Dr Luke Davies

2024

• Gurney, M. et al. 2024. Lentiviral vector preparation for efficient gene and microRNA modulation of peritoneal cavity tissue-resident macrophages in vivo in mice. Journal of Visualized Experiments 204, article number: e64926. (10.3791/64926)

2023

• Oruganti, S. et al. 2023. Immune and metabolic markers for identifying and investigating severe Coronavirus disease and Sepsis in children and young people (pSeP/COVID ChYP study): protocol for a prospective cohort study. BMJ Open 13, article number: e067002. (10.1136/bmjopen-2022-067002)

2022

• Sharma, S., Rodrigues, P. R. S., Zaher, S., Davies, L. C. and Ghazal, P. 2022. Immune-metabolic adaptations in pregnancy: A potential stepping-stone to sepsis. EBioMedicine 86, article number: 104337. (10.1016/j.ebiom.2022.104337)
• Dievernich, A., Achenbach, P., Davies, L. and Klinge, U. 2022. Characterization of innate and adaptive immune cells involved in the foreign body reaction to polypropylene meshes in the human abdomen. Hernia 26, pp. 309-323. (10.1007/s10029-021-02396-7)
• Misheva, M. et al. 2022. Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation. Nature Communications 13(1), article number: 139. (10.1038/s41467-021-27766-8)

2021

• Chakraborty, M. et al. 2021. nSeP: immune and metabolic biomarkers for early detection of neonatal sepsis-protocol for a prospective multicohort study. BMJ Open 11(12), article number: e050100. (10.1136/bmjopen-2021-050100)
• Crittenden, S. et al. 2021. Prostaglandin E2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells. Science Advances 7(7), article number: eabd7954. (10.1126/sciadv.abd7954)

2020

• Dievernich, A., Achenbach, P., Davies, L. and Klinge, U. 2020. Tissue remodeling macrophages morphologically dominate at the interface of polypropylene surgical meshes in the human abdomen. Hernia 24, pp. 1175-1189. (10.1007/s10029-020-02315-2)
• Rodrigues, P. R. S. et al. 2020. Innate immunology in COVID-19-a living review. Part II: dysregulated inflammation drives immunopathology. Oxford Open Immunology 1(1), article number: iqaa005. (10.1093/oxfimm/iqaa005)
• Coveney, C. et al. 2020. Innate immunology in COVID-19?a living review. Part I: viral entry, sensing and evasion. Oxford Open Immunology 1(1), article number: iqaa004. (10.1093/oxfimm/iqaa004)
• Klinge, U., Dievernich, A., Tolba, R., Klosterhalfen, B. and Davies, L. 2020. CD68 + macrophages as crucial components of the foreign body reaction demonstrate an unconventional pattern of functional markers quantified by analysis with double fluorescence staining. Journal of Biomedical Materials Research Part B: Applied Biomaterials 108(8), pp. 3134-3145. (10.1002/jbm.b.34639)
• Ipseiz, N. et al. 2020. Tissue‐resident macrophages actively suppress IL‐1beta release via a reactive prostanoid/IL‐10 pathway. EMBO Journal 39(14), article number: e103454. (10.15252/embj.2019103454)
• Ipseiz, N., Czubala, M. A., Bart, V. M., Davies, L. C., Jenkins, R. H., Brennan, P. and Taylor, P. R. 2020. Effective in vivo gene modification in mouse tissue-resident peritoneal macrophages by intraperitoneal delivery of lentiviral vectors. Molecular Therapy - Methods and Clinical Development 16, pp. 21-31. (10.1016/j.omtm.2019.10.004)
• Palmieri, E. M. et al. 2020. Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase. Nature Communications 11(1), article number: 698. (10.1038/s41467-020-14433-7)

2019

• Thompson, A. et al. 2019. The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors. PLoS Pathogens 15(6), article number: e1007850. (10.1371/journal.ppat.1007850)
• Davies, L. C., Rice, C. M., McVicar, D. W. and Weiss, J. M. 2019. Diversity and environmental adaptation of phagocytic cell metabolism. Journal of Leukocyte Biology 105(1), pp. 37-48. (10.1002/JLB.4RI0518-195R)

2018

• Rice, C. M. et al. 2018. Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression. Nature Communications 9, article number: 5099. (10.1038/s41467-018-07505-2)
• Weiss, J. et al. 2018. Itaconic acid mediates crosstalk between macrophage metabolism and and peritoneal tumors. Journal of Clinical Investigation 128(9), pp. 3794-3805. (10.1172/JCI99169)

2017

• Davies, L., Rice, C. M., Palmieri, E. M., Taylor, P., Kuhns, D. B. and McVicar, D. W. 2017. Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels. Nature Communications 8(1), article number: 2074. (10.1038/s41467-017-02092-0)
• McLean, M. H. et al. 2017. Interleukin-27 is a potential rescue therapy for acute severe colitis through Interleukin-10–Dependent, T-Cell–independent attenuation of colonic mucosal innate immune responses. Inflammatory Bowel Diseases 23(11), pp. 1983-1995. (10.1097/MIB.0000000000001274)

2016

• Baseler, W. A. et al. 2016. Autocrine IL-10 functions as a rheostat for M1 macrophage glycolytic commitment by tuning nitric oxide production. Redox Biology 10, pp. 12-23. (10.1016/j.redox.2016.09.005)
• Liao, C. et al. 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46(9), pp. 2222-2232. (10.1002/eji.201646528)

2015

• Davies, L. C. and Taylor, P. R. 2015. Tissue-resident macrophages: then and now. Immunology 144(4), pp. 541-548. (10.1111/imm.12451)

2014

• Rosas, M. et al. 2014. The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal. Science 344(6184), pp. 645-648. (10.1126/science.1251414)
• Jenkins, R. H. et al. 2014. miR-192 induces G2/M growth arrest in aristolochic acid nephropathy. American Journal of Pathology 184(4), pp. 996-1009. (10.1016/j.ajpath.2013.12.028)
• Davies, L. C. 2014. Control of macrophage homeostasis. PhD Thesis, Cardiff University.

2013

• Davies, L. C. et al. 2013. Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation. Nature Communications 4, article number: 1886. (10.1038/ncomms2877)
• Davies, L. C., Jenkins, S., Allen, J. and Taylor, P. R. 2013. Tissue-resident macrophages [review]. Nature Immunology 14(10), pp. 986-995. (10.1038/ni.2705)

2011

• Rosas, M. et al. 2011. Hoxb8 conditionally immortalised macrophage lines model inflammatory monocytic cells with important similarity to dendritic cells. European Journal of Immunology 41(2), pp. 356-365. (10.1002/eji.201040962)
• Liddiard, K., Rosas, M., Davies, L. C., Jones, S. A. and Taylor, P. R. 2011. Macrophage heterogeneity and acute inflammation. European Journal of Immunology 41(9), pp. 2503-2508. (10.1002/eji.201141743)
• Davies, L. C., Rosas, M., Smith, P. J., Fraser, D. J., Jones, S. A. and Taylor, P. R. 2011. A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation. European Journal of Immunology 41(8), pp. 2155-2164. (10.1002/eji.201141817)