Dr Oleg Gerasimenko

2022

• Kusiak, A. A. et al. 2022. Activation of pancreatic stellate cells attenuates intracellular Ca 2+ signals due to downregulation of TRPA1 and protects against cell death induced by alcohol metabolites. Cell Death and Disease 13(8), article number: 744. (10.1038/s41419-022-05186-w)
• Gerasimenko, O. V. and Gerasimenko, J. V. 2022. CRAC channel inhibitors in pancreatic pathologies. Journal of Physiology 600(7), pp. 1597-1598. (10.1113/JP282826)
• Gerasimenko, J. V., Petersen, O. H. and Gerasimenko, O. V. 2022. SARS-CoV-2 S Protein Subunit 1 Elicits Ca2+ Influx – Dependent Ca2+ Signals in Pancreatic Stellate Cells and Macrophages In Situ. Function 3(2) (10.1093/function/zqac002)

2021

• Petersen, O. H., Gerasimenko, J., Gerasimenko, O. V., Gryshchenko, O. and Peng, S. 2021. The roles of calcium and ATP in the physiology and pathology of the exocrine pancreas. Physiological Reviews 101(4), pp. 1691-1744. (10.1152/physrev.00003.2021)

2020

• Gryshchenko, O., Gerasimenko, J., Petersen, O. H. and Gerasimenko, O. V. 2020. Calcium signaling in pancreatic immune cells in situ. Function 2(1), article number: zqaa026. (10.1093/function/zqaa026)
• Petersen, O. H., Gerasimenko, O. V. and Gerasimenko, J. V. 2020. Endocytic uptake of SARS-CoV-2: the critical roles of pH, Ca2+ and NAADP. Function 1(1), article number: zqaa003. (10.1093/function/zqaa003)

2019

• Jakubowska, M. A. et al. 2019. ABT‐199 (Venetoclax), a BH3‐mimetic Bcl‐2 inhibitor, does not cause Ca2+‐signalling dysregulation or toxicity in pancreatic acinar cells. British Journal of Pharmacology 176(22), pp. 4402-4415. (10.1111/bph.14505)

2018

• Peng, S., Gerasimenko, J. V., Tsugorka, T. M., Gryshchenko, O., Samarasinghe, S., Petersen, O. H. and Gerasimenko, O. V. 2018. Galactose protects against cell damage in mouse models of acute pancreatitis. Journal of Clinical Investigation 128(9), pp. 3769-3778. (10.1172/JCI94714)
• Gryshchenko, O., Gerasimenko, J., Peng, S., Gerasimenko, O. V. and Petersen, O. H. 2018. Calcium signalling in the acinar environment of the exocrine pancreas: physiology and pathophysiology. Journal of Physiology 596(14), pp. 2663-2678. (10.1113/JP275395)
• Vervliet, T., Gerasimenko, J. V., Ferdek, P. E., Jakubowska, M. A., Petersen, O. H., Gerasimenko, O. V. and Bultynck, G. 2018. BH4 domain peptides derived from Bcl-2/Bcl-XL as novel tools against acute pancreatitis. Cell Death Discovery 4, article number: 58. (10.1038/s41420-018-0054-5)
• Gerasimenko, J. V., Peng, S., Tsugorka, T. and Gerasimenko, O. V. 2018. Ca 2+ signalling underlying pancreatitis. Cell Calcium 70, pp. 95-101. (10.1016/j.ceca.2017.05.010)

2017

• Ferdek, P. E., Jakubowska, M. A., Polina, N., Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2017. BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell Death and Disease 8, article number: e2640. (10.1038/cddis.2017.41)
• Bittremieux, M. et al. 2017. DPB162-AE, an inhibitor of store-operated Ca2+ entry, can deplete the endoplasmic reticulum Ca2+ store. Cell Calcium 62 (10.1016/j.ceca.2017.01.015)

2016

• Ferdek, P. E., Jakubowska, M. A., Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2016. Bile acids induce necrosis in pancreatic stellate cells dependent on calcium entry and sodium-driven bile uptake. Journal of Physiology 594(21), pp. 6147-6164. (10.1113/JP272774)
• Peng, S., Gerasimenko, J. V., Tsugorka, T., Gryshchenko, O., Samarasinghe, S., Petersen, O. H. and Gerasimenko, O. V. 2016. Calcium and adenosine triphosphate control of cellular pathology: asparaginase-induced pancreatitis elicited via protease-activated receptor 2. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 371(1700), article number: 20150423. (10.1098/rstb.2015.0423)
• Jakubowska, M. A., Ferdek, P. E., Gerasimenko, O. V., Gerasimenko, J. V. and Petersen, O. H. 2016. Nitric oxide signals are interlinked with calcium signals in normal pancreatic stellate cells upon oxidative stress and inflammation. Open Biology 6(8), article number: 160149. (10.1098/rsob.160149)
• Gryshchenko, O., Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2016. Calcium signalling in pancreatic stellate cells: mechanisms and potential roles. Cell Calcium 59(2-3), pp. 140-144. (10.1016/j.ceca.2016.02.003)
• Gryshchenko, O., Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2016. Ca2+ signals mediated by bradykinin type 2 receptors in normal pancreatic stellate cells can be inhibited by specific Ca2+ channel blockade. Journal of Physiology 594(2), pp. 281-293. (10.1113/JP271468)

2015

• Gerasimenko, J. et al. 2015. Both RyRs and TPCs are required for NAADP-induced intracellular Ca2+ release. Cell Calcium 58(3), pp. 237-245. (10.1016/j.ceca.2015.05.005)

2014

• Gerasimenko, J. V., Peng, S. and Gerasimenko, O. V. 2014. Role of acidic stores in secretory epithelia. Cell Calcium 55(6), pp. 346-354. (10.1016/j.ceca.2014.04.002)
• Gerasimenko, J. V., Petersen, O. H. and Gerasimenko, O. V. 2014. Monitoring of intra-ER free Ca2+. Wiley Interdisciplinary Reviews: Membrane Transport and Signaling 3(3), pp. 63-71. (10.1002/wmts.106)
• Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2014. The role of Ca2+ in the pathophysiology of pancreatitis. The Journal of Physiology 592(2), pp. 269-280. (10.1113/jphysiol.2013.261784)

2013

• Gerasimenko, J. V. et al. 2013. Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy. Proceedings of the National Academy of Sciences of the United States of America 110(32), pp. 13186-13191. (10.1073/pnas.1300910110)

2012

• Ferdek, P., Gerasimenko, J. V., Peng, S., Tepikin, A. V., Petersen, O. H. and Gerasimenko, O. V. 2012. A novel role for Bcl-2 in regulation of cellular calcium extrusion. Current Biology 22(13), pp. 1241-1246. (10.1016/j.cub.2012.05.002)
• Gerasimenko, O. V., Petersen, O. H. and Gerasimenko, J. V. 2012. Role of intracellular acid Ca2+ stores in pathological pancreatic protease activation [Editorial]. Expert Review of Gastroenterology & Hepatology 6(2), pp. 129-131. (10.1586/EGH.12.5)
• Petersen, O. H., Gerasimenko, O. V. and Gerasimenko, J. V. 2012. The war within - unraveling the molecular causes of acute pancreatitis - a potentially deadly disease in which the pancreas essentially digests itself - is yielding clues to how it might be treated. The Scientist 26(2), pp. 40-44.
• Gerasimenko, O. V. and Gerasimenko, J. V. 2012. Mitochondrial function and malfunction in the pathophysiology of pancreatitis. Pflugers Archiv European Journal of Physiology 464(1), pp. 89-99. (10.1007/s00424-012-1117-8)

2011

• Petersen, O. H., Gerasimenko, O. V., Tepikin, A. and Gerasimenko, J. V. 2011. Aberrant Ca2+ signalling through acidic calcium stores in pancreatic acinar cells. Cell Calcium 50(2), pp. 193-199. (10.1016/j.ceca.2011.02.010)
• Petersen, O. H., Gerasimenko, O. V. and Gerasimenko, J. V. 2011. Pathobiology of acute pancreatitis: focus on intracellular calcium and calmodulin. F1000 Medicine Reports(3), article number: 15. (10.3410/M3-15)
• Booth, D. et al. 2011. Reactive oxygen species induced by bile acid induce apoptosis and protect against necrosis in pancreatic acinar cells. Gastroenterology 140(7), pp. 2116-2125. (10.1053/j.gastro.2011.02.054)
• Gerasimenko, J. V. et al. 2011. Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through IP3 receptors. Proceedings of the National Academy of Sciences of the United States of America 108(14), pp. 5873-5878. (10.1073/pnas.1016534108)

2010

• Voronina, S. G. et al. 2010. Dynamic changes in cytosolic and mitochondrial ATP levels in pancreatic acinar cells. Gastroenterology 138(5), pp. 1976-1987. (10.1053/j.gastro.2010.01.037)
• Gerasimenko, O. V. and Gerasimenko, J. V. 2010. Two-photon permeabilization and calcium measurements in cellular organelles. In: Live Cell Imaging: Methods and Protocols., Vol. 591. Methods in Molecular Biology Vol. 2. Springer, pp. 201-210., (10.1007/978-1-60761-404-3_12)

2009

• Lur, G. et al. 2009. Ribosome-free terminals of rough ER allow formation of STIM1 puncta and segregation of STIM1 from IP3 receptors. Current Biology 19(19), pp. 1648-1653. (10.1016/j.cub.2009.07.072)
• Baumgartner, H. K. et al. 2009. Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening. Journal of Biological Chemistry 284(31), pp. 20796-20803. (10.1074/jbc.M109.025353)
• Petersen, O. H., Tepikin, A. V., Gerasimenko, J. V., Gerasimenko, O. V., Sutton, R. and Criddle, D. N. 2009. Fatty acids, alcohol and fatty acid ethyl esters: Toxic Ca2+ signal generation and pancreatitis. Cell Calcium 45(6), pp. 634-642. (10.1016/j.ceca.2009.02.005)
• Gerasimenko, J. V. et al. 2009. Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors. Proceedings of the National Academy of Sciences of the United States of America 106(26), pp. 10758-10763. (10.1073/pnas.0904818106)
• Fedirko, N., Gerasimenko, J. V., Tepikin, A. V. and Gerasimenko, O. V. 2009. Regulation of early response genes in pancreatic acinar cells: external calcium and nuclear calcium signalling aspects. Acta Physiologica 195(1), pp. 51-60. (10.1111/j.1748-1716.2008.01935.x)

2008

• Barrow, S. L. et al. 2008. ATP depletion inhibits Ca2+ release, influx and extrusion in pancreatic acinar cells but not pathological Ca2+ responses induced by bile. Pflügers Archiv - European Journal of Physiology 455(6), pp. 1025-1039. (10.1007/s00424-007-0360-x)
• Chvanov, M. et al. 2008. ATP depletion induces translocation of STIM1 to puncta and formation of STIM1-ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP. Pflugers Archiv-European Journal of Physiology 457(2), pp. 505-517. (10.1007/s00424-008-0529-y)
• Murphy, J. A. et al. 2008. Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells. Gastroenterology 135(2), pp. 632-641. (10.1053/j.gastro.2008.05.026)

2007

• Baumgartner, H. K. et al. 2007. Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins. American Journal of Physiology-Gastrointestinal and Liver Physiology 293(1), pp. G296-G307. (10.1152/ajpgi.00103.2007)
• Voronina, S. G., Sherwood, M. W., Gerasimenko, O. V., Petersen, O. H. and Tepikin, A. V. 2007. Visualizing formation and dynamics of vacuoles in living cells using contrasting dextran-bound indicator: endocytic and nonendocytic vacuoles. American Journal of Physiology-Gastrointestinal and Liver Physiology 293(6), pp. G1333-G1338. (10.1152/ajpgi.00275.2007)
• Criddle, D. N. et al. 2007. Calcium signalling and pancreatic cell death: apoptosis or necrosis?. Cell Death and Differentiation 14(7), pp. 1285-1294. (10.1038/sj.cdd.4402150)
• Sherwood, M. W. et al. 2007. Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells. Proceedings of the National Academy of Sciences of the United States of America 104(13), pp. 5674-5679. (10.1073/pnas.0700951104)

2006

• Criddle, D. N. et al. 2006. Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells. Journal of Biological Chemistry 281(52), pp. 40485-40492. (10.1074/jbc.M607704200)
• Gerasimenko, J. V., Flowerdew, S. E., Voronina, S. G., Sukhomlin, T. K., Tepikin, A. V., Petersen, O. H. and Gerasimenko, O. V. 2006. Bile acids induce Ca2+ release from both the endoplasmic reticulum and acidic intracellular calcium stores through activation of inositol trisphosphate receptors and ryanodine receptors. Journal of Biological Chemistry 281(52), pp. 40154-40163. (10.1074/jbc.M606402200)
• Chvanov, M., Gerasimenko, O. V., Petersen, O. H. and Tepikin, A. V. 2006. Calcium-dependent release of NO from intracellular S-nitrosothiols. EMBO Journal 25(13), pp. 3024. (10.1038/sj.emboj.7601207)
• Gerasimenko, J. V., Sherwood, M., Tepikin, A., Petersen, O. H. and Gerasimenko, O. V. 2006. NAADP, cADPR and IP3 all release Ca2+ from the endoplasmic reticulum and an acidic store in the secretory granule area. Journal of Cell Science 119(2), pp. 226-238. (10.1242/jcs.02721)
• Yu, L. G. et al. 2006. Galectin-3 interaction with Thomsen-Friedenreich Disaccharide on cancer-associated MUC1 causes increased cancer cell endothelial adhesion. Journal of Biological Chemistry 282(1), pp. 773-781. (10.1074/jbc.M606862200)
• Burdakov, D. et al. 2006. Tandem-Pore K+ channels mediate inhibition of orexin neurons by glucose. Neuron -Cambridge Ma- 50(5), pp. 711-722. (10.1016/j.neuron.2006.04.032)
• Sherwood, M. W., Barrow, S. L., Dolman, N. J., Gerasimenko, O. V., Voronina, S. G. and Tepikin, A. V. 2006. Movement of calcium signals and calcium-binding proteins: firewalls, traps and tunnels. Biochemical Society Transactions 34(3), pp. 381-384. (10.1042/BST0340381)

2005

• Dolman, N. J., Gerasimenko, J. V., Gerasimenko, O. V., Voronina, S. G., Petersen, O. H. and Tepikin, A. V. 2005. Stable Golgi-mitochondria complexes and formation of Golgi Ca2+ gradients in pancreatic acinar cells. Journal of Biological Chemistry 280(16), pp. 15794-15799. (10.1074/jbc.M412694200)
• Voronina, S. G., Gryshchenko, O. V., Gerasimenko, O. V., Green, A. K., Petersen, O. H. and Tepikini, A. V. 2005. Bile acids induce a cationic current, depolarizing pancreatic acinar cells and increasing the intracellular Na+ concentration. Journal of Biological Chemistry 280(3), pp. 1764-1770. (10.1074/jbc.M410230200)
• Watson, A. J. et al. 2005. Epithelial barrier function in vivo is sustained despite gaps in epithelial layers. Gastroenterology 129(3), pp. 902-912. (10.1053/j.gastro.2005.06.015)
• Gerasimenko, O. V. and Tepikin, A. 2005. How to measure Ca2+ in cellular organelles?. Cell Calcium 38(3-4), pp. 201-211. (10.1016/j.ceca.2005.06.025)
• Burdakov, D., Gerasimenko, O. V. and Verkhratsky, A. 2005. Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ. Journal of Neuroscience 25(9), pp. 2429-2433. (10.1523/JNEUROSCI.4925-04.2005)

2004

• Voronina, S. G., Barrow, S. L., Gerasimenko, O. V., Petersen, O. H. and Tepikin, A. V. 2004. Effects of secretagogues and gile acids on mitochondrial membrane potential of pancreatic acinar cells: comparison of different modes of evaluating ΔΨm. Journal of Biological Chemistry 279(26), pp. 27327-27338. (10.1074/jbc.M311698200)
• Gerasimenko, O. V. and Gerasimenko, J. V. 2004. New aspects of nuclear calcium signalling. Journal of Cell Science 117(15), pp. 3087-3094. (10.1242/jcs.01295)

2003

• Gerasimenko, J. V., Maruyama, Y., Yano, K., Dolman, N. J., Tepikin, A. V., Petersen, O. H. and Gerasimenko, O. V. 2003. NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors. Journal of Cell Biology 163(2), pp. 271-282. (10.1083/jcb.200306134)
• Ashby, M. C., Camello-Almaraz, C., Gerasimenko, O. V., Petersen, O. H. and Tepikin, A. V. 2003. Long distance communication between muscarinic receptors and Ca2+ release channels revealed by carbachol uncaging in cell-attached patch pipette. Journal of Biological Chemistry 278(23), pp. 20860-20864. (10.1074/jbc.M302599200)
• Gerasimenko, O. V., Maruyama, Y., Tepikin, A., Petersen, O. H. and Gerasimenko, J. V. 2003. Calcium signalling in and around the nuclear envelope. Biochemical Society Transactions 31(1), pp. 76-78.

2002

• Yu, L. et al. 2002. An N-terminal truncated form of Orp150 Is a cytoplasmic ligand for the anti-proliferative mushroom Agaricus bisporus lectin and is required for nuclear localization sequence-dependent nuclear protein import. Journal of Biological Chemistry 277(27), pp. 24538-24545. (10.1074/jbc.M203550200)
• Gerasimenko, J. V., Gerasimenko, O. V., Palejwala, A., Tepikin, A., Petersen, O. H. and Watson, A. J. M. 2002. Menadione-induced apoptosis: Roles of cytosolic Ca2+ elevations and the mitochondrial permeability transition pore. Journal of Cell Science 115, pp. 485-497.
• Gerasimenko, O. V., Gerasimenko, J. V., Rizzuto, R. R., Treiman, M., Tepikin, A. V. and Petersen, O. H. 2002. The distribution of the endoplasmic reticulum in living pancreatic acinar cells. Cell Calcium 32(5-6), pp. 261-268. (10.1016/S0143416002001938)
• Ashby, M. C., Craske, M., Park, M. K., Gerasimenko, O. V., Burgoyne, R. D., Petersen, O. H. and Tepikin, A. V. 2002. Localized Ca2+ uncaging reveals polarized distribution of Ca2+-sensitive Ca2+ release sites: mechanism of unidirectional Ca2+ waves. Journal of cell biology 158(2), pp. 283-292.

2001

• Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2001. Membrane repair: Ca2+-elicited lysosomal exocytosis. Current Biology 11(23), pp. R971-R974. (10.1016/S0960-9822(01)00577-2)

2000

• Cansela, J. M., Gerasimenko, O. V., Gerasimenko, J. V., Tepikin, A. V. and Petersen, O. H. 2000. Two different but converging messenger pathways to intracellular Ca2+ release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate. Embo Journal 19(11), pp. 2549-2557. (10.1093/emboj/19.11.2549)