Ewch i’r prif gynnwys
Yr Athro Aled Clayton

Yr Athro Aled Clayton

Senior Lecturer

Yr Ysgol Meddygaeth

Email:
claytona@cardiff.ac.uk
Telephone:
+44 (0)29 2251 0589
Location:
GF16, Adeilad Tenovus, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN

Career overview

  • Snr Lecturer (08/2013-present), Division of Cancer & Genetics, Cardiff University
  • Lecturer; (08/2004 to 07/2013), School of Medicine, Cardiff University
  • Research Fellow (01/1999 to 07/2004) School of Medicine, Cardiff University
  • Research Fellow, (10/1996 to 12/1998) School of Medicine, Cardiff University

Education & qualifications

  • 1997: PhD (Medicine), Institute of Nephrology, University of Wales College of Medicine.
  • 1998: Diploma in Biomedical methods, University of Wales College of Medicine.
  • 1993: BSc (Hons) Biochemistry,  University of Wales College Cardiff

Aelodaethau proffesiynol

Safleoedd academaidd blaenorol

  • Snr Lecturer (08/2013-present), Division of Cancer & Genetics, Cardiff University
  • Lecturer; (08/2004 to 07/2013), School of Medicine, Cardiff University
  • Research Fellow (01/1999 to 07/2004) School of Medicine, Cardiff University
  • Research Fellow, (10/1996 to 12/1998) School of Medicine, Cardiff University

Ymrwymiadau siarad cyhoeddus

  • 2017: Science Seminar, The School of Clinical Dentistry, Sheffield, UK.
  • 2016: Frontiers of Science, University of Turku, Finland
  • 2016: Meet the Experts, International Society for Extracellular Vesicles Annual Congress, Rotterdam, NL
  • 2015: Plenary Speaker, 11th World Congress on urological Research (ESUR-SBUR15), Nijmegen, NL
  • 2014: University of Oslo, Science Seminar Series
  • 2013: United Kingdom Extracellular Vesicle Forum, Society for Endocrinology, Royal Veterinary College, London
  • 2013: Cancer Research Wales Symposium, Cardiff.
  • 2012: Cancer Biology Seminar Series, CR-UK Patterson Institute, Manchester, UK.
  • 2012: Science Seminar Series, The School of Pharmacy & Pharmaceutical Science Cardiff

Session Chair

  • 2017: International Society for Extracellular Vesicles, Toronto
  • 2016: International Society for Extracellular Vesicles, Rotterdam. Diamond Session and others
  • 2015: United Kingdom Extracellular Vesicle Forum, Host.
  • 2014: International Society for Extracellular Vesicles, Rotterdam.
  • 2014: United Kingdom Extracellular Vesicle Forum.
  • 2013: International Society for Extracellular Vesicles, Boston

Pwyllgorau ac adolygu

External Committees

  • 2015-2017: NCRI Clinical Studies Group - Molecular Biomarkers Advisory Group
  • 2015- United Kingdom Extracellular vesicle Forum, annual conference organiser and co-organiser 2014, 2016 ongoing.
  • 2016- International Society for Extracellular vesicles, Annual Conference Local Organising Committee, Rotterdam
  • 2016-2017- Organising Committee, Royal Society Discussion Meeting, EV in the Cancer Microenvironment, London 2017.

PhD Examiner

  • 2017. External Examiner, PhD St Andrews
  • 2016. External Examiner, PhD Leicester University
  • 2015. Second Opponent, PhD Oslo, Norway
  • 2014. External Examiner, PhD Oxford Brookes
  • 2013. Internal Examiner, PhD, Cardiff

Editor

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Intercalated BSc and Pharmacology degrees:

  • Develop and mark lab-based reseach projects.
  • Mark student research presentations

College of Biomedical Life Science

  • MSc in Cancer Biology (2016)

Postgraduate Students

Primary Supervisor:

  • Mr Vincent Yeung (2013- end 2016), co-supervisor Dr Jason Webber
  • Mr Alex Cocks (2015-2018), co-supervisors Prof. Arwyn T Jones (PHRMY) and Dr Peter Watson (BIOSCI)

Co-Supervisor

  • Mr Rhodri Thomas (Vesicle RNA in Alzheimer's Disease), supervised with Prof Julie Williams
  • Miss Donna Mathews (Vesicles in Cardio Vascular Disease), supervised with Dr Aled Rees & Prof Philip James
  • Mr Robert Knight (Vesicles in wound healing), supervised with Prof Philip Stephens and Dr Julie Albon
  • Mr Ben Lanning (micro RNA and vesicles in cancer), supervised with Dr Alwyn Dart & Dr Bronwen Evans

additional contributions through collaborative interactions with PhD candidates

  • Miss Hope Roberts Dalton, (PHRMY), supervised by Prof Arwyn T Jones.

We are interested in understanding how cells produce small fat-bubbles (vesicles), and why they seem to do this so extensively. Our studies focus on the role of such bubbles in changing the immediate surroundings of the cancer tissue. it seems these bubbles (exosomes) can interfere with the correct function of immune cells, they can encourage formation of blood vessels, and can hijack other neighbouring cells to behave abnormally- all of these effects assist the growth and ultimate spread of the tumour.

We can also detect exosomes in the urine and blood of cancer patients, and we are working hard on developing new methods to isolate exosomes from biological fluids, and to use these as means of discovering new indicators of disease. We have examined the complex array of protein molecules on the vesicles, and are beginning to also look at RNA-molecules, which hide inside the bubble.

Together, these studies will provide much needed information about how the cancer cells can dominate and take-over their microenvironments. Learning how to block these effects is likely to be very useful therapeutically. Pperhaps we can also use the presence of exosomes in urine/blood as future tests to support diagnoses and monitoring of cancer.

Funding sources

  • Cancer Research Wales, Programme grant:
  • Movember: The Movember Revolutionary Team Award
  • Prostate Cancer UK: British Heart Foundation:
  • British Lung Foundation:
  • CU & ReNeuron:
  • Tenovus Cancer Care:
  • Welsh Assembly Government NRN Sêr Cymru Award: