and 0.5 mg intrathecal morphine for postoperative analgesia after total knee replacement. Anaesthesia -London- 60(5), pp. 449-452. (10.1111/j.1365-2044.2005.04174.x)