Prof. Nick Craddock
Based at the Mood Disorders Group, School of Medicine
Research Keywords
Bipolar disorder, depression, psychosis, schizophrenia, molecular genetics, genetic epidemiology
Research Interests and Facilities
Professor Craddock’s research focus is the molecular genetic investigation of mood and psychotic disorders with an emphasis on using findings to inform understanding of psychopathology and diagnosis. He has a particular interest in post-natal triggering of episodes of illness. Related interests include molecular genetic investigation of other major neuropsychiatric disorders and Darier’s disease and theoretical developments in genetic epidemiology.
Professor Craddock leads the bipolar disorder component of the landmark Wellcome Trust Case Control Consortium (WTCCC) genome-wide association study of common diseases (2000 cases, 3000 controls, 500,000 SNPs). Through WTCCC, his Wellcome Trust programme grant and several international collaborations, his team has unparallelled access to clinical samples and laboratory and statistical resources for follow up and characterization of susceptibility genes involved in mood disorders and psychoses.
Available PhD Projects
- Genetic dissection of the mood-psychosis spectrum.
- Susceptibility gene identification using phenotype refinement.
Publications
- Grozeva D, Kirov G, Ivanov D, Jones IR, Jones L, Green EK, St Clair DM, Young AH, Ferrier N, Farmer AE, McGuffin P, Holmans PA, Owen MJ, O'Donovan MC, Craddock N; Wellcome Trust Case Control Consortium. Rare copy number variants: a point of rarity in genetic risk for bipolar disorder and schizophrenia. Arch Gen Psychiatry. 2010 Apr;67(4):318-27. PubMed PMID: 20368508.
- Craddock N, Jones L, Jones IR, Kirov G, Green EK, Grozeva D, Moskvina V, Nikolov I, Hamshere ML, Vukcevic D, Caesar S, Gordon-Smith K, Fraser C, Russell E, Norton N, Breen G, St Clair D, Collier DA, Young AH, Ferrier IN, Farmer A, McGuffin P, Holmans PA; Wellcome Trust Case Control Consortium (WTCCC), Donnelly P, Owen MJ, O'Donovan MC. Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype. Mol Psychiatry. 2010 Feb;15(2):146-53.
- Wellcome Trust Case Control Consortium Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007 Jun 7;447(7145):661-78.
- Williams NM, Green E, Macgregor S, Dwyer S, Norton N, Williams H, Raybould R, Grozeva D, Hamshere M, Zammit S, Jones L, Cardno A, Kirov G, Jones I, O’Donovan M, Owen MJ, Craddock N.(2006) Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder. Arch Gen Psychiatry 63: 366-373