Biomedicine

Biomedicine is a research area within which you can focus your studies as part of our suite of Biosciences research programmes (PhD, MPhil, MD).

Biomedicine focuses on the molecular mechanisms underpinning physiology, disease and the processes that drive repair and regeneration. The Division has a broad strength that spans biochemistry, cell biology, molecular genetics and signal transduction. The groups within Biomedicine focus on a variety of biological systems both in vivo and in vitro, and augment studies on human cell lines and tissues with studies in model organisms such as the mouse and Xenopus.

Biomedicine is a well-funded Division with excellent modern facilities for a broad range of techniques. It has close links with The European Cancer Stem Cell Research Institute, the Cardiff Institute of Tissue Engineering and Repair (CITER), the Arthritis Research UK Biomechanics and Bioengineering Centre and also with the Cardiff CR-UK Cancer Centre. The Division also has numerous global academic and industrial partners.

Contacts

Administrative contact(s)

School of Biosciences Education Office

Research within the Division is relevant to several areas of human disease, but is particularly strongly linked to cancer and tissue repair. The spectrum of research activities include:

  • genetically engineered murine models of human cancer
  • epigenetics of normal development and disease
  • mammary cancer and cell death
  • stem/progenitor cells in mammalian organogenesis
  • pathophysiology of calcium signalling specifically related to pancreatitis
  • stem cell fate determination
  • inflammation, atherosclerosis and regulation of gene expression
  • molecular mechanisms of nutrient sensing
  • monoclonal antibody technologies to study onset of degenerative joint diseases
  • synovial joint biology
  • structure and function of the minor collagens of cartilage, cell signalling pathways associated with mechanical and cytokine-mediated cartilage degeneration
  • cartilage proteoglycan metabolism in osteoarthritis
  • cellular control of extracellular matrix secretion and organisation in connective tissues
  • signalling mechanisms regulating bone and cartilage turnover, in osteoporosis, rheumatoid arthritis and osteoarthritis
  • how Epigenetic Marks direct Mammalian Development and drive Human Disease
  • connective tissue mechanobiology
  • functional significance of synuclein proteins in the normal and degenerating nervous system
  • investigation of cell death mechanisms
  • cell fate determination in Xenopus
  • elucidating the function of lysosomes in health and disease
  • the role of normal mammary stem and progenitor cells in the generation of breast cancer phenotypic heterogeneity and cancer stem cells
  • cell preservation technology
  • development of autologous cell-based methods for repair of the degenerate nervous and immune systems
  • molecular mechanisms mediating channel regulation by reversible protein phosphorylation and mechanisms underlying volume regulation
  • morphogenetic mechanisms in the organisation of oriented connective tissues.

For details of ongoing projects and collaborations, please visit the web pages of individual Biomedicine Division members.

Projects

We currently have a range of projects available to apply for within the School of Biosciences, some of which are offered as part of our range of DTP involvements.

Examining the programming of offspring behaviour by maternal diet and abnormal maternal care

There is a well-defined association between early life adversity (either prenatally or in early childhood) and significantly poorer outcomes for children.

Role of the lysosome, and the lysosomal protein NPC1 in the pathogenesis and treatment of Mycobacteriumtuberculosis

Tuberculosis (TB) is a chronic disease that in it’s latent form affects approximately one third of the worlds population with an estimated 10 million new cases and 1.5 million deaths per year.

Towards the clinical development of calcium-sensing receptor antagonists as novel therapeutics for inflammatory lung diseases

G protein-coupled receptors (GPCRs) have crucial roles in almost every physiological process from cardiac function, immune responses and neurotransmission to sensory functions comprising sight, taste and smell.

Characterisation of microRNAs regulated by dihomo-gamma-linolenic acid in macrophages in relation to atherosclerosis

Atherosclerosis, the underlying cause of myocardial infarction, stroke and peripheral vascular disease, is responsible for more deaths in the western world than any other disease with mortality increasing at a marked rate in developing countries.

Funding

There are currently no funding opportunities available.

Tuition fees

UK and EU students (2017/18)

Get the latest information on postgraduate fees.

Students from outside the EU (2017/18)

Get the latest information on postgraduate fees.

Programme information

For programme structure, entry requirements and how to apply, visit the Biosciences programme.

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Postgraduate students on campus

Open Day

Meet us at our Postgraduate Open Day on 22 November 2017.

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