Dr George Kirov
Based at the Department of Psychological Medicine & Neurology
Copy number variation and next generation sequencing in schizophrenia.
Research Interests and Facilities
It is becoming increasingly evident that Copy number variation (CNV) is widespread in the general population, and even accounts for more differences between individual genomes, than SNPs. CNVs, especially de novo occurring ones, have been shown to play important role in neurodevelopmental disorders. We are analysing CNV data on several thousand new patients. This will allow us to examine the role of very rare CNVs in this disorder. In parallel, we are analysing next generation sequencing data on a sample of 600 parent-offspring trios. We are interested in the role of de novo mutations, but also in the role of inherited rare DNA variants.
Dr Kirov has extensive experience in psychiatric genetics and work with microarrays and CNVs.
Lab facilities: PCR, sequencers, Illumina station.
Available PhD Projects
Any projects within the remit of my research interests described above will be considered.
Kirov G, Grozeva D, Norton N, Ivanov D, Mantripragada KK, Holmans P, International Schizophrenia Consortium, the Wellcome Trust Case Control Consortium, Craddock N, Owen MJ, O'Donovan MC. Support for the involvement of large CNVs in the pathogenesis of schizophrenia. Hum Mol Genet. 2009 Apr 15;18(8):1497-1503.
Kirov G, Rujescu D, Ingason A, Collier DA, O’Donovan MC and Owen MJ. Neurexin 1 (NRXN1) deletions in schizophrenia. Schizophrenia Bulletin, 2009 Sep;35(5):851-854.
Moskvina V, Smith M, Ivanov D, Blackwood D, Stclair D, Hultman C, Toncheva D, Gill M, Corvin A, O'Dushlaine C, Morris DW, Wray NR, Sullivan P, Pato C, Pato MT, Sklar P, Purcell S, Holmans P, O'Donovan MC, Owen MJ, Kirov G. Genetic Differences between Five European Populations. Hum Hered. 2010 Jul 8;70(2):141-149.
Ingason A, Kirov G, Giegling I, Hansen T, Isles AR, Jakobsen KD, Kristinsson KT, le Roux L, Gustafsson O, Craddock N, Möller HJ, McQuillin A, Muglia P, Cichon S, Rietschel M, Ophoff RA, Djurovic S, Andreassen OA, Pietiläinen OP, Peltonen L, Dempster E, Collier DA, St Clair D, Rasmussen HB, Glenthøj BY, Kiemeney LA, Franke B, Tosato S, Bonetto C, Saemundsen E, Hreidarsson SJ; GROUP Investigators, Nöthen MM, Gurling H, O'Donovan MC, Owen MJ, Sigurdsson E, Petursson H, Stefansson H, Rujescu D, Stefansson K, Werge T. Maternally Derived Microduplications at 15q11-q13: Implication of Imprinted Genes in Psychotic Illness. Am J Psychiatry. 2011 Apr;168(4):408-17. Epub 2011 Feb 15.
Rees E, Moskvina V, Owen MJ, O'Donovan MC, Kirov G. De Novo Rates and Selection of Schizophrenia-Associated Copy Number Variants. Biol Psychiatry. 2011 Dec 15;70(12):1109-14. Epub 2011 Aug 19.
Kirov G, Pocklington AJ, Holmans P, Ivanov D, Ikeda M, Ruderfer D, Moran J, Chambert K, Toncheva D, Georgieva L, Grozeva D, Fjodorova M, Wollerton R, ReesE, Nikolov I, van de Lagemaat LN, Bayés À, Fernandez E, Olason PI, Böttcher Y, Komiyama NH, Collins MO, Choudhary J, Stefansson K, Stefansson H, Grant SGN, Purcell S, Sklar P, O’Donovan MC, Owen MJ. De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia. Molecular Psychiatry 2012 Feb;17(2):142-53. Epub 2011 Nov 15.
Grozeva D, Conrad DF, Barnes CP, Hurles M, Owen MJ, O'Donovan MC, Craddock N, Kirov G, WTCCC Independent estimation of the frequency of rare CNVs in the UK population confirms their role in schizophrenia. Schizophrenia Research 2012 Mar;135(1-3):1-7. Epub 2011 Nov 29.