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Research Overview

I plan to conduct a body of research to clarify a number of aspects of cell-cell communication in the cornea. In order to do this, keratocytes will be cultivated in 3D culture systems to investigate the structures responsible for such communication to occur (i.e. gap junctions, integrins, and cadherins). These findings will then facilitate the study of the type of cell-cell communication that occurs in human induced pluripotent stem (iPS) cell derived constructs via immunofluorescence microscopy and 3D electron microscopy. This knowledge will aid in constructing more robust ex-vivo corneal epithelial cell constructs for transplantation to treat ocular surface disease.

Research Collaborators

Professor Julie Daniels, Institute of Ophthalmology, University College London: Co-author of review Article about tissue engineering of the corneal epithelium for the treatment of ocular surface disease
Professor Kohji Nishida, Department of Ophthalmology, Osaka University Graduate School of Medicine, Japan

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