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Dr Mathew Clement
Cymrawd Ymchwil
- ClementM@caerdydd.ac.uk
- +44 29206 87337
- Adeilad Henry Wellcome ar gyfer Ymchwil Biofeddygol, Ystafell 3F08, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
Trosolwyg
Rwy'n Gymrawd Ymchwil a gefnogir gan Ganolfan Ymchwil Canser Cymru a'r Sefydliad Ymchwil Imiwnedd Systemau sy'n astudio rôl bioleg celloedd imiwnedd yn ystod Glioblastoma a chanserau eraill yr ymennydd, gan weithio gyda'r Athro Awen Gallimore yn yr Is-adran Heintiau ac Imiwnedd, Ysgol Meddygaeth
Cyn hynny, roeddwn yn Asscoiate Ymchwil yn gweithio gyda'r Athro Ian Humphreys yn labordy Ymchwil Humphreys yn yr Is-adran Heintiau ac Imiwnedd, Ysgol Meddygaeth o dan thema Heintiau Parhaus ac Gwrthiannol. Roeddwn hefyd yn aelod o'r grŵp ymchwil Imiwnoleg Feirysol yn yr Is-adran.
Cyhoeddiad
2023
- Whiteside, S. K. et al. 2023. Acquisition of suppressive function by conventional T cells limits antitumor immunity upon Treg depletion. Science Immunology 8(90), article number: eabo5558. (10.1126/sciimmunol.abo5558)
- Clement, M. 2023. The association of microbial infection and adaptive immune cell activation in Alzheimer's disease. Discovery Immunology 2(1), article number: kyad015. (10.1093/discim/kyad015)
- Knezevic, L. et al. 2023. High-affinity CD8 variants enhance the sensitivity of pMHCI antigen recognition via low-affinity TCRs. Journal of Biological Chemistry 299(8), article number: 104981. (10.1016/j.jbc.2023.104981)
- Clement, M. et al. 2023. Inhibitory IL-10-producing CD4+ T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1. eLife 12, article number: e79165. (10.7554/eLife.79165)
2022
- Clement, M. et al. 2022. IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses. Nature Communications 13(1), article number: 5294. (10.1038/s41467-022-32587-4)
2021
- Dimonte, S., Gimeno-Brias, S., Marsden, M., Chapman, L., Sabberwal, P., Clement, M. and Humphreys, I. R. 2021. Optimal CD8+ T-cell memory formation following subcutaneous cytomegalovirus infection requires virus replication but not early dendritic cell responses. Immunology 164(2), pp. 279-291. (10.1111/imm.13368)
- Clement, M. et al. 2021. IFITM3 regulates virus-induced inflammatory cytokine production by titrating Nogo-B orchestration of TLR responses. [Online]. bioRxiv. Available at: https://doi.org/10.1101/2021.07.23.453513
- Clement, M. et al. 2021. CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor. Proceedings of the National Academy of Sciences 118(29), article number: e2019639118. (10.1073/pnas.2019639118)
2020
- Forbester, J. L. et al. 2020. IRF5 promotes influenza-induced inflammatory responses in human iPSC-derived myeloid cells and murine models. Journal of Virology 94(9), article number: e00121-20. (10.1128/JVI.00121-20)
2019
- Thompson, A. et al. 2019. The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors. PLoS Pathogens 15(6), article number: e1007850. (10.1371/journal.ppat.1007850)
- Smith, S. E. et al. 2019. Interferon-induced Transmembrane Protein 1 restricts replication of virus that enter cells via the plasma membrane.. Journal of Virology 93(6), article number: e02003-18. (10.1128/JVI.02003-18)
- McLaren, J. et al. 2019. IL-33 augments virus-specific memory T Cell inflation and potentiates the efficacy of an attenuated cytomegalovirus-based vaccinea. Journal of Immunology 202(3), pp. 943-955. (10.4049/jimmunol.1701757)
- Clement, M. and Humphreys, I. R. 2019. Cytokine-mediated induction and regulation of tissue damage during cytomegalovirus infection. Frontiers in Immunology 10, article number: 78. (10.3389/fimmu.2019.00078)
2018
- Gimeno Brias, S. et al. 2018. Interferon lambda is required for interferon gamma-expressing NK cell responses but does not afford antiviral protection during acute and persistent murine cytomegalovirus infection. PLoS ONE 13(5), article number: e0197596. (10.1371/journal.pone.0197596)
- Miles, J. J. et al. 2018. Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry. Journal of Clinical Investigation 128(4), pp. 1569-1580. (10.1172/JCI91512)
- Lissina, A. et al. 2018. Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions. Scientific Reports 8(1), article number: 2534. (10.1038/s41598-017-18062-x)
2017
- Sowerby, J. M. et al. 2017. NBEAL2 is required for neutrophil and NK cell function and pathogen defense. Journal of Clinical Investigation 127(9), pp. 3521-3526. (10.1172/JCI91684)
- Stacey, M. A. et al. 2017. The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis. Journal of Clinical Investigation 127(4), pp. 1463-1474. (10.1172/JCI84889)
- Cole, D. K. et al. 2017. Structural mechanism underpinning cross-reactivity of a CD8+ T-cell clone that recognises a peptide derived from human telomerase reverse transcriptase. Journal of Biological Chemistry 292(3), pp. 802-813. (10.1074/jbc.M116.741603)
- Dockree, T. et al. 2017. CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold. Immunology and Cell Biology 95(1), pp. 68-76. (10.1038/icb.2016.85)
2016
- Clement, M. et al. 2016. Cytomegalovirus-specific IL-10-producing CD4+ T cells are governed by type-I IFN-induced IL-27 and promote virus persistence. Plos Pathogens 12(12), article number: e1006050. (10.1371/journal.ppat.1006050)
- Clement, M. et al. 2016. Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies. Scientific Reports 6, article number: 35332. (10.1038/srep35332)
- Szomolay, B. et al. 2016. Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors. Immunology and Cell Biology 94(6), pp. 573-582. (10.1038/icb.2016.12)
- Patin, E. et al. 2016. IL-27 induced by Select Candida spp. via TLR7/NOD2 signaling and IFN-β production inhibits fungal clearance. The Journal of Immunology 197(1), pp. 208-221. (10.4049/jimmunol.1501204)
2015
- Neller, M. A. et al. 2015. Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics. Immunology and Cell Biology 93, pp. 625-633. (10.1038/icb.2015.17)
2013
- Lauder, S. N. et al. 2013. Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology. European Journal of Immunology 43(10), pp. 2613-2625. (10.1002/eji.201243018)
- van den Berg, H. A. et al. 2013. Cellular-level versus receptor-level response threshold hierarchies in T-cell activation. Frontiers in Immunology 4, article number: 250. (10.3389/fimmu.2013.00250)
- Eukeruche-Makinde, J. et al. 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood -New York- 121(7), pp. 1112-1123. (10.1182/blood-2012-06-437202)
- Ekeruche, J. et al. 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood 121(7), pp. 1112-1123. (10.1182/blood-2012-06-437202)
- Clement, M. 2013. The role of the CD8 co-receptor in CD8+ T-cell activation. PhD Thesis, Cardiff University.
2012
- Humphreys, I. R. et al. 2012. Avidity of influenza-specific memory CD8+T-cell populations decays over time compromising antiviral immunity. European Journal of Immunology 42(12), pp. 3235-3242. (10.1002/eji.201242575)
- Ekeruche, J. et al. 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287(44), pp. 37269-37281. (10.1074/jbc.M112.386409)
- Ekeruche-Makinde, J. et al. 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287(44), pp. 37269-37281. (10.1074/jbc.M112.386409)
- Cole, D. K., Laugel, B., Clement, M., Price, D. A., Wooldridge, L. and Sewell, A. K. 2012. The molecular determinants of CD8 co-receptor function. Immunology 137(2), pp. 139-148. (10.1111/j.1365-2567.2012.03625.x)
- Cole, D., Laugel, B. F., Clement, M., Price, D., Wooldridge, L. and Sewell, A. K. 2012. The molecular determinants of CD8 co-receptor function. Immunology 137(2), pp. 139-148. (10.1111/j.1365-2567.2012.03625.x)
- Wooldridge, L. et al. 2012. A single autoimmune T cell receptor recognizes more than a million different peptides. Journal of Biological Chemistry 287(2), pp. 1168-1177. (10.1074/jbc.M111.289488)
2011
- Iglesias, M. C. et al. 2011. Escape from highly effective public CD8+ T-cell clonotypes by HIV. Blood 118(8), pp. 2138-2149. (10.1182/blood-2011-01-328781)
- Clement, M. et al. 2011. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. The Journal of Immunology 187(2), pp. 654-663. (10.4049/jimmunol.1003941)
- Laugel, B. F., Cole, D., Clement, M., Wooldridge, L., Price, D. and Sewell, A. K. 2011. The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells. Journal of Leukocyte Biology 90(6), pp. 1089-1099. (10.1189/jlb.0611316)
- Iglesias, M. C. et al. 2011. Escape from highly effective public CD8+ T-cell clonotypes by HIV. Blood 118(8), pp. 2138-2149. (10.1182/blood-2011-01-328781)
2010
- Li, N., McLaren, J. E., Michael, D. R., Clement, M., Fielding, C. A. and Ramji, D. P. 2010. ERK is integral to the IFN-γ-mediated activation of STAT1, the expression of key genes implicated in atherosclerosis, and the uptake of modified lipoproteins by human macrophages. The Journal of Immunology 185(5), pp. 3041-3048. (10.4049/jimmunol.1000993)
- Cole, D. et al. 2010. Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition. The Journal of Immunology 185(4), pp. 2600-2610. (10.4049/jimmunol.1000629)
- Wooldridge, L., Laugel, B. F., Ekeruche, J., Clement, M., van den Berg, H. A., Price, D. and Sewell, A. K. 2010. CD8 controls T cell cross-reactivity. The Journal of Immunology 185(8), pp. 4625-4632. (10.4049/jimmunol.1001480)
- Wooldridge, L. et al. 2010. MHC Class I molecules with superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs. Journal of Immunology 184(7), pp. 3357-3366. (10.4049/jimmunol.0902398)
2009
- Brennan, P. et al. 2009. Quantitative nuclear proteomics reveals new phenotypes altered in lymphoblastoid cells. Proteomics - Clinical Applications 3(3), pp. 359-369. (10.1002/prca.200800137)
- Lissina, A. et al. 2009. Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers. Journal of Immunological Methods 340(1), pp. 11-24. (10.1016/j.jim.2008.09.014)
2008
- Hewamana, S. et al. 2008. The NF-κB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target. Blood 111(9), pp. 4681-4689. (10.1182/blood-2007-11-125278)
- Weichsel, R. et al. 2008. Profound inhibition of antigen-specific T-cell effector functions by dasatinib. Clinical Cancer Research 14(8), pp. 2484-2491. (10.1158/1078-0432.CCR-07-4393)
2006
- White, P. C., Shore, A. M., Clement, M., McLaren, J. E., Soeiro, I., Lam, E. W. and Brennan, P. 2006. Regulation of cyclin D2 and the cyclin D2 promoter by protein kinase A and CREB in lymphocytes. Oncogene 25(15), pp. 2170-2180. (10.1038/sj.onc.1209255)
2005
- Breslin, E. M., White, P., Shore, A. M., Clement, M. and Brennan, P. 2005. LY294002 and rapamycin co-operate to inhibit T-cell proliferation. British Journal of Pharmacology 144(6), pp. 791-800. (10.1038/sj.bjp.0706061)
2004
- Williams, N. M. et al. 2004. Identification in two independent samples of a novel schizophrenia risk haplotype of the dystobrevin binding protein gene (DTNBP1). Archives of general psychiatry 61(4), pp. 336-344. (10.1001/archpsyc.61.4.336)
Articles
- Whiteside, S. K. et al. 2023. Acquisition of suppressive function by conventional T cells limits antitumor immunity upon Treg depletion. Science Immunology 8(90), article number: eabo5558. (10.1126/sciimmunol.abo5558)
- Clement, M. 2023. The association of microbial infection and adaptive immune cell activation in Alzheimer's disease. Discovery Immunology 2(1), article number: kyad015. (10.1093/discim/kyad015)
- Knezevic, L. et al. 2023. High-affinity CD8 variants enhance the sensitivity of pMHCI antigen recognition via low-affinity TCRs. Journal of Biological Chemistry 299(8), article number: 104981. (10.1016/j.jbc.2023.104981)
- Clement, M. et al. 2023. Inhibitory IL-10-producing CD4+ T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1. eLife 12, article number: e79165. (10.7554/eLife.79165)
- Clement, M. et al. 2022. IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses. Nature Communications 13(1), article number: 5294. (10.1038/s41467-022-32587-4)
- Dimonte, S., Gimeno-Brias, S., Marsden, M., Chapman, L., Sabberwal, P., Clement, M. and Humphreys, I. R. 2021. Optimal CD8+ T-cell memory formation following subcutaneous cytomegalovirus infection requires virus replication but not early dendritic cell responses. Immunology 164(2), pp. 279-291. (10.1111/imm.13368)
- Clement, M. et al. 2021. CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor. Proceedings of the National Academy of Sciences 118(29), article number: e2019639118. (10.1073/pnas.2019639118)
- Forbester, J. L. et al. 2020. IRF5 promotes influenza-induced inflammatory responses in human iPSC-derived myeloid cells and murine models. Journal of Virology 94(9), article number: e00121-20. (10.1128/JVI.00121-20)
- Thompson, A. et al. 2019. The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors. PLoS Pathogens 15(6), article number: e1007850. (10.1371/journal.ppat.1007850)
- Smith, S. E. et al. 2019. Interferon-induced Transmembrane Protein 1 restricts replication of virus that enter cells via the plasma membrane.. Journal of Virology 93(6), article number: e02003-18. (10.1128/JVI.02003-18)
- McLaren, J. et al. 2019. IL-33 augments virus-specific memory T Cell inflation and potentiates the efficacy of an attenuated cytomegalovirus-based vaccinea. Journal of Immunology 202(3), pp. 943-955. (10.4049/jimmunol.1701757)
- Clement, M. and Humphreys, I. R. 2019. Cytokine-mediated induction and regulation of tissue damage during cytomegalovirus infection. Frontiers in Immunology 10, article number: 78. (10.3389/fimmu.2019.00078)
- Gimeno Brias, S. et al. 2018. Interferon lambda is required for interferon gamma-expressing NK cell responses but does not afford antiviral protection during acute and persistent murine cytomegalovirus infection. PLoS ONE 13(5), article number: e0197596. (10.1371/journal.pone.0197596)
- Miles, J. J. et al. 2018. Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry. Journal of Clinical Investigation 128(4), pp. 1569-1580. (10.1172/JCI91512)
- Lissina, A. et al. 2018. Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions. Scientific Reports 8(1), article number: 2534. (10.1038/s41598-017-18062-x)
- Sowerby, J. M. et al. 2017. NBEAL2 is required for neutrophil and NK cell function and pathogen defense. Journal of Clinical Investigation 127(9), pp. 3521-3526. (10.1172/JCI91684)
- Stacey, M. A. et al. 2017. The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis. Journal of Clinical Investigation 127(4), pp. 1463-1474. (10.1172/JCI84889)
- Cole, D. K. et al. 2017. Structural mechanism underpinning cross-reactivity of a CD8+ T-cell clone that recognises a peptide derived from human telomerase reverse transcriptase. Journal of Biological Chemistry 292(3), pp. 802-813. (10.1074/jbc.M116.741603)
- Dockree, T. et al. 2017. CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold. Immunology and Cell Biology 95(1), pp. 68-76. (10.1038/icb.2016.85)
- Clement, M. et al. 2016. Cytomegalovirus-specific IL-10-producing CD4+ T cells are governed by type-I IFN-induced IL-27 and promote virus persistence. Plos Pathogens 12(12), article number: e1006050. (10.1371/journal.ppat.1006050)
- Clement, M. et al. 2016. Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies. Scientific Reports 6, article number: 35332. (10.1038/srep35332)
- Szomolay, B. et al. 2016. Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors. Immunology and Cell Biology 94(6), pp. 573-582. (10.1038/icb.2016.12)
- Patin, E. et al. 2016. IL-27 induced by Select Candida spp. via TLR7/NOD2 signaling and IFN-β production inhibits fungal clearance. The Journal of Immunology 197(1), pp. 208-221. (10.4049/jimmunol.1501204)
- Neller, M. A. et al. 2015. Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics. Immunology and Cell Biology 93, pp. 625-633. (10.1038/icb.2015.17)
- Lauder, S. N. et al. 2013. Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology. European Journal of Immunology 43(10), pp. 2613-2625. (10.1002/eji.201243018)
- van den Berg, H. A. et al. 2013. Cellular-level versus receptor-level response threshold hierarchies in T-cell activation. Frontiers in Immunology 4, article number: 250. (10.3389/fimmu.2013.00250)
- Eukeruche-Makinde, J. et al. 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood -New York- 121(7), pp. 1112-1123. (10.1182/blood-2012-06-437202)
- Ekeruche, J. et al. 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood 121(7), pp. 1112-1123. (10.1182/blood-2012-06-437202)
- Humphreys, I. R. et al. 2012. Avidity of influenza-specific memory CD8+T-cell populations decays over time compromising antiviral immunity. European Journal of Immunology 42(12), pp. 3235-3242. (10.1002/eji.201242575)
- Ekeruche, J. et al. 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287(44), pp. 37269-37281. (10.1074/jbc.M112.386409)
- Ekeruche-Makinde, J. et al. 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287(44), pp. 37269-37281. (10.1074/jbc.M112.386409)
- Cole, D. K., Laugel, B., Clement, M., Price, D. A., Wooldridge, L. and Sewell, A. K. 2012. The molecular determinants of CD8 co-receptor function. Immunology 137(2), pp. 139-148. (10.1111/j.1365-2567.2012.03625.x)
- Cole, D., Laugel, B. F., Clement, M., Price, D., Wooldridge, L. and Sewell, A. K. 2012. The molecular determinants of CD8 co-receptor function. Immunology 137(2), pp. 139-148. (10.1111/j.1365-2567.2012.03625.x)
- Wooldridge, L. et al. 2012. A single autoimmune T cell receptor recognizes more than a million different peptides. Journal of Biological Chemistry 287(2), pp. 1168-1177. (10.1074/jbc.M111.289488)
- Iglesias, M. C. et al. 2011. Escape from highly effective public CD8+ T-cell clonotypes by HIV. Blood 118(8), pp. 2138-2149. (10.1182/blood-2011-01-328781)
- Clement, M. et al. 2011. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. The Journal of Immunology 187(2), pp. 654-663. (10.4049/jimmunol.1003941)
- Laugel, B. F., Cole, D., Clement, M., Wooldridge, L., Price, D. and Sewell, A. K. 2011. The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells. Journal of Leukocyte Biology 90(6), pp. 1089-1099. (10.1189/jlb.0611316)
- Iglesias, M. C. et al. 2011. Escape from highly effective public CD8+ T-cell clonotypes by HIV. Blood 118(8), pp. 2138-2149. (10.1182/blood-2011-01-328781)
- Li, N., McLaren, J. E., Michael, D. R., Clement, M., Fielding, C. A. and Ramji, D. P. 2010. ERK is integral to the IFN-γ-mediated activation of STAT1, the expression of key genes implicated in atherosclerosis, and the uptake of modified lipoproteins by human macrophages. The Journal of Immunology 185(5), pp. 3041-3048. (10.4049/jimmunol.1000993)
- Cole, D. et al. 2010. Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition. The Journal of Immunology 185(4), pp. 2600-2610. (10.4049/jimmunol.1000629)
- Wooldridge, L., Laugel, B. F., Ekeruche, J., Clement, M., van den Berg, H. A., Price, D. and Sewell, A. K. 2010. CD8 controls T cell cross-reactivity. The Journal of Immunology 185(8), pp. 4625-4632. (10.4049/jimmunol.1001480)
- Wooldridge, L. et al. 2010. MHC Class I molecules with superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs. Journal of Immunology 184(7), pp. 3357-3366. (10.4049/jimmunol.0902398)
- Brennan, P. et al. 2009. Quantitative nuclear proteomics reveals new phenotypes altered in lymphoblastoid cells. Proteomics - Clinical Applications 3(3), pp. 359-369. (10.1002/prca.200800137)
- Lissina, A. et al. 2009. Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers. Journal of Immunological Methods 340(1), pp. 11-24. (10.1016/j.jim.2008.09.014)
- Hewamana, S. et al. 2008. The NF-κB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target. Blood 111(9), pp. 4681-4689. (10.1182/blood-2007-11-125278)
- Weichsel, R. et al. 2008. Profound inhibition of antigen-specific T-cell effector functions by dasatinib. Clinical Cancer Research 14(8), pp. 2484-2491. (10.1158/1078-0432.CCR-07-4393)
- White, P. C., Shore, A. M., Clement, M., McLaren, J. E., Soeiro, I., Lam, E. W. and Brennan, P. 2006. Regulation of cyclin D2 and the cyclin D2 promoter by protein kinase A and CREB in lymphocytes. Oncogene 25(15), pp. 2170-2180. (10.1038/sj.onc.1209255)
- Breslin, E. M., White, P., Shore, A. M., Clement, M. and Brennan, P. 2005. LY294002 and rapamycin co-operate to inhibit T-cell proliferation. British Journal of Pharmacology 144(6), pp. 791-800. (10.1038/sj.bjp.0706061)
- Williams, N. M. et al. 2004. Identification in two independent samples of a novel schizophrenia risk haplotype of the dystobrevin binding protein gene (DTNBP1). Archives of general psychiatry 61(4), pp. 336-344. (10.1001/archpsyc.61.4.336)
Thesis
- Clement, M. 2013. The role of the CD8 co-receptor in CD8+ T-cell activation. PhD Thesis, Cardiff University.
Websites
- Clement, M. et al. 2021. IFITM3 regulates virus-induced inflammatory cytokine production by titrating Nogo-B orchestration of TLR responses. [Online]. bioRxiv. Available at: https://doi.org/10.1101/2021.07.23.453513
Ymchwil
Ar hyn o bryd mae fy ymchwil yn archwilio pa rôl mae celloedd imiwnedd, yn enwedig celloedd-T, yn ei chwarae yn ystod Glioblastoma (GBM). Mae gen i ddiddordeb mewn archwilio sut y gallwn ddylunio triniaethau newydd ar gyfer y clefyd angheuol hwn sy'n un o'r canserau sydd wedi goroesi'n wael. Nid oes unrhyw therapïau effeithiol ar gyfer GBM gyda chyfraddau goroesi o rhwng 12 a 15 mis, felly nod y gwaith a wnawn yw mynd i'r afael â'r broblem hon a gwneud newidiadau cam allweddol yn ein dealltwriaeth o'r rhyngwyneb rhwng y system imiwnedd a thiwmor yr ymennydd.
Addysgu
I currently perform lecturing and laboratory supervision of self-selected component of the MB BCh undergraduate medical course as part of the Cardiff University C21 medical curriculum that includes;
Year 1 - Small Group (PCS) Tutor, Applied Immunology, C21
Year 1 - Literature review component tutor, C21
Year 2 - Virology Tutor, C21
SSC Year 2 – Interactive Immunology Laboratory Placement Supervisor, C21
SSC Year 2 – Applied Interactive Immunology lectures, C21
MSc in Applied Experimental and Clinical Immunology.
Bywgraffiad
Education:
2013 - PhD in Immunology, Cardiff University, Cardiff
2001 - BSc in Biomedical Sciences, UWIC, Cardiff
Career overview:
Cardiff University:
2003 - present - Division of Infection & Immunity
2002 - 2003 - Dept of Psychological Medicine
Anrhydeddau a dyfarniadau
2022 - CMV 2022 merit based award
2021 - ICIS - International Cytokine & Inteferon Society annual meeting Milstein award
2021 - Cardiff University Infection & Immunity annual meeting oral presentation award
2019 - CMV 2019 merit based award
2019 - CURE Infection annual meeting oral presentation award
2018 - Hodge Centre for Neuropsychiatric Immunology project grant award
2017 - Hodge Centre for Neuropsychiatric Immunology seedcorn award
2016 - BSI Bright Spark in Immunology oral presentation award (post-doc session)
2016 - Cardiff University Animal Welfare Symposium NC3Rs award
2015 - BSI travel award
2014 - Cardiff University Infection & Immunity annual meeting oral presentation award
2013 - Cardiff University Independent Researcher Secondment Lecturer position
Aelodaethau proffesiynol
British Society of Immunology
International Cytokine & Interferon Society
Safleoedd academaidd blaenorol
Cardiff University:
2013 - present - Research Asscoiate - Division of Infection & Immunity, Cardiff University
2003 - 2013 - Research Assistant - Division of Infection & Immunity, Cardiff University
2002 - 2003 - Research Technician - Division of Psychological Medicine, Cardiff University
Pwyllgorau ac adolygu
I am a regular peer reviewer for journals including Immunology, Scientific Reports and have assisted in the review of multiple articles in Journal of Virology, Journal of General Virology, Journal of Immunology and Therapy Cancer, European Journal of Immunology, Journal of Pathology and PNAS.
I have also chaired sessions at the British Society of Immunology Annual meetings.
I am also the Early Career Representative for the Division of Infection and immunity
Ymgysylltu
2010 - Participation in the Wellcome Trust funded Researchers in Residence scheme, which included a featured article written about my teaching experience; http://wellcometrust.wordpress.com/2011/03/02/guest-post-researchers-in-residence/
(2006-Present) - Participated in coordination of the Immunology section of Cardiff University's Annual Science in Health Day, promoting biomedical research to students from South Wales and Southwest England.
2018 - Participated in St Brides Major primary school life sciences event, highlighting infectious diseases to Year 4 students, including practical use of Microscopes, buiding Lego antibodies and having fun making various types of 'snot & slime'.
2019 - Presented at the annual 'Pint of Science' series of public lectures.
2019 - Presented as guest sepaker and subsequent panel discussion at the Royal Society of Biology South Wales division annual meeting.
2019 - Participated in the 'future leavers career fayre' as a representative of Cardiff University School of Medicine, promoting an academic career to Yr11 and Yr12 students at St Martins High School, Caerphilly.
