Ewch i’r prif gynnwys

Abhishek Chakraborty

Myfyriwr ymchwil,

Mae'r cynnwys hwn ar gael yn Saesneg yn unig.

Trosolwg

Calcium (Ca2+) signaling and its interplay with cellular mechanics plays a crucial role in development as well as in most other body processes, but it is poorly understood. Recent technical advances in molecular and live imaging provide an unprecedented opportunity to understand the complex mechanochemical processes of development. However, the large imaging datasets generated should now be carefully interpreted. 


That's where I come in!


In embryogenesis, malformations and cancer can result when the complex mechanochemical mechanisms go wrong. My role is to investigate the role of Ca2+ signalling in the development of the central nervous system (CNS) in embryos by developing computational models.


During the development of the CNS, cells undergo a dramatic shape change termed Apical Constriction. When Apical Constriction goes amiss, it can result in Spina Bifida - the second most frequent embryo malformation. I aim to elucidate the mechanism of Apical Constriction and, ultimately, inform clinical practice in order to reduce the number of cases with Spina Bifida.

Ymchil

Diddordebau ymchwil

Modelling Calcium Signalling in Embryogenesis

Goruchwyliaeth

KaterinaPhoto

Dr Katerina Kaouri

Lecturer in Applied Mathematics

Tim Phillips photograph

Yr Athro Tim Phillips

Head of School