One of the most remarkable features of the brain is its plasticity and adaptability. Such plasticity is seen through development, but also in the adult brain in processes such as learning and memory.

Abnormalities in the pathways underlying plasticity in the brain are increasingly recognised to increase vulnerability for psychiatric disorders such as schizophrenia, bipolar disorder and autism. Deficits in learning and memory are also central to dementia and related disorders of old age.

Within the Research Institute we are interested in both the basic molecular and the physiological processes underlying learning, prediction and plasticity in the brain, and in their relevance to the understanding and treatment of neuropsychiatric disorders. We address these issues using studies which span from cellular approaches to human brain imaging studies in patients.