Biological and Organic Chemistry Research Group
Research in biological and organic chemistry covers a diverse range of themes including enzyme catalysis, manipulating biomolecular interactions, biomolecular nmr spectroscopy, organic synthesis and medicinal chemistry, organic materials chemistry, physical organic chemistry and theoretical organic chemistry.
Research in this area has the goals of probing enzymatic reaction mechanisms, elucidating the role of protein dynamics and quantum mechanical effects in catalysis, and tailoring substrate selectivity for synthetic chemistry purposes.
Current projects include:
- the enzymology of terpenoid biosynthesis and synthetic biology approaches for expansion of the pool of these secondary metabolites to include novel terpenoid-like compounds with applications as drugs and crop protection agents
- investigation of the role of protein motions and hydride tunnelling in enzyme catalysis, using dihydrofolate reductase as a model system
- development of inhibitors of the enzyme calpain-1, a potential target for anti-inflammatory therapy in diseases such as rheumatoid arthritis.
Manipulating biomolecular interactions
Our research aims to control interactions between biomolecules by inducing conformational switching using small molecules or light.
Current projects include:
- photonic control of protein-protein interactions to regulate the apoptotic pathway in cells
- chemical and enzymatic synthesis of flavins and their analogues and application of these cofactors in protein photoswitches
- controlling interactions of RNA molecules in cells using peptides and nucleic acid analogues
- investigation of the immunogenic properties of cyclic peptides with potential applications in anti-cancer vaccines.
Biomolecular NMR spectroscopy
This work investigates the relationship between the structure, dynamics and function of enzymes, with emphasis on how binding partners (small molecules, nucleic acids or other proteins) affect a protein's dynamics and how a protein affects its binding partners.
This work is performed using our flagship 600 MHz Bruker NMR spectrometer equipped with a quadruple resonance QCI cryoprobe, as well as national high-field NMR facilities. Current projects involve dihydrofolate reductase and phototropin domains.
Organic synthesis and medicinal chemistry
Much attention within the section is focused on the synthesis of natural and non-natural compounds with important biological properties. Target compounds include alkaloids and terpenoids, with a range of methodologies – particularly hypervalent iodine chemistry, electrophile-driven cyclisation, multicomponent coupling and desymmetrisation – being developed and applied.
New efficient technologies for chemical synthesis such as flow chemistry and green chemistry are also active areas. Medicinal chemistry, particularly calpain-1 inhibition and production of artemisinin analogues for treatment of inflammatory diseases and malaria respectively, is a strong theme.
Organic materials chemistry
Research is centred on the preparation, characterisation and application of new microporous organic polymers. Among a wide range of exciting new applications, these are currently generating promise for their potential in adsorption and separation technologies.
Physical organic chemistry
We work on the rational development of functional chemical systems through quantitative understanding of processes. This typically involves the synthesis of designed molecules and subsequent testing of their physical properties.
- design and synthesis of compounds for artificial photosynthesis
- quantification of configurational stability of chiral drug-like molecules
- optoelectronically active DNA-binding molecules and nanoparticle-based systems for use in biosensors and directed assembly
- mechanistic studies of palladium-catalysed coupling reactions.
Theoretical organic chemistry
Modern ab initio and DFT methods, along with atomistic and coarse-grained forcefields, are used to model the structure, properties, reactivity and recognition of organic, inorganic and biological molecules.
Recent highlights include elucidation of the mechanism of iminium ion catalysis, development of methods for accurate description of non-covalent interactions and their application to biological and drug molecules, modelling of shape and dynamics of polymers for drug delivery and the description of unusual electronic states in inorganic species. Investigation into the origin of non-statistical reaction dynamics caused by the breakdown of traditional kinetic models such as Transition State Theory, and application of such fundamental knowledge to the design of molecular systems for harvesting of solar energy into fuels.
Professor of Organic Chemistry
- +44 (0)29 2087 6968
Head of School and Distinguished Research Professor
- +44 (0)29 2087 9014
Lecturer in Synthetic Organic Chemistry
- +44 (0)29 2087 5571
Lecturer in Physical Organic Chemistry
- +44 (0)29 2087 0301
Professor of Organic Chemistry/Director of the Physical Organic Chemistry Centre
- +44 (0)29 2087 5844
Senior Lecturer in Organic Chemistry
- +44 (0)29 2087 4686
Lecturer in NMR Spectroscopy
- +44 (0)29 2087 4029
Research Fellow in Chemical Biology
- +44 (0)29 2087 4068
Reader in Computational Chemistry
- +44 (0)29 2087 4950
Lecturer in Chemical Biology
- +44 (0)29 2087 6273
Professor of Chemical Biology
- +44 (0)29 2087 6364