Trosolwyg
Mae fy ymchwil yn canolbwyntio ar sut y gellir cyfuno a dadansoddi'r ffrwydrad o ddata sy'n cael ei gasglu a'i gynhyrchu gan ymchwilwyr, treialon clinigol a'r GIG i yrru datblygiadau mewn opsiynau triniaeth i gleifion yn ogystal â hyrwyddo ein dealltwriaeth wyddonol o glefydau.
I wneud hyn mae angen nifer o dechnolegau a thechnegau sy'n sail i hyn, felly mae gen i arbenigedd mewn dylunio, defnyddio a rheoli seilwaith cyfrifiadura perfformiad uchel (gan gynnwys dadansoddiad GPU) a storio data ar raddfa petabyte yn ogystal â'r technegau biowybodeg ac AI sydd eu hangen i ddadansoddi a thynnu gwybodaeth o setiau data patholeg genomeg, trawsgrifiomig, radiomig a digidol.
Mae fy ngwaith presennol yn canolbwyntio ar fanteisio ar y cyfleoedd y gall Amgylcheddau Ymchwil Dibynadwy eu datgloi i ddod â data a gasglwyd at ei gilydd ar gyfer claf sengl yn ystod eu taith driniaeth a sut y gallwn wedyn gymhwyso technegau dysgu peiriannau i ddatgloi gwybodaeth o'r setiau data rhyng-gysylltiedig hyn.
Cyhoeddiad
2023
- West, H. D. et al. 2023. Targeted genomic sequencing of TSC1 and TSC2 reveals causal variants in individuals for whom previous genetic testing for tuberous sclerosis complex was normal. Human Mutation: Variation, Informatics and Disease 2023, article number: 4899372. (10.1155/2023/4899372)
- Lohana, P. et al. 2023. Role of enzymic antioxidants in mediating oxidative stress and contrasting wound healing capabilities in oral mucosal/skin fibroblasts and tissues. Antioxidants 12(7), article number: 1374. (10.3390/antiox12071374)
2021
- Shephard, A. P. et al. 2021. Stroma-derived extracellular vesicle mRNA signatures inform histological nature of prostate cancer. Journal of Extracellular Vesicles 10(12), article number: e12150. (10.1002/jev2.12150)
- Ordonez, L. D. et al. 2021. Reproductive history determines ErbB2 locus amplification, WNT signalling and tumour phenotype in a murine breast cancer model. Disease Models and Mechanisms 14(5), article number: dmm048736. (10.1242/dmm.048736)
- Lewis, T. et al. 2021. Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers. Haematologica 106(4), pp. 958-967. (10.3324/haematol.2019.238584)
- Lawson, H. et al. 2021. JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells. Blood Advances 5(3), pp. 889-899. (10.1182/bloodadvances.2020002702)
- Almotiri, A. et al. 2021. Zeb1 modulates hematopoietic stem cell fates required for suppressing acute myeloid leukemia. Journal of Clinical Investigation 131(1), article number: e129115. (10.1172/JCI129115)
2020
- Holzhauser, S. et al. 2020. Sensitivity of human papillomavirus-positive and -negative oropharyngeal cancer cell lines to ionizing irradiation. Oncology Reports (10.3892/or.2020.7709)
- Short, E. et al. 2020. APC transcription studies and molecular diagnosis of familial adenomatous polyposis. European Journal of Human Genetics 28(1), pp. 118-121. (10.1038/s41431-019-0486-2)
2019
- Menendez Gonzalez, J. B. et al. 2019. Gata2 as a crucial regulator of stem cells in adult hematopoiesis and acute myeloid leukemia. Stem Cell Reports 13(2), pp. 291-306. (10.1016/j.stemcr.2019.07.005)
2018
- Pirotte, E. F. et al. 2018. Sensitivity to inhibition of DNA repair by Olaparib in novel oropharyngeal cancer cell lines infected with Human Papillomavirus. PLoS ONE 13(12), pp. -., article number: e0207934. (10.1371/journal.pone.0207934)
- Johnson, C. E. et al. 2018. Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir−bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death. Oncogene 37, pp. 5913-5925. (10.1038/s41388-018-0381-2)
- Caley, M., Wall, I., Peake, M., Kipling, D., Giles, P., Thomas, D. and Stephens, P. 2018. Development and characterisation of a human chronic skin wound cell line - towards an alternative for animal experimentation. International Journal of Molecular Sciences 19(4), article number: 1001. (10.3390/ijms19041001)
2016
- Liao, C. et al. 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46(9), pp. 2222-2232. (10.1002/eji.201646528)
2015
- Bayram-Weston, Z. et al. 2015. Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntington's disease are not reflected in mutant Huntingtin inclusion prevalence. BMC Genomics 16, pp. -., article number: 1079. (10.1186/s12864-015-2251-4)
2014
- Giles, J. L., Choy, E., van den Berg, C., Morgan, B. P. and Harris, C. L. 2014. Functional analysis of a complement polymorphism (rs17611) associated with Rheumatoid Arthritis. Immunology 143(s2), pp. 181-182. (10.1111/imm.12407)
- Bryant, D. et al. 2014. mRNA sequencing of novel cell lines from human papillomavirus type-16 related vulval intraepithelial neoplasia: Consequences of expression of HPV16 E4 and E5. Journal of Medical Virology 86(9), pp. 1534-1541. (10.1002/jmv.23994)
- Peake, M. A. et al. 2014. Identification of a transcriptional signature for the wound healing continuum. Wound Repair and Regeneration 22(3), pp. 399-405. (10.1111/wrr.12170)
- Rosas, M. et al. 2014. The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal. Science 344(6184), pp. 645-648. (10.1126/science.1251414)
2012
- Giles, P. J., Elliston, L. A., Higgs, G., Brooks, S. P., Dunnett, S. B. and Jones, L. 2012. Longitudinal analysis of gene expression and behaviour in the HdhQ150 mouse model of Huntington's disease. Brain Research Bulletin 88(2-3), pp. 199-209. (10.1016/j.brainresbull.2011.10.001)
- Bennett, M. R. et al. 2012. Bioinformatic analyses of genome wide nucleotide excision repair datasets in Saccharomyces cerevisiae [Abstract]. Mutagenesis 27(1), pp. 121. (10.1093/mutage/ger068)
- Feyeux, M. et al. 2012. Early transcriptional changes linked to naturally occurring Huntington's disease mutations in neural derivatives of human embryonic stem cells. Human Molecular Genetics 21(17), pp. 3883-3895. (10.1093/hmg/dds216)
2010
- Enoch, S. et al. 2010. 'Young' oral fibroblasts are geno/phenotypically distinct. Journal of Dental Research 89(12), pp. 1407-1413. (10.1177/0022034510377796)
- Welton, J. L. et al. 2010. Proteomics analysis of bladder cancer exosomes. Molecular & Cellular Proteomics 9(6), pp. 1324-1338. (10.1074/mcp.M000063-MCP201)
2009
- Enoch, S. et al. 2009. Increased oral fibroblast lifespan is telomerase-independent. Journal of Dental Research 88(10), pp. 916-921. (10.1177/0022034509342979)
- Zhang, L. et al. 2009. Thyrotropin receptor activation increases hyaluronan production in preadipocyte fibroblasts: Contributory role in hyaluronan accumulation in thyroid dysfunction. Journal of Biological Chemistry 284(39), pp. 26447-26455. (10.1074/jbc.M109.003616)
- Brennan, P. et al. 2009. Quantitative nuclear proteomics reveals new phenotypes altered in lymphoblastoid cells. Proteomics - Clinical Applications 3(3), pp. 359-369. (10.1002/prca.200800137)
- Rees, D. A., Giles, P. J., Lewis, M. D. and Ham, J. 2009. Adenosine regulates thrombomodulin and endothelial protein C receptor expression in folliculostellate cells of the pituitary gland. Purinergic Signalling 6(1), pp. 19-29. (10.1007/s11302-009-9172-0)
- Kipling, D. G. et al. 2009. A transcriptomic analysis of the EK1.Br strain of human fibroblastoid keratocytes: the effects of growth, quiescence and senescence. Experimental Eye Research 88(2), pp. 277-285. (10.1016/j.exer.2008.11.030)
- Burton, D. G. A. et al. 2009. Microarray analysis of senescent vascular smooth muscle cells: a link to atherosclerosis and vascular calcification. Experimental Gerontology 44(10), pp. 659-665. (10.1016/j.exger.2009.07.004)
2008
- Wall, I. B. et al. 2008. Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers. Journal of Investigative Dermatology 128(10), pp. 2526-2540. (10.1038/jid.2008.114)
- Peake, M. A., Giles, P. J., Wall, I. B., Enoch, S., Kipling, D. G., Thomas, D. W. and Stephens, P. 2008. Identifying a Gene signature for the wound healing continuum [Abstract]. Wound Repair and Regeneration 16(6), pp. A71. (10.1111/j.1524-475X.2008.00424.x)
2005
- Giles, P. J. 2005. Microarray-based expression profiling: improving data mining and the links to biological knowledge pools. PhD Thesis, Cardiff University.
2002
- Myers, A. et al. 2002. Full genome screen for Alzheimer disease: Stage II analysis. American Journal Of Medical Genetics Part A 114(2), pp. 235-244. (10.1002/ajmg.10183)
2001
- Hamshere, M. L., Giles, P., Krawczak, M. and Owen, M. J. 2001. Statistical analysis of genotypic association data with HAPMAXII. AMERICAN JOURNAL OF HUMAN GENETICS 69(4), pp. 390-390.
Erthyglau
- West, H. D. et al. 2023. Targeted genomic sequencing of TSC1 and TSC2 reveals causal variants in individuals for whom previous genetic testing for tuberous sclerosis complex was normal. Human Mutation: Variation, Informatics and Disease 2023, article number: 4899372. (10.1155/2023/4899372)
- Lohana, P. et al. 2023. Role of enzymic antioxidants in mediating oxidative stress and contrasting wound healing capabilities in oral mucosal/skin fibroblasts and tissues. Antioxidants 12(7), article number: 1374. (10.3390/antiox12071374)
- Shephard, A. P. et al. 2021. Stroma-derived extracellular vesicle mRNA signatures inform histological nature of prostate cancer. Journal of Extracellular Vesicles 10(12), article number: e12150. (10.1002/jev2.12150)
- Ordonez, L. D. et al. 2021. Reproductive history determines ErbB2 locus amplification, WNT signalling and tumour phenotype in a murine breast cancer model. Disease Models and Mechanisms 14(5), article number: dmm048736. (10.1242/dmm.048736)
- Lewis, T. et al. 2021. Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers. Haematologica 106(4), pp. 958-967. (10.3324/haematol.2019.238584)
- Lawson, H. et al. 2021. JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells. Blood Advances 5(3), pp. 889-899. (10.1182/bloodadvances.2020002702)
- Almotiri, A. et al. 2021. Zeb1 modulates hematopoietic stem cell fates required for suppressing acute myeloid leukemia. Journal of Clinical Investigation 131(1), article number: e129115. (10.1172/JCI129115)
- Holzhauser, S. et al. 2020. Sensitivity of human papillomavirus-positive and -negative oropharyngeal cancer cell lines to ionizing irradiation. Oncology Reports (10.3892/or.2020.7709)
- Short, E. et al. 2020. APC transcription studies and molecular diagnosis of familial adenomatous polyposis. European Journal of Human Genetics 28(1), pp. 118-121. (10.1038/s41431-019-0486-2)
- Menendez Gonzalez, J. B. et al. 2019. Gata2 as a crucial regulator of stem cells in adult hematopoiesis and acute myeloid leukemia. Stem Cell Reports 13(2), pp. 291-306. (10.1016/j.stemcr.2019.07.005)
- Pirotte, E. F. et al. 2018. Sensitivity to inhibition of DNA repair by Olaparib in novel oropharyngeal cancer cell lines infected with Human Papillomavirus. PLoS ONE 13(12), pp. -., article number: e0207934. (10.1371/journal.pone.0207934)
- Johnson, C. E. et al. 2018. Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir−bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death. Oncogene 37, pp. 5913-5925. (10.1038/s41388-018-0381-2)
- Caley, M., Wall, I., Peake, M., Kipling, D., Giles, P., Thomas, D. and Stephens, P. 2018. Development and characterisation of a human chronic skin wound cell line - towards an alternative for animal experimentation. International Journal of Molecular Sciences 19(4), article number: 1001. (10.3390/ijms19041001)
- Liao, C. et al. 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46(9), pp. 2222-2232. (10.1002/eji.201646528)
- Bayram-Weston, Z. et al. 2015. Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntington's disease are not reflected in mutant Huntingtin inclusion prevalence. BMC Genomics 16, pp. -., article number: 1079. (10.1186/s12864-015-2251-4)
- Giles, J. L., Choy, E., van den Berg, C., Morgan, B. P. and Harris, C. L. 2014. Functional analysis of a complement polymorphism (rs17611) associated with Rheumatoid Arthritis. Immunology 143(s2), pp. 181-182. (10.1111/imm.12407)
- Bryant, D. et al. 2014. mRNA sequencing of novel cell lines from human papillomavirus type-16 related vulval intraepithelial neoplasia: Consequences of expression of HPV16 E4 and E5. Journal of Medical Virology 86(9), pp. 1534-1541. (10.1002/jmv.23994)
- Peake, M. A. et al. 2014. Identification of a transcriptional signature for the wound healing continuum. Wound Repair and Regeneration 22(3), pp. 399-405. (10.1111/wrr.12170)
- Rosas, M. et al. 2014. The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal. Science 344(6184), pp. 645-648. (10.1126/science.1251414)
- Giles, P. J., Elliston, L. A., Higgs, G., Brooks, S. P., Dunnett, S. B. and Jones, L. 2012. Longitudinal analysis of gene expression and behaviour in the HdhQ150 mouse model of Huntington's disease. Brain Research Bulletin 88(2-3), pp. 199-209. (10.1016/j.brainresbull.2011.10.001)
- Bennett, M. R. et al. 2012. Bioinformatic analyses of genome wide nucleotide excision repair datasets in Saccharomyces cerevisiae [Abstract]. Mutagenesis 27(1), pp. 121. (10.1093/mutage/ger068)
- Feyeux, M. et al. 2012. Early transcriptional changes linked to naturally occurring Huntington's disease mutations in neural derivatives of human embryonic stem cells. Human Molecular Genetics 21(17), pp. 3883-3895. (10.1093/hmg/dds216)
- Enoch, S. et al. 2010. 'Young' oral fibroblasts are geno/phenotypically distinct. Journal of Dental Research 89(12), pp. 1407-1413. (10.1177/0022034510377796)
- Welton, J. L. et al. 2010. Proteomics analysis of bladder cancer exosomes. Molecular & Cellular Proteomics 9(6), pp. 1324-1338. (10.1074/mcp.M000063-MCP201)
- Enoch, S. et al. 2009. Increased oral fibroblast lifespan is telomerase-independent. Journal of Dental Research 88(10), pp. 916-921. (10.1177/0022034509342979)
- Zhang, L. et al. 2009. Thyrotropin receptor activation increases hyaluronan production in preadipocyte fibroblasts: Contributory role in hyaluronan accumulation in thyroid dysfunction. Journal of Biological Chemistry 284(39), pp. 26447-26455. (10.1074/jbc.M109.003616)
- Brennan, P. et al. 2009. Quantitative nuclear proteomics reveals new phenotypes altered in lymphoblastoid cells. Proteomics - Clinical Applications 3(3), pp. 359-369. (10.1002/prca.200800137)
- Rees, D. A., Giles, P. J., Lewis, M. D. and Ham, J. 2009. Adenosine regulates thrombomodulin and endothelial protein C receptor expression in folliculostellate cells of the pituitary gland. Purinergic Signalling 6(1), pp. 19-29. (10.1007/s11302-009-9172-0)
- Kipling, D. G. et al. 2009. A transcriptomic analysis of the EK1.Br strain of human fibroblastoid keratocytes: the effects of growth, quiescence and senescence. Experimental Eye Research 88(2), pp. 277-285. (10.1016/j.exer.2008.11.030)
- Burton, D. G. A. et al. 2009. Microarray analysis of senescent vascular smooth muscle cells: a link to atherosclerosis and vascular calcification. Experimental Gerontology 44(10), pp. 659-665. (10.1016/j.exger.2009.07.004)
- Wall, I. B. et al. 2008. Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers. Journal of Investigative Dermatology 128(10), pp. 2526-2540. (10.1038/jid.2008.114)
- Peake, M. A., Giles, P. J., Wall, I. B., Enoch, S., Kipling, D. G., Thomas, D. W. and Stephens, P. 2008. Identifying a Gene signature for the wound healing continuum [Abstract]. Wound Repair and Regeneration 16(6), pp. A71. (10.1111/j.1524-475X.2008.00424.x)
- Myers, A. et al. 2002. Full genome screen for Alzheimer disease: Stage II analysis. American Journal Of Medical Genetics Part A 114(2), pp. 235-244. (10.1002/ajmg.10183)
- Hamshere, M. L., Giles, P., Krawczak, M. and Owen, M. J. 2001. Statistical analysis of genotypic association data with HAPMAXII. AMERICAN JOURNAL OF HUMAN GENETICS 69(4), pp. 390-390.
Gosodiad
- Giles, P. J. 2005. Microarray-based expression profiling: improving data mining and the links to biological knowledge pools. PhD Thesis, Cardiff University.
Bywgraffiad
Trosolwg gyrfa
2022 Cynghorydd Proffesiynol presennol ar gyfer Gwyddor Data - Is-adran Canser a Geneteg, Prifysgol Caerdydd
Rheolwr Biowybodeg a Biowybodeg Arweiniol 2019-2022 - Parc Geneteg Cymru, Prifysgol Caerdydd
2011-2019 Cydymaith Ymchwil yn NGS Biowybodeg - Canolfan Ymchwil Canser Cymru, Prifysgol Caerdydd
Cymrawd Ymchwil 2005-2011 mewn Biowybodeg Microarray - Central Biotechnology Services, Prifysgol Caerdydd
2000-2001 Cynorthwy-ydd Ymchwil mewn Biowybodeg a Chyfrifiadureg - Coleg Meddygaeth Prifysgol Cymru
Addysg a chymwysterau
2005 - PhD Meddygaeth, Prifysgol Caerdydd - Proffilio mynegiant ar sail microarray: gwella mwyngloddio data a'r cysylltiadau â phyllau gwybodaeth fiolegol [goruchwyliwr Yr Athro David Kipling]
2002 - Diploma mewn Dulliau Biofeddygol, Coleg Meddygaeth Prifysgol Cymru
1999 - BSc (Anrh) Ffarmacoleg, Prifysgol Caerdydd
Arbenigeddau
- Gwyddor data
- Biowybodeg a bioleg gyfrifiadurol
- Cyfrifiadura perfformiad uchel
- Amgylcheddau ymchwil dibynadwy (TREs)
- Dysgu peirianyddol