Prof. Mark Good
Based at the Behavioural Neuroscience Laboratory, School of Psychology
Hippocampus, memory, emotion, Alzheimer’s disease, synaptic plasticity
Research Interests and Facilities
My research interests fall into three main areas: (1) Investigation of the role played by the hippocampus and related cortical areas in learning, memory and emotion in rodents; (2) The role played by synaptic plasticity mechanisms in learning and memory in rodents; (3) Characterisation of murine models of Alzheimer’s disease and evaluation of putative therapeutic interventions.
My multi-disciplinary laboratory is equipped with: computer-controlled operant chambers for mice and rats (including standard operant chambers, 9-hole boxes and fear conditioning chambers); access to three state-of-the-art watermaze testing facilities and standard maze testing environments, two histology and immunohistochemistry facilities, two surgical facilities (each with 4 work stations); in vivo field recording and unit recording facilities; histology microscopes, PCR and ELISA facilities.
Available PhD Projects
- Investigating the effects of exercise on cognitive impairments and pathology in amyloid and tau mouse models of dementia.
- Investigating the effects of tau mutations on neural network activity during memory formation and retrieval.
- Investigating the effects of antibodies against the amyloid precursor protein pathology on cognition and pathology in APP transgenic mice.
- Synaptic plasticity and the formation of configural memory in rodents.
- Lelos MJ, Good MA. (2012) c-Fos expression reveals aberrant neural network activity during cued fear conditioning in APPswe transgenic mice. Neurobiol Learn Mem., in press
- Thomas RS, Lelos MJ, Good MA, Kidd EJ. (2011) Clathrin-mediated endocytic proteins are upregulated in the cortex of the Tg2576 mouse model of Alzheimer's disease-like amyloid pathology. Biochem Biophys Res Commun. 415(4):656-61.
- Falinska, A.M; Bascoul-Colombo, C.; Guschina, I.A., Good, M. and Harwood, J.L. (2011) The role of n-3 dietary polyunsaturated fatty acids in brain function and ameliorating Alzheimer's disease: opportunities for biotechnology in the development of nutraceuticals New Biotechnology, in press.
- Poirier, G.L, Amin E, Good MA, Aggleton JP. (2011) Early-onset dysfunction of retrosplenial cortex precedes overt amyloid plaque formation in Tg2576 mice. Neuroscience, 174:71-83.
Iordanova, M.D., Good, M.A., & Honey, R.C. (2011) Retrieval-mediated learning involving episodes requires synaptic plasticity in the hippocampus. Journal of Neuroscience, 31(19), 7156-62.
- Iordanova MD,Burnett, D.J., Good MA, Honey RC. (2011) Pattern memory involves both elemental and configural processes:Evidence from the effects of hippocampal lesions. Behavioral Neuroscience, 125(4), 567-77,
Lelos, M, Thomas, R, Kidd, E. & Good, MA. (2011) Outcome-specific satiety reveals a deficit in context-outcome, but not stimulus- or action-outcome, associations in aged Tg2576 mice. Behavioral Neuroscience, 125(3), 412-25
- Reichelt, A.C., Lin, T.E., Harrison, J.J., Honey, R.C. & Good, M.A. (2011) Differential role of the hippocampus in response-outcome and context-outcome learning: Evidence from selective satiation procedures. Neurobiology of Learning & Memory, 96(2), 248-53.
- Dachtler, J, Fox, K & Good MA (2011) Gender specific requirement of GluR1 receptors in contextual conditioning but not spatial learning. Neurobiology of Learning & Memory, 96(3), 461-7
- Palmer, A & Good, M.A (2011) Hippocampal synaptic activity, pattern separation and episodic-like memory: Implications for mouse models of Alzheimer’s pathology. Biochemical Society Transactions, 39(4), 902-9
- Thomas RS, Lelos MJ, Good MA, Kidd EJ. (2011) Clathrin-mediated endocytic proteins are upregulated in the cortex of the Tg2576 mouse model of Alzheimer's disease-like amyloid pathology. Biochem Biophys Res Commun., 415(4), 656-61.
Honey R.C , Iordanova, M, Good, M (2010) Latent inhibition and habituation: evaluation of an associative analysis. In Latent Inhibition: Cognition, Neuroscience and Applications to Schizophrenia, Ed. Lubow R & Weiner I Cambridge University Press.
- Sanderson DJ, McHugh SB, Good MA, Sprengel R, Seeburg PH, Rawlins JN, Bannerman DM. (2010) Spatial working memory deficits in GluA1 AMPA receptor subunit knockout mice reflect impaired short-term habituation: Evidence for Wagner's dual-process memory model. Neuropsychologia, 48(8) 2303-2315.