Vincenzo Crunelli

Based at the Neuroscience Group, School of Biosciences

Research interests

Well-characterised EEG oscillations and rhythms are key to a healthy physiological state and their pathological alterations are associated with many neurological syndromes. 

I am interested in the cellular and network mechanisms that underlie some of the brain oscillations that are generated in the thalamus and cortex during sleep and in absence epilepsy. Recently, we also developed an interest in the mechanisms involved in oscillations linked to astrocyte-neuron signalling.

Facilities

My multi-disciplinary laboratory is equipped with:

  • six electrophysiological stations (three for patch- and three for sharp-electrode recordings)
  • one confocal microscope with in vitro patch-electrode recording facilities
  • one 2-photon laser scanning microscope with in vivo and in vitro patch- and sharp-electrode recording facilities
  • a dedicated suite for in vivo electrical recordings and localised drug application in freely moving animals
  • a dedicated cluster of 11 dual-processor nodes for computer simulations
  • facilities for post-hoc morphological and immunocytochemical analysis of neurons and astrocytes.

Available PhD projects

  1. Electrophysiological and Ca2+ imaging analysis of dendritic signalling during the UP state of the slow sleep oscillation
  2. Role of the slow sleep oscillation in synaptic strengthening and memory consolidation
  3. Network dynamics in the cortical initiation site of absence seizures in monogenic and polygenic models of absence epilepsy
  4. Role of astrocyte-neuron signalling in different sleep stages

Research keywords

Brain oscillations, sleep, absence epilepsy, astrocyte-neuron signalling