PhD in Biosciences: Reprogramming Patient-derived Cells to Model Neuropsychiatric Disorders

This funding opportunity has expired.

Key facts

Application deadline 13 February 2017
Start date 1 April or 1 July 2017
Duration 3 years
Level of study Postgraduate research
Award type PhD studentship
Number of studentships 1

As part of a wide-reaching international outlook, the College of Biomedical and Life Sciences has a long-standing collaboration with a number of prominent Universities in China.

A recent £2.5m University commitment to these Chinese collaborations has led to the appointment of four research fellows whose efforts are focused on developing research which has global impact.

In support of these activities, we now seek to employ a smart and motivated PhD student to work on this translational project by developing human glial models of neuropsychiatric disorders.

Neuropsychiatric disorders (NPDs) such as schizophrenia and mood disorders begin early in life, affect 1 in 17 people worldwide and have no effective treatments. Glial dysfunction plays a leading role in the pathogenesis of NPDs.

Modelling NPDs using patient-derived induced pluripotent stem cells (iPSCs) by subsequent differentiation into glial cells will provide a novel insight into altered glial dysfunction and help to develop novel therapeutic approaches.

The successful applicant will work on this translational project by developing human glial models of NPDs from patient derived- iPSCs, with genetic backgrounds permissive to the disease state. The generated cells will be characterized and functionality validated in relevant animal models.

Experience in mammalian tissue culture, genetic engineering and/or imaging would be an advantage.

As part of this international programme, the student will not only receive a world class research and wider skills training but will also have the opportunity to visit and work in close collaboration with our Chinese partners.

The College of Biomedical and Life Sciences at Cardiff University offers an outstanding environment for clinical and non-clinical research training.

Cardiff University is ranked 5th in the UK for the quality of our research and 2nd nationally for the impact of our research. Our ambition is to be among the top 100 universities in the world, supported with a new £300m Innovation Campus helping us turn research questions into ‘real world’ answers.

Supervisors

  • Dr Yasir Ahmed Syed

Contact

Research Office

Funding details

Tuition fee support Other
This studentship covers full UK/EU and full overseas fees.
Maintenance stipend Doctoral stipend matching UK Research Council National Minimum

Eligibility criteria

Residency Open to all students of any nationality without restrictions(UK/EU and International)
Academic criteria

Applicants should have obtained, or be about to obtain, a 2:1 degree or higher in any subject relating to Biosciences, or the equivalent.

English language requirements

Applicants whose first language is not English are normally expected to meet the minimum University requirements (eg 6.5 IELTS). Please see our English Language Requirements guidance for more details.

For international students only (non-EU): To study at Cardiff University you must hold a valid visa which entitles you to study at this University.

Contact

Research Office

Applicants should submit an application for postgraduate study via our online application service.

Applicants should select Doctorate of Philosophy in Biosciences, with a start date of April or July 2017 depending on preference. The mode of study should be entered as full-time.

In the research proposal section of your application, please specify the project title and supervisors of this project and copy the project description in the text box provided. In the funding section, please select 'I will be applying for a scholarship/grant'.

If are applying for more than one Cardiff University project, please note this in the research proposal section.

We reserve the right to close applications early should sufficient applications be received.

Contact

Research Office

Find out more about Postgraduate study at our Open Day on 21 November 2018.

Eligible research programmes

Eligible research areas