Internationally recognised, we pursue a broad range of neurobiological research, aimed at finding out how the brain works.
We strive to gain a better understanding of the function of the healthy nervous system and the mechanisms leading to neurological disease states. We aim to translate our knowledge into pharmacological and cell-based therapies and improved clinical practice.
We are a member of the Neuroscience & Mental Health Research Institute (NMHRI), which brings together research in neuroscience, psychology and psychiatric genetics and genomics, and are a major participant in the Wellcome Trust 4 year PhD programme in Integrative Neuroscience. We have strong links with the new Dementia Research Institute as well as the Drug Discovery Centre. We also host the experimental MRI centre (EMRIC).
We have particular strengths in the three areas of synaptic biology, cellular and developmental neurobiology, and systems neuroscience.
We welcome approaches by potential fellowship applicants and funded PhD students to host their research and expand our research in strategic areas.
|Name||Area of interest|
|Professor Frank Sengpiel - Head of Division||Developmental plasticity in the visual cortex and developmental disorders of vision.|
|Professor Nick Allen||The mechanisms of neural differentiation of human and mouse embryonic stem cells with the aim of developing protocols to direct the differentiation of neural progenitors to acquire specific neural fates and phenotypes.|
|Dr Sheila Amici-Dargan||Synaptic plasticity, learning and memory. Autonomic nervous system and neuromuscular pathophysiology.|
|Professor John Atack||The identification and development of novel drugs for the treatment of psychiatric and neurodegenerative disorders, such as schizophrenia, anxiety disorders, Alzheimer's disease and Huntington's disease.|
|Professor Yves Barde||Molecular and cellular mechanisms underlying brain function in health and disease.|
|Dr Benjamin Bax||Using structure-guided drug design to make new medicines to improve human health.|
|Professor Riccardo Brambilla||The roles of intracellular signalling pathways in learning and memory.|
|Professor David Carter||Mechanisms that regulate gene expression in neurons in response to physiological stimuli, and also during pathological states.|
|Professor Vincenzo Crunelli||Molecular, genetic and cellular mechanisms that operate in single neurons and neuronal networks of the thalamus and cortex during the expression of different stages of sleep and the generation of epileptic syndromes.|
|Professor Alun Davies FRS||Vertebrate neuron development.|
|Professor Kevin Fox||The molecular and cellular mechanisms underlying sensory processing and synaptic plasticity in the cerebral cortex.|
|Professor William Gray||Clinical research in epilepsy, the hippocampus, learning and memory.|
|Dr Olivera Grubisha||Drug discovery with focus on psychiatric and neurodegenerative disorders. Pharmacological profiling of compounds using biochemical and cellular methods and use in drug target validation.|
|Professor Adrian Harwood||Neuro cell biology, mental disorders and psychotropic drugs.|
|Professor Tim Jacob||How and why we detect odours, whether smell discrimination is innate and to what extent we use smell to communicate.|
|Dr Emyr Lloyd-Evans||Elucidating the function of lysosomes in health and disease.|
|Dr Mariah Lelos||Understanding neuropathological changes in Parkinson’s and Huntington’s disease and the effect on cognitive function. Investigating therapeutic interventions, including cell and gene therapies.|
|Professor Meng Li||Neuronal subtype specification of pluripotent stem cells, their use in elucidating the cellular basis of mental disorders, and transplantation-based cell therapy.|
|Dr Guy Major||The fundamental computations carried out by small neural networks, including the generation of local spikes, plateau potentials and direction selectivity in single cortical pyramidal neuron dendrites.|
|Dr Isabel Martinez-Garay||Cellular and molecular mechanism of cortical development.|
|Dr David McGonigle||Function of the somatosensory system in both health and disease, the neural correlates of skill training and perceptual learning in sensory systems.|
|Dr Owen Peters||Molecular mechanisms associated with neurodegeneration and maintenance of the ageing brain.|
|Professor Anne Rosser||Co-directs the Brain Repair Group whose mission is to develop cell-based therapies for Neurodegenerative disease, especially Huntington's disease and Parkinson's disease, based on primary fetal, progenitor and stem cell transplantation in the brain.|
|Dr Yasir Ahmed Syed||Stem cell modelling of neurological disorders|
|Dr Kerrie Thomas||Molecular, cellular and neural processes that underlie long-term memory, particularly emotional memory.|
|Dr Alan Watson||Physiological basis of musical performance, musculoskeletal problems in musicians, sensory circuitry of the dorsal horn, invertebrate neuroethology.|
|Dr Tim Wells||Regulation of neuroendocrine and endocrine processes by metabolic status, with particular interest in the actions of ghrelin.|
|Dr Sean Wyatt||Mechanisms that lead to the acquisition of distinct functional phenotypes by different subsets of adult peripheral sensory neurons.|