Yr Athro Peter Ghazal
Sêr Cymru Chair in Systems Medicine, Systems Immunity Research Institute
Prof Ghazal's research interests are aimed towards understanding how host-gene networks control infection, especially with those host-pathways associated with sepsis and the immune-metabolic axis.
His recent studies have pioneered the field of host genomics of early-life infection, mapping and deciphering gene metabolic signatures of systemic host response to infection in pre-term infants and neonates and understanding the molecular wiring and mechanisms for coupling lipid metabolism to immune (interferon) response.
These studies are specifically aimed at the development of new diagnostic and therapeutic strategies, including predictive modelling of host-defence against infection in sepsis, and the development of new computational and functional genomic methods for gaining a deeper understanding of complex dynamical biological systems of viral (cytomegaloviral) and microbial diseases.
Professor Peter Ghazal FMedSci holds the Sêr Cymru II Chair of Systems Medicine at Cardiff Medical School, Systems Immunity Research Institute and is Honorary Professor of Molecular Genetics and Biomedicine at the University of Edinburgh Medical School. He was founding Director of the Scottish Centre for Genomic Technology and Informatics and former Head of the Division of Pathway Medicine, Associate Director of Centre for Synthetic and Systems Biology at Edinburgh. Prior to joining Edinburgh Medical School, he was Associate Professor at the Scripps Research Institute in La Jolla, California and a Scholar of the American Leukemia Society.
His research interests are in the field of host genomics of early-life infection, mapping immune (interferon) networks of systemic host response to infection and understanding the link between lipid metabolism and host protection pathways.
These studies are specifically aimed at the development of new diagnostic and therapeutic strategies, including predictive modelling of host-defence against infection. He has been actively involved in a range of collaborative clinical investigations conducted in the UK and in Africa with the MRC Gambia unit using a systems biology approach to better understand neonatal sepsis, and deciphering the molecular systems immunology of childhood pneumonia and vaccine responses.
His career spans 15 years in the USA (as a Fellow at NIH and subsequently as Faculty member at The Scripps Research Institute, Department of Immunology) and the last 17 years in the UK, he has published over 200 papers and 9 patents and founder of three start-up companies.
Professor Ghazal has served on a number of national and international advisory boards, think tanks, and review committees within both academia, industry, charitable and government bodies in the UK, EU, USA and Canada, including most recently Chair of the Virus Scientific Advisory Board for the Wellcome Trust Sanger Institute, and a member of the Scientific Advisory Board for the NIH NIAID Human Immunology Project Consortium in the USA. He was elected Fellow of the Academy of Medical Sciences in 2015.