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CogTrainHD is a feasibility study exploring computerised cognitive training for people with Huntington’s disease.
Cognitive impairments, especially deficits of executive function, are a core and early feature in Huntington’s disease (HD). Computerised cognitive training interventions focused on improving executive function present an exciting non-pharmacological treatment option. Novel work conducted in mouse models of HD has demonstrated that cognitive training, administered from an early stage in the disease, can improve motor performance at an older age, even in the absence of further training in the intervening time.
Executive function training has been shown to improve both cognitive and motor outcomes in a variety of neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease.
In this study, we aim to establish the feasibility and effectiveness of using computerised cognitive training in people with HD. We will also investigate the most appropriate outcome measures to use in this study and gather feedback on the cognitive training intervention from participants and nominated carers, family members or friends.
Although you do not have to have an MRI brain scan to take part in the study, we will also establish proof of concept via the study of brain structure and function, using MRI scanning techniques with colleagues in the Cardiff University Brain Research Imaging Centre (CUBRIC).
Contact Dr Emma Yhnell to find out more about this study: