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Dr Monica Busse 

My research has mainly focused on developing evidence and guidelines for targeted physical interventions in Huntington’s disease (HD) and Parkinson’s Disease (PD). Such interventions are complex, and involve many components. It is therefore essential that the main “active components” within the intervention are defined and benefits evaluated in terms of relevant outcomes. We have adopted the Medical Research Council (MRC) Framework for design and evaluating complex interventions to provide a structure that should ultimately lead to full scale, robust controlled clinical trials. Over the course of the last 5 years, we have validated outcome measures, consulted service users to develop appropriate interventions, conducted case studies and 2 larger feasibility studies (MOVE TO EXERCISE and COMMET-HD). We are currently conducting multi-centre feasibility study of task specific physiotherapy (TRAIN-HD) and setting up a new home based multi-centre exercise study for people with HD.

Research grants


  • Jacques and Gloria Gossweiler Foundation "ExeRT-HD Exercise Rehabilitation Trial in Huntington's Disease". £172,805
  • National Institute of Social Care and Health Research/ National Institute of Health Research "Move to Exercise: Home based exercise for people with Huntington’s Disease". £687,362


  • Linden. Morris, Subramanian, Busse Wellcome Trust ISSF Seedcorn “Real Time fMRI neurofeedback as a treatment for Parkinson’s Disease”. £45,000


  • Neil Glendinning Research Grant Huntington's Disease Association: Task Training in Huntington's Disease £99,230
  • European Huntington’s Disease Network. Feasibility and benefit of inspiratory muscle training in people with Huntington’s disease. (co-applicant; £38,384)


  • National Institute for Social Care and Health Research Health Research Funding Scheme: Can community supported exercise benefit subjective wellbeing, physical activity levels and abilities in people with Huntington’s disease? A randomised feasibility study and process evaluation (COMMET-HD) £122,720
  • Medical Research Council. National Prevention Research Initiative. Health Eating and Lifestyle in Pregnancy Study (HELP) (collaboration with South East Wales Trials Unit) (co-applicant; £1,041,422)


  • European Huntington’s Disease Network. Reliability and minimal detectable change of measures of participation, functional activities and impairments in individuals with Huntington’s disease (£36,000)
  • Physiotherapy Research Foundation Scheme B. Respiratory Function in people with Huntington’s disease: a cross sectional study (co-applicant; £6,500)
  • Research Capacity Building Consortium Wales PhD studentship. Respiratory Function in people with Huntington’s disease: a cross sectional study (co-applicant; £51,558)


  • Chief Medical Officer for Wales Research Budget. Development and evaluation of a DVD resource for people with a neurodegenerative disease who may be at risk of falls.  £9,938.
  • Paul Jeffries Waters Bequest Fund to support research in Huntington’s disease £2,820.


  • Physiotherapy Research Society. Mobility and Falls in Huntington’s Disease. £500