![Hannah Chandler](https://profiles-cardiff.imgix.net/attachments/274?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Miss Hannah Chandler
Research Associate
- ChandlerHL1@caerdydd.ac.uk
- +44 29208 74000 ext 20057
- Canolfan Ymchwil Delweddu'r Ymennydd Prifysgol Caerdydd, Heol Maendy, Caerdydd, CF24 4HQ
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
Crynodeb ymchwil
Mae'r ymennydd yn gofyn am gyflenwad cyson o egni, lle mae angen coreograffu llif y gwaed trwy rwydwaith cymhleth o bibellau gwaed i ateb gofynion ynni meinwe. Mae fy ymchwil wedi datgelu bod unigolion ifanc sydd â mwy o risg genetig ar gyfer clefyd Alzheimer (AD) wedi lleihau llif gwaed yr ymennydd yn sylweddol sy'n parhau i fod yn gyson ar draws y rhychwant oes, lle mae mynegiant genynnau risg AD rhanbarthol uwch yn gysylltiedig â llai o lif gwaed yr ymennydd. Mae fy ymchwil ynghyd ag eraill ym maes dementia wedi dangos bod dadansoddiad yn rheoleiddio system fasgwlaidd yr ymennydd yn un o'r newidiadau cynharaf y gellir eu canfod yng nghlwy'r clefyd Alzheimer. Felly, gall targedu system fasgwlaidd yr ymennydd ar gyfer strategaethau ataliol helpu i liniaru dysregulation fasgwlaidd yn y rhai sydd mewn perygl, ac oedi dilyniant pathoffisioleg sy'n gysylltiedig ag AD.
Rwyf wedi cefnogi dilysu dulliau MRI newydd sydd â chyfleustodau clinigol ar gyfer diagnosio dysregulation fasgwlaidd mewn clefydau. Rwyf bellach yn cymhwyso'r dulliau delweddu MRI newydd hyn i nifer o garfannau clinigol gan gynnwys sglerosis ymledol, dementia, epilepsi, ac arthritis gwynegol. Mae fy ngwaith hefyd yn cynnwys defnyddio methodolegau delweddu PET i asesu ffisioleg yr ymennydd. Fel ECR mewn delweddu PET, rwyf wedi ymuno â Dr Mattia Veronese a'r Athro Federico Turkheimer yng Ngholeg y Brenin, Llundain, lle gwnaethom gyd-sefydlu Partneriaeth PET y DU (PPUK). Datblygwyd y PPUK i alluogi cydweithrediadau ar raddfa fwy ledled y DU a thu hwnt i fynd i'r afael â chwestiynau ymchwil pwysig wrth astudio clefydau. Mae hefyd yn darparu adnodd i ECR ddod o hyd i gymorth gyda dylunio astudiaeth ddelweddu PET, casglu a dadansoddi data.
Ar gyfer PPUK gweler: https://petpartnershipuk.com
Cyhoeddiad
2023
- Lancaster, T. et al. 2023. Proof-of-concept recall-by-genotype study of extremely low and high Alzheimer’s polygenic risk reveals autobiographical deficits and cingulate cortex correlates. Alzheimer's Research and Therapy 15, article number: 213. (10.1186/s13195-023-01362-y)
- Chandler, H. L. et al. 2023. Reduced brain oxygen metabolism in patients with multiple sclerosis: Evidence from dual-calibrated functional MRI. Journal of Cerebral Blood Flow and Metabolism 43(1), pp. 115-128. (10.1177/0271678X221121849)
2022
- Chiarelli, A. M. et al. 2022. A flow-diffusion model of oxygen transport for quantitative mapping of cerebral metabolic rate of oxygen (CMRO2) with single gas calibrated fMRI. Journal of Cerebral Blood Flow and Metabolism 42(7), pp. 1192-1209. (10.1177/0271678X221077332)
2021
- Steventon, J. et al. 2021. Changes in white matter microstructure and MRI-derived cerebral blood flow after one-week of exercise training. Scientific Reports 11, article number: 22061. (10.1038/s41598-021-01630-7)
- Shaw, A. D., Chandler, H. L., Hamandi, K., Muthukumaraswamy, S. D., Hammers, A. and Singh, K. D. 2021. Tiagabine induced modulation of oscillatory connectivity and activity match PET-derived, canonical GABA-A receptor distributions. European Neuropsychopharmacology 50, pp. 34-45. (10.1016/j.euroneuro.2021.04.005)
- Smith, R. L., Chandler, H., Alsyed, E., Bartley, L., Fielding, P. and Marshall, C. 2021. Deep learning PET epilepsy detection with a novel symmetric loss convolutional autoencoder. Presented at: 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Boston, MA, USA, 31 October -7 November 20202020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). IEEE pp. 1-3., (10.1109/NSS/MIC42677.2020.9507980)
- Murray, A. N., Chandler, H. L. and Lancaster, T. M. 2021. Multimodal hippocampal and amygdala subfield volumetry in polygenic risk for Alzheimer's disease. Neurobiology of Aging 98, pp. 33-41. (10.1016/j.neurobiolaging.2020.08.022)
- Chandler, H. L. et al. 2021. Using dual-calibrated functional MRI to map brain oxygen supply and consumption in multiple sclerosis. [Online]. bioRxiv. Available at: https://doi.org/10.1101/2021.01.07.425819
- Chandler, H. L., Wise, R. G., Linden, D. E., Williams, J., Murphy, K. and Lancaster, T. M. 2021. Alzheimer's genetic risk effects on cerebral blood flow are spatially consistent and proximal to gene expression across the lifespan. [Online]. bioRxiv. (10.1101/2020.12.31.424949v1) Available at: https://doi.org/10.1101/2020.12.31.424949
2020
- Chandler, H. L., Hodgetts, C. J., Caseras, X., Murphy, K. and Lancaster, T. M. 2020. Polygenic risk for Alzheimer's disease shapes hippocampal scene-selectivity. Neuropsychopharmacology 45, pp. 1171-1178. (10.1038/s41386-019-0595-1)
- Shaw, A. D., Chandler, H. L., Hamandi, K., Muthukumaraswamy, S. D., Hammers, A. and Singh, K. D. 2020. GABAA receptor mapping in human using non-invasive electrophysiology. [Online]. bioRxiv. Available at: https://doi.org/10.1101/2020.05.11.087726
- Germuska, M., Chandler, H., Okell, T., Fasano, F., Tomassini, V., Murphy, K. and Wise, R. 2020. A frequency-domain machine learning method for dual-calibrated fMRI mapping of oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen consumption (CMRO2). Frontiers in Artificial Intelligence 3, article number: 12. (10.3389/frai.2020.00012)
2019
- Chandler, H. L., Wise, R. G., Murphy, K., Tansey, K. E., Linden, D. E. J. and Lancaster, T. M. 2019. Polygenic impact of common genetic risk loci for Alzheimer's disease on cerebral blood flow in young individuals. Scientific Reports 9, article number: 467. (10.1038/s41598-018-36820-3)
- Germuska, M. et al. 2019. Dual-calibrated fMRI measurement of absolute cerebral metabolic rate of oxygen consumption and effective oxygen diffusivity. NeuroImage 184, pp. 717-728. (10.1016/j.neuroimage.2018.09.035)
Articles
- Lancaster, T. et al. 2023. Proof-of-concept recall-by-genotype study of extremely low and high Alzheimer’s polygenic risk reveals autobiographical deficits and cingulate cortex correlates. Alzheimer's Research and Therapy 15, article number: 213. (10.1186/s13195-023-01362-y)
- Chandler, H. L. et al. 2023. Reduced brain oxygen metabolism in patients with multiple sclerosis: Evidence from dual-calibrated functional MRI. Journal of Cerebral Blood Flow and Metabolism 43(1), pp. 115-128. (10.1177/0271678X221121849)
- Chiarelli, A. M. et al. 2022. A flow-diffusion model of oxygen transport for quantitative mapping of cerebral metabolic rate of oxygen (CMRO2) with single gas calibrated fMRI. Journal of Cerebral Blood Flow and Metabolism 42(7), pp. 1192-1209. (10.1177/0271678X221077332)
- Steventon, J. et al. 2021. Changes in white matter microstructure and MRI-derived cerebral blood flow after one-week of exercise training. Scientific Reports 11, article number: 22061. (10.1038/s41598-021-01630-7)
- Shaw, A. D., Chandler, H. L., Hamandi, K., Muthukumaraswamy, S. D., Hammers, A. and Singh, K. D. 2021. Tiagabine induced modulation of oscillatory connectivity and activity match PET-derived, canonical GABA-A receptor distributions. European Neuropsychopharmacology 50, pp. 34-45. (10.1016/j.euroneuro.2021.04.005)
- Murray, A. N., Chandler, H. L. and Lancaster, T. M. 2021. Multimodal hippocampal and amygdala subfield volumetry in polygenic risk for Alzheimer's disease. Neurobiology of Aging 98, pp. 33-41. (10.1016/j.neurobiolaging.2020.08.022)
- Chandler, H. L., Hodgetts, C. J., Caseras, X., Murphy, K. and Lancaster, T. M. 2020. Polygenic risk for Alzheimer's disease shapes hippocampal scene-selectivity. Neuropsychopharmacology 45, pp. 1171-1178. (10.1038/s41386-019-0595-1)
- Germuska, M., Chandler, H., Okell, T., Fasano, F., Tomassini, V., Murphy, K. and Wise, R. 2020. A frequency-domain machine learning method for dual-calibrated fMRI mapping of oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen consumption (CMRO2). Frontiers in Artificial Intelligence 3, article number: 12. (10.3389/frai.2020.00012)
- Chandler, H. L., Wise, R. G., Murphy, K., Tansey, K. E., Linden, D. E. J. and Lancaster, T. M. 2019. Polygenic impact of common genetic risk loci for Alzheimer's disease on cerebral blood flow in young individuals. Scientific Reports 9, article number: 467. (10.1038/s41598-018-36820-3)
- Germuska, M. et al. 2019. Dual-calibrated fMRI measurement of absolute cerebral metabolic rate of oxygen consumption and effective oxygen diffusivity. NeuroImage 184, pp. 717-728. (10.1016/j.neuroimage.2018.09.035)
Conferences
- Smith, R. L., Chandler, H., Alsyed, E., Bartley, L., Fielding, P. and Marshall, C. 2021. Deep learning PET epilepsy detection with a novel symmetric loss convolutional autoencoder. Presented at: 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Boston, MA, USA, 31 October -7 November 20202020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). IEEE pp. 1-3., (10.1109/NSS/MIC42677.2020.9507980)
Websites
- Chandler, H. L. et al. 2021. Using dual-calibrated functional MRI to map brain oxygen supply and consumption in multiple sclerosis. [Online]. bioRxiv. Available at: https://doi.org/10.1101/2021.01.07.425819
- Chandler, H. L., Wise, R. G., Linden, D. E., Williams, J., Murphy, K. and Lancaster, T. M. 2021. Alzheimer's genetic risk effects on cerebral blood flow are spatially consistent and proximal to gene expression across the lifespan. [Online]. bioRxiv. (10.1101/2020.12.31.424949v1) Available at: https://doi.org/10.1101/2020.12.31.424949
- Shaw, A. D., Chandler, H. L., Hamandi, K., Muthukumaraswamy, S. D., Hammers, A. and Singh, K. D. 2020. GABAA receptor mapping in human using non-invasive electrophysiology. [Online]. bioRxiv. Available at: https://doi.org/10.1101/2020.05.11.087726
Ymchwil
Cyllid
ESRC - Cyllid PhD
MRC - Hyder mewn Cysyniad.
Grŵp ymchwil
MRI dulliau datblygu a chymhwyso mewn iechyd a chlefydau.
Cydweithredwyr ymchwil
Mewnol:
- Yr Athro Julie Williams (UK DRI)
- Yr Athro Neil Harrison (CUBRIC)
- Yr Athro Christopher Marshall (PETIC)
- Yr Athro Kevin Murphy (CUBRIC/Ffiseg)
- Yr Athro Ernest Choy (Clinigydd Ymgynghorol, Rheumatoleg)
- Dr Chineze Ivenso (Seiciatrydd Ymgynghorol yn Aneurin Bevan, UHB)
Allanol:
- Yr Athro Felix Wehrli (Prifysgol Pennsylvania, UDA)
- Yr Athro Xiang He (Prifysgol Stony Brook, Efrog Newydd, UDA)
- Yr Athro Federico Turkheimer a Dr Mattia Veronese (Coleg y Brenin, Llundain, y DU)
- Yr Athro Alexander Hammers (Coleg y Brenin, Llundain)
- Yr Athro Andy Jones (Prifysgol Caerwysg, y DU)
- Dr Thomas Lancaster (Prifysgol Caerfaddon)
- Yr Athro Clive Ballard a Dr Byron Creese (Prifysgol Caerwysg, y DU).
- Dr Axel Montagne (UK DRI, Caeredin).
- Yr Athro Richard Wise (Prifysgol Chieti-Pescara, Yr Eidal)
Addysgu
BSc Seicoleg - Dulliau Ymchwil ac Ystadegau
MSc Niwroddelweddu - MRI / fMRI dulliau a dadansoddiad
MSc Niwroddelweddu - sesiynau ymarferol MRI.
MSc Niwroddelweddu - Clybiau cyfnodolion
Bywgraffiad
Addysg israddedig
- Seicoleg gyda Niwroseicoleg (Anrhydedd Dosbarth Cyntaf)
Addysg ôl-raddedig
- M.Sc niwroddelweddu (gwahaniaethu)
- Ph.D Niwrowyddoniaeth Gwybyddol a niwroddelweddu
Cyflogaeth
- Ariannwyd MRC-CiC Cyswllt Ymchwil (Rhagfyr 2017 - Ebrill 2018)
- Gwobr Strategol Ymddiriedolaeth Wellcome Prifysgol Caerdydd Cyswllt ymchwil ôl-ddoethurol (Ebrill 2018- presennol)
