Dr Monica Busse
My research has mainly focused on developing evidence and guidelines for targeted physical interventions in Huntington’s disease (HD) and Parkinson ’s disease (PD). Such interventions are complex, and involve many components. It is therefore essential that the main “active components” within the intervention are defined and benefits evaluated in terms of relevant outcomes. Our group has adopted the Medical Research Council (MRC) Framework for design and evaluating complex interventions to provide a structure that should ultimately lead to full scale, robust controlled clinical trials.
Our group has now successfully conducted and published data from the first randomised and controlled multi-centre studies investigating different physiotherapy and exercise interventions for HD (MOVE TO EXERCISE, TRAIN-HD and COMMET-HD). This work has now led to further funding for exercise intervention trials related in HD. ENGAGE-HD is a trial that aims to develop psychosocial support systems for changing physical activity behaviours whilst ExERT-HD will test the benefit of aerobic exercise training protocols in HD. The growing recognition of the importance of physical activity and physiotherapy in HD is further evidenced by the FP-7 funded programme of work being conducted in REPAIR-HD ( http://www.repair-hd.eu/) where I am a principle investigator along with a consortia of researchers based in Germany, France and Italy.
I am a reviewer for a range of international peer reviewed journals in the field and have presented our work at a variety of national and international conferences over the last 6 years.
- FP7-HEALTH-2013-INNOVATION-1 "REPAIR-HD Human pluripotent stem cell differentiation, safety and preparation for therapeutic transplantation in Huntington’s disease". £1,705,800
- Jacques and Gloria Gossweiler Foundation "ExeRT-HD Exercise Rehabilitation Trial in Huntington's Disease". £172,805
- National Institute of Social Care and Health Research/ National Institute of Health Research "Move to Exercise: Home based exercise for people with Huntington’s Disease". £687,362
- Linden. Morris, Subramanian, Busse Wellcome Trust ISSF Seedcorn “Real Time fMRI neurofeedback as a treatment for Parkinson’s Disease”. £45,000
- Neil Glendinning Research Grant Huntington's Disease Association: Task Training in Huntington's Disease £99,230
- European Huntington’s Disease Network. Feasibility and benefit of inspiratory muscle training in people with Huntington’s disease. (co-applicant; £38,384)
- National Institute for Social Care and Health Research Health Research Funding Scheme: Can community supported exercise benefit subjective wellbeing, physical activity levels and abilities in people with Huntington’s disease? A randomised feasibility study and process evaluation (COMMET-HD) £122,720
- Medical Research Council. National Prevention Research Initiative. Health Eating and Lifestyle in Pregnancy Study (HELP) (collaboration with South East Wales Trials Unit) (co-applicant; £1,041,422)
- European Huntington’s Disease Network. Reliability and minimal detectable change of measures of participation, functional activities and impairments in individuals with Huntington’s disease (£36,000)
- Physiotherapy Research Foundation Scheme B. Respiratory Function in people with Huntington’s disease: a cross sectional study (co-applicant; £6,500)
- Research Capacity Building Consortium Wales PhD studentship. Respiratory Function in people with Huntington’s disease: a cross sectional study (co-applicant; £51,558)
- Chief Medical Officer for Wales Research Budget. Development and evaluation of a DVD resource for people with a neurodegenerative disease who may be at risk of falls. £9,938.
- Paul Jeffries Waters Bequest Fund to support research in Huntington’s disease £2,820.
- Physiotherapy Research Society. Mobility and Falls in Huntington’s Disease. £500