Ewch i’r prif gynnwys
 Alex Voisey

Alex Voisey

Myfyriwr ymchwil,

Mae'r cynnwys hwn ar gael yn Saesneg yn unig.

Trosolwg

Thesis Title:


Pharmacology of vascular responses to dietary amines (see Research - Thesis)


Biography:


I gained by bachelor’s degree in anatomical sciences at the University of Manchester in 2014. My final year project investigated defects in heart development due to a mutation of a spliceosome component PRPF8. Following this I undertook a Master of Research in Biomedical research at Cardiff University within the School of Medicine. I undertook three research projects:



  1. Developing an assay to assess the ability of anti-cancer agents to target breast cancer stem cells

  2. Investigating the role of Hepatocyte growth factor in mediating oral mucosal fibroblast wound healing responses

  3. Assessing the roles of epidermal growth factor and transferrin on the pro-wound healing effects of EBC-46 in epidermal keratinocytes


I then undertook work as a research technician in the laboratory of Professor Bernhard Moser in the School of Medicine, working on tissue-resident immune cells during homeostasis. I am currently in the 3rd year of my PhD Studies in the Cardiff University School of Pharmacy working on the pharmacology of vascular responses to trace amines.



Conference/Seminar presentations:


December 2019: British Pharmacological Society annual meeting (Oral and Poster)


September 2019: 6th BHF Fellows meeting (Poster)


May 2019: School of Pharmacy PGR research day (Poster)


March 2019: Speaking of Science Interdisciplinary Conference (Oral)


December 2018: British Pharmacological Society annual meeting (Poster)


Education and Professional Qualifications:


2017-Present: PhD, Pharmacology of vascular responses to dietary amines, Cardiff University, School of Pharmacy


2014-2015: MRes Biomedical Research, Cardiff University, School of Medicine


2011-2014: BSc. (2:1 Honours) Anatomical Sciences, University of Manchester


 Positions held:


2015-2017: Research Technician, Cardiff University, School of Medicine, Institute of Infection and Immunity

Ymchil

Diddordebau ymchwil

Research Interests


Cardiovascular Pharmacology/Physiology: trace amine associated receptors, research techniques, cannabinoids, hypertension.


Research Techniques


Isolated blood vessels, wire myography, organ perfusion, pharmacology, cell culture, molecular biology, flow cytometry



Public engagement


STEM ambassador


Pint of Science City Coordinator 2020, Event Manager 2019


Brain Games 2018


Traethawd ymchwil

Pharmacology of vascular responses to dietary amines

Trace amines are biologically active amines that occur naturally in the body but are also commonly ingested in the diet from foods such as cheeses, wine and chocolate. They are related to classical neurotransmitters such as adrenaline, noradrenaline, dopamine and serotonin. Elevated levels of trace amines in the circulation are associated with negative cardiovascular events including hypertension. The pressor response to trace amines is recognised as trace amines acting indirectly as sympathomimetic amines. This is achieved by promoting efflux of noradrenaline from sympathetic neurones causing activation of adrenoreceptors resulting in a sympathetic effect such as vasoconstriction. This may be an oversimplification as evidence has implicated that noradrenaline independent mechanisms play an important role. The trace amine-associated receptors (TAARs) are a likely candidate for this. However; it is unknown whether TAARs mediate the vascular response to trace amines. My project aims to identify a role for TAARs in mediating vasoconstriction and to characterise trace amine vascular responses in both conductance (aorta) and resistance (mesentery) vessels. This project is funded by the British Heart Foundation under the supervision of Dr William Ford.

Ffynhonnell ariannu

British Heart Foundation

Goruchwyliaeth

Wiliaml Ford

Dr William Ford

Senior Lecturer

Yr Athro Kenneth Broadley

Emeritus Professor

Dr Emma Kidd

Darllenydd mewn Ffarmacoleg a Chyfarwyddwr Astudiaethau Ymchwil Ȏl-raddedig/Cydlynydd Erasmus+ a Chydlynydd Symudoldeb Myfyrwyr Rhyngwladol