Stem Cell Fate Dynamics
Mae'r cynnwys hwn ar gael yn Saesneg yn unig.
Led by Dr Joaquin de Navascués, this research group focuses on understanding the molecular mechanisms whereby tissue stem cells balance differentiation and self-renewal.
Adult stem cells have the remarkable capacity to produce several differentiated cell types whilst self-renewing themselves. This is essential to maintaining tissues that are subject to constant wear and tear, such as the skin or the gut; defects in stem cell behaviour can lead to malfunction or malignancies.
The Navascués lab uses the vinegar fly Drosophila melanogaster, a tractable model organism, to investigate intestinal stem cell regulation in great detail in in the context of a whole organism, with a view to identifying strategies to target both normal and cancer stem cells.