Yr Athro Mark Good

BSc, DPhil

Professor

Yr Ysgol Seicoleg

: good@cardiff.ac.uk
: +44 (0)29 2087 5867
: Adeilad y Tŵr, Plas y Parc, Caerdydd, CF10 3AT

Research summary

The medial temporal lobe and particularly the hippocampus has long been associated with memory function in humans and non-human animals. This region is often involved in psychiatric and neurodegenerative conditions, such as schizophrenia and Alzheimer’s disease. My current research is aimed at addressing two main questions:

What role does the hippocampus and associated brain structures play in memory?
How do neurodegenerative conditions influence the function of the hippocampus?

In addressing these questions I use preclinical models of brain pathology synaptic including genetic models of heritable neurodegenerative conditions, such as Alzheimer’s disease and frontotemporal dementia.

Current projects include:

assessment of the psychological and neural substrates of configural and episodic-like memory, characterisation of transgenic models of Alzheimer’s disease;
investigation of the psychological and neural benefits of dietary supplements on Alzheimer’s pathology;
assessment of a novel antibody treatment for amyloid pathology;
investigation of cannabinoid receptors in memory and neurodegenerative diseases;
the role of maternal priming in the onset of Alzheimer’s disease in later life.

Teaching summary

My teaching includes: lectures on biological psychology to level 2 undergraduate students; a complete level 3 module on the neuroscience of learning and memory; lectures to neuroscience students and medical students on preclinical models of Alzheimer’s disease and higher cortical function in humans, respectively.

Undergraduate education

BSc. Psychology (2.1) University of London

Postgraduate education

DPhil. Behavioural Neuroscience University of York

Employment

1990-1994. University of Edinburgh. Post-doc. associate.

1994-to present. Lecturer, Reader and Personal Chair Cardiff University

2023

Webberley, T. S. et al. 2023. Assessment of Lab4P probiotic effects on cognition in 3xTg-AD Alzheimer’s disease model mice and the SH-SY5Y neuronal cell line. International Journal of Molecular Sciences 24(5), article number: 4683. (10.3390/ijms24054683)

2022

Sedgwick, K. S., Dwyer, D., Good, M. A. and Saito, T. 2022. The role of the Locus Coeruleus in depression in Alzheimer's disease. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 18(S7), article number: e062257. (10.1002/alz.062257)
MacLachlan, R., Evans, C. E., Chai, S. Y., Good, M. A., Kehoe, P. G. and Miners, J. S. 2022. Age-related reduction in brain ACE-2 is not exacerbated by Alzheimer?s disease pathology in mouse models of Alzheimer?s disease. Aging Brain 3, article number: 100062. (10.1016/j.nbas.2022.100062)

2021

Lana-Elola, E. et al. 2021. Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes. Disease Models and Mechanisms 14(10), article number: 49157. (10.1242/dmm.049157)
D'Souza, H., Brady, D., Wiseman, F. K., Good, M. A. and Thomas, M. S. C. 2021. Aligning cognitive studies in mouse models and human infants/toddlers: the case of Down Syndrome. In: Thomas, M. S. C., Mareschal, D. and Knowland, V. eds. Taking Development Seriously A Festschrift for Annette Karmiloff-Smith: Neuroconstructivism and the multi-disciplinary approach to understanding the emergence of mind. Taylor and Francis, pp. 213-238.

2020

Bevan, R. J., Hughes, T. R., Williams, P. A., Good, M. A., Morgan, B. P. and Morgan, J. E. 2020. Retinal ganglion cell degeneration correlates with hippocampal spine loss in experimental Alzheimer's disease. Acta Neuropathologica Communications 8(1), article number: 216. (10.1186/s40478-020-01094-2)
Bevan, R. J. et al. 2020. OPA1 deficiency accelerates hippocampal synaptic remodelling and age-related deficits in learning and memory. Brain Communications 2(2), article number: fcaa101. (10.1093/braincomms/fcaa101)
Evans, C. E. et al. 2020. ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease. Acta Neuropathologica 139, pp. 485-502. (10.1007/s00401-019-02098-6)
Michael, D. R. et al. 2020. A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being. Scientific Reports 10(1), pp. -., article number: 4183. (10.1038/s41598-020-60991-7)
Chang, P. et al. 2020. Altered hippocampal-prefrontal neural dynamics in mouse models of Down syndrome. Cell Reports 30(4), pp. 1152-1163.e4. (10.1016/j.celrep.2019.12.065)

2019

Evans, C. E., Thomas, R. S., Freeman, T. J., Hvoslef-Eide, M., Good, M. A. and Kidd, E. J. 2019. Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice. Neurobiology of Aging 75, pp. 136-149. (10.1016/j.neurobiolaging.2018.11.011)
Michael, D., Davies, T., Loxley, K., Allen, M., Good, M., Hughes, T. and Plummer, S. 2019. In vitro neuroprotective activities of two distinct probiotic consortia. Beneficial Microbes 10(4), pp. 437-447. (10.3920/BM2018.0105)

2018

Baruchin, L. J., Ranson, A., Good, M. and Crunelli, V. 2018. Absence of neuronal response modulation with familiarity in perirhinal cortex. Neuroscience 394, pp. 23-29. (10.1016/j.neuroscience.2018.10.020)
Evans, C., Hvoslefeide, M., Thomas, R., Kidd, E. and Good, M. 2018. A rapidly acquired foraging-based working memory task, sensitive to hippocampal lesions, reveals age-dependent and age-independent behavioural changes in a mouse model of amyloid pathology. Neurobiology of Learning and Memory 149, pp. 46-57. (10.1016/j.nlm.2018.02.004)

2017

O'Hagan, C., Li, J. V., Marchesi, J. R., Plummer, S., Garaiova, I. and Good, M. A. 2017. Long-term multi-species Lactobacillus and Bifidobacterium dietary supplement enhances memory and changes regional brain metabolites in middle-aged rats. Neurobiology of Learning and Memory 144, pp. 36-47. (10.1016/j.nlm.2017.05.015)
Thomas, R., Alsaqati, M., Bice, J., Hvoslef-Eide, M., Good, M. and Kidd, E. 2017. Alterations in endocytic protein expression with increasing age in the transgenic APP695 V717I London mouse model of amyloid pathology - implications for Alzheimer's disease. NeuroReport 28(15), pp. 963-968. (10.1097/WNR.0000000000000861)
Dumigan, N. M., Lin, T., Good, M. A. and Honey, R. C. 2017. Conditioning with spatio-temporal patterns: Constraining the contribution of the hippocampus to configural learning. Neurobiology of Learning and Memory 142(B), pp. 244-251. (10.1016/j.nlm.2017.05.004)

2016

Bascoul-Colombo, C., Guschina, I. A., Maskrey, B. H., Good, M., O'Donnell, V. B. and Harwood, J. L. 2016. Dietary DHA supplementation causes selective changes in phospholipids from different brain regions in both wild type mice and the Tg2576 mouse model of Alzheimer's disease. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1861(6), pp. 524-537. (10.1016/j.bbalip.2016.03.005)
Lin, T. E., Dumigan, N. M., Good, M. and Honey, R. C. 2016. Novel sensory preconditioning procedures identify a specific role for the hippocampus in pattern completion. Neurobiology of Learning and Memory 130, pp. 142-148. (10.1016/j.nlm.2016.02.006)
Hall, J. H., Wiseman, F. K., Fisher, E. M. C., Tybulewicz, V. L. J., Harwood, J. L. and Good, M. A. 2016. Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory. Neurobiology of Learning and Memory 130, pp. 118-128. (10.1016/j.nlm.2016.02.002)

2010

Sanderson, D. J., McHugh, S. B., Good, M. A., Sprengel, R., Seeburg, P. H., Rawlins, J. N. P. and Bannerman, D. M. 2010. Spatial working memory deficits in GluA1 AMPA receptor subunit knockout mice reflect impaired short-term habituation: Evidence for Wagner's dual-process memory model. Neuropsychologia 48(8), pp. 2303-2315. (10.1016/j.neuropsychologia.2010.03.018)
Honey, R. C., Iordanova, M. D. and Good, M. A. 2010. Latent inhibition and habituation: evaluation of an associative analysis. In: Lubow, R. and Weiner, I. eds. Latent Inhibition: Cognition, Neuroscience and Applications to Schizophrenia. Cambridge: Cambridge University Press, pp. 163-182., (10.1017/CBO9780511730184.009)

2009

Sanderson, D. J., Good, M. A., Skelton, K., Sprengel, R., Seeburg, P. H., Rawlins, J. N. P. and Bannerman, D. M. 2009. Enhanced long-term and impaired short-term spatial memory in GluA1 AMPA receptor subunit knockout mice: evidence for a dual-process memory model. Learning & Memory 16(6), pp. 379-386. (10.1101/lm.1339109)
Iordanova, M. D., Burnett, D. J., Aggleton, J. P., Good, M. A. and Honey, R. C. 2009. The role of the hippocampus in mnemonic integration and retrieval: complementary evidence from lesion and inactivation studies. European Journal of Neuroscience 30(11), pp. 2177-2189. (10.1111/j.1460-9568.2009.07010.x)
Rhodes, S. E. V., Creighton, G., Killcross, A. S., Good, M. A. and Honey, R. C. 2009. Integration of geometric with luminance information in the rat: Evidence from within-compound associations. Journal of Experimental Psychology: Animal Behavior Processes 35(1), pp. 92-98. (10.1037/0097-7403.35.1.92)
McLeod, J., Curtis, N., Lewis, H. D., Good, M. A., Fagan, M. J. and Genever, P. G. 2009. γ-Secretase-dependent cleavage of amyloid precursor protein regulates osteoblast behavior. FASEB Journal 23(9), pp. 2942-2955. (10.1096/fj.08-121657)

2008

Coles, B., Wilton, L. A. K., Good, M. A., Chapman, P. F. and Wann, K. T. 2008. Potassium channels in hippocampal neurones are absent in a transgenic but not in a chemical model of Alzheimer's disease. Brain Research 1190, pp. 1-14. (10.1016/j.brainres.2007.10.071)
Iordanova, M. D., Good, M. A. and Honey, R. C. 2008. Configural learning without reinforcement: Integrated memories for correlates of what, where, and when. Quarterly Journal of Experimental Psychology 61(12), pp. 1785-1792. (10.1080/17470210802194324)
Good, M. A. 2008. Spatio-temporal context and object recognition memory in rodents. In: Dere, E. et al. eds. Handbook of episodic memory. Handbook of behavioural neuroscience Vol. 18. Amsterdam: Elsevier, pp. 301-316.
Sanderson, D. J., Good, M. A., Seeburg, P. H., Sprengel, R., Rawlins, J. N. P. and Bannerman, D. M. 2008. The role of the GluR-A (GluR1) AMPA receptor subunit in learning and memory. In: Sossin, W. S. et al. eds. Essence of memory. Progress in brain research Vol. 169. Amsterdam: Elsevier, pp. 159-178., (10.1016/S0079-6123(07)00009-X)

2007

Jones, P. M., Pearce, J. M., Davies, V. J., Good, M. A. and McGregor, A. 2007. Impaired processing of local geometric features during navigation in a water maze following hippocampal lesions in rats. Behavioral Neuroscience 121(6), pp. 1258-1271. (10.1037/0735-7044.121.6.1258)
Johnson, A. W., Bannerman, D., Rawlins, N., Sprengel, R. and Good, M. A. 2007. Targeted deletion of the GluR-1 AMPA receptor in mice dissociates general and outcome-specific influences of appetitive rewards on learning. Behavioral Neuroscience 121(6), pp. 1192-1202. (10.1037/0735-7044.121.6.1192)
Good, M. A. and Hale, G. 2007. The "Swedish" mutation of the amyloid precursor protein (APPswe) dissociates components of object-location memory in aged Tg2576 mice. Behavioral Neuroscience 121(6), pp. 1180-1191. (10.1037/0735-7044.121.6.1180)
Humeau, Y. et al. 2007. A pathway-specific function for different AMPA receptor subunits in amygdala long-term potentiation and fear conditioning. Journal of Neuroscience 27(41), pp. 10947-10956. (10.1523/JNEUROSCI.2603-07.2007)
Sanderson, D. J. et al. 2007. Deletion of glutamate receptor-A (GluR-A) AMPA receptor subunits impairs one-trial spatial memory. Behavioral Neuroscience 121(3), pp. 559-569. (10.1037/0735-7044.121.3.559)
Good, M. A., Hale, G. and Staal, V. A. 2007. Impaired "episodic-like" object memory in adult APPswe transgenic mice. Behavioral Neuroscience 121(2), pp. 443-448. (10.1037/0735-7044.121.2.443)
Honey, R. C., Marshall, V. J., McGregor, A., Futter, J. E. and Good, M. A. 2007. Revisiting places passed: sensitization of exploratory activity in rats with hippocampal lesions. Quarterly Journal of Experimental Psychology 60(5), pp. 625-634. (10.1080/17470210601155252)
Good, M. A., Barnes, P. A., Staal, V. A., McGregor, A. and Honey, R. C. 2007. Context- but not familiarity-dependent forms of object recognition are impaired following excitotoxic hippocampal lesions in rats. Behavioral Neuroscience 121(1), pp. 218-223. (10.1037/0735-7044.121.1.218)

2006

Bingman, V. P., Erichsen, J. T., Anderson, J. . D., Good, M. A. and Pearce, J. M. 2006. Spared feature-structure discrimination but diminished salience of environmental geometry in hippocampal-lesioned homing pigeons (Columba livia). Behavioral Neuroscience 120(4), pp. 835-841. (10.1037/0735-7044.120.4.835)
Pearce, J. M., Graham, M. A., Good, M. A., Jones, P. M. and McGregor, A. 2006. Potentiation, overshadowing, and blocking of spatial learning based on the shape of the environment. Journal of Experimental Psychology: Animal Behavior Processes 32(3), pp. 201-214. (10.1037/0097-7403.32.3.201)
Graham, M. A., Good, M. A., McGregor, A. and Pearce, J. M. 2006. Spatial learning based on the shape of the environment is influenced by properties of the objects forming the shape. Journal of Experimental Psychology: Animal Behavior Processes 32(1), pp. 44-59. (10.1037/0097-7403.32.1.44)
McGregor, A., Jones, P. M., Good, M. A. and Pearce, J. M. 2006. Further evidence that rats rely on local rather than global spatial information to locate a hidden goal: reply to Cheng and Gallistel (2005). Journal of Experimental Psychology: Animal Behavior Processes 32(3), pp. 314-321. (10.1037/0097-7403.32.3.314)
Barnes, P. A., Staal, V. A., Muir, J. L. and Good, M. A. 2006. 17-ß estradiol administration attenuates deficits in sustained and divided attention in young ovariectomized rats and aged acyclic female rats. Behavioral Neuroscience 120(6), pp. 1225-1234. (10.1037/0735-7044.120.6.1225)
Bannerman, D. M., Rawlins, J. N. P. and Good, M. A. 2006. The drugs don't work - or do they? Pharmacological and transgenic studies of the contribution of NMDA and GluR-A-containing AMPA receptors to hippocampal-dependent memory. Psychopharmacology 188(4), pp. 552-566. (10.1007/s00213-006-0403-6)
Sloan, H. L., Good, M. A. and Dunnett, S. B. 2006. Double dissociation between hippocampal and prefrontal lesions on an operant delayed matching task and a water maze reference memory task. Behavioural Brain Research 171(1), pp. 116-126. (10.1016/j.bbr.2006.03.030)

2005

Pearce, J. M., George, D. N., Haselgrove, M., Erichsen, J. T. and Good, M. A. 2005. The influence of hippocampal lesions on the discrimination of structure and on spatial memory in pigeons (Columba livia). Behavioral Neuroscience 119(5), pp. 1316-1330. (10.1037/0735-7044.119.5.1316)
Hale, G. and Good, M. A. 2005. Impaired visuo-spatial recognition memory but normal object novelty detection and relative familiarity judgements in adult mice expressing the APPswe Alzheimer's disease mutation. Behavioral Neuroscience 119(4), pp. 884-891. (10.1037/0735-7044.119.4.884)
Johnson, A. W., Bannerman, D. M., Rawlins, N. P., Sprengel, R. and Good, M. A. 2005. Impaired outcome-specific devaluation of instrumental responding in mice with a targeted deletion of the AMPA receptor GluR-1 subunit. Journal of Neuroscience 25(9), pp. 2359-2365. (10.1523/JNEUROSCI.4146-04.2005)
Barnes, P. and Good, M. A. 2005. Impaired Pavlovian cued fear conditioning in Tg2576 mice expressing a human mutant amyloid precursor protein gene. Behavioural Brain Research 157(1), pp. 107-117. (10.1016/j.bbr.2004.06.014)
Ramos-Esber, G., McGregor, A., Good, M. A., Hayward, A. and Pearce, J. M. 2005. Transfer of spatial behaviour controlled by a landmark array with a distinctive shape. Quarterly Journal of Experimental Psychology. B: Comparative and Physiological Psychology 58(1), pp. 69-91. (10.1080/02724990444000069)
Day, M. and Good, M. A. 2005. Ovariectomy-induced disruption of long-term synaptic depression in the hippocampal CA1 region in vivo is attenuated with chronic estrogen replacement. Neurobiology of Learning and Memory 83(1), pp. 13-21. (10.1016/j.nlm.2004.06.009)

2004

Barnes, P. A., Hale, G. and Good, M. A. 2004. Intramaze and extramaze cue processing in Tg2465 APPswe mutant mice. Behavioral Neuroscience 118(6), pp. 1184-1195. (10.1037/0735-7044.118.6.1184)
McGregor, A., Hayward, A. J., Pearce, J. M. and Good, M. A. 2004. Hippocampal lesions disrupt navigation based on the shape of the environment. Behavioral Neuroscience 118(5), pp. 1011-1021. (10.1037/0735-7044.118.5.1011)
Hayward, A. J., Good, M. A. and Pearce, J. M. 2004. Failure of a landmark to restrict spatial learning based on the shape of the environment. Quarterly Journal of Experimental Psychology. B: Comparative and Physiological Psychology 57(4), pp. 289-314. (10.1080/02724990344000150)
Pearce, J. M., Good, M. A., Jones, P. M. and McGregor, A. 2004. Transfer of spatial behavior between different environments: implications for theories of spatial learning and for the role of the hippocampus in spatial learning. Journal of Experimental Psychology: Animal Behavior Processes 30(2), pp. 135-147. (10.1037/0097-7403.30.2.135)
McGregor, A., Good, M. A. and Pearce, J. M. 2004. Absence of an interaction between navigational strategies based on local and distal landmarks. Journal of Experimental Psychology: Animal Behavior Processes 30(1), pp. 34-44. (10.1037/0097-7403.30.1.34)
Marshall, V. J., McGregor, A., Good, M. A. and Honey, R. C. 2004. Hippocampal Lesions Modulate Both Associative and Nonassociative Priming. Behavioral Neuroscience 118(2), pp. 377-382. (10.1037/0735-7044.118.2.377)

2003

Hayward, A., McGregor, A., Good, M. A. and Pearce, J. M. 2003. Absence of overshadowing and blocking between landmarks and the geometric cues provided by the shape of a test arena. Quarterly Journal of Experimental Psychology. B: Comparative and Physiological Psychology 56(1), pp. 114-126. (10.1080/02724990244000214)
Zheng, Y., Pearce, J. M., Vann, S. D., Good, M. A., Jenkins, T. A., Smith, P. F. and Aggleton, J. P. 2003. Using Idiothetic Cues to Swim a Path With a Fixed Trajectory and Distance: Necessary Involvement of the Hippocampus, but Not the Retrosplenial Cortex. Behavioral Neuroscience 117(6), pp. 1363-1377. (10.1037/0735-7044.117.6.1363)
Oswald, C. J. P., Bannerman, D. M., Yee, B. K., Rawlins, J. N. P., Honey, R. C. and Good, M. A. 2003. Entorhinal cortex lesions disrupt the transition between the use of intra- and extramaze cues for navigation in the water maze. Behavioral Neuroscience 117(3), pp. 588-595. (10.1037/0735-7044.117.3.588)

2002

Coutureau, E., Killcross, A. S., Good, M. A., Marshall, V. J., Ward-Robinson, J. and Honey, R. C. 2002. Acquired equivalence and distinctiveness of cues: II. Neural manipulations and their implications. Journal of Experimental Psychology: Animal Behavior Processes 28(4), pp. 388-396. (10.1037/0097-7403.28.4.388)
Oswald, C. J. P., Yee, B. K., Rawlins, J. N. P., Bannerman, D. B., Good, M. A. and Honey, R. C. 2002. The influence of selective lesions to components of the hippocampal system on the orientating response, habituation and latent inhibition. European Journal of Neuroscience 15(12), pp. 1983-1990. (10.1046/j.1460-9568.2002.02028.x)
Good, M. A. 2002. Spatial memory and hippocampal function: Where are we now?. Psicologica 23(1), pp. 109-138.
Bannerman, D., Lemaire, M., Yee, B., Iversen, S., Oswald, C., Good, M. A. and Rawlins, J. 2002. Selective cytotoxic lesions of the retrohippocampal region produce a mild deficit in social recognition memory. Experimental Brain Research 142(3), pp. 395-401. (10.1007/s00221-001-0938-z)

2001

Ward-Robinson, J., Coutureau, E., Good, M. A., Honey, R. C., Killcross, A. S. and Oswald, C. J. P. 2001. Excitotoxic lesions of the hippocampus leave sensory preconditioning intact: Implications for models of hippocampal function. Behavioral Neuroscience 115(6), pp. 1357-1362. (10.1037/0735-7044.115.6.1357)
Pearce, J. M., Ward-Robinson, J., Good, M. A., Fussell, C. J. and Aydin, A. 2001. Influence of a beacon on spatial learning based on the shape of the test environment. Journal of Experimental Psychology: Animal Behavior Processes 27(4), pp. 329-344. (10.1037/0097-7403.27.4.329)
Oswald, C. J. P., Yee, B. K., Rawlins, J. N. P., Bannerman, D. B., Good, M. A. and Honey, R. C. 2001. Involvement of the entorhinal cortex in a process of attentional modulation: Evidence from a novel variant of an IDS/EDS procedure. Behavioral Neuroscience 115(4), pp. 841-849. (10.1037/0735-7044.115.4.841)
Gray, N. S., Williams, J., Fernandez, M., Ruddle, R. A., Good, M. A. and Snowden, R. J. 2001. Context dependent latent inhibition in adult humans. Quarterly Journal of Experimental Psychology. B: Comparative and Physiological Psychology 54(3), pp. 233-245. (10.1080/713932760)
Bannerman, D. et al. 2001. The role of the entorhinal cortex in two forms of spatial learning and memory. Experimental Brain Research 141(3), pp. 281-303. (10.1007/s002210100868)
Bannerman, D., Yee, B., Lemaire, M., Jarrard, L., Iversen, S., Rawlins, J. and Good, M. A. 2001. Contextual fear conditioning is disrupted by lesions of the subcortical, but not entorhinal, connections to the hippocampus. Experimental Brain Research 141(3), pp. 304-311. (10.1007/s002210100869)

2000

Honey, R. C. and Good, M. A. 2000. Associative components of recognition memory. Current Opinion in Neurobiology 10(2), pp. 200-204. (10.1016/S0959-4388(00)00069-6)
Oswald, C. J. P. and Good, M. A. 2000. The effects of combined lesions of the subicular complex and the entorhinal cortex on two forms of spatial navigation in the water maze. Behavioral Neuroscience 114(1), pp. 211-217. (10.1037/0735-7044.114.1.211)
Aggleton, J. P., Vann, S. D., Oswald, C. J. P. and Good, M. A. 2000. Identifying cortical inputs to the rat hippocampus that subserve allocentric spatial processes: a simple problem with a complex answer. Hippocampus 10(4), pp. 466-474. (10.1002/1098-1063(2000)10:4<466::AID-HIPO13>3.0.CO;2-Y)
Honey, R. C. and Good, M. A. 2000. Associative modulation of the orienting response: Distinct effects revealed by hippocampal lesions. Journal of Experimental Psychology: Animal Behavior Processes 26(1), pp. 3-14. (10.1037/0097-7403.26.1.3)

1999

Chapman, P. F. et al. 1999. Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nature Neuroscience 2(3), pp. 271-276. (10.1038/6374)
Bannerman, D. M., Yee, B. K., Good, M. A., Heupel, M. J., Iversen, S. D. and Rawlins, J. N. P. 1999. Double dissociation of function within the hippocampus: A comparison of dorsal, ventral, and complete hippocampal cytotoxic lesions.. Behavioral Neuroscience 113(6), pp. 1170-1188. (10.1037/0735-7044.113.6.1170)
Good, M. A., Day, M. and Muir, J. L. 1999. Cyclical changes in endogenous levels of oestrogen modulate the induction of LTD and LTP in the hippocampal CA1 region. European Journal of Neuroscience 11(12), pp. 4476-4480. (10.1046/j.1460-9568.1999.00920.x)

1998

Pearce, J. M., Roberts, A. D. L. and Good, M. A. 1998. Hippocampal lesions disrupt navigation based on cognitive maps but not heading vectors. Nature 396(6706), pp. 75-77. (10.1038/23941)
Honey, R. C., Watt, A. A. and Good, M. A. 1998. Hippocampal lesions disrupt an associative mismatch process. The Journal of Neuroscience 18(6), pp. 2226-2230.
Good, M. A., de Hoz, L. and Morris, R. G. M. 1998. Contingent versus incidental context processing during conditioning: Dissociation after excitotoxic hippocampal plus dentate gyrus lesions. Hippocampus 8(2), pp. 147-159. (10.1002/(SICI)1098-1063(1998)8:2<147::AID-HIPO7>3.0.CO;2-I)

1997

Redhead, E. S., Roberts, A., Good, M. A. and Pearce, J. M. 1997. Interaction between piloting and beacon homing by rats in a swimming pool. Journal of Experimental Psychology: Animal Behavior Processes 23(3), pp. 340-350. (10.1037/0097-7403.23.3.340)
Good, M. A. and Honey, R. C. 1997. Dissociable effects of selective lesions to hippocampal subsystems on exploratory behavior, contextual learning, and spatial learning. Behavioral Neuroscience 111(3), pp. 487-493. (10.1037//0735-7044.111.3.487)
Bannerman, D. M., Butcher, S. P., Good, M. A. and Morris, R. G. M. 1997. Intracerebroventricular infusion of the NMDA receptor-associated glycine site antagonist 7-chlorokynurenate impairs water maze performance but fails to block hippocampal long-Term potentiation in vivo. Neurobiology of Learning and Memory 68(3), pp. 252-270. (10.1006/nlme.1997.3797)

1996

Good, M. A. 1996. Targeted deletion of neuronal nitric oxide: A step closer to understanding its functional significance?. Trends in Neurosciences 19(3), pp. 83-84. (10.1016/S0166-2236(96)80031-2)
Morris, R. G. M., Bannerman, D. M. and Good, M. A. 1996. NMDA receptors and spatial learning: Differential pretraining dissociates the behavioral effects of the receptor antagonist AP5 and selective hippocampal lesions. Presented at: Satellite Symposium of the Fourth IBRO World Congress of Neuroscience, Kyoto, Japan, 15-16 July 1995 Presented at Katō, N. ed.The Hippocampus: Functions and Clinical Relevance: proceedings of the satellite symposium of the Fourth IBRO World Congress of Neuroscience, Kyoto, Japan, 15-16 July, 1995. Developments in Neurology Vol. 11. Amsterdam: Elsevier pp. 55-76.

1995

Macphail, E. M., Good, M. A., Honey, R. C. and Willis, A. 1995. Relational learning in pigeons: The role of perceptual processes in between-key recognition of complex stimuli. Animal Learning & Behaviour 23(1), pp. 83-92. (10.3758/BF03198019)
Macphail, E. M., Good, M. A. and Honey, R. C. 1995. Recognition Memory in Pigeons for Stimuli Presented Repeatedly: Perceptual Learning or Reduced Associative Interference?. Quarterly Journal of Experimental Psychology Series B Comparative and Physiological Psychology 48(1), pp. 13-31. (10.1080/14640749508401434)
Morris, R. G. M., Bannerman, D. M., Good, M. and Ramsey, M. 1995. Prior experience dissociates components of N-Methyl-D-Aspartate- dependent forms of spatial learning in the watermaze [Abstract]. Behavioural Pharmacology 6(5-6), pp. 627.

1993

Honey, R. C. and Good, M. A. 1993. Selective hippocampal lesions abolish the contextual specificity of latent inhibition and conditioning. Behavioral Neuroscience 107(1), pp. 23-33. (10.1037/0735-7044.107.1.23)

1991

Good, M. A. and Honey, R. C. 1991. Conditioning and contextual retrieval in hippocampal rats. Behavioral Neuroscience 105(4), pp. 499-509. (10.1037/0735-7044.105.4.499)

Funding

BBSRC: Attention and predictive learning (John Pearce) £574,671, 2010-2013

KTP: Improved lipid containing neutraceuticals (John Harwood) £208,748, 2009-2011

Alzheimer’s Society Studentship: Evaluation of a novel antibody therapy for AD (Emma Kidd) £75,000, 2009-1011

Alzheimer’s Research Trust: Molecular basis for beneficial effects of omega-3 fatty acids (John Harwood £296,000, 2007-2011

NIH service contract: with Prof Steve Goldberg: Cannabinoid receptor modulation of GABA activity in APP mice $20,000 pa, 2010-11

Research group

Behavioural Neuroscience

Research collaborators

Professor Robert Honey (Cardiff University)

Professor John Harwood (Cardiff University)

Professor John Pearce (Cardiff University)

Dr. Emma Kidd (Cardiff University)

Dr. David Bannerman (Oxford University)

Dr. Robert Williams (University of Bath)

Postgraduate research interests

Postgraduate students currently carry out research directed at investigating the neural substrates of animal cognition and or evaluating putative therapies for amyloid pathology (see below)

If you are interested in applying for a PhD, or for further information regarding my postgraduate research, please contact me directly (contact details available on the 'Overview' page), or submit a formal application.

Current students

John Anderson – (writing up) The role of insulin resistance in the development of amyloid pathology. BBSRC/GSK CASE award

Katie Hall (current) The infuence of dietary supplements on memory and amyloid pathology in mouse models of Alzheimer’s Disease

Martha Hvoslefeide – (current) The effect of steric hindrance of Ab processing on cognition in APP mice

Laura Middleton (current) Maternal priming & Alzheimer’s Disease:The influence of diet and exercise on amyloid pathology in a mouse model of Alzheimer’s Disease

Caroline O’Hagan (current) The influence of probiotics on emotion and executive function in rodents

Alice Palmer (current) Amyloid pathology and hippocampal synaptic plasticity in mouse models of Alzheimer’s Disease

Past projects

Previous students

Phil Barnes – (submitted)Characterisation of a transgenic mouse model of Alzheimer’s disease. MRC

Cecile Bascoul – (submitted) Inflammatory processes in Alzheimer’s Disease: Investigation of dietary doxosahexanoec acid supplements in a mouse transgenic model. Department funded.

Dean Burnett – (submitted) Episodic-like memory in rats. BBSRC

James Dachtler- (submitted) GluR-1 roles in learning and synaptic plasticity

Mark Day – (submitted) The role of oestrogen in cognition. GSK

Gemma Hale – (submitting) Memory processes in a mouse transgenic model of Alzheimer’s disease. MRC

Andrew Hayward – (submitted) Cue competition in spatial learning. BBSRC

Alex Johnson – (submitted) The role of GluR1A receptors in learning and memory. Department funded

Peter Jones – (submitted) The role of the hippocampus in processing the geometry of the environment. Department funded

Mariah Lelos – (submitted) Frontal-amygdala interactions in an APP model of Alzheimer’s disease. MRC

Jo Oswald – (submitted) An analysis of entorhinal cortex function in the rat. MRC

Pippa Pugh – (submitted) Models of inflammation in Alzheimer’s disease. GlaxoSmithKline

Amy Reichelt – (submitted) Neurobiology of response conflict resolution- BBSRC/Eli Lilly

Kristina Wilton – (submitted) The effects of protein phosphorylation inhibition on tau production and cognition in rats. MRC