Themes

There are currently ten research teams within the European Cancer Stem Cell Research Institute, each working on a variety of themes, all with a common goal - to bring the aim of creating personalised treatments for cancer patients closer to reality. These themes explain the latest research taking place in our lab, ranging from cancer stem cell research in pancreatic cancer to understanding the link between diet and cancer.

Studying the relationship between stem cells and neoplasia

Professor Clarke’s main interest is in the molecular basis of cancer, particularly in the very early stages when cells initially diverge from normality.

Stem cells and breast cancer heterogeneity

Understanding the origins of breast cancers, and the biological basis of the differences between them, could open up new avenues in both treatment and prevention.

Targeting the causes of metastatic disease

The Clarkson lab is identifying strategies to prevent malignant disease progression.

Haematopoietic stem cells and cancer stem cells in leukaemia

We are identifying the transcriptional and post-transcriptional mechanisms regulating haematopoietic stem and progenitor cells and their dysregulation in the context of the pre-malignant blood disorder, myelodysplasia, and in acute myeloid leukaemia.

Neutral competition during intestinal homeostasis and repair

Dr Joaquín de Navascués is interested in how cells make fate decisions.

Maternal regulation of reprogramming and stem cells

Uncovering the mechanistic similarity between early embryonic development and cancerous cell initiation may help develop a new strategy to treat cancers.

Modelling heterotypic cell-cell interactions in early pancreatic cancer

We are investigating how transformed cells expand to form precursor lesions within an environment of tightly regulated growth control and homeostasis.

Understanding the interactions that link diet to cancer

This research focusses on understanding the common mechanisms which link the environment to intestinal disease.

Skin cancer stem cells

We are exploring the origin and evolution of cancer stem cells in primary and metastatic skin cancers and their role in disease recurrences.

Mechanisms of glioblastoma recurrence

Dr Florian Siebzhenrubl researches glioblastoma recurrence