Mae'r cynnwys hwn ar gael yn Saesneg yn unig.
Calcium (Ca2+) signaling and its interplay with cellular mechanics plays a crucial role in development as well as in most other body processes, but it is poorly understood. Recent technical advances in molecular and live imaging provide an unprecedented opportunity to understand the complex mechanochemical processes of development. However, the large imaging datasets generated should now be carefully interpreted.
That's where I come in!
In embryogenesis, malformations and cancer can result when the complex mechanochemical mechanisms go wrong. My role is to investigate the role of Ca2+ signalling in the development of the central nervous system (CNS) in embryos by developing computational models.
During the development of the CNS, cells undergo a dramatic shape change termed Apical Constriction. When Apical Constriction goes amiss, it can result in Spina Bifida - the second most frequent embryo malformation. I aim to elucidate the mechanism of Apical Constriction and, ultimately, inform clinical practice in order to reduce the number of cases with Spina Bifida.
Modelling Calcium Signalling in Embryogenesis