Yr Athro Richard Adams

2019

• Barber, P. R.et al. 2019. HER2-HER3 heterodimer quantification by FRET-FILM and patient subclass analysis of the COIN colorectal trial. JNCI: Journal of the National Cancer Institute (10.1093/jnci/djz231)
• Joharatnam-Hogan, N.et al. 2019. Aspirin as an adjuvant treatment for cancer: feasibility results from the Add-Aspirin randomised trial. Lancet Gastroenterology and Hepatology 4(11), pp. 854-862. (10.1016/S2468-1253(19)30289-4)

2018

• Fish, R.et al. 2018. A core outcome set for clinical trials of chemoradiotherapy interventions for anal cancer (CORMAC): a patient and health-care professional consensus. Lancet Gastroenterology and Hepatology 3(12), pp. 865-873. (10.1016/S2468-1253(18)30264-4)
• Elwood, P.et al. 2018. Systematic review update of observational studies further supports aspirin role in cancer treatment: Time to share evidence and decision-making with patients?. PLoS ONE 13(9), pp. e0203957. (10.1371/journal.pone.0203957)
• West, H.et al. 2018. Role for nucleotide-excision repair gene variants in oxaliplatin-induced peripheral neuropathy. JCO Precision Oncology 2, pp. 1-18. (10.1200/PO.18.00090)
• Madi, A.et al. 2018. Pharmacogenetic analyses of 2,183 patients with advanced colorectal cancer; Potential role for common dihydropyrimidine dehydrogenase variants in toxicity to chemotherapy.. European Journal of Cancer 102, pp. 31-39. (10.1016/j.ejca.2018.07.009)
• Goey, K. K.et al. 2018. Consensus statement on essential patient characteristics in systemic treatment trials for metastatic colorectal cancer: Supported by the ARCAD Group. European Journal of Cancer 100, pp. 35-45. (10.1016/j.ejca.2018.05.010)
• Gollins, S.et al. 2018. A prospective phase II study of pre-operative chemotherapy then short-course radiotherapy for high risk rectal cancer: COPERNICUS. British Journal of Cancer (10.1038/s41416-018-0209-4)
• Jones, C. M.et al. 2018. Toxicity, tolerability, and compliance of concurrent capecitabine or 5-fluorouracil in radical management of anal cancer with single-dose mitomycin-C and intensity modulated radiation therapy: evaluation of a national cohort. International Journal of Radiation Oncology - Biology - Physics 101(5), pp. 1202-1211. (10.1016/j.ijrobp.2018.04.033)
• Sjoquist, K. M.et al. 2018. Personalizing survival predictions in advanced colorectal cancer: the ARCAD nomogram project. JNCI: Journal of the National Cancer Institute 110(6), pp. 638-648. (10.1093/jnci/djx253)
• Rose, G.et al. 2018. The cardiopulmonary exercise test grey zone; optimising fitness stratification by application of critical difference. British Journal of Anaesthesia 120(6), pp. 1187-1194. (10.1016/j.bja.2018.02.062)
• Alderdice, M.et al. 2018. Prospective patient stratification into robust cancer-cell intrinsic subtypes from colorectal cancer biopsies. The Journal of Pathology 245(1), pp. 19-28. (10.1002/path.5051)

2017

• Scurr, M.et al. 2017. Effect of modified vaccinia Ankara–5T4 and low-dose cyclophosphamide on antitumor immunity in metastatic colorectal cancer: A randomized clinical trial. JAMA Oncology 3(10), article number: e172579. (10.1001/jamaoncol.2017.2579)
• Scurr, M. J.et al. 2017. Low-dose cyclophosphamide induces anti-tumor T-cell responses which associate with survival in metastatic colorectal cancer. Clinical Cancer Research, article number: clincanres.0895.2017. (10.1158/1078-0432.CCR-17-0895)
• Scurr, M.et al. 2017. MVA-5T4 immunotherapy and low-dose cyclophosphamide for advanced colorectal cancer (TaCTiCC): An open-label, randomized phase I/II trial.. Journal of Clinical Oncology 35(7), pp. 154-154. (10.1200/JCO.2017.35.7_suppl.154)
• Seligmann, J.et al. 2017. Investigating the poor outcomes of BRAF-mutant advanced colorectal cancer: Analysis from 2530 patients in randomised clinical trials. Annals of Oncology 28(3), pp. 562-568. (10.1093/annonc/mdw645)
• Adams, R. 2017. Surveillance of anal canal cancers. Surgical Oncology Clinics of North America 26(1), pp. 127-132. (10.1016/j.soc.2016.07.007)
• Wood, G.et al. 2017. Derived neutrophil to lymphocyte ratio as a prognostic factor in patients with advanced colorectal cancer according to RAS and BRAF status. Anti-Cancer Drugs 28(5), pp. 546-550. (10.1097/CAD.0000000000000488)

2016

• Franko, J.et al. 2016. Prognosis of patients with peritoneal metastatic colorectal cancer given systemic therapy: an analysis of individual patient data from prospective randomised trials from the Analysis and Research in Cancers of the Digestive System (ARCAD) database. Lancet Oncology 17(12), pp. 1709-1719. (10.1016/S1470-2045(16)30500-9)
• Muirhead, R.et al. 2016. Initial results from the Royal College of Radiologists' UK national audit of anal cancer radiotherapy 2015. Clinical Oncology 29(3), pp. 188-197. (10.1016/j.clon.2016.10.005)
• Weber, A. M.et al. 2016. Phenotypic consequences of somatic mutations in the ataxia-telangiectasia mutated gene in non-small cell lung cancer. Oncotarget 7(38), pp. 60807-60822. (10.18632/oncotarget.11845)
• Sharma, R. A.et al. 2016. Clinical development of new drug-radiotherapy combinations. Nature Reviews Clinical Oncology 13, pp. 627-642. (10.1038/nrclinonc.2016.79)
• Hendry, M.et al. 2016. Talking about human papillomavirus and cancer: protocol for a patient-centred study to develop scripted consultations. BMJ Open 6(4), article number: e011205. (10.1136/bmjopen-2016-011205)
• Ciardiello, F.et al. 2016. Awareness, understanding, and adoption of precision medicine to deliver personalized treatment for patients with cancer: a multinational survey comparison of physicians and patients. The Oncologist 21(3), pp. 292-300. (10.1634/theoncologist.2015-0279)
• Morris, E. J. A.et al. 2016. Wide variation in the use of radiotherapy in the management of surgically treated rectal cancer across the English National Health Service. Clinical Oncology 28(8), pp. 522-531. (10.1016/j.clon.2016.02.002)
• Grenader, T.et al. 2016. Derived neutrophil lymphocyte ratio is predictive of survival from intermittent therapy in advanced colorectal cancer: a post hoc analysis of the MRC COIN study. British Journal of Cancer 114(6), pp. 612-615. (10.1038/bjc.2016.23)
• Renfro, L. A.et al. 2016. Body mass index is prognostic in metastatic colorectal cancer: pooled analysis of patients from first-line clinical trials in the ARCAD database. Journal of Clinical Oncology 34(2), pp. 144-150. (10.1200/JCO.2015.61.6441)
• Hubbard, G.et al. 2016. Is referral of postsurgical colorectal cancer survivors to cardiac rehabilitation feasible and acceptable? A pragmatic pilot randomised controlled trial with embedded qualitative study. BMJ Open 6(1), article number: e009284. (10.1136/bmjopen-2015-009284)

2015

• Richman, S. D.et al. 2015. Pre-trial inter-laboratory analytical validation of the FOCUS4 personalised therapy trial. Journal of Clinical Pathology 69(1), pp. 35-41. (10.1136/jclinpath-2015-203097)
• Hutchinson, R. A.et al. 2015. Epidermal growth factor receptor immunohistochemistry: new opportunities in metastatic colorectal cancer. Journal of Translational Medicine 13, article number: 217. (10.1186/s12967-015-0531-z)
• Shi, Q.et al. 2015. Individual patient data analysis of progression-free survival versus overall survival as a first-line end point for metastatic colorectal cancer in modern randomized trials: findings from the analysis and research in cancers of the digestive system database. Journal of Clinical Oncology 33(1), pp. 22-28. (10.1200/JCO.2014.56.5887)

2014

• Baillie, J.et al. 2014. Developing meaningful public involvement in a cancer clinical trials unit. Presented at: COMET IV Meeting: Core Outcome Measures in Effectiveness Trials, Rome, Italy, 20-21 November 2014.
• Muirhead, R.et al. 2014. Anal cancer: developing an intensity-modulated radiotherapy solution for ACT2 fractionation. Clinical Oncology 26(11), pp. 720-721. (10.1016/j.clon.2014.08.001)
• Glynne-Jones, R.et al. 2014. End points in anal cancer: hopes for a common language. Journal of Clinical Oncology 32(12), pp. 1281-1282. (10.1200/JCO.2014.55.1515)
• Maughan, T.et al. 2014. A feasibility study testing four hypotheses with phase II outcomes in advanced colorectal cancer (MRC FOCUS3): A model for randomised controlled trials in the era of personalised medicine?. British Journal of Cancer 110, pp. 2178-2186. (10.1038/bjc.2014.182)
• Munro, J.et al. 2014. CRIB-the use of cardiac rehabilitation services to aid the recovery of patients with bowel cancer: a pilot randomised controlled trial (RCT) with embedded feasibility study. BMJ Open 4(2), article number: e004684. (10.1136/bmjopen-2013-004684)

2013

• Smith, C.et al. 2013. Somatic profiling of the epidermal growth factor receptor pathway in tumors from patients with advanced colorectal cancer treated with chemotherapy ± cetuximab. Clinical Cancer Research 19(15), pp. 4104-4113. (10.1158/1078-0432.CCR-12-2581)
• Smith, C.et al. 2013. Exome resequencing identifies potential tumor-suppressor genes that predispose to colorectal cancer. Human Mutation 34(7), pp. 1026-1034. (10.1002/humu.22333)
• Glynne-Jones, R.et al. 2013. Prognostic factors for recurrence and survival in anal cancer. Cancer 119(4), pp. 748-755. (10.1002/cncr.27825)
• Türbachova, I.et al. 2013. The cellular ratio of immune tolerance (immunoCRIT) is a definite marker for aggressiveness of solid tumors and may explain tumor dissemination patterns. Epigenetics 8(11), pp. 1226-1235. (10.4161/epi.26334)

2012

• Vale, C. L.et al. 2012. Does anti-EGFR therapy improve outcome in advanced colorectal cancer? A systematic review and meta-analysis. Cancer Treatment Reviews 38(6), pp. 618-625. (10.1016/j.ctrv.2011.11.002)
• Dunlop, M. G.et al. 2012. Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk [Letter]. Nature Genetics 44(7), pp. 770-776. (10.1038/ng.2293)
• Gwynne, S. H.et al. 2012. Image-guided Radiotherapy for Rectal Cancer - A Systematic Review. Clinical Oncology 24(4), pp. 250-260. (10.1016/j.clon.2011.07.012)
• Gwynne, S. H.et al. 2012. Imaging for Target Volume Delineation in Rectal Cancer Radiotherapy - A Systematic Review. Clinical Oncology 24(1), pp. 52-63. (10.1016/j.clon.2011.10.001)

2011

• Glynne-Jones, R.et al. 2011. "Mind the gap" - The impact of variations in the duration of the treatment gap and overall treatment time in the first UK anal cancer trial (ACT I). International Journal of Radiation Oncology*Biology*Physics 81(5), pp. 1488-1494. (10.1016/j.ijrobp.2010.07.1995)
• Maughan, T. S.et al. 2011. Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. The Lancet 377(9783), pp. 2103-2114. (10.1016/S0140-6736(11)60613-2)
• Adams, R. A.et al. 2011. Intermittent versus continuous oxaliplatin and fluoropyrimidine combination chemotherapy for first-line treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. The Lancet Oncology 12(7), pp. 642-653. (10.1016/S1470-2045(11)70102-4)
• Shaw, P. and Adams, R. A. 2011. Where now for anti-EGF receptor therapies in colorectal cancer?. Expert Review of Anticancer Therapy 11(10), pp. 1543-1553. (10.1586/era.11.143)

2010

• Maughan, T. S.et al. 2010. Chemotherapy-Free Intervals for Patients With Metastatic Colorectal Cancer Remain an Option [Letter]. Journal of Clinical Oncology 28(17), pp. e275-e276. (10.1200/JCO.2009.27.8218)

2009

• Adams, R. A.et al. 2009. Toxicity associated with combination oxaliplatin plus fluoropyrimidine with or without cetuximab in the MRC COIN trial experience. British Journal of Cancer 100(2), pp. 251-258. (10.1038/sj.bjc.6604877)
• Wadhawan, A., Stephens, R. and Adams, R. A. 2009. Intermittent therapy in the palliative treatment of metastatic colorectal cancer. Expert Review of Anticancer Therapy 9(1), pp. 125-134. (10.1586/14737140.9.1.125)
• Morgan, M. A.et al. 2009. Stage-for-stage comparison of definitive chemoradiotherapy, surgery alone and neoadjuvant chemotherapy for oesophageal carcinoma. British Journal of Surgery 96(11), pp. 1300-1307. (10.1002/bjs.6705)

2008

• Adams, R. A.et al. 2008. Cetuximab therapy in first-line metastatic colorectal cancer and intermittent palliative chemotherapy: review of the COIN trial. Expert Review of Anticancer Therapy 8(8), pp. 1237-1245. (10.1586/14737140.8.8.1237)

2007

• Shaw, P.et al. 2007. A clinical review of the investigation and management of carcinoma of unknown primary in a single cancer network. Clinical Oncology 19(1), pp. 87-95. (10.1016/j.clon.2006.09.009)

1993

• Hardie, K. R., Adams, R. A. and Towner, K. J. 1993. Transferrin-binding ability of invasive and commensal isolates of Haemophilus spp.. Journal of Medical Microbiology 39(3), pp. 218-224. (10.1099/00222615-39-3-218)